Compuestos policíclicos

<p>Applications 5-(2-Bromo-1-oxobutyl)-8-hydroxy-2(1H)-quinolinone is an intermediate in the synthesis of metabolites of procaterol hydrochloride (Meptin) (P155490), a β2-adrenergic agonist used in the treatment of asthma.<br>References Yoshizaki, S., et al.: Chem. Pharma. Bull., 26, 1611 (1978);<br></p>

<p>Stability Hygroscopic<br>Applications 3-Oxo-2,3-dihydro-1H-indazole-5-carboxylic acid (cas# 787580-93-2) is a useful research chemical.<br></p>

<p>Applications 9-(Trimethylsilyl)-2,6-bis[(trimethylsilyl)oxy]-9H-purine is an intermediate used in the synthesis of Xanthosine-13C5 (X742102), which is the labeled analogue of Xanthosine (X742100), the deamination product of Guanosine. It is also a potential biomarker for detecting radiation exposure.<br>References Magasanik, B, et al.: J. Bio. Chem., 206, 83 (1954);<br></p>

<p>Applications 2-​Quinolinecarboxylic acid can be found in the studying of ligands for the purpose of copper-catalyzed Ullmann reactions with aryl ethers and aryl iodides.<br></p>

<p>Applications 1-Ethyl-5-fluoroindoline-2,3-dione (cas# 776-47-6) is a useful research chemical.<br></p>

<p>Applications 3-Amino-3-benzyl-3,4-dihydroquinolin-2(1H)-one<br></p>

<p>Applications Can be used in the preparation of serotoninergic S2 antagonists.<br>References Andersen, K. et al.: J. Med. Chem. 39, 3723(1996); Perregaard, J. et al.: J. Med. Chem. 35, 1092(1992)<br></p>

<p>Applications 7-Chloro-3-isoquinolinemethanol is an intermediate in the preparation of pyrrolopyrimidinones as P2X3 receptor antagonists.<br>References Bayrakdarian, M., et al.: PCT Int. Appl. (2008), WO 2008136756 A1 20081113;<br></p>

<p>Applications 7-Bromo-2,3-dihydro-1H-indole is a compound useful in organic synthesis.<br></p>

<p>Applications Protected nucleoside.<br>References Elzein, E., et al.: Bioorg. Med. Chem. Lett., 17, 161 (2007), Franchetti, P., et al.: J. Med. Chem., 52, 2393 (2009),<br></p>

<p>Applications An indolinone derivative used for the preparation of p38α inhibitors as potential antiinflammatories.<br>References Eastwood, P., et al.: Bioorg. Med. Chem. Lett., 21, 5270 (2011),<br></p>

<p>Applications 2-Cyclobutenyl-3-trifluoromethyl-5-chloro-1H-indole-1-carboxylic acid ethyl ester is synthesized from 5-chloro-2-oxindole (C375030), which is used in the preparation of novel GSK-3β inhibitors as anticancer agents.<br>References Choi, M.J., et al.: Bull. Korean. Chem. Soc., 32, 2015 (2011); Otani, M., et al.: Bioorg. Med. Chem. Lett.. 20, 4259 (2010); Jhan, Y.H., et al.: Tetrahedron. Lett., 54, 1155 (2013); Hsieh, J.C., et al.: Org. Biomolec. Chem., 10, 6404 (2012);<br></p>

<p>Applications 4-Chloro-6,7-dimethoxyquinoline, can be used as an intermediate for the synthesis of various pharmaceutical and biologically active compounds. It is used for the preparation of Tivozanib (T447205), and Cabozantinib (C051500), acting as anticancer agents.<br>References Fu, Y., Zhongguo Xinyao Zazhi, 22, 26 (2013); Liu, M., Adv. Mat. Res., 396, 1490 (2012); Camp, R., et al.: Cancer, 86, 2259 (1999);<br></p>

<p>Applications 1R,3S,5R)-2-(tert-Butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic Acid acts as a reagent in the preparation of fused bicycles end-capped with peptide derivatives as HCV inhibitors. Synthesis of (tert-butoxycarbonyl)azabicyclohexanecarboxylic acid via stereoselective cyclopropanation of pyrroline<br>References Wang, G., et al.: Tetrahedron Lett., 54, 6722 (2013); Belema, M., et al.: From U.S. Pat. Appl. Publ. (2012), US 20120195857 A1 20120802<br></p>

<p>Applications 1-oxa-3,8-diazaspiro[4.5]decan-2-one hydrochloride (cas# 5052-96-0) is a useful research chemical.<br></p>

<p>Applications 1-(2-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline (cas# 1017125-85-7) is a useful research chemical.<br></p>

<p>Applications 3-(ETHOXYCARBONYL)BICYCLO[1.1.1]PENTANE-1-CARBOXYLIC ACID (cas# 1823373-90-5) is a useful research chemical.<br></p>

<p>Applications 6-[N,N-Di(2-hydroxybenzyl)amino]-2-[(3-hydroxypropyl)amino]-9-isopropylpurine (cas# 1076200-04-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 8$l^{6}-thia-9-azatricyclo[8.4.0.0^{2,7}]tetradeca-1(14),2,4,6,10,12-hexaene-8,8-dione (cas# 1864-33-1) is a useful research chemical.<br></p>

<p>Applications 5-Chloroindole-2-carboxylic Acid is used in the synthesis of 4-(3-aminomethylphenyl)piperidine-1-carboxamides as potent, selective, and orally bioavailable inhibitors of βII tryptase. It is also a reagent used to prepare indole amides with possible antihistaminic activities.<br>References Levell, J., et al.: Bioorg. Med. Chem., 13, 2859 (2005); Battaglia, S., et al.: Eur. J. Med. Chem., 34, 93 (1999)<br></p>

<p>Applications (1R,​4S)​-1,​3,​3-​Trimethylbicyclo[2.2.1]​heptan-​2-​one also known more commonly as (-)-Fenchone is a chiral intermediate of Fenchone and is currently being used for studies ranging from inhibitory effects of monoterpenes on human TRPA1 and odorant receptor of the malaria vector Anopheles gambiae.<br>References Rahman, S., et al. J. Biol. Chem., 292, 18916-23 (2017); Takaishi, M., et al.: J Physio. Sci., 64, 47-57 (2014)<br></p>

<p>Stability Hygroscopic<br>Applications 3-Bromo-4-fluoro-1H-indazole (cas# 885521-60-8) is a useful research chemical.<br></p>

<p>Applications Indole derivative with anticancer activity.<br>References Lavrenov, S. et al.: Bioorgan. Med. Chem. 18, 6905 (2010)<br></p>

<p>Applications 4,4'-Diamino-2,2'-bipyridine is a bidendate chelator.<br></p>

<p>Applications Methyl 2-(1-(Hex-5-en-1-yl)-1H-indole-3-carboxamido)-3,3-dimethylbutanoate is a useful intermediate for organic synthesis.<br></p>

<p>Applications 2,3,3-Trimethylindolenine is an indole derivative used in the preparation of cyanine dye labelleing reagents and other imaging agents.<br>References Mujumdar, R. et al.: Cytometry, 10, 3 (1989); Mushkalko, I.L. et al.: Ukr. Khim. Zhur., 52, 509 (1986);<br></p>

<p>Applications 2-(pyridin-3-yl)pyrido[2,3-d]pyrimidine has been used in the preparation of divalent transition metal aminonicotinaldehyde chloride complexes, antimicrobial, antioxidant and antitumor activities, electrochemical and molecular docking with EGFR protein.<br>References Konakanchi R., et al., Res. Chem. Intermed., 44, 27-53 (2018)<br></p>

<p>Stability Light Sensitive<br>Applications 3,3'-Bipyridine-6,6'-dicarbonitrile<br></p>

<p>Stability Hygroscopic<br>Applications 5-Amino-6-nitroquinoline is a reagent used in the synthesis of benzodiazepine sulfonamide-based bombesin receptor 3 agonists. It is also used in the synthesis of quinoxalinediones.<br>References Liu, P. et al.: ACS. Med. Chem. Lett., 2, 933 (2011); Bigge, C. et al.: J. Med. Chem., 38, 5720 (1995);<br></p>

<p>Applications Indole derivative as substrate-binding; N297Q and I300V mutants of cytochrome P 450 2A6 display expansion of substrate specificity of cytochrome P 450 2A6 to oxidize substituted indoles.<br>References Gotoh, O., et al.: J. Biol. Chem., 267, 83 (1992), Guengerich, F., et al.: Chem. Res. Toxicol., 14, 611 (2001), Kim, D., et al.: Biochemistry, 43, 981 (2004),<br></p>

<p>Applications 2,6-Dimethylphenanthrene have been used in investigating Polycyclic Aromatic Hydrocarbons Profiles in Higher Plants Using Statistical Models.<br>References Sojinu O., et al.: Int. J. Phytoremediat., 15, 439-451 (2013)<br></p>

<p>Applications 5-Fluoroindole-3-butyric Acid is used in preparation of Aminochroman and Aminotetralin derivatives, which are useful in the treatment of serotonin-mediated disorders.<br>References Hatzenbuhler, N., et al.: PCT Int. Appl., (2005);<br></p>

<p>Applications 2-(1-Cyanoethyl)indole-13C215N is an isotope labelled intermediate for the synthesis of pharmaceutical actives, intermediates and fine chemicals.<br>References Pezzuto, J.M., et al.: Biochem., 20, 298 (1981), Takeda, K., et al.: Chem. Pharm. Bull., 29, 1280 (1981),<br></p>

<p>Applications 4-Hydroxymethylbicyclo[2.2.2]octane-1-carboxylic Acid Methylamide is a useful synthetic intermediate.<br></p>

<p>Applications 6-fluoroquinoline-8-carboxylic acid (cas# 1306605-84-4) is a useful research chemical.<br></p>

<p>Applications tert-Butyl 6-amino-3,4-dihydroquinoline-1(2H)-carboxylate (cas# 1152923-36-8) is a useful research chemical.<br></p>

<p>Applications 3-(4-Aminobutyl)-1H-indole-5-carbonitrile could be a useful reagent for preparing CNS agents.<br>References Boettcher, H., et al.: Ger. Offen. (1992), DE 4101686 A1<br></p>

<p>Applications 1,2,3,4-Tetrahydroisoquinoline-6,7-diol hydrobromide (cas# 52768-23-7) is a useful research chemical.<br></p>

<p>Applications XANTHENE-9-CARBOXAMIDE (cas# 5813-90-1) is a useful research chemical.<br></p>

<p>Applications Methyl indoline-5-carboxylate<br></p>

<p>Applications 5,7-dihydroxy-4-methyl-2H-chromen-2-one (cas# 2107-76-8) is a useful research chemical.<br></p>

<p>Applications 5,6,7,8-TETRAHYDROISOQUINOLIN-1-AMINE (cas# 75704-51-7) is a useful research chemical.<br></p>

<p>Applications 3,5-Diphenylpyrazole (cas# 1145-01-3) is a useful research chemical.<br></p>

<p>Applications 3-Isocyanato-1H-indole (cas# 57778-78-6) is a useful research chemical.<br></p>

<p>Applications 1-Benzylindole-5-boronic Acid Pinacol Ester acts as a reagent in the synthesis of 3,3-difluoro-2-oxindoles via electrophilic fluorination of indoles using N-fluorobenzenesulfonimide. Preparation of triazolopyridine compounds as JAK kinase inhibitors useful in the treatment of neurodegenerative and inflammatory diseases.<br>References : Lim, Y., et al.: Org. Lett., 14, 5676; Menet, C., et al.: PCT Int. Appl. (2010), WO 2010010190 A1 20100128.<br></p>

<p>Applications 5-Nitroisoindoline is used as a reagent in organic synthesis of several compounds including that of biphenylcarboxamidoisoindoline derivatives, which act as apolipoprotein B secretion inhibitors, and of benzenesulfonamides which may act as antipsychotic agents.<br>References Yamada, H., et al.: Preparation of biphenylcarboxamidoisoindoline derivatives as apolipoprotein B secretion inhibitors, WO Patent 2002014277, Feb 21, 2002; Cooper, D., et al.: Preparation of benzenesulfonamides as antipsychotic agents, WO Patent 2003068732, Aug 21, 2003;<br></p>

<p>Applications 4-Fluoro-7-azaindole (cas# 640735-23-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Oxyquinoline Sulfate is used as a food preservative.<br>References Gendy, A. et al.: Aud. J. Basic. App. Sci., 6, 260 (2012); Abou El-Ghait, E. et al.: Res. J. Agri. Biol. Sci., 8, 261 (2012);<br></p>

<p>Applications 1H-Indole-3-carboxylic acid hydrazide<br></p>

<p>Applications 2-(chloroacetyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (cas# 111631-72-2) is a useful research chemical.<br></p>

<p>Applications A 6-substituted 8-quinolinecarboxylic acid as antimicrobial and genotoxic agent.<br>References Weyer, R., et al.: Arzneim.-Forsch., 24, 269 (1974),<br></p>

<p>Applications 6-hydroxyquinoline-2-carboxylic acid (cas# 75434-18-3) is a useful research chemical.<br></p>

<p>Applications 3-Cyanoindole (cas# 5457-28-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 1,2,3,4-Tetrahydroquinolin-3-amine (cas# 40615-02-9) is a useful research chemical.<br></p>