Compuestos policíclicos

Applications 3-Bicyclo[3.2.1]octanone is used as a reactant in the synthesis of polycyclic acid derivatives as selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1).
References Ye, X., et. al.: Bioorg. Med. Chem. Lett., 21, 6699 (2011)

Applications 3-Amino-3-benzyl-3,4-dihydroquinolin-2(1H)-one

Applications 3-(ETHOXYCARBONYL)BICYCLO[1.1.1]PENTANE-1-CARBOXYLIC ACID (cas# 1823373-90-5) is a useful research chemical.

Applications 1-Benzylindole-5-boronic Acid Pinacol Ester acts as a reagent in the synthesis of 3,3-difluoro-2-oxindoles via electrophilic fluorination of indoles using N-fluorobenzenesulfonimide. Preparation of triazolopyridine compounds as JAK kinase inhibitors useful in the treatment of neurodegenerative and inflammatory diseases.
References : Lim, Y., et al.: Org. Lett., 14, 5676; Menet, C., et al.: PCT Int. Appl. (2010), WO 2010010190 A1 20100128.

Applications Methyl indoline-5-carboxylate

Applications 1,2,3,4-Tetrahydroisoquinoline-6,7-diol hydrobromide (cas# 52768-23-7) is a useful research chemical.

Applications 2-(quinolin-4-yl)ethan-1-amine (cas# 860720-12-3) is a useful research chemical.

Applications 2-(1-Cyanoethyl)indole-13C215N is an isotope labelled intermediate for the synthesis of pharmaceutical actives, intermediates and fine chemicals.
References Pezzuto, J.M., et al.: Biochem., 20, 298 (1981), Takeda, K., et al.: Chem. Pharm. Bull., 29, 1280 (1981),

Applications 5-Fluoroindole-3-butyric Acid is used in preparation of Aminochroman and Aminotetralin derivatives, which are useful in the treatment of serotonin-mediated disorders.
References Hatzenbuhler, N., et al.: PCT Int. Appl., (2005);

Applications Indole derivative as substrate-binding; N297Q and I300V mutants of cytochrome P 450 2A6 display expansion of substrate specificity of cytochrome P 450 2A6 to oxidize substituted indoles.
References Gotoh, O., et al.: J. Biol. Chem., 267, 83 (1992), Guengerich, F., et al.: Chem. Res. Toxicol., 14, 611 (2001), Kim, D., et al.: Biochemistry, 43, 981 (2004),

Stability Hygroscopic
Applications 3-Bromo-4-fluoro-1H-indazole (cas# 885521-60-8) is a useful research chemical.

Applications 4,7-Dimethylquinolin-2(1H)-one is a reagent in the preparartion of citralidene hydrazido quinolinones which has antibacterial activity.
References Piste, P. B., et al.: J. Chem. Biol. Phy. Sci., 3, 1746 (2013);

Applications 4,4'-Diamino-2,2'-bipyridine is a bidendate chelator.

Applications 2-tert-Butyl-1H-indole (cas# 1805-65-8) is a useful research chemical.

Applications 6-Bromo-2-(4-bromophenyl)indole (cas# 28718-96-9) is a compound useful in organic synthesis.

Applications 2,5-Dimethyl-2,3-dihydro-1H-indole (cas# 90874-56-9) is a useful research chemical.

Applications 3,4-DIHYDRO-2H-PYRIDO[1,2-A]PYRIMIDIN-2-ONE (cas# 5439-14-5) is a useful research chemical.

Please enquire for more information about 4,7-Diazaspiro[2.5]octane dihydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

N10-Methyl pteroic acid is a novel immunosuppressant that inhibits T-cell proliferation and promotes regression of inflammatory bowel disease. It has been shown to be effective in treating cancer patients, with the terminal half-life being approximately 20 hours. N10-Methyl pteroic acid is a potent inhibitor of human acute lymphoblastic leukemia cells. It can also be used as an immunosuppressant for organ transplantation, with desorption from gels using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI TOF MS) and bioanalytical methods such as high performance liquid chromatography (HPLC).

Please enquire for more information about 4-Amino-2,2'-bipyridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Fraxinol is a natural lignan, which is a small class of polyphenols, derived from the inner bark of the Ash tree (Fraxinus species). Its primary action is believed to involve antioxidant and anti-inflammatory pathways, where it scavenages reactive oxygen species and modulates cytokine production. This activity suggests potential modulation of cellular oxidative stress responses, contributing to its therapeutic interest.

N-Acetylimidazole is a drug that belongs to the class of glycol esters. It is an inhibitor of the enzyme acetylcholinesterase and has been used in the treatment of autoimmune diseases, such as myasthenia gravis. N-Acetylimidazole can inhibit the activity of other enzymes, such as p-nitrophenyl phosphate oxidase, which may be responsible for its anti-inflammatory properties. This drug has been shown to inhibit microbial growth in vitro by inhibiting the synthesis of choline and acetylcholine in the body. N-Acetylimidazole also inhibits bacterial growth by acting as a substrate molecule for bacterial enzymes that catalyze transfer reactions, including phosphotransferases and hydrolases.

4,7,13,16,21-Pentaoxa-1,10-diazabicyclo[8.8.5]tricosane (POD) is a nitrogen containing heterocycle that is used as a fungicide and insecticide. POD has significant antifungal activity against various species of fungi such as Trichophyton mentagrophytes and Candida albicans. It also inhibits the growth of some Gram-positive bacteria such as Clostridium botulinum. The compound may be used to treat conditions associated with elevated blood pressure by inhibiting the conversion of tyrosine to dihydroxyphenylalanine (DOPA). POD forms stable complexes with metal hydroxides in the presence of water and hydrochloric acid, which are important intermediates for chemical reactions. The frequency shift of positron emission in POD is due to the electron capture during positron annihilation.

8-Bromoisoquinoline is a bifunctional alkylating agent that is used to synthesize esters and amides. It is commonly used for the synthesis of amino acids, peptides, and other biologically active molecules. 8-Bromoisoquinoline has been shown to have a synergistic effect with hydroxyalkyl carbamates, which may be due to its ability to form an ionic bond with the carboxylic acid in these compounds. This chemical can also react with nitro groups and serve as a chlorinating agent, as well as react with anions such as phosphate and acetate. 8-Bromoisoquinoline can be synthesized by reacting ethyl bromoacetate with tetrahydroisoquinolinium chloride in hydrochloric acid or isopropyl alcohol.

Pangelin is a novel biochemical agent, which is meticulously derived from a unique microbial source with advanced bioconversion techniques. This product functions primarily through a targeted enzymatic mechanism that modulates specific biochemical pathways, ensuring high specificity and efficacy in its action. The enzymatic process engages with targeted substrates to yield predictable and controlled outcomes, making it a potentially valuable tool in biochemical research and applications.

4-Hydroxy-7-methoxyquinoline is an anti-malarial drug that belongs to the class of trimethyl, trifluoromethyl group. It is a cyclic compound and its synthesis starts with cyclization of the methyl derivative, which forms a ring. This product is used in clinical practice as an inhibitor of malarial protozoa and has been shown to have mechanistic effects on the cytochrome bc1 complex containing red blood cells. 4-Hydroxy-7-methoxyquinoline also inhibits the growth of bacteria by binding to the enzyme methionine synthase, which is involved in the biosynthesis of methionine from homocysteine. The product also has an inhibitory effect on DNA synthesis and protein synthesis.

3-Chloro-1H-indole-2-carbaldehyde is a bifunctional reagent that can be used to form amides. It reacts with primary and secondary amines, as well as dialkyl and methylene amines, to produce the corresponding chloro-, phenylhydrazine-, or nitrosoaminoureas. This reaction is intramolecular and yields the desired product in high yield. The reactant can also be used as a chloride source. 3-Chloro-1H-indole-2-carbaldehyde is manufactured by reacting phenylhydrazine with chloroacetic acid in an organic solvent at room temperature (25°C).

8-Cyclopentyl-1,3-dimethylxanthine (CPT) is a xanthine derivative that binds to the adenosine receptor and inhibits the phosphodiesterase enzyme. CPT is used in vivo as a model for measuring locomotor activity, dopamine receptors, adenosine receptors, and glutamate receptors. The binding of CPT to these receptors can lead to bronchoconstriction by stimulating the release of vasoactive substances from airway cells and increasing the sensitivity of airway cells to bronchoconstrictor stimuli. This drug also has been shown to inhibit calcium ion influx into cytosol and increase intracellular levels of cAMP.

Please enquire for more information about Heratomol including the price, delivery time and more detailed product information at the technical inquiry form on this page

7-Azaindole-5-carboxylic acid methyl ester is an ester derivative that can be synthesized from the reaction of acetyl chloride and diazotization. 7-Azaindole-5-carboxylic acid methyl ester has been used in research for its biological activity, specifically as a cytotoxic agent. It has also been shown to inhibit the growth of cancer cells by alkylation reactions and cyclization reactions. 7-Azaindole-5-carboxylic acid methyl ester has been shown to have antitumor properties with a mechanism that is not yet fully understood.

Indole-3-acetyl-L-phenylalanine is a plant growth regulator that inhibits the transport of auxin in the plant. It is used as a regulatory agent to inhibit the growth of plants by interfering with their natural regulatory mechanisms. Indole-3-acetyl-L-phenylalanine is an effective inhibitor of auxin transport and has been shown to have an inhibitory effect on plant growth. This compound also binds to acid conjugates, which are found in plants, and blocks their ability to bind to auxin receptors, preventing them from activating the cell's responses. This inhibition leads to decreased cell division and reduced root growth.

1,1'-Bicyclo[1,1,1]pentane-1,3-dicarboxylic acid monomethyl ester is a chemical compound used in research and as a building block for complex compounds. It is a high quality and versatile compound that has a wide range of uses in the production of fine chemicals. This compound is an intermediate for the synthesis of 1,4-benzodioxan. CAS No. 83249-10-9

Indole-3-acetyl-L-glutamic acid is an endogenous substance that is found in plants. It is the conjugated form of indole-3-acetaldehyde and L-glutamic acid. Indole-3-acetylglutamic acid has shown to have antioxidant potential and can be used to regulate plant growth, as well as protect against environmental stresses. Indole-3-acetylglutamic acid also has a role in regulating the production of other hormones, such as ethylene and auxin, which are involved in plant growth regulation.

Fraxetin is a chemical compound known as a coumarin derivative, which is a natural product primarily sourced from various plant species. As a member of the coumarin family, fraxetin is often extracted from the roots, bark, and leaves of plant sources like Fraxinus species and other related flora. The compound operates through an array of biochemical pathways, prominently exhibiting antioxidant and anti-inflammatory properties. It acts by scavenging free radicals and modulating oxidative stress-related pathways, while also influencing the expression of various inflammatory cytokines.

5-Bromo-1H-indole-2-carboxylic acid methyl ester is a drug that belongs to the class of carboxylates. It has been shown to inhibit the growth of tumor cells in vitro and in vivo. The antitumor activity of this compound may be due to its ability to stabilize planar indole moieties, which are cytotoxic. 5-Bromo-1H-indole-2-carboxylic acid methyl ester interacts with other molecules through intermolecular interactions and can form an indole ring system that has a trifluoromethyl group and a carboxylate group in its structure.