Compuestos policíclicos

<p>Applications 5-Amino-2H-isoquinolin-1-one is a reactant used in the synthesis of glucoorticoid receptor agonists as well as PARP inhibitors used in the treatment of tumors.<br>References Berger, M. et al.: Bioorg. Med. Chem. Lett., 27, 437 (2017); Goodfellow, E. et al.: Bioorg. Med. Chem. Lett., 27, 688 (2017);<br></p>

<p>Applications 4-Bromo-2,8-Bis(Trifluoromethyl)Quinoline (cas# 35853-45-3) is a useful research chemical.<br></p>

<p>Applications 1,4-Dihydro-7-hydroxy-3(2H)-isoquinolinone, can be involved in the photocyclization of N-(chloroactyl)benzylamines to isoquinoline derivatives.<br>References Ikeda, M., et al.: Tetrahedron Lett., 13, 1181 (1974);<br></p>

<p>Applications 1-Ethyl-1,4-dihydro-4-oxo-7-(4-pyridyl)quinoline-3-carboxylic Acid Ethyl Ester is an intermediate in the synthesis of Rosoxacin (R693580), an antibacterial agent used against Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pneumoniae.<br>References Koba, M., et. al.: J. Mol. Modeling, 16, 327 (2010)<br></p>

<p>Applications 1,3-Dihydro-N-nitro-1,3-dioxo-2H-isoindole-2-carboximidothioic acid Methyl Ester is an intermediate in the synthesis of Dinoteturan (D482100), a neonicotinoid insecticide.<br>References Wakita, T., et al.: J. Pesticide. Sci., 29, 348 (2004);<br></p>

<p>Applications Methyl 3-cyanoindole-4-carboxylate<br></p>

<p>Applications 5-[(1R)-2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-(phenylmethoxy)-2(1H)-quinolinone is used as a reactant in the preparation of Indacaterol (I499745), a β-adrenoreceptor agonist.<br>References Baur, Francois, et al.: J. of Med. Chem., 53(9), 3675-3684 (2010)<br></p>

<p>Applications Indole derivative with anticancer activity.<br>References Lavrenov, S. et al.: Bioorgan. Med. Chem. 18, 6905 (2010)<br></p>

<p>Applications 4-Hydroxymethylbicyclo[2.2.2]octane-1-carboxylic Acid Methylamide is a useful synthetic intermediate.<br></p>

<p>Applications 1,2,3,4-Tetrahydroisoquinoline-6,7-diol hydrobromide (cas# 52768-23-7) is a useful research chemical.<br></p>

<p>Applications 5,7-dihydroxy-4-methyl-2H-chromen-2-one (cas# 2107-76-8) is a useful research chemical.<br></p>

<p>Applications 1-Ethyl-5-fluoroindoline-2,3-dione (cas# 776-47-6) is a useful research chemical.<br></p>

<p>Applications 5-Nitroisoindoline is used as a reagent in organic synthesis of several compounds including that of biphenylcarboxamidoisoindoline derivatives, which act as apolipoprotein B secretion inhibitors, and of benzenesulfonamides which may act as antipsychotic agents.<br>References Yamada, H., et al.: Preparation of biphenylcarboxamidoisoindoline derivatives as apolipoprotein B secretion inhibitors, WO Patent 2002014277, Feb 21, 2002; Cooper, D., et al.: Preparation of benzenesulfonamides as antipsychotic agents, WO Patent 2003068732, Aug 21, 2003;<br></p>

<p>Applications 2-tert-Butyl-1H-indole (cas# 1805-65-8) is a useful research chemical.<br></p>

<p>Applications 1H-Indole-3-carboxylic acid hydrazide<br></p>

<p>Applications A 6-substituted 8-quinolinecarboxylic acid as antimicrobial and genotoxic agent.<br>References Weyer, R., et al.: Arzneim.-Forsch., 24, 269 (1974),<br></p>

<p>Applications 6-Hydroxy-1H-indole-3-carboxylic acid (cas# 24370-78-3) is a useful research chemical.<br></p>

<p>Applications 9-(Trimethylsilyl)-2,6-bis[(trimethylsilyl)oxy]-9H-purine is an intermediate used in the synthesis of Xanthosine-13C5 (X742102), which is the labeled analogue of Xanthosine (X742100), the deamination product of Guanosine. It is also a potential biomarker for detecting radiation exposure.<br>References Magasanik, B, et al.: J. Bio. Chem., 206, 83 (1954);<br></p>

<p>Stability Hygroscopic<br>Applications 3-Oxo-2,3-dihydro-1H-indazole-5-carboxylic acid (cas# 787580-93-2) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications N10-Trifluoroacetylpteroic acid is a derivative of Pteroic acid (P840110), both of which are used as reagents to synthesize target ligands, like Folic acid (F680300), that have the ability to deliver chemotherapeutic agents specifically to cancer cells.<br>References Leamon, C., et al.: Bioconjugate Chem., 14, 738 (2003); Leamon, C., et al.: J. Drug Target., 7, 157 (1999); Yonghua, Z., et al.: Anal. Biochem., 332, 168 (2004)<br></p>

<p>Applications 2-Deuteroindole is a useful reagent in the preparation of deuterated labeled indoles.<br>References Lautie, M. F., et al.: J. Label. Compd. Radiopharm., 16, 735 (1979); Ibaceta-Lizana, J. S. L., et al.: J. Chem. Soc. Perkin Trans 2., 9, 1221 (1987)<br></p>

<p>Applications 1,2,3,4-Tetrahydroquinolin-3-amine (cas# 40615-02-9) is a useful research chemical.<br></p>

<p>Applications 6-Chloro-2,3-dihydro-2-oxo-1H-indole-5-carboxylic Acid is an intermediate used in the synthesis of EPZ031686, the first orally bioavailable small molecule SMYD3 inhibitor.<br>References Mitchell, L., et al.: ACS Med. Chem. Lett. (2015)<br></p>

<p>Applications 2-(2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL)ACETIC ACID (cas# 61164-71-4) is a useful research chemical.<br></p>

<p>Applications 2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline]-1',3'-dione (cas# 31267-07-9) is a useful research chemical.<br></p>

<p>Applications 5-Fluoro-2-oxindole (cas# 56341-41-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Azabicyclo[2.2.2]octan-3-one (cas# 3306-69-2) is a useful research chemical.<br></p>

<p>Applications 8-Chloro-5-isoquinolinesulfonic Acid (cas# 1246816-17-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Azabicyclo[3.3.0]octane Hydrochloride is a reactant in the preparation of substituted pyrimidines derivatives as novel hedgehog signaling pathway inhibitors.<br>References Xin, M. et al.: Med. Chem. Res., 23, 3784 (2014); Xin, M. et al.: Bioorg. Med. Chem. Lett., 24, 983 (2014);<br></p>

<p>Applications Isotope labelled 6-Bromopurine is a brominated derivative of purine used in various organic syntheses. Used in the synthesis of several benzo-fused scaffolds with purine or pyrimidine moietes which display antitumor and anticancer properties.<br>References Morales, F. et al.: Eur, J. Med. Chem., 76, 118 (2014); Cushing, T. et al.: J. Med. Chem., 58, 480 (2015); Jansen, R., et al.: Clin. Biochem., 38, 362 (2005),<br></p>

<p>Applications 2-Aminoquinoline-6-carboxylic Acid tert-Butyl ester is a substituted quinoline used in pharmaceuticals for treatment of obesity and related conditions.<br>References Bertinato, P., et al.:PCT Int. Appl. (2005), WO 2005080373 A1 20050901<br></p>

<p>Applications 2-[3-(3,5-Dimethylphenoxy)-2-hydroxypropyl]-1H-isoindole-1,3(2H)-dione is an intermediate used in the synthesis of 1-Amino-3-(3,5-dimethylphenoxy)-2-propanol (A607300), which is a degradation product of Metaxalone (M225850); a muscle relaxant used to relax muscles and relieve pain.<br>References Rao, R.N., et al.: Biomed. Chromatogr., 27, 1733 (2013)<br></p>

<p>Applications 4-(ethoxymethylidene)-1,2,3,4-tetrahydroisoquinoline-1,3-dione (cas# 18630-93-8) is a useful research chemical.<br></p>

<p>Applications 6-Quinolinol is used in the preparation of potential antifungal agents containing a quinoline structure. Also used in the preparation of novel pyridocoumarins.<br>References Galariniotou, E. et al.: Tetrahedron 63, 8298 (2007); Vandekerckhove, S. et al.: Bioorg. Med. Chem. Lett., 23, 4641 (2013);<br></p>

<p>Applications 3-Hydroxyquinoline-d6 is labelled 3-Hydroxyquinoline (H953140) which is a chemical reagent used in the preparation cyclic peptides with an antitumor functionality. Quinoline derivative as a result of the metabolism by cytochrome P 450.<br>References Riego, E. et al.: Tetrahedron, 61, 1407 (2005); Kanou, M. et al.: Fund. Clin. Pharmacol., 16, 513 (2002)<br></p>

<p>Applications 1-(4-Chlorobutyl)-7-hydroxyquinolin-2(1H)-one is a useful research chemical.<br></p>

<p>Applications 2-(prop-2-yn-1-yl)-1,2,3,4-tetrahydroisoquinoline-1,3-dione (cas# 410538-30-6) is a useful research chemical.<br></p>

<p>Applications 6-Hydroxyquinoline-(1H)-2-one (cas# 19315-93-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Chloroquinolin-6-ol can be used for hair dye compositions.<br>References Lagrange, A., et.al., PCT Int. Appl., 87, (2012);<br></p>

<p>Applications 5,7-Dichloro-4-hydroxyquinoline is an intermediate in synthesizing Quinoxyfen-d4 (Q765502), an isotope labelled Quinoxyfen acts as an agricultural fungicide.<br>References Corrales, M., et al.: Food Chem. Toxicol., 48, 3471 (2010); Lagunas-Allue, L., et al.: Anal. Bioanal. Chem., 398, 1509 (2010); Wong, J., et al.: J. Agric. Food Chem., 58, 5897 (2010)<br></p>

<p>Applications 2’,3’,5’-Tri-O-benzoyl Xanthine-13C5 is an intermediate used in the synthesis of Xanthosine-13C5 (X742102), which is the labeled analogue of Xanthosine (X742100), the deamination product of Guanosine. It is also a potential biomarker for detecting radiation exposure.<br>References Magasanik, B, et al.: J. Bio. Chem., 206, 83 (1954);<br></p>

<p>Applications 5,7-Dichloro-3,4-dihydro-2H-isoquinolin-1-one (cas# 885273-81-4) is a useful research chemical.<br></p>

<p>Applications 3,5-Dichloro-4-pyridone-1-acetic acid<br></p>

<p>Applications 4-Isoquinolin-4-yl-benzylamine is an analog of amino isoquinolin (A611600). Amino isoquinolin ( A611600) is used for synthesis of Rho kinase inhibitors.<br>References Kimura, K; Science, 273, 245 (1996);Amano, M; J Biol Chem 274, 32418 (1999)Gassel, M; J Mol Biol, 329, 1021 (2003);<br></p>

<p>Applications Quinoline-3-sulfonyl Chloride (cas# 159182-40-8) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Oxyquinoline Sulfate is used as a food preservative.<br>References Gendy, A. et al.: Aud. J. Basic. App. Sci., 6, 260 (2012); Abou El-Ghait, E. et al.: Res. J. Agri. Biol. Sci., 8, 261 (2012);<br></p>

<p>Applications 4-Fluoro-7-azaindole (cas# 640735-23-5) is a compound useful in organic synthesis.<br></p>

<p>Applications XANTHENE-9-CARBOXAMIDE (cas# 5813-90-1) is a useful research chemical.<br></p>

<p>Applications 1,2,3,4,5,6,7,8-OCTAHYDROPHENANTHRENE (cas# 5325-97-3) is a useful research chemical.<br></p>

<p>Applications 7-Chloro-2-[(E)-2-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]ethenyl]quinoline is a reagent in the synthesis of dithioacetals, which are intermediates in the preparation of potent LTD4 antagonist L-660,711.<br>References McNamara, J. M., et al.: J. Org. Chem., 54, 3718 (1989)<br></p>

<p>Stability Store under Argon<br>Applications 3,6-Thioxanthenediamine-10,10-dioxide (cas# 10215-25-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-(pyridin-3-yl)pyrido[2,3-d]pyrimidine has been used in the preparation of divalent transition metal aminonicotinaldehyde chloride complexes, antimicrobial, antioxidant and antitumor activities, electrochemical and molecular docking with EGFR protein.<br>References Konakanchi R., et al., Res. Chem. Intermed., 44, 27-53 (2018)<br></p>

<p>Applications 2,3,3-Trimethylindolenine is an indole derivative used in the preparation of cyanine dye labelleing reagents and other imaging agents.<br>References Mujumdar, R. et al.: Cytometry, 10, 3 (1989); Mushkalko, I.L. et al.: Ukr. Khim. Zhur., 52, 509 (1986);<br></p>

<p>Stability Hygroscopic<br>Applications 3-Bromo-4-fluoro-1H-indazole (cas# 885521-60-8) is a useful research chemical.<br></p>

<p>Applications 5-Chloroindole-2-carboxylic Acid is used in the synthesis of 4-(3-aminomethylphenyl)piperidine-1-carboxamides as potent, selective, and orally bioavailable inhibitors of βII tryptase. It is also a reagent used to prepare indole amides with possible antihistaminic activities.<br>References Levell, J., et al.: Bioorg. Med. Chem., 13, 2859 (2005); Battaglia, S., et al.: Eur. J. Med. Chem., 34, 93 (1999)<br></p>