Compuestos policíclicos

Applications 5-Chloroindole-2-carboxylic Acid is used in the synthesis of 4-(3-aminomethylphenyl)piperidine-1-carboxamides as potent, selective, and orally bioavailable inhibitors of βII tryptase. It is also a reagent used to prepare indole amides with possible antihistaminic activities.
References Levell, J., et al.: Bioorg. Med. Chem., 13, 2859 (2005); Battaglia, S., et al.: Eur. J. Med. Chem., 34, 93 (1999)

Stability Hygroscopic
Applications 3-Bromo-4-fluoro-1H-indazole (cas# 885521-60-8) is a useful research chemical.

Applications Indole derivative with anticancer activity.
References Lavrenov, S. et al.: Bioorgan. Med. Chem. 18, 6905 (2010)

Applications 4,4'-Diamino-2,2'-bipyridine is a bidendate chelator.

Stability Light Sensitive
Applications 3,3'-Bipyridine-6,6'-dicarbonitrile

Applications 2,4-Dimethylquinoline, �� 95.0% (cas# 1198-37-4) is a useful research chemical.

Applications Indole derivative as substrate-binding; N297Q and I300V mutants of cytochrome P 450 2A6 display expansion of substrate specificity of cytochrome P 450 2A6 to oxidize substituted indoles.
References Gotoh, O., et al.: J. Biol. Chem., 267, 83 (1992), Guengerich, F., et al.: Chem. Res. Toxicol., 14, 611 (2001), Kim, D., et al.: Biochemistry, 43, 981 (2004),

Applications 5-Fluoroindole-3-butyric Acid is used in preparation of Aminochroman and Aminotetralin derivatives, which are useful in the treatment of serotonin-mediated disorders.
References Hatzenbuhler, N., et al.: PCT Int. Appl., (2005);

Applications 2-(1-Cyanoethyl)indole-13C215N is an isotope labelled intermediate for the synthesis of pharmaceutical actives, intermediates and fine chemicals.
References Pezzuto, J.M., et al.: Biochem., 20, 298 (1981), Takeda, K., et al.: Chem. Pharm. Bull., 29, 1280 (1981),

Applications 4-Hydroxymethylbicyclo[2.2.2]octane-1-carboxylic Acid Methylamide is a useful synthetic intermediate.

Applications 2-(quinolin-4-yl)ethan-1-amine (cas# 860720-12-3) is a useful research chemical.

Applications 6-fluoroquinoline-8-carboxylic acid (cas# 1306605-84-4) is a useful research chemical.

Applications Methyl indoline-5-carboxylate

Applications (2R,3aS,7aS)-Octahydroindole-2-carboxylic Acid Hydrochloride is an intermediate in the synthesis of Perindoprilat (P287530), an angiotensin-converting enzyme (ACE) inhibitor. Antihypertensive.
References Vincent, M., et al.: Drug Design Disc., 9, 11 (1992), Pascard, C., et al.: J. Med. Chem., 34, 663 (1991)

Applications 1-Benzylindole-5-boronic Acid Pinacol Ester acts as a reagent in the synthesis of 3,3-difluoro-2-oxindoles via electrophilic fluorination of indoles using N-fluorobenzenesulfonimide. Preparation of triazolopyridine compounds as JAK kinase inhibitors useful in the treatment of neurodegenerative and inflammatory diseases.
References : Lim, Y., et al.: Org. Lett., 14, 5676; Menet, C., et al.: PCT Int. Appl. (2010), WO 2010010190 A1 20100128.

Applications 3,4-DIHYDRO-2H-PYRIDO[1,2-A]PYRIMIDIN-2-ONE (cas# 5439-14-5) is a useful research chemical.

Applications 5-Nitroisoindoline is used as a reagent in organic synthesis of several compounds including that of biphenylcarboxamidoisoindoline derivatives, which act as apolipoprotein B secretion inhibitors, and of benzenesulfonamides which may act as antipsychotic agents.
References Yamada, H., et al.: Preparation of biphenylcarboxamidoisoindoline derivatives as apolipoprotein B secretion inhibitors, WO Patent 2002014277, Feb 21, 2002; Cooper, D., et al.: Preparation of benzenesulfonamides as antipsychotic agents, WO Patent 2003068732, Aug 21, 2003;

Applications 6-Bromo-2-(4-bromophenyl)indole (cas# 28718-96-9) is a compound useful in organic synthesis.

Applications 4-Fluoro-7-azaindole (cas# 640735-23-5) is a compound useful in organic synthesis.

Applications 1H-Indole-3-carboxylic acid hydrazide

Applications Quinoline-3-sulfonyl Chloride (cas# 159182-40-8) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications A 6-substituted 8-quinolinecarboxylic acid as antimicrobial and genotoxic agent.
References Weyer, R., et al.: Arzneim.-Forsch., 24, 269 (1974),

Applications 7-Phenyl-7H-purine (cas# 18346-05-9) is a compound useful in organic synthesis.

Applications 1-benzyl-1,2,3,4-tetrahydroisoquinoline hydrochloride (cas# 155413-72-2) is a useful research chemical.

Applications 1,2,3,4-Tetrahydroquinolin-3-amine (cas# 40615-02-9) is a useful research chemical.

Applications 4-Isoquinolin-4-yl-benzylamine is an analog of amino isoquinolin (A611600). Amino isoquinolin ( A611600) is used for synthesis of Rho kinase inhibitors.
References Kimura, K; Science, 273, 245 (1996);Amano, M; J Biol Chem 274, 32418 (1999)Gassel, M; J Mol Biol, 329, 1021 (2003);

Applications 7-BROMOMETHYLQUINOLINE HYDROBROMIDE (cas# 188874-61-5) is a useful research chemical.

Applications 9-Oxo-9H-thioxanthene-2-carboxylic acid (cas# 25095-94-7) is a useful research chemical.

Applications 4-Chloro-8-(trifluoromethyl)quinoline is used as a reagent for the potent CRTh2 (DP2) receptor antagonists discovery which is used for treatment of asthma, allergic rhinitis and other inflammatory diseases.
References Birkinshaw, T.N., et al.: Bioorg. Med. Chem. Lett., 16, 4287 (2006)

Applications 4-Fluoro-1H-indazole