PI3K
Los inhibidores de PI3K son compuestos que bloquean la actividad de las fosfoinosítido 3-quinasas (PI3Ks), una familia de enzimas involucradas en una amplia gama de procesos celulares, incluidos el crecimiento, la proliferación, la supervivencia y el metabolismo. La vía PI3K/Akt/mTOR a menudo está desregulada en el cáncer, lo que convierte a PI3K en un objetivo clave para la terapia contra el cáncer. Los inhibidores de PI3K son herramientas fundamentales para estudiar la transducción de señales, la biología del cáncer y el desarrollo de terapias dirigidas. En CymitQuimica, ofrecemos una variedad de inhibidores de PI3K para apoyar su investigación en señalización celular, oncología y desarrollo terapéutico.
Se han encontrado 236 productos de "PI3K"
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AZD3458
CAS:AZD3458 is a potent and remarkably selective inhibitor of PI3Kγ (PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ with pIC50s of 9.1, 5.1, <4.5, and 6.5 , respectively).Fórmula:C20H23N3O4S2Forma y color:SolidPeso molecular:433.54PI3K-IN-10
CAS:PI3K-IN-10 is a potent inhibitor of pan-PI3K .Fórmula:C23H19ClN6OPureza:98%Forma y color:SolidPeso molecular:430.89PI3Kα/mTOR-IN-1
CAS:<p>PI3Kα/mTOR-IN-1 is a potent dual inhibitor of PI3Kα/mTOR.</p>Fórmula:C16H18N6OPureza:99.89%Forma y color:SolidPeso molecular:310.35CHMFL-PI3KD-317
CAS:CHMFL-PI3KD-317: potent PI3Kδ inhibitor, IC50=6 nM, orally active, >10x selective vs. PI3K isoforms, anti-cancer.Fórmula:C21H24ClN5O3S2Pureza:99.16%Forma y color:SolidPeso molecular:494.03PI3Kγ inhibitor 1
CAS:PI3Kγ inhibitor 1 is a inhibitor of PI3Kδ and PI3Kγ.Fórmula:C32H26N8O2SPureza:98%Forma y color:SolidPeso molecular:586.67PI3K-IN-38
CAS:PI3K-IN-38: oral PI3K inhibitor, IC50 of 0.541 µM, anticancer, anti-inflammatory, halts tumors in vivo.Fórmula:C20H24N6O2Pureza:99.89%Forma y color:SolidPeso molecular:380.44PI3K-IN-9
CAS:PI3K-IN-9 is a potent and selective inhibitor of PI3Kδ(IC50 of 8.9 nM).Fórmula:C19H23N7OPureza:98%Forma y color:SolidPeso molecular:365.43GS-9901
CAS:GS-9901 is a selective, orally active and potent PI3Kδ inhibitor (IC50: 1 nM) for the study of non-Hodgkin's lymphoma and chronic lymphocytic leukemia.Fórmula:C22H17ClFN9OPureza:98.60% - 99.92%Forma y color:SolidPeso molecular:477.88PQR514
CAS:<p>PQR514: more potent pan-PI3K inhibitor than predecessor PQR309, exhibits strong anticancer activity in vitro and in OVCAR-3 model.</p>Fórmula:C16H20F2N8O2Pureza:98.77% - 99.19%Forma y color:SolidPeso molecular:394.38NVP-BAG956
CAS:NVP-BAG956 is an ATP-competitive PI3K inhibitor (IC50s: 34/56/112/444 nM for PI3Kδ/PI3Kα/PI3Kγ/PI3Kβ).Fórmula:C28H21N5Pureza:99.25% - 99.80%Forma y color:SolidPeso molecular:427.5AZ044
CAS:<p>AZ044 is a potent, selective inhibitor of type III phosphatidylinositol-4-kinase alpha-subtype (PI4KIIIalpha).</p>Fórmula:C24H27N3O3SPureza:99.5%Forma y color:SolidPeso molecular:437.55TGX-115
CAS:TGX-115 inhibits PI 3-K p110β (IC50=0.13μM) & p110δ (IC50=0.63μM), treats various cardiovascular diseases.Fórmula:C20H20N2O3Pureza:99.48%Forma y color:SolidPeso molecular:336.38SRX3207
CAS:SRX3207 is an inhibitor of Syk and PI3K and relieves tumor immunosuppression.Fórmula:C29H29N7O3SPureza:99.85%Forma y color:SolidPeso molecular:555.65MSC2360844
CAS:MSC2360844 is a potent, orally active and selective inhibitor of PI3Kδ(IC50 of 145 nM).Fórmula:C26H27FN4O5SPureza:99.54% - 99.9%Forma y color:SolidPeso molecular:526.58PI3Kδ-IN-17
CAS:<p>PI3Kδ-IN-17 (Compound S5) is a potent PI3K δ inhibitor, exhibiting an IC50 value of 2.82 nM and demonstrates significant efficacy in suppressing the</p>Fórmula:C23H24F3N7O2Pureza:98%Forma y color:SolidPeso molecular:487.48PI3Kγ inhibitor 2
CAS:<p>PI3Kγ inhibitor 2 is an orally bioavailable inhibitor of PI3Kγ(Ki of 4 nM).</p>Fórmula:C20H18F3N5O3Pureza:98%Forma y color:SolidPeso molecular:433.38GNE-490
CAS:GNE-490 is an effective inhibitor of pan-PI3K with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively.Fórmula:C18H22N6O2SPureza:99.77%Forma y color:SolidPeso molecular:386.47PIK-inhibitors
CAS:PIK-inhibitors (MDK34597) is a pan PI3K inhibitors, an analog of PI-103.Fórmula:C19H17N5O2Pureza:96.98%Forma y color:SolidPeso molecular:347.37Ginsenoside Rk1
CAS:Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.Fórmula:C42H70O12Pureza:98.46% - 99.13%Forma y color:SolidPeso molecular:767.00NVP-QAV-572
CAS:NVP-QAV-572 is a inhibitor of PI3K(IC50 of 10 nM).Fórmula:C17H19F2N7O3S2Pureza:98%Forma y color:SolidPeso molecular:471.5CAL-130 Racemate
CAS:CAL-130 Racemate is the racemate of CAL-130. CAL-130 is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).Fórmula:C23H22N8OPureza:98%Forma y color:SolidPeso molecular:426.47PI3Kδ-IN-1
CAS:<p>PI3Kδ-IN-1 is an efficacious PI3Kδ inhibitor (IC50 of 1.7 nM).</p>Fórmula:C22H20F3N7O2Pureza:99.85%Forma y color:SolidPeso molecular:471.44MIPS-21335
CAS:<p>MIPS-21335 is a potent PI3KC2α inhibitor with an IC50 value of 7 nM and additionally exhibits inhibitory activity against PI3KC2β, p110α, p110β, and p110δ with</p>Fórmula:C24H21N7O5Pureza:98%Forma y color:SolidPeso molecular:487.47LAS191954
CAS:<p>LAS191954 is a selective, potent and orally active PI3Kδ inhibitor for inflammatory diseases treatment(IC50 : 2.6 nM).</p>Fórmula:C20H15N9OPureza:98%Forma y color:SolidPeso molecular:397.39SAR-260301
CAS:<p>SAR-260301 is an orally available and selective inhibitor of PI3Kβ (IC50: 23 nM).</p>Fórmula:C19H22N4O3Pureza:99.74%Forma y color:SolidPeso molecular:354.4Zandelisib
CAS:Zandelisib is an inhibitor of phosphatidylinositol 3-kinase (PI3K)(p110δ, IC50 of 3.5 nM), and with antineoplastic activity.Fórmula:C31H38F2N8OPureza:99.88%Forma y color:SolidPeso molecular:576.68GDC-0349
CAS:<p>GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.</p>Fórmula:C24H32N6O3Pureza:96.00% - 98.17%Forma y color:SolidPeso molecular:452.55GSK-F1
CAS:GSK-F1 (PI4KA inhibitor-F1) is a novel potent PI4KA inhibitor.Fórmula:C27H18F5N5O4SPureza:97.03%Forma y color:SolidPeso molecular:603.52PF-04979064
CAS:<p>PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).</p>Fórmula:C24H26N6O3Pureza:98.20% - ≥98%Forma y color:SolidPeso molecular:446.5VVD-699
CAS:<p>VVD-699 is a covalent inhibitor of RAS-PI3K. It forms a covalent bond with cysteine at position 242 within the RAS-binding domain of PI3Kp110α, thereby obstructing the ability of RAS to activate PI3K. VVD-699 is capable of inhibiting the growth of tumors with RAS mutations and HER2 overexpression. It is applicable in research related to RAS mutation-associated cancers, such as those involving H358 lung cancer cells, A549 cells, and FaDu cells.</p>Fórmula:C25H30ClFN2O6S2Forma y color:SolidPeso molecular:573.097PI3Kδ-IN-23
CAS:<p>PI3Kδ-IN-23 (compound A11) is a potent inhibitor of PI3Kδ, with an IC50 of 0.27 nM. It binds to PI3Kδ through covalent interaction with Lys779 and plays a significant role in cancer research.</p>Fórmula:C30H30N6O5Forma y color:SolidPeso molecular:554.596PI3kδ inhibitor 1
CAS:<p>PI3kδ inhibitor 1 is a selective inhibitor of PI3Kδ (IC50 of 3.8 nM).</p>Fórmula:C28H33FN6O2Pureza:98%Forma y color:SolidPeso molecular:504.60UNI418
CAS:<p>UNI418 is a dual inhibitor targeting PIKfyve and PIP5K1C, exhibiting antiviral activity against SARS-CoV-2 (EC50=1.4 μM). It inhibits the endocytosis of the virus mediated by ACE2 by suppressing PIP5K1C (IC50=60.1 nM; Kd=61 nM). Additionally, UNI418 impedes the entry of SARS-CoV-2 into host cells by inhibiting the proteolytic activation regulated by PIKfyve (Kd=0.78 nM).</p>Fórmula:C22H16N6Forma y color:SolidPeso molecular:364.40Sonolisib
CAS:Sonolisib is an irreversible and pan-isoform inhibitor of PI3K (IC50=0.1 nM (p110α), 1.0 nM (p120γ), 2.9 nM (p110δ)).Fórmula:C29H35NO8Pureza:98%Forma y color:SolidPeso molecular:525.59Duvelisib (R enantiomer)
CAS:Duvelisib R enantiomer (IPI-145 R enantiomer) is an enantiomer of Duvelisib with lower activity. Duvelisib is a PI3K inhibitor.Fórmula:C22H17ClN6OPureza:98%Forma y color:SolidPeso molecular:416.86PI3Kδ-IN-13
CAS:<p>PI3Kδ-IN-13 (compound 89), with an IC50 value of 2.6 nM, is an inhibitor of PI3Kδ, applicable for researching diseases involving cell proliferation, including</p>Fórmula:C27H39N7O4S2Forma y color:SolidPeso molecular:589.77
