mTOR
Los inhibidores de mTOR son compuestos que inhiben la actividad de la Proteína diana de la rapamicina en mamíferos (mTOR), un regulador central del crecimiento celular, la proliferación, el metabolismo y la supervivencia. La vía de mTOR se altera con frecuencia en el cáncer y otras enfermedades, lo que convierte a mTOR en un objetivo crítico para la intervención terapéutica. Los inhibidores de mTOR se utilizan ampliamente en la investigación relacionada con el cáncer, el envejecimiento y los trastornos metabólicos. En CymitQuimica, ofrecemos una variedad de inhibidores de mTOR para apoyar su investigación en transducción de señales, oncología y desarrollo terapéutico.
Se han encontrado 144 productos de "mTOR"
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JR-AB2-011
CAS:<p>JR-AB2-011: selective mTORC2 inhibitor, IC50 = 0.36μM, blocks Rictor-mTOR, Ki = 0.19μM, cytotoxic in glioblastoma.</p>Fórmula:C17H14Cl2FN3OSPureza:98.33% - 98.33%Forma y color:SolidPeso molecular:398.28PI3K/mTOR Inhibitor-1
CAS:<p>PI3K/mTOR Inhibitor-1 is a potent, orally bioavailable dual inhibitor of PI3K/mTOR (PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ/mTOR with IC50s of 20/376/204/46/186 nM)</p>Fórmula:C18H22FN5O3SPureza:98%Forma y color:SolidPeso molecular:407.46mTOR inhibitor 9b
CAS:<p>mTOR inhibitor 9b is an enzyme inhibitor of protein kinase mTOR he phosphatidylinositol 3-kinase PIK3CA with IC50s of 0.76 nm and 1.262 µM, respectively.mTOR</p>Fórmula:C21H23N5O2SPureza:99.52%Forma y color:SoildPeso molecular:409.5GNE-490
CAS:<p>GNE-490 is an effective inhibitor of pan-PI3K with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively.</p>Fórmula:C18H22N6O2SPureza:99.77%Forma y color:SolidPeso molecular:386.47CC214-1
CAS:<p>CC214-1 is an mTOR inhibitor that inhibits protein translation, induces autophagy, and is an in vitro tool compound for exploring the biology of mTOR kinases.</p>Fórmula:C20H21N7O2Pureza:97.16%Forma y color:SolidPeso molecular:391.43mTOR inhibitor-11
CAS:<p>mTOR inhibitor-11 (Compound 9) is a brain-penetrant compound capable of inhibiting mTOR with an IC50 of 21 nM for pS6.</p>Fórmula:C21H26N6O2Pureza:98%Forma y color:SolidPeso molecular:394.47mTOR inhibitor-3
CAS:<p>mTOR inhibitor-3 is a selective mTOR inhibitor (Ki= 1.5 nM). mTOR inhibitor-3 inhibits mTORC1 and mTORC2 in cellular and in vivo experiments.</p>Fórmula:C25H30N8O2Pureza:99% - 99.64%Forma y color:SolidPeso molecular:474.56MTI-31
CAS:<p>MTI-31 (LXI-15029) is a potent oral mTORC1/2 inhibitor with a Kd of 0.20 nM, >5,000-fold selectivity, and an IC50 of 39 nM.</p>Fórmula:C26H30N6O3Pureza:99.97%Forma y color:SolidPeso molecular:474.55PI3K/mTOR Inhibitor-14
CAS:<p>PI3K/mTOR Inhibitor-14 (compound Y-2) serves as a dual inhibitor of PI3K and mTOR, exhibiting IC50 values of 171.4 nM and 10.1 nM , respectively, and</p>Fórmula:C28H30N8O3SPureza:98%Forma y color:SolidPeso molecular:558.66PI3K/mTOR Inhibitor-12
CAS:<p>PI3K/mTOR Inhibitor-12: oral, potent, selective; IC50: PI3Kα 0.06 nM, mTOR 3.12 nM; strong antitumor; less liver toxicity.</p>Fórmula:C27H27F2N9O4SPureza:98%Forma y color:SolidPeso molecular:611.62WYE-23
CAS:<p>WYE-23 is an inhibitor of mammalian target of rapamycin (mTOR).</p>Fórmula:C26H32N8O4Forma y color:SolidPeso molecular:520.58PI3K/mTOR Inhibitor-5
CAS:<p>PI3K/mTOR Inhibitor-5 is a potent dual inhibitor of PI3K and mTOR, displaying IC50 values of 86.9 nM (for PI3K) and 14.6 nM (for mTOR), respectively.</p>Fórmula:C32H40N10O3Forma y color:SolidPeso molecular:612.73PI3K/mTOR Inhibitor-7
CAS:<p>Potent PI3K/mTOR inhibitor, 4.7x stronger than gedatolisib; IC50: 1.4 μM (PI3K), 0.3 μM (mTOR); impacts PI3K/Akt/mTOR pathway; research in cancer.</p>Fórmula:C29H33N9O4Forma y color:SolidPeso molecular:571.63PI3K/mTOR Inhibitor-6
CAS:<p>Potent, stable PI3K/mTOR Inhibitor-6 surpasses gedatolisib in gastric fluid; 10 μM hinders PI3K/Akt/mTOR pathway, aids cancer research.</p>Fórmula:C30H34N10O4Forma y color:SolidPeso molecular:598.66WYE-132
CAS:<p>WYE-125132: potent mTOR inhibitor, IC50 0.19 nM, selective over PI3Ks/hSMG1/ATR.</p>Fórmula:C27H33N7O4Pureza:99.16%Forma y color:SolidPeso molecular:519.6WAY-600
CAS:<p>WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM; blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308).</p>Fórmula:C28H30N8OPureza:99.88%Forma y color:SolidPeso molecular:494.59Rheb inhibitor NR1
CAS:<p>Rheb inhibitor NR1 is a Rheb inhibitor and selective mTORC1 inhibitor that promotes phosphorylation of S473pAKT.</p>Fórmula:C25H19BrCl2N2O3SPureza:99.72%Forma y color:SolidPeso molecular:578.3GDC-0349
CAS:<p>GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.</p>Fórmula:C24H32N6O3Pureza:96.00% - 98.17%Forma y color:SolidPeso molecular:452.55PF-04979064
CAS:<p>PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).</p>Fórmula:C24H26N6O3Pureza:98.20% - ≥98%Forma y color:SolidPeso molecular:446.5PD-M6
CAS:<p>PD-M6 is an mTOR PROTAC degrader with a DC50 of 4.8 μM, which facilitates the ubiquitination and degradation of mTOR. It inhibits the proliferation of cancer cell lines HeLa, MCF-7, and HepG2 with IC50 values of 11.3, 2.58, and 3.23 μM, respectively, and induces autophagy. Additionally, PD-M6 specifically targets the degradation of the key protein LAMTOR1 in the mTOR signaling pathway.</p>Fórmula:C30H39N9O6Forma y color:SolidPeso molecular:621.69
