Compuestos policíclicos

<p>Applications 6-Bromo-3-cyanoindole<br></p>

<p>Applications 5,7-Dichloro-1,2,3,4-tetrahydro-2-(triphenylmethyl)-6-isoquinolinecarboxylic Acid, can be sued in the preparation of novel series of compounds which has been found to be a potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for treating dry eye.<br>References Zhong, M. et al,: ACS Med. Chem. Let. Vol. 3, page 203-206 (2012);<br></p>

<p>Applications N-(2,6-Dichlorophenyl)isatin can be obtained from 2,6-Dichloroiodobenzene (D434690) which is a reactant in the synthesis of 3-(phenoxy-phenyl-methyl)-pyrrolidines as potent and balanced norepinephrine and serotonin reuptake inhibitors. Also an impurity of Diclofenac (D436465).<br>References Van Orden, L.J., et. al.: Bioorg. Med. Chem. Lett., 23, 1456 (2013)<br></p>

<p>Applications 2-amino-N-(quinolin-8-yl)acetamide (cas# 587832-36-8) is a useful research chemical.<br></p>

<p>Applications 2,5-Dimethyl-2,3-dihydro-1H-indole (cas# 90874-56-9) is a useful research chemical.<br></p>

<p>Applications 5-Fluoro-8-nitroquinoline (cas# 152167-85-6) is a useful research chemical.<br></p>

<p>Applications 5-Aminotricyclo[3.3.1.13,7]decane-1,3-diol is an intermediate used in the synthesis of Hydroxy Vildagliptin (V305035), which is an impurity of Vildagliptin (V305000). Vildagliptin is a DPP-​4 enzyme inhibitor, has anti-oxidant properties and used as an apoptotic agent on pancreatic cancer . Vildagliptin is used to treat type 2 diabetes mellitus (T2DM) and improve the endothelial function of patients.<br>References Amritha, C.A., et al.: J. Clin. Diagn. Res., 9, FC14 (2015); Cosenso-Martin, L.N., et al.: Diabetol. Metab. Syndr., 7, 70/1 (2015)<br></p>

<p>Applications Tricyclohexylchlorotin is used as in the synthesis of organotin derivatives of 2-thiophene carboxylic acid as enzyme inhibitors and antibacterial agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Abbas, S. et al.: J. Organometal. Chem., 724, 255 (2003); Zia-ur-Rehman et al.: J. Coord. Chem., 65, 3238 (2012);<br></p>

<p>Applications tert-​Butyl 5-​(4,​4,​5,​5-​tetramethyl-​1,​3,​2-​dioxaborolan-​2-​yl)​isoindoline-​2-​carboxylate is a reactant in the synthesis of tyrosine kinase inhibitors in the treatment of proliferative diseases.<br>References WO Patent 2014089324 (2014); CN 104016979 (2014);<br></p>

<p>Applications 4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline-1,3-dione (cas# 5488-36-8) is a useful research chemical.<br></p>

<p>Applications 2-[(Dimethylamino)methyl]indole (cas# 3978-16-3) is a compound useful in organic synthesis.<br>References Inion, H., et al.: Eur. J. Med. Chem., 10, 276 (1975),<br></p>

<p>Applications 2-chloro-1-{1H,2H,3H,4H,5H-pyrido[4,3-b]indol-2-yl}ethan-1-one (cas# 1087784-16-4) is a useful research chemical.<br></p>

<p>Applications tert-butyl 7-hydroxy-3,4-dihydroisoquinoline-2(1h)-carboxylate (cas# 188576-49-0) is a useful research chemical.<br></p>

<p>Applications 4,7-Dichloro-2-phenyl-1H-isoindole-1,3(2H)-dione is an intermediate in the synthesis of phthalic compounds, phthalazines, and quinones with antimicrobial activity.<br>References Marriott, G. J., et al.: J. Chem. Soc., 134 (1939); Katayama, H., et al.: Tetrahedron., 63, 6642 (2007);<br></p>

<p>Applications 4,4'-Dicyano-2,2'-bipyridine is a photosensitizers for solar fuel generation<br>References Mills, I. N., et al.: Polyhedron, 82, 104 (2014)<br></p>

<p>Applications 4,4-Dimethyl-1,2,3,4-tetrahydroquinoline<br></p>

<p>Stability Air Sensitive<br>Applications Alpha-Pyridoin (cas# 1141-06-6) is a useful research chemical.<br></p>

<p>Applications 2,3-dihydrobenzo[g]quinolin-4(1H)-one (cas# 21516-07-4) is a useful research chemical.<br></p>

<p>Applications 9,10-Phenanthrenequinone is used in the formation of spirophosphoranes containing acyclic 5-methyl-2-phenyl-2H-1,2,3-diazaphosphol-4-yl substituent.<br>References Mironov, V. F., et al.: Russ. J. Electrochem., 88, 430-438 (2018)<br></p>

<p>Applications 2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline]-1',3'-dione (cas# 31267-07-9) is a useful research chemical.<br></p>

<p>Applications 5-Chloroisoindoline hydrochloride (cas# 912999-79-2) is a useful research chemical.<br></p>

<p>Applications Ethyl 2-Aminoindole-3-carboxylate (cas# 6433-72-3) is a compound useful in organic synthesis.<br></p>

<p>Stability Hygroscopic<br>Applications 2-AMINO-1,2,3,4-TETRAHYDROISOQUINOLINE-1,3-DIONE (cas# 22177-46-4) is a useful research chemical.<br></p>

<p>Applications 6-Fluoroquinoline, is a versatile building block used in the synthesis of various chemical compounds.<br></p>

<p>Applications 2,6-Dichloro-9-nitroso-9H-purine is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Hydroxy-quinoline-6-carboxylic acid<br></p>

<p>Applications N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)acetamide is used in synthesis of an antitumor agent, neratinib (N390090).<br>References Zhang, P., et al.: Zhongguo Yaowu Huaxue Zazhi, 18, 355 (2008);<br></p>

<p>Applications 2,2'-Bipyridine-4,4'-dicarboxamide<br></p>

<p>Applications 6-Fluoroquinolin-2(1H)-one<br></p>

<p>Applications Tert-Butyl 4-(Aminomethyl)Indoline-1-Carboxylate (cas# 1086392-32-6) is a useful research chemical.<br></p>

<p>Applications 2-(Chloroacetyl)isoindoline was used in the reaction with potassium thiocyanate to synthesize N-​(α-​Thiocyanatoacetyl)​indolines, which is useful as agricultural fungicides.<br>References Richter, S.: U.S. (1975), US 3929830 A 19751230.<br></p>

<p>Applications 6-Bromo-1h-Pyrido[2,3-B][1,4]Oxazin-2(3h)-One (cas# 1245708-13-7) is a useful research chemical.<br></p>

<p>Applications 2,6-Diazaspiro[3.3]heptane-2-carboxylic Acid tert-Butyl Ester Hemioxylate is preparation of pyrimidine derivatives and related heterocycles as CDK inhibitors for treatment of diseases.<br>References Katamreddy, S. R., et al.: PCT Int. Appl. (2020), WO 2020140055 A1<br></p>

<p>Applications 3,4-Dihydro-6-nitro-2(1H)-quinolinone is a useful intermediate for organic synthesis. It is used in the synthesis of triazolyl dihydroquinoliinones with anticonvulsant and antidepressant activity.<br>References Deng, X., et al.: Eur. J. Med. Chem., 73, 217 (2014)<br></p>

<p>Applications Triclocarban Related Compound A (cas# 1219-99-4) is a useful research chemical.<br></p>

<p>Applications 2,2'-(2-Hydroxypropane-1,3-diyl)bis(1H-isoindole-1,3(2H)-dione) is a reagent used for the preparation of functionalized tripodal ligands and their metal complexes for imaging applications.<br>References Dunn, T.J., et al.: PCT Int. Appl., 1995:494561 (1995)<br></p>

<p>Applications 4,4-difluoro-1,2,3,4-tetrahydroisoquinoline-1,3-dione (cas# 1443981-83-6) is a useful research chemical.<br></p>

<p>Applications 2,2'-Bipyridyl-d8 was a useful compound in the NMR study of soft porous nanocrystal and a bulk crystal.<br>References Hijikata, Y., et al.: Chem. Commun. (Cambridge, UK), 47, 7632 (2011)<br></p>

<p>Applications 2-​Quinolinecarboxylic acid can be found in the studying of ligands for the purpose of copper-catalyzed Ullmann reactions with aryl ethers and aryl iodides.<br></p>

<p>Applications 2-Chloro-6-amino-9-(2’,3’,5’-tri-O-acetyl-β-D-ribofuranosyl)purine (cas# 79999-39-6) is a compound useful in organic synthesis.<br></p>

<p>Stability Moisture Sensitive<br>Applications 1,3-dimethyl-2,4-dioxo-1H,2H,3H,4H-pyrido[2,3-d]pyrimidine-6-sulfonyl chloride (cas# 1240529-56-9) is a useful research chemical.<br></p>

<p>Applications 4-Acetoxyindole is a useful intermediate for organic synthesis of Psilocine and Psilocine analogs.<br>References Julia, M., et al.: Chimica Therapeutica, 5, 279 (1970); Repke, D. B., et al.: J. Heterocycl. Chem., 14, 71 (1977)<br></p>

<p>Stability Moisture Sensitive<br>Applications Isoquinoline-5-sulfonyl Chloride, Hydrochloride (cas# 105627-79-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Aminoquinoline-2-carboxylic acid (cas# 887245-74-1) is a useful research chemical.<br></p>

<p>Applications 7-Aminoindole<br></p>

<p>Stability Light Sensitive<br>Applications Reacts with aldehydes to produce highly fluorescent imidazole derivatives. A fluorometric labeling reagent.<br></p>

<p>Applications 3-Hydroxy-2,3-dihydro-1H-indol-2-one is a useful reagent for the distereoselective preparation of spiro[furo[3,4-c]chromene-1,3'-indoline]triones.<br>References Lei, C. W., et al.: Org. Biomol. Chem., 18, 845 (2020)<br></p>

<p>Applications 6-Azabicyclo[3.2.1]octane is used in preparation of substituted Piperidine Carboxamides for use as 11βHSD1 modulators for use in treating metabolic disorders.<br>References Kilburn, John P., et al.: PCT Int. Appl., (2007);<br></p>

<p>Applications 1H-Indole-d5-3-acetamide is the isotope labelled analogue of Indole-3-acetamide, a compound that is converted to indole-3-acetic acid by indole-3-acetamide hydrolase in auxin biosynthesis in plants.<br>References Mano, Y., et al.: J. Exp. Bot., 61, 25 (2010);<br></p>

<p>Applications 1,10-Phenanthroline-d8 (CAS# 90412-47-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Methyl 2-(1-(5-Fluoropentyl)-1H-indole-3-carboxamido)-3-phenylpropanoate is a useful intermediate for organic synthesis. It is a derivative of I-AMB (I110000(M)), which is an analog of 5-fluoro AMB that was developed on an indole base instead of the indazole base typically associated with AB-PINACA.<br>References Shevyrin, V., et al.: Chem. Heterocyclic Comp., 50, 583 (2014)<br></p>