Compuestos policíclicos

<p>Applications 9-Oxo-9H-thioxanthene-2-carboxylic acid (cas# 25095-94-7) is a useful research chemical.<br></p>

<p>Applications N’,N’-Dimethylindole-2-carboxamide (cas# 7511-14-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Fluoro-1H-indazole<br></p>

<p>Applications 3,5-Dichloro-4-pyridone-1-acetic acid<br></p>

<p>Applications 4-Chloro-7-(trifluoromethyl)quinoline is a reagent in the preparation of piperazinylquinolines as breast cancer inhibitors.<br>References Solomon, V., et al.: Bioorg. Med. Chem., 18, 1563 (2010);<br></p>

<p>Applications 5,7-Dichloro-3,4-dihydro-2H-isoquinolin-1-one (cas# 885273-81-4) is a useful research chemical.<br></p>

<p>Applications 8-aza-9-boratricyclo[8.4.0.0,2,7]tetradeca-1(14),2,4,6,10,12-hexaen-9-ol (cas# 17012-25-8) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications 2-(1,3-Dioxo-3,4-dihydroisoquinolin-2(1H)-yl)acetic Acid (cas# 52208-61-4) is a useful research chemical.<br></p>

<p>Applications 4-Hydroxymethylbicyclo[2.2.2]octane-1-carboxylic Acid Isopropylamide is a useful synthetic intermediate.<br></p>

<p>Applications 1,8,8-trimethyl-3-azabicyclo[3.2.1]octane hydrochloride is a useful research chemical, a camphidine derivative with multiple synthetic applications.<br>References Rubinstein, K., et al.: Acta Chem. Scand., 17, 2061 (1963); Manzoor-I-Khuda, M., et al.: Pak. J. Sci. Ind. Res., 10, 97 (1967)<br></p>

<p>Applications 3-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)propanoic Acid (cas# 923163-76-2) is a useful research chemical.<br></p>

<p>Applications 6-Chloro-3,4-dihydro-4-hydroxy-3-(phenylsulfonyl)-4-(trifluoromethyl)-2(1H)-quinolinone is an intermediate in the synthesis of novel quinolinones as HIV-1 reverse transcriptase inhibitors.<br>References Patel, M., et al.: Bioorg. Med. Chem. Lett., 11, 1943 (2001);<br></p>

<p>Applications 6-Propylamino-7-deazapurine (cas# 60972-21-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Methyl 4-formylbicyclo[2.2.2]octane-1-carboxylate (cas# 94994-25-9) is a useful research chemical.<br></p>

<p>Applications (1R,6R)-2,8-Diazabicyclo[4.3.0]nonane is a chiral reagent used in the synthesis of pyrrolopyrimidine derivatives as dual DNA gyrase B and topoisomerase IV inhibitors and potential antibacterial agents.<br>References Bioorg. Med. Chem. Lett., 23, 1529 (2013);<br></p>

<p>Applications 2’,3’,5’-Tri-O-benzoyl Xanthine-13C5 is an intermediate used in the synthesis of Xanthosine-13C5 (X742102), which is the labeled analogue of Xanthosine (X742100), the deamination product of Guanosine. It is also a potential biomarker for detecting radiation exposure.<br>References Magasanik, B, et al.: J. Bio. Chem., 206, 83 (1954);<br></p>

<p>Applications 4-Ethyl-2(1H)-quinolinone has been use as a reactant in the preparation of 6-bisalkylamino-2-quinolinones as selective androgen receptor modulators.<br>References Van Oeveren, A., et. al.: Bioorg. Med. Chem. Lett., 17, 1527 (2007)<br></p>

<p>Applications Indoline-2-carboxylic acid is used in the synthesis of D-43787, which is a novel immunomodulating compound; antiasthmatic and immunosuppressant.<br>References Blackham, A., et al.: Clin. Exp. Immunol., 86, 224 (1991), Barnes, P., et al.: Clin. Sci., 1998, 94, 557 (1998), Cohn, L., et al.: Pharmacol. Ther., 88, 187 (2000), Asanuma, F., et al.: Inflamm. Res., 50, 136 (2001), Zenke, G., et al.: J. Immunol., 166, 7165 (2001),<br></p>

<p>Applications 7-Phenoxyquinolin-2(1H)-one is a useful research chemical.<br></p>

<p>Applications (2R,3aR,7aR)-rel-OctahydroIndole-2-carboxylic Acid is a reactant in the preparation of Perindoprilat (P287530), an angiotensin-converting enzyme (ACE) inhibitor. Antihypertensive.<br>References Blankley, C.J., et. al.: J. Med. Chem., 30, 992 (1987)<br></p>

<p>Applications 5,7-Dichloro-4-hydroxyquinoline is an intermediate in synthesizing Quinoxyfen-d4 (Q765502), an isotope labelled Quinoxyfen acts as an agricultural fungicide.<br>References Corrales, M., et al.: Food Chem. Toxicol., 48, 3471 (2010); Lagunas-Allue, L., et al.: Anal. Bioanal. Chem., 398, 1509 (2010); Wong, J., et al.: J. Agric. Food Chem., 58, 5897 (2010)<br></p>

<p>Applications 4,7-difluoro-1H-indole-2-carboxylic acid (cas# 247564-67-6) is a useful research chemical.<br></p>

<p>Applications 2-Chloroquinolin-6-ol can be used for hair dye compositions.<br>References Lagrange, A., et.al., PCT Int. Appl., 87, (2012);<br></p>

<p>Applications 2,3,3-Trimethylindolenine-5-sulfonic Acid, Potassium Salt (cas# 184351-56-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 6-Hydroxyquinoline-(1H)-2-one (cas# 19315-93-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-(prop-2-yn-1-yl)-1,2,3,4-tetrahydroisoquinoline-1,3-dione (cas# 410538-30-6) is a useful research chemical.<br></p>

<p>Applications 5-Amino-2H-isoquinolin-1-one is a reactant used in the synthesis of glucoorticoid receptor agonists as well as PARP inhibitors used in the treatment of tumors.<br>References Berger, M. et al.: Bioorg. Med. Chem. Lett., 27, 437 (2017); Goodfellow, E. et al.: Bioorg. Med. Chem. Lett., 27, 688 (2017);<br></p>

<p>Applications 1-(4-Chlorobutyl)-7-hydroxyquinolin-2(1H)-one is a useful research chemical.<br></p>

<p>Applications 3-Hydroxyquinoline-d6 is labelled 3-Hydroxyquinoline (H953140) which is a chemical reagent used in the preparation cyclic peptides with an antitumor functionality. Quinoline derivative as a result of the metabolism by cytochrome P 450.<br>References Riego, E. et al.: Tetrahedron, 61, 1407 (2005); Kanou, M. et al.: Fund. Clin. Pharmacol., 16, 513 (2002)<br></p>

<p>Applications 4-Bromo-2,8-Bis(Trifluoromethyl)Quinoline (cas# 35853-45-3) is a useful research chemical.<br></p>

<p>Applications 6-Quinolinol is used in the preparation of potential antifungal agents containing a quinoline structure. Also used in the preparation of novel pyridocoumarins.<br>References Galariniotou, E. et al.: Tetrahedron 63, 8298 (2007); Vandekerckhove, S. et al.: Bioorg. Med. Chem. Lett., 23, 4641 (2013);<br></p>

<p>Applications 4-(ethoxymethylidene)-1,2,3,4-tetrahydroisoquinoline-1,3-dione (cas# 18630-93-8) is a useful research chemical.<br></p>

<p>Applications 1,4-Dihydro-7-hydroxy-3(2H)-isoquinolinone, can be involved in the photocyclization of N-(chloroactyl)benzylamines to isoquinoline derivatives.<br>References Ikeda, M., et al.: Tetrahedron Lett., 13, 1181 (1974);<br></p>

<p>Applications 1,1,2-Trimethyl-1H-benzo[e]indole (cas# 41532-84-7) is a useful research chemical.<br></p>

<p>Applications 2-[3-(3,5-Dimethylphenoxy)-2-hydroxypropyl]-1H-isoindole-1,3(2H)-dione is an intermediate used in the synthesis of 1-Amino-3-(3,5-dimethylphenoxy)-2-propanol (A607300), which is a degradation product of Metaxalone (M225850); a muscle relaxant used to relax muscles and relieve pain.<br>References Rao, R.N., et al.: Biomed. Chromatogr., 27, 1733 (2013)<br></p>

<p>Applications Quinoline derivative as antibacterial agents.<br>References O'Neill, P., et al.: Pharmacol. Ther., 77, 29 (1998), Dorn, C., et al.: Bioorg. Med. Chem. Lett., 11, 259 (2001), Scozzafava, A., et al.: Curr. Med. Chem., 10, 925 (2003),<br></p>

<p>Applications 1,4-Dihydro-1-phenyl-3(2H)-isoquinolinone is used as a reagent in the synthesis of a series of 1-aryl-3-dimethylamino-1,4-dihydroisoquinolines which display anti-arthritic activity. Also used as a reagent in the synthesis of 1-aryl-1,4-dihydro-3(2H)-isoquinolinones which have potential antiserotoninergic activity.<br>References Bermudez, J., et al.: Bioorg. Med. Chem. Lett., 3, 2571 (1993); Zara-Kaczian, E., et al.: Acta Chim. Hung., 127, 607 (1990)<br></p>

<p>Applications Used for the preparation of heterocyclic sulfonamide compounds as Edg-1 antagonists useful in the treatment of cancer.<br></p>

<p>Applications α-Furil is an important industrial chemical that is used as a building block for synthesis in the pharmaceutical industry. α-Furil is also part of a group of diketones that act as skin sensitizers.<br>References Roberts, D., et al.: Contact Dermatitis, 41, 14 (1999); Wang, L., et al.: Adv. Mat. Res., 554, 764 (2012)<br></p>

<p>Applications An intermediate in the preparation of Azasetron.<br>References Baker, S., et al.: Bioorg. Med. Chem. Lett., 15, 4727 (2005), Odzak, R., et al.: Bioorg. Chem., 34, 90 (2006), Anand, R., et al.: J. Med. Chem., 52, 1602 (2009),<br></p>

<p>Applications A useful intermediate for the synthesis of pharmaceutical actives, intermediates and fine chemicals.<br>References Pezzuto, J.M., et al.: Biochem., 20, 298 (1981), Takeda, K., et al.: Chem. Pharm. Bull., 29, 1280 (1981),<br></p>

<p>Applications 2-Aminoquinoline-6-carboxylic Acid tert-Butyl ester is a substituted quinoline used in pharmaceuticals for treatment of obesity and related conditions.<br>References Bertinato, P., et al.:PCT Int. Appl. (2005), WO 2005080373 A1 20050901<br></p>

<p>Applications Isotope labelled 6-Bromopurine is a brominated derivative of purine used in various organic syntheses. Used in the synthesis of several benzo-fused scaffolds with purine or pyrimidine moietes which display antitumor and anticancer properties.<br>References Morales, F. et al.: Eur, J. Med. Chem., 76, 118 (2014); Cushing, T. et al.: J. Med. Chem., 58, 480 (2015); Jansen, R., et al.: Clin. Biochem., 38, 362 (2005),<br></p>

<p>Applications Used in the synthesis of 5-chloro-8-mercaptoquinoline and its salts.<br></p>

<p>Applications 3-Azabicyclo[3.3.0]octane Hydrochloride is a reactant in the preparation of substituted pyrimidines derivatives as novel hedgehog signaling pathway inhibitors.<br>References Xin, M. et al.: Med. Chem. Res., 23, 3784 (2014); Xin, M. et al.: Bioorg. Med. Chem. Lett., 24, 983 (2014);<br></p>

<p>Applications 7-Chloro-4-nitroquinoline is used in the synthesis of aminonitropyridine.<br></p>

<p>Applications (3S)-Aminoquinuclidine is an intermediate used in the synthesis of Palonosetron-3-ene Hydrochloride (P165825), which is an impurity of Palonosetron (P165800), a serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.<br>References Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993); Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995); Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003); Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004); Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004)<br></p>

<p>Applications 8-Chloro-5-isoquinolinesulfonic Acid (cas# 1246816-17-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Benzyl-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid (cas# 54329-48-5) is a useful research chemical.<br></p>