Compuestos policíclicos

Applications Indole derivative

Applications 7-(4-(4-Chlorobutoxy)butoxy)-3,4-dihydroquinolin-2(1H)-one is an internmediate in the synthesis of Aripiprazole (A771000) related compounds, a selective dopamine D2-receptor antagonist with dopamine autoreceptor agonist activity.
References Nagasaka, Y., et al.: Biopharma. Drug. Dispo., 33, 304 (2012); Chen, X., et al.: J. Med. Chem., 55, 7141 (2012);

Applications 2-(Cyanomethyl)-1H-indole-1-carboxylic Acid tert-Butyl Ester-13C,15N is an isotope labelled intermediate in the synthesis of endothelial lipase inhibitors.

Applications 6-Chloropurine, Hydrochloride (cas# 88166-54-5 ) is a compound useful in organic synthesis.

Applications Methyl 1-(Cyclohexylmethyl)-1H-indazole-3-carboxylate is an intermediate in the synthesis of MDMB-CHMINACA (M203515), a synthetic cannabinoid with potential neurochemical effects at the CB1 receptor.
References Banister, S. ET AL.: ACS Chem. Neurosci., 7, 1241 (2016);

Applications 3-Amino-4-bromo-5-phenylpyrazole (cas# 2845-78-5) is a compound useful in organic synthesis.

Applications 1-Benzyl-5-bromoindole

Applications 2-Acetamido-6-chloro-9-(2’,3’,5’-tri-O-acetyl-β-D-ribofuranosyl)purine (cas# 137896-02-7) is a compound useful in organic synthesis.
References Matsuda, A., et al.: J. Med. Chem., 35, 241 (1992),

Applications (1S)-3,4-Dihydro-1-phenyl-2(1H)-isoquinolinecarboxylic Acid 2,5-Dioxo-1-pyrrolidinyl Ester is an intermediate in the synthesis of ((R)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)((S)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)methanone (P309025). ((R)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)((S)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)methanone is a possible impurity of solifenacin (S676700) which is a muscarinic M3 receptor antagoinst. Solifenacin is used in treatment of urinary incontinence.
References Ikeda K., et al.: Arch. Pharmacol., 366, 97, (2002); Chapple, C.R., et al.: Br. J. Urol., 93, 303 (2004); Ohtake, A., et al.: Eur. J. Pharmacol., 492, 243 (2004); Brunton, S., et al.: Curr. Med. Res. Opin., 21, 71 (2005); Habb, F., et al.: Eur. Urol. 47, 376 (2005); Payne, C.K., et al.: Drugs, 66, 175 (2006)

Applications 2,3,3-Trimethylindolenine is an indole derivative used in the preparation of cyanine dye labelleing reagents and other imaging agents.
References Mujumdar, R. et al.: Cytometry, 10, 3 (1989); Mushkalko, I.L. et al.: Ukr. Khim. Zhur., 52, 509 (1986);

Applications 2-Chloro-5-nitroquinoline is used in the synthesis of potent, orally active corticotropin-releasing factor-1 receptor antagonists.
References Takeda, K., et al.: BIoorg. Med. Chem., 20, 6559 (2012); Verheij, M.H.P., et al.: J. Med. Chem., 55, 8603 (2012); Takeda, K., et al.: Bioorg. Med. Chem. Lett., 22, 5372 (2012);

Stability Light Sensitive
Applications 2-Chloroindole is used to prepare 2-pyrrolidinone derivatives as anticonvulsants.
References Kenda, B., et al.: PCT Int. Appl. (2006), WO 2006128692 A2 20061207

Applications 4,6,7,8-Tetrahydro-2,5(1H,3H)-quinolinedione (cas# 5057-12-5) is a compound useful in organic synthesis.

Applications 2-[(Diethylamino)methyl]indole Methiodide is an intermediate in the preparation of carcinogenic indole derivatives.
References Eenkhoom, J.A., et al.: CND. J. Chem., 51, 792 (1973);

Stability Store in freezer at -20°C
Applications 5-Amino-6-(methylamino)quinoline (cas# 14204-98-9) is a compound useful in organic synthesis.

Applications Used for synthesis of Rho kinase inhibitors.
References Biggadike, K., et al.: J. Med. Chem., 50, 6519 (2007), Cheng, Y., et al.: Bioorg. Med. Chem., 16, 4617 (2008),

Oxythiamine chloride is a compound that binds to DNA in the nucleus of cells. It has been shown to inhibit cell growth and induce apoptosis by binding to a number of cellular molecules, including hydrogen bonding interactions with enzymes. Oxythiamine chloride also inhibits energy metabolism by inhibiting mitochondrial respiration and mitochondrial ATP production, and is toxic to cells. This drug has potent inducers, such as cell factor, which are necessary for the production of new cells. It also inhibits thiamine-dependent enzymes, such as pyruvate dehydrogenase kinase (PDK) and pyruvate dehydrogenase (PDH). The wild-type strain of Escherichia coli was used for these studies.

5-Methyl-2-phenyl-1H-imidazole-4-carboxylic acid (MPICA) is a potent inhibitor of xanthine oxidase. It is also an inhibitor of β-glucuronidase and enzymes that maintain the integrity of bacterial DNA. MPICA has been shown to inhibit xanthine oxidase in a dose dependent manner and can be used as a lead compound for new inhibitors of this enzyme.

2-Boc-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid is a useful scaffold with a high quality. It can be used as a building block in the synthesis of complex compounds and fine chemicals. 2-Boc-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid is also a useful intermediate and reagent in organic synthesis. This compound has CAS number 362492-00-0.

Ethyl-2-aminoquinoline-3-carboxylate is an intramolecular reductive coupling product. It was synthesized by the reductive coupling of nitrobenzene with triethylamine in the presence of a copper salt. The use of ethyl cyanoacetate as a starting material for this synthesis has been shown to produce regioselective products with high yields. Ethyl-2-aminoquinoline-3-carboxylate is used in the synthesis of quinoline derivatives and fluoroquinolone antibiotics. This compound has been shown to have optimum properties for GC/MS analysis, which makes it an advance in the field of chemistry.

2,2'-Bipyridine-6-carboxylic acid is a reagent that is used in organic synthesis as a reaction component and building block for the synthesis of heterocyclic compounds. 2,2'-Bipyridine-6-carboxylic acid is also used as a precursor to produce other compounds. 2,2'-Bipyridine-6-carboxylic acid has been shown to be useful in the synthesis of complex compounds with diverse structures, making it a versatile building block. It can also be used as an intermediate in the synthesis of various drugs and speciality chemicals.

Quinoline-2,8-diol is a bacterial strain that can be used to remove fatty acids from wastewater. The recombinant cytochrome P450 in this strain can degrade fatty acids, which are carcinogenic and have been shown to cause hepatic steatosis. In addition, the quinoline-2,8-diol strain has shown an ability to inhibit xenograft tumor growth in mice by activating cytochrome P450 and inducing apoptosis. This bacterial strain also has the potential to produce xanthurenic acid from tyrosine. Xanthurenic acid is toxic and has been shown to inhibit polymerase chain reaction (PCR) amplification of DNA. Quinoline-2,8-diol may be used as a model for experimental studies of xanthurenic acid's effects on energy metabolism and DNA synthesis.

2-Amino-5(6)-benzoylbenzimidazole is an antifilarial and anthelmintic drug that belongs to the benzimidazole class. It is used for the treatment of filarial infections in humans, including lymphatic filariasis, which is caused by worms transmitted by mosquitoes. 2-Amino-5(6)-benzoylbenzimidazole has low bioavailability due to its poor water solubility. The drug can be administered orally or topically and is metabolized in the liver. The metabolites are excreted in urine as glucuronides and sulfates.

6-Bromo-7-azaindole is a homologous molecule. It is an electron deficient compound with a piperidine moiety at the 6 position and a nitrogen atom at the 7 position. The nitrogen atom substitutes for an oxygen atom, making this molecule reactive. The electron deficient nature of this molecule makes it suitable for use in transistors and other physicochemical devices. 6-Bromo-7-azaindole has been shown to be effective against carcinoma cells in vitro, as well as to inhibit tumor growth in vivo. This drug also causes homologous recombination by interacting with DNA in mammalian cells. 6-Bromo-7-azaindole binds to DNA, forming a covalent bond with the guanine base of DNA through the nitrogen atom, which is electron deficient.

3-Aminoquinuclidine dihydrochloride (3-AQDH) is a chiral quinuclidine derivative that is an acetylcholine receptor agonist. It has been shown to bind to the α7 nicotinic acetylcholine receptor with high affinity and selectivity. 3-AQDH has also been shown to crosslink the cholinergic receptor, which may lead to increased sensitivity of the receptor. The binding constants between 3-AQDH and the α7 nicotinic acetylcholine receptors are very high and it has been shown to be enantiopure in its synthesis. 3-AQDH also has a hydrophilic interaction chromatography profile, which separates it from other compounds. This agent may have potential use as a drug for treating Alzheimer's disease and Parkinson's disease due to its ability to inhibit acetylcholinesterase activity.

5,7-Dimethoxyindole is a potent inhibitor of the enzyme oxidase. 5,7-Dimethoxyindole has been shown to inhibit the growth of a number of fungi, including Phytophthora infestans and Cryptococcus neoformans. The molecular modeling studies have shown that this molecule can form an H-bond with the acceptor in the active site of the enzyme and prevent access by substrate. This inhibition has been shown to be competitive with respect to ferrous ions and noncompetitive with respect to other cofactors. 5,7-Dimethoxyindole also inhibits integrase enzymes, which are involved in DNA integration during viral replication. 5,7-Dimethoxyindole was found to bind to a pharmacophore model for integrase inhibitors and formylation reactions. This compound is also magnetic due to its high electron density at the methoxy group.