PI3K
Los inhibidores de PI3K son compuestos que bloquean la actividad de las fosfoinosítido 3-quinasas (PI3Ks), una familia de enzimas involucradas en una amplia gama de procesos celulares, incluidos el crecimiento, la proliferación, la supervivencia y el metabolismo. La vía PI3K/Akt/mTOR a menudo está desregulada en el cáncer, lo que convierte a PI3K en un objetivo clave para la terapia contra el cáncer. Los inhibidores de PI3K son herramientas fundamentales para estudiar la transducción de señales, la biología del cáncer y el desarrollo de terapias dirigidas. En CymitQuimica, ofrecemos una variedad de inhibidores de PI3K para apoyar su investigación en señalización celular, oncología y desarrollo terapéutico.
Se han encontrado 238 productos de "PI3K"
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Flupentixol dihydrochloride
CAS:<p>Flupentixol dihydrochloride is used in therapy of schizophrenia as well as in anxiolytic and depressive disorders.</p>Fórmula:C23H27Cl2F3N2OSPureza:98.76% - >99.99%Forma y color:White Or Off-White SolidPeso molecular:507.43VS-5584
CAS:<p>VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.</p>Fórmula:C17H22N8OPureza:97.82% - 99.54%Forma y color:SolidPeso molecular:354.41ETP-46321
CAS:ETP-46321 is an effective and orally bioavailable PI3Kα/PI3Kδ inhibitor (Ki: 2.3/14.2 nM).Fórmula:C20H27N9O3SPureza:99.8%Forma y color:SolidPeso molecular:473.55Autophinib
CAS:Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay andFórmula:C14H11ClN6O3Pureza:99.25% - 99.41%Forma y color:SolidPeso molecular:346.73Taselisib
CAS:Taselisib (GDC-0032) is an oral PI3K alpha inhibitor with potential cancer-treating properties.Fórmula:C24H28N8O2Pureza:99.62% - 99.79%Forma y color:SolidPeso molecular:460.53IITZ-01
CAS:<p>IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity ( IC50 of 2.62 μM for PI3Kγ.)</p>Fórmula:C26H23FN8OPureza:99.31%Forma y color:SolidPeso molecular:482.51Lupiwighteone
CAS:Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.Fórmula:C20H18O5Pureza:98.92%Forma y color:SolidPeso molecular:338.35Leniolisib
CAS:<p>Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).</p>Fórmula:C21H25F3N6O2Pureza:99.88%Forma y color:SolidPeso molecular:450.46Arnicolide D
CAS:<p>Arnicolide D is a sesquiterpene lactone.</p>Fórmula:C19H24O5Pureza:96.66%Forma y color:SolidPeso molecular:332.39BGT226
CAS:BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.Fórmula:C28H25F3N6O2Pureza:95.74% - 99.78%Forma y color:SolidPeso molecular:534.53NIH-12848
CAS:<p>NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.</p>Fórmula:C20H14F3N3SPureza:99.84% - 99.9%Forma y color:SolidPeso molecular:385.41GNE-493
CAS:<p>GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for</p>Fórmula:C17H20N6O2SPureza:98%Forma y color:SolidPeso molecular:372.44Rigosertib sodium
CAS:<p>Rigosertib sodium (ON-01910), a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.</p>Fórmula:C21H24NNaO8SPureza:98% - 99.37%Forma y color:SolidPeso molecular:473.47SKI V
CAS:<p>SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM),</p>Fórmula:C15H10O4Pureza:98.78%Forma y color:SolidPeso molecular:254.24(+)-Nortrachelogenin
CAS:<p>(+)-Nortrachelogenin is a lignan isolated from Wikstroemia indica C.A. Meyer (Thymelaeaceae). (+)-Nortrachelogenin possesses antileukemic activity.</p>Fórmula:C20H22O7Pureza:99.88%Forma y color:SolidPeso molecular:374.38Samotolisib
CAS:<p>Samotolisib (LY3023414) inhibits PI3K, DNA-PK, mTOR; tested for solid tumors including breast and colon cancer.</p>Fórmula:C23H26N4O3Pureza:98.41% - 99.69%Forma y color:SolidPeso molecular:406.48Heterophyllin B
CAS:<p>Heterophyllin B hinders esophageal cancer cell adhesion/invasion via PI3K/AKT/β-catenin and gene regulation.</p>Fórmula:C40H58N8O8Pureza:99.12% - 99.85%Forma y color:SolidPeso molecular:778.94AMG319
CAS:AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.Fórmula:C21H16FN7Pureza:98.9% - 99.24%Forma y color:Crystalline SolidPeso molecular:385.4P7C3-A20
CAS:P7C3-A20 is a derivative of P7C3 that has proneurogenic and neuroprotective activity.Fórmula:C22H19Br2FN2OPureza:96.83% - ≥98%Forma y color:SolidPeso molecular:506.21Voxtalisib
CAS:Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.Fórmula:C13H14N6OPureza:98.21% - 99.69%Forma y color:SolidPeso molecular:270.29
