Compuestos policíclicos

<p>Applications 7-Bromoisoquinoline (cas# 58794-09-5) is a compound useful in organic synthesis. It can be used for the preparation of estrone cortistatin analogs via Suzuki-Miyaura coupling. It could also be used for the preparation of pyrazolopyrimidinamine derivatives.<br>References Sato, Y., et al.: Biosci., Biotechnol., Biochem., 72, 2992 (2008), Apsel, B., et al.: Nat. Chem. Biol., 4, 691 (2008)<br></p>

<p>Applications 1-oxa-3,8-diazaspiro[4.5]decan-2-one hydrochloride (cas# 5052-96-0) is a useful research chemical.<br></p>

<p>Applications 3-AMINOQUINOLINE (cas# 580-17-6) is a useful research chemical.<br></p>

<p>Applications An indolinone derivative used for the preparation of p38α inhibitors as potential antiinflammatories.<br>References Eastwood, P., et al.: Bioorg. Med. Chem. Lett., 21, 5270 (2011),<br></p>

<p>Applications 4-(1-Piperazinyl)-1H-indole Dihydrochloride (cas# 84807-09-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 7-Bromo-2,3-dihydro-1H-indole is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Isocyanato-1H-indole (cas# 57778-78-6) is a useful research chemical.<br></p>

<p>Applications 6-[N,N-Di(2-hydroxybenzyl)amino]-2-[(3-hydroxypropyl)amino]-9-isopropylpurine (cas# 1076200-04-8) is a compound useful in organic synthesis.<br></p>

<p>Applications Methyl 2-(1-(Hex-5-en-1-yl)-1H-indole-3-carboxamido)-3,3-dimethylbutanoate is a useful intermediate for organic synthesis.<br></p>

<p>Applications 1-Chloro-5-isoquinolinesulfonic Acid (cas# 105627-80-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 6-Hydroxy-1H-indole-3-carboxylic acid (cas# 24370-78-3) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications N10-Trifluoroacetylpteroic acid is a derivative of Pteroic acid (P840110), both of which are used as reagents to synthesize target ligands, like Folic acid (F680300), that have the ability to deliver chemotherapeutic agents specifically to cancer cells.<br>References Leamon, C., et al.: Bioconjugate Chem., 14, 738 (2003); Leamon, C., et al.: J. Drug Target., 7, 157 (1999); Yonghua, Z., et al.: Anal. Biochem., 332, 168 (2004)<br></p>

<p>Applications Ethyl 6-Cyano-1H-indole-2-carboxylate is a chemical reagent used in the synthesis of benzofuran inhibitors for mitogen-activated protein kinase phosphatase-1. Applications towards diabetes, obesity and insulin-resistant metabolic disorders. Also a reagent in the preparation of platelet receptor glycoprotein (Gp) IIb/IIIa antagonists used as ati-thrombotic agents.<br>References Lazo, J. et al.: Bioorg. Med. Chem., 14, 5643 (2006); Ono, S. et al.: Chem. Pharm. Bull.,<br></p>

<p>Applications 1H-Indole-d5-3-acetamide is the isotope labelled analogue of Indole-3-acetamide, a compound that is converted to indole-3-acetic acid by indole-3-acetamide hydrolase in auxin biosynthesis in plants.<br>References Mano, Y., et al.: J. Exp. Bot., 61, 25 (2010);<br></p>

<p>Applications 2-Amino-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine (cas# 16321-99-6) is a compound useful in organic synthesis.<br></p>

<p>Applications (Z)-9-(2-Propen-1-ylidene)-2-(trifluoromethyl)-9H-thioxanthene is an intermediate used in the synthesis of (E/Z)-Flupentixol-d4 Dihydrochloride (F597982), which is a neuroleptic agent related structurally to thiothixene. Antipsychotic; neuroleptic agent; dopamine receptor antagonist.<br>References Nielsen, et al.: Acta Pharmacol. Toxicol., 32, 363 (1973), Post, M.L., et al.: Nature, 256, 342 (1975), Peuch, et al.: Neuropharmacology, 20, 1279 (1981),<br></p>

<p>Applications 1,10-Phenanthroline-d8 (CAS# 90412-47-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 5,7-Dichloro-1,2,3,4-tetrahydro-2-(triphenylmethyl)-6-isoquinolinecarboxylic Acid, can be sued in the preparation of novel series of compounds which has been found to be a potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for treating dry eye.<br>References Zhong, M. et al,: ACS Med. Chem. Let. Vol. 3, page 203-206 (2012);<br></p>

<p>Applications 5-Chloroisoindoline hydrochloride (cas# 912999-79-2) is a useful research chemical.<br></p>

<p>Applications 6-Azabicyclo[3.2.1]octane is used in preparation of substituted Piperidine Carboxamides for use as 11βHSD1 modulators for use in treating metabolic disorders.<br>References Kilburn, John P., et al.: PCT Int. Appl., (2007);<br></p>

<p>Applications 4-Ethyl-2(1H)-quinolinone has been use as a reactant in the preparation of 6-bisalkylamino-2-quinolinones as selective androgen receptor modulators.<br>References Van Oeveren, A., et. al.: Bioorg. Med. Chem. Lett., 17, 1527 (2007)<br></p>

<p>Applications 6-Propylamino-7-deazapurine (cas# 60972-21-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Aminoquinoline-2-carboxylic acid (cas# 887245-74-1) is a useful research chemical.<br></p>

<p>Applications 3-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)propanoic Acid (cas# 923163-76-2) is a useful research chemical.<br></p>

<p>Applications 2-Chloroquinolin-6-ol can be used for hair dye compositions.<br>References Lagrange, A., et.al., PCT Int. Appl., 87, (2012);<br></p>

<p>Applications 5-Amino-2H-isoquinolin-1-one is a reactant used in the synthesis of glucoorticoid receptor agonists as well as PARP inhibitors used in the treatment of tumors.<br>References Berger, M. et al.: Bioorg. Med. Chem. Lett., 27, 437 (2017); Goodfellow, E. et al.: Bioorg. Med. Chem. Lett., 27, 688 (2017);<br></p>

<p>Applications 1-(4-Chlorobutyl)-7-hydroxyquinolin-2(1H)-one is a useful research chemical.<br></p>

<p>Applications 1,1,2-Trimethyl-1H-benzo[e]indole (cas# 41532-84-7) is a useful research chemical.<br></p>