PI3K
Los inhibidores de PI3K son compuestos que bloquean la actividad de las fosfoinosítido 3-quinasas (PI3Ks), una familia de enzimas involucradas en una amplia gama de procesos celulares, incluidos el crecimiento, la proliferación, la supervivencia y el metabolismo. La vía PI3K/Akt/mTOR a menudo está desregulada en el cáncer, lo que convierte a PI3K en un objetivo clave para la terapia contra el cáncer. Los inhibidores de PI3K son herramientas fundamentales para estudiar la transducción de señales, la biología del cáncer y el desarrollo de terapias dirigidas. En CymitQuimica, ofrecemos una variedad de inhibidores de PI3K para apoyar su investigación en señalización celular, oncología y desarrollo terapéutico.
Se han encontrado 231 productos de "PI3K"
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Samotolisib
CAS:Samotolisib (LY3023414) inhibits PI3K, DNA-PK, mTOR; tested for solid tumors including breast and colon cancer.Fórmula:C23H26N4O3Pureza:98.41% - 99.69%Forma y color:SolidPeso molecular:406.48Heterophyllin B
CAS:Heterophyllin B hinders esophageal cancer cell adhesion/invasion via PI3K/AKT/β-catenin and gene regulation.Fórmula:C40H58N8O8Pureza:99.12% - 99.85%Forma y color:SolidPeso molecular:778.94AMG319
CAS:AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.Fórmula:C21H16FN7Pureza:98.9% - 99.24%Forma y color:Crystalline SolidPeso molecular:385.4P7C3-A20
CAS:P7C3-A20 is a derivative of P7C3 that has proneurogenic and neuroprotective activity.Fórmula:C22H19Br2FN2OPureza:96.83% - ≥98%Forma y color:SolidPeso molecular:506.21Voxtalisib
CAS:Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.Fórmula:C13H14N6OPureza:98.21% - 99.69%Forma y color:SolidPeso molecular:270.29Ref: TM-T7014
1mg35,00€2mg50,00€5mg74,00€10mg117,00€25mg226,00€50mg364,00€100mg532,00€1mL*10mM (DMSO)74,00€Umbralisib
CAS:Umbralisib (TGR 1202) is a PI3Kδ inhibitor.Fórmula:C31H24F3N5O3Pureza:99.56% - 99.56%Forma y color:White SolidPeso molecular:571.55Ref: TM-T4976
1mg46,00€2mg62,00€5mg90,00€10mg166,00€25mg324,00€50mg425,00€100mg623,00€1mL*10mM (DMSO)114,00€AZD-8835
CAS:AZD-8835 is a mixed inhibitor of PI3Kα/δ (IC50: 6.2/5.7 nM), also with selectivity against PI3Kβ/γ (IC50: 431/90 nM).Fórmula:C22H31N9O3Pureza:98.22% - 99.88%Forma y color:SolidPeso molecular:469.54AS-604850
CAS:AS-604850: ATP-competitive PI3Kγ inhibitor, IC50 250 nM, 18x > PI3Kα, 80x > PI3Kδ/β.Fórmula:C11H5F2NO4SPureza:99.65%Forma y color:SolidPeso molecular:285.22PIK-93
CAS:PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.Fórmula:C14H16ClN3O4S2Pureza:97.72%Forma y color:SolidPeso molecular:389.88Ref: TM-T2616
1mg42,00€5mg85,00€10mg105,00€25mg200,00€50mg305,00€100mg427,00€200mg613,00€1mL*10mM (DMSO)94,00€CH5132799
CAS:CH5132799 has been used in trials studying the treatment of Solid Tumors.Fórmula:C15H19N7O3SPureza:99.41% - 99.87%Forma y color:SolidPeso molecular:377.42Ref: TM-T2619
1mg60,00€2mg92,00€5mg137,00€10mg215,00€25mg399,00€50mg590,00€100mg838,00€500mg1.693,00€Seletalisib
CAS:Seletalisib (UCB5857) (UCB5857) is a potent and specific PI3Kδ inhibitor (IC50: 12 nM).Fórmula:C23H14ClF3N6OPureza:99.81%Forma y color:SolidPeso molecular:482.85Ref: TM-TQ0044
1mg54,00€2mg77,00€5mg114,00€10mg178,00€25mg313,00€50mg447,00€100mg625,00€1mL*10mM (DMSO)119,00€α-Linolenic acid
CAS:α-Linolenic Acid (ALA) is an essential fatty acid. α-Linolenic acid improves memory, inhibits thrombosis, and lowers blood lipids. Cost-effective and quality-assured.Fórmula:C18H30O2Pureza:97.05% - 99.81%Forma y color:Physical Description Clear Colorless Liquid (Ntp 1992)Peso molecular:278.43GSK2636771
CAS:GSK2636771, an effective, specific, orally bioavailable, PI3Kβ inhibitor, has been used in cancer, lymphoma, solid neoplasm, recurrent solid neoplasm, and
Fórmula:C22H22F3N3O3Pureza:98.58% - ≥95%Forma y color:SolidPeso molecular:433.42Vps34-IN-1
CAS:Vps34-IN-1: potent, selective Vps34 inhibitor, 25 nM IC50, spares class I/II PI3Ks.Fórmula:C21H24ClN7OPureza:97.04%Forma y color:SolidPeso molecular:425.91Ref: TM-T7015
1mg43,00€2mg56,00€5mg88,00€10mg124,00€25mg207,00€50mg333,00€100mg477,00€1mL*10mM (DMSO)96,00€SAR405
CAS:SAR-405 inhibits PIK3C3/Vps34 (IC50: 1.2 nM, Kd: 1.5 nM), blocks autophagy, and enhances MTOR inhibitor effects on cancer cells.Fórmula:C19H21ClF3N5O2Pureza:99.42% - 99.99%Forma y color:SolidPeso molecular:443.85Ref: TM-T12831L
1mg56,00€5mg108,00€10mg167,00€25mg269,00€50mg399,00€100mg590,00€1mL*10mM (DMSO)105,00€PIK-90
CAS:PIK-90, a DNA-PK and PI3K inhibitor, suppresses p110α( IC50=11 nM), p110γ(IC50=18 nM) and DNA-PK(IC50=13 nM) .
Fórmula:C18H17N5O3Pureza:98.25% - ≥95%Forma y color:SolidPeso molecular:351.36A66
CAS:A66 is a specific and effective p110α inhibitor(IC50=32 nM).Fórmula:C17H23N5O2S2Pureza:99.51% - ≥95%Forma y color:SolidPeso molecular:393.53Ref: TM-T2418
2mg34,00€5mg52,00€10mg79,00€25mg137,00€50mg234,00€100mg344,00€200mg485,00€1mL*10mM (DMSO)52,00€Linperlisib
CAS:Linperlisib (PI3Kδ-IN-2) is a potent and selective inhibitor of PI3KδFórmula:C28H37FN6O5SPureza:99.01%Forma y color:SolidPeso molecular:588.69Ref: TM-T6330
1mg34,00€2mg46,00€5mg66,00€10mg90,00€25mg192,00€50mg295,00€100mg462,00€1mL*10mM (DMSO)87,00€Vps34-IN-4
CAS:VPS34 inhibitor 1 (Compound 19, PIK-III analogue) (PIK-III analogue) is a potent and selective inhibitor of VPS34( IC50 : 15 nM)Fórmula:C21H25N7OPureza:98.6%Forma y color:SolidPeso molecular:391.47Ref: TM-T7944
1mg63,00€5mg137,00€10mg215,00€25mg378,00€50mg537,00€100mg713,00€200mg982,00€1mL*10mM (DMSO)150,00€740 Y-P
CAS:740 Y-P (740YPDGFR) is a PI3K activator with cell permeability,binds GST fusion proteins containing the N-and C-terminal SH2 domains of p85. Low-Cost!Fórmula:C141H222N43O39PS3Pureza:98.3% - 99.87%Forma y color:SolidPeso molecular:3270.7
