ATM / ATR
Los inhibidores de ATM (Ataxia Telangiectasia Mutada) y ATR (ATM y Rad3-relacionada) se dirigen a quinasas clave involucradas en la respuesta al daño del ADN (DDR) que se activan en respuesta a rupturas de doble hebra de ADN y estrés replicativo. Estos inhibidores interrumpen la capacidad de estas quinasas para detectar y reparar el daño del ADN, lo que puede llevar a una mayor inestabilidad genómica y muerte celular, particularmente en células cancerosas que dependen de mecanismos robustos de reparación del ADN para sobrevivir. Los inhibidores de ATM/ATR son herramientas cruciales en la investigación y terapia contra el cáncer, especialmente en combinación con agentes que dañan el ADN. En CymitQuimica, ofrecemos una amplia gama de inhibidores de ATM/ATR de alta calidad para apoyar su investigación en la respuesta al daño del ADN, biología del cáncer y desarrollo terapéutico.
Se han encontrado 71 productos de "ATM / ATR"
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Elimusertib hydrochloride(1876467-74-1 free base)
<p>Elimusertib hydrochloride(1876467-74-1 free base) (BAY-1895344 hydrochloride) is a effective, orally available and selective ATR inhibitor with anti-tumor</p>Fórmula:C20H22ClN7OPureza:98.8% - 99.03%Forma y color:SolidPeso molecular:411.89Garcinone C
CAS:<p>Garcinone C, a xanthone from Garcinia oblongifolia, is anti-inflammatory, promotes healing, and may fight some cancers.</p>Fórmula:C23H26O7Pureza:99.13% - 99.92%Forma y color:SolidPeso molecular:414.45FEN1-IN-1
CAS:<p>FEN1-IN-1 (LNT-1), a FEN1 active site inhibitor, partly works by coordinating Mg2+ ions.</p>Fórmula:C15H12N2O5SPureza:99.65% - 99.80%Forma y color:SolidPeso molecular:332.33GJ071 oxalate
CAS:<p>GJ071 oxalate is a Nonsense suppressor that induces readthrough by inserting amino acids at premature termination codons.</p>Fórmula:C20H29N3O7SPureza:99.97%Forma y color:SolidPeso molecular:455.53Berzosertib
CAS:<p>Berzosertib (VE-822) is an ATR inhibitor (Ki<0.2 nM) that also inhibits ATM (Ki=34 nM). Berzosertib has antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C24H25N5O3SPureza:97.34% - >99.99%Forma y color:SolidPeso molecular:463.55Hexapeptide-11
CAS:<p>Hexapeptide-11 is a novel proteostasis network modulator in human diploid fibroblasts.</p>Fórmula:C36H48N6O7Pureza:98%Forma y color:SolidPeso molecular:676.8ATM Inhibitor-8
<p>ATM Inhibitor-8 (Compound 10r) is a potent, selective, and orally active inhibitor of ATM, exhibiting anti-tumor activity [1], characterized by an IC50 value of</p>Fórmula:C26H34N6O2Pureza:98%Forma y color:SolidPeso molecular:462.59ATM Inhibitor-9
<p>ATM Inhibitor-9 (Compd 7a) is a potent inhibitor of ATM kinase, exhibiting an IC50 value of 5 nM, and is utilized in cancer research [1].</p>Fórmula:C25H32N6O2Pureza:98%Forma y color:SolidPeso molecular:448.56CA-M11
CA-M11 (compound CA-M11) is capable of entering the liver's bile salt transport system to release Mirin.Fórmula:C34H46N2O6SForma y color:SolidPeso molecular:610.80Abd110
CAS:<p>Abd110 (compound 42i), a Lenalidomide-based PROTAC ATR kinase degrader, selectively reduces levels of ATR and phospho-ATR while not impacting the related kinases ATM and DNA-PKcs [1].</p>Fórmula:C41H42N8O7SForma y color:SolidPeso molecular:790.89Antitumor agent-28
CAS:<p>Antitumor agent-28 inhibits ATM kinase, blocking ATM disease progression and showing anti-cancer effects.</p>Fórmula:C25H32N6O4SForma y color:SolidPeso molecular:512.63GJ103 sodium salt
CAS:<p>GJ103 sodium salt, a GJ072 analog, lowers surface tension, viscosity, and pH in aqueous solutions, aiding molecular movement.</p>Fórmula:C16H13N4NaO3SPureza:99.70% - 99.91%Forma y color:SolidPeso molecular:364.36Ceralasertib
CAS:<p>Ceralasertib (AZD6738) is an ATR kinase inhibitor (IC50=1 nM) with selective and oral activity. Ceralasertib has antitumor activity. Cost effective and quality assured.</p>Fórmula:C20H24N6O2SPureza:98% - 99.99%Forma y color:SolidPeso molecular:412.51AZD0156
CAS:<p>AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing.</p>Fórmula:C26H31N5O3Pureza:99.13% - 99.87%Forma y color:SolidPeso molecular:461.56CP-466722
CAS:<p>CP-466722, an effective and reversible ATM inhibitor, does not inhibit ATR and PI3K or PIKK family members in cells.</p>Fórmula:C17H15N7O2Pureza:99.1% - 99.14%Forma y color:SolidPeso molecular:349.35KU-55933
CAS:<p>KU-55933 (ATM Kinase Inhibitor) is an ATM inhibitor that is selective and ATP-competitive. KU-55933 has antitumor effects. Cost-effective and quality-assured.</p>Fórmula:C21H17NO3S2Pureza:97.21% - >99.99%Forma y color:SolidPeso molecular:395.49AZ20
CAS:<p>AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR.</p>Fórmula:C21H24N4O3SPureza:98% - 99.69%Forma y color:SolidPeso molecular:412.51NU6027
CAS:<p>NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-</p>Fórmula:C11H17N5O2Pureza:98.36%Forma y color:SolidPeso molecular:251.29PIK-93
CAS:PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.Fórmula:C14H16ClN3O4S2Pureza:97.72%Forma y color:SolidPeso molecular:389.88AZD-7648
CAS:<p>AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.</p>Fórmula:C18H20N8O2Pureza:99.03% - 99.85%Forma y color:SolidPeso molecular:380.4CGK733
CAS:<p>CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR.</p>Fórmula:C23H18Cl3FN4O3SPureza:98% - 99.67%Forma y color:SolidPeso molecular:555.84Adefovir dipivoxil
CAS:<p>Adefovir dipivoxil (GS 0840) is a dipivoxil formulation of adefovir, a nucleoside reverse transcriptase inhibitor analog of adenosine with activity against</p>Fórmula:C20H32N5O8PPureza:98% - 99.80%Forma y color:It Has Broad-Spectrum Antiviral ActivityPeso molecular:501.47KU60019
CAS:<p>Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50: 6.3 nM). It is much less effective or without effect against a panel of 229 other kinases.</p>Fórmula:C30H33N3O5SPureza:95.9% - 99.36%Forma y color:SolidPeso molecular:547.67VE-821
CAS:<p>VE-821 (ATR Inhibitor IV) is a selective ATP competitive inhibitor of ATR( Ki/IC50: 13/26 nM in cell-free assays).</p>Fórmula:C18H16N4O3SPureza:97.19% - 99.97%Forma y color:SolidPeso molecular:368.41AZ32
CAS:<p>AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.</p>Fórmula:C20H16N4OPureza:98.68% - 99.68%Forma y color:SolidPeso molecular:328.37Elimusertib
CAS:<p>Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy in</p>Fórmula:C20H21N7OPureza:98.72% - 99.84%Forma y color:SolidPeso molecular:375.43Dactolisib
CAS:<p>Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).</p>Fórmula:C30H23N5OPureza:97.64% - 99.85%Forma y color:SolidPeso molecular:469.54azd1390
CAS:<p>AZD1390: Potent ATM inhibitor (IC50: 0.78 nM), >10,000-fold selectivity vs. PIKK enzymes.</p>Fórmula:C27H32FN5O2Pureza:97.41% - 99.72%Forma y color:SolidPeso molecular:477.57ETP-46464
CAS:<p>ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).</p>Fórmula:C30H22N4O2Pureza:97.76%Forma y color:SolidPeso molecular:470.52Mirin
CAS:<p>Mirin is a Mre11-Rad50-Nbs1 (MRN) complex inhibitor and also inhibits Mre11-associated exonuclease activity.Mirin induces cell cycle arrest in G1 phase.</p>Fórmula:C10H8N2O2SPureza:99.24%Forma y color:SolidPeso molecular:220.25ART0380
CAS:<p>ART0380 is a potent, antitumor, selective, orally available, ATP-competitive ATR kinase inhibitor for the study of ataxia telangiectasia mutated (ATM) cancer.</p>Fórmula:C18H24N6O2SPureza:99.06% - >99.99%Forma y color:SolidPeso molecular:388.49SKLB-197
CAS:<p>SKLB-197 targets ATR, inhibiting it at 0.013 μM, and is inactive on 402 other kinases, showing potent antitumor effects on ATM-deficient tumors.</p>Fórmula:C25H24N6OForma y color:SolidPeso molecular:424.5ATR-IN-10
CAS:<p>ATR-IN-10 is a potent and highly selective inhibitor of ATR kinase (IC50: 2.978 μM).</p>Fórmula:C27H24N4OForma y color:SolidPeso molecular:420.51Ceralasertib formate
CAS:<p>Ceralasertib: an oral ATR kinase inhibitor that blocks CHK1 phosphorylation, disrupts DNA repair, and triggers tumor cell apoptosis.</p>Fórmula:C21H26N6O4SForma y color:SolidPeso molecular:458.54ATR-IN-15
CAS:<p>ATR-IN-15, an ATR kinase inhibitor, has an IC50 of 8 nM and also targets LoVo cells, DNA-PK, and PI3K with higher IC50 values.</p>Fórmula:C19H22N8OForma y color:SolidPeso molecular:378.43Gartisertib
CAS:<p>Gartisertib (VX-803) is an ATR inhibitor with anti-tumor activity, inhibiting the anti-proliferative effects induced in ccRCC cells.</p>Fórmula:C25H29F2N9O3Pureza:99.52%Forma y color:SolidPeso molecular:541.55ATR-IN-16
CAS:<p>ATR-IN-16 (compound 46) is an ATR kinase inhibitor with potent anticancer effects in LoVo cells, IC50 of 410 nM.</p>Fórmula:C19H25N7OForma y color:SolidPeso molecular:367.45ATR-IN-23
CAS:<p>ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and induces</p>Fórmula:C20H22N6O3S2Pureza:98%Forma y color:SolidPeso molecular:458.56ATR-IN-6
CAS:<p>ATR-IN-6: potent ATR kinase inhibitor for cancer treatment, referenced in patent WO2021233376A1 as compound A22.</p>Fórmula:C28H28FN7O2Forma y color:SolidPeso molecular:513.57ATR-IN-18
CAS:<p>ATR-IN-18: oral ATR inhibitor, IC50 0.69 nM; halts LoVo cell growth, IC50 37.34 nM; anti-tumor.</p>Fórmula:C19H22F3N7O5SForma y color:SolidPeso molecular:517.48ATR-IN-29
CAS:<p>ATR-IN-29, a potent, orally active inhibitor of ATR kinase, exhibits an IC50 of 1 nM and demonstrates antiproliferative activity [1].</p>Fórmula:C19H22N8OPureza:98%Forma y color:SolidPeso molecular:378.43ATR-IN-13
CAS:<p>ATR-IN-13 is a potent inhibitor of ATR kinases (IC50: 2 nM) and can be used to study ATR kinase-mediated diseases (e.g. proliferative diseases, cancer).</p>Fórmula:C24H24FN9OForma y color:SolidPeso molecular:473.51AZ 5704
CAS:<p>ATM kinase inhibitor with 0.6 nM IC50, >600-fold selective, enhances irinotecan effects, oral use.</p>Fórmula:C23H23FN6O2Forma y color:SolidPeso molecular:434.47ATR-IN-8
CAS:<p>ATR-IN-8 is a potent inhibitor of ATR. ATR-IN-8 has shown potential research value in cancer diseases.</p>Fórmula:C20H22N6O2SForma y color:SolidPeso molecular:410.49ATR-IN-22
CAS:<p>ATR-IN-22 (Compound 34), an orally active ATR inhibitor, exhibits potent anti-proliferative effects on MIAPaCa-2 cells with an IC50 value of less than 1 μM and</p>Fórmula:C25H31N7OPureza:98%Forma y color:SolidPeso molecular:445.56ATR-IN-20
<p>ATR-IN-20: potent ATR inhibitor, IC50=3nM; inhibits mTOR, IC50=18nM; selective vs PI3Kα, ATM, DNA-PK; good pharmacokinetics; anticancer.</p>Fórmula:C29H31N5O4SForma y color:SolidPeso molecular:545.65ATR-IN-5
CAS:<p>ATR-IN-5 is a potent inhibitor of ATR, a member of the PIKK family of proteins involved in genome stability and DNA damage repair.</p>Fórmula:C27H32F3N9OForma y color:SolidPeso molecular:555.6(S)-Ceralasertib
CAS:<p>(S)-Ceralasertib: Potent, selective ATR inhibitor with strong preclinical physicochemical and PK profiles.</p>Fórmula:C20H24N6O2SForma y color:SolidPeso molecular:412.51ATR-IN-21
CAS:<p>ATR-IN-21, also known as compound 60, is a potent inhibitor of ATR, exhibiting an IC50 of less than 1000 nM [1].</p>Fórmula:C23H27N7OPureza:98%Forma y color:SolidPeso molecular:417.51ATM-IN-1
CAS:<p>ATM-IN-1 is a potent inhibitor of ATM. ATM-IN-1 has shown research potential in cancer and neurological diseases.</p>Fórmula:C30H36N6O3Forma y color:SolidPeso molecular:528.65Camonsertib
CAS:<p>Camonsertib (RP-3500) is a novel, potent and selective ATR kinase inhibitor (ATRi) that exhibits potent antitumor effects with an IC50: 1.00 nM in biochemical assays.Cost-effective and quality-assured.</p>Fórmula:C21H26N6O3Pureza:99.6% - 99.93%Forma y color:SolidPeso molecular:410.47AZ31
CAS:<p>AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM,</p>Fórmula:C24H28N4O3Pureza:98.01%Forma y color:SolidPeso molecular:420.5Lartesertib
CAS:<p>Lartesertib (ATM Inhibitor-5) is an inhibitor of the serine/threonine protein kinase ATM with potential anticancer activity and can be used to study lung cancer</p>Fórmula:C23H21FN6O3Pureza:99.9%Forma y color:SolidPeso molecular:448.45ATR-IN-17
CAS:<p>ATR-IN-17 is a potent inhibitor of ATR kinase with good anti-cancer effects in LoVo cells (IC50: 1 nM).</p>Fórmula:C22H28N6O2SForma y color:SolidPeso molecular:440.56ATM Inhibitor-4
<p>ATM Inhibitor -4: selective, potent (IC50: 0.32 nM), inhibits PI3K family, stable, stops mTOR at 1 μM.</p>Fórmula:C26H29FN6O3Forma y color:SolidPeso molecular:492.55ATM Inhibitor-2
<p>ATM Inhibitor -2 is a potent and selective inhibitor of ATM (IC50<1 nM).</p>Fórmula:C26H31N7O3Forma y color:SolidPeso molecular:489.57ATM Inhibitor-3
<p>ATM Inhibitor-3 selectively inhibits ATM (IC50: 0.71 nM), targets PI3K kinase family, and is metabolically stable.</p>Fórmula:C25H29FN6O3Forma y color:SolidPeso molecular:480.53Decarbamoylmitomycin C
CAS:<p>Decarbamoylmitomycin C, an analog of Mitomycin C (MC), functions as a DNA alkylating agent. It is capable of activating chromatin relaxation by the ataxia-telangiectasia and Rad3-related protein (ATR) in a p53-independent manner.</p>Fórmula:C14H17N3O4Forma y color:SolidPeso molecular:291.302WSD0628
CAS:<p>WSD0628 is a brain-penetrant and potent ATM inhibitor with a significant radiosensitizing effect [1].</p>Fórmula:C23H23F2N5O2Forma y color:SolidPeso molecular:439.46ATM Inhibitor-1
CAS:<p>ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibito (IC50: 0.7 nM) anti-tumor activity.</p>Fórmula:C27H36N6O3Pureza:98%Forma y color:SolidPeso molecular:492.61ATR-IN-14
CAS:<p>ATR-IN-14: potent ATR kinase inhibitor; 98.03% inhibition at 25 nM; IC50 of 64 nM in LoVo cells.</p>Fórmula:C20H20FN7OForma y color:SolidPeso molecular:393.42KU 59403
CAS:<p>KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM for ATM, DNA-PK, and PI3K, respectively).</p>Fórmula:C29H32N4O4S2Pureza:99.10%Forma y color:SolidPeso molecular:564.72ATR kinase-IN-2
CAS:<p>ATRkinase-IN-2 (Compound I-G-27) is an inhibitor of the ATR protein kinase, with a Ki value ranging from 0.01 to 1 μΜ. It is utilized in tumor research.</p>Fórmula:C24H29F2N9O2Forma y color:SolidPeso molecular:513.54ATM Inhibitor-11
CAS:<p>ATMInhibitor-11 (Compound 1) is an inhibitor of ATM with an IC50 of 0.32 nM. It also inhibits KAP1 phosphorylation with an IC50 of 0.97 nM. This compound exhibits high exposure in the brain, heart, and plasma of ICR mice. Furthermore, ATMInhibitor-11 demonstrates antitumor activity in the NCI-H441 xenograft mouse model.</p>Fórmula:C27H33FN6O2Forma y color:SolidPeso molecular:492.59ATR kinase-IN-3
CAS:<p>ATRkinase-IN-3 (Compound I-G-28) is an inhibitor of the ATR protein kinase, exhibiting a Ki value ranging from 0.01 to 1 μM, and is utilized in cancer research.</p>Fórmula:C24H27F2N9O2Forma y color:SolidPeso molecular:511.53ATR-IN-12
<p>ATR-IN-12, a potent ATR kinase inhibitor with IC50 of 0.007 μM, shows promise for drug development.</p>Fórmula:C22H27N5O3SForma y color:SolidPeso molecular:441.55ATR-IN-19
CAS:<p>ATR-IN-19 (Compound 15 R-configure) is an ATR inhibitor [1].</p>Fórmula:C18H19N7OSForma y color:SolidPeso molecular:381.45(S)-WSD0628
CAS:<p>(S)-WSD0628 is the S isomer of WSD0628 and serves as an ATM inhibitor, effectively suppressing ATM phosphorylation in MCF-7 cells with an IC50 of less than 100 nM. This compound also demonstrates radiosensitizing activity and is capable of penetrating the blood-brain barrier.</p>Fórmula:C23H23F2N5O2Forma y color:SolidPeso molecular:439.458ATR-IN-11
<p>ATR-IN-11, a potent ATR kinase inhibitor, shows promise as a lead for DNA damage response-targeted cancer drugs.</p>Fórmula:C25H30N6O2Forma y color:SolidPeso molecular:446.54KU-60019
CAS:<p>KU-60019 is a specific inhibitor of ATM kinase (IC50: 6.3 nM).</p>Fórmula:C30H33N3O5SPureza:98.05% - 98.50%Forma y color:SolidPeso molecular:547.67ATR-IN-24
CAS:<p>ATR-IN-24 (Compound 1) is an ATR inhibitor with demonstrated anticancer activity [1].</p>Fórmula:C23H26N6O2Pureza:98%Forma y color:SolidPeso molecular:418.49Ref: TM-T79058
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