Compuestos policíclicos

Applications 1,4-Dioxa-8-azaspiro[4.5]decane-8-carboxylic Acid 1,1-Dimethylethyl Ester (cas# 123387-51-9) is a compound useful in organic synthesis.

Applications 8-Hydroxyquinoline (cas# 148-24-3) is a compound useful in organic synthesis.

Applications 1,2,3,4-Tetrahydroquinolin-3-amine (cas# 40615-02-9) is a useful research chemical.

Applications alpha-Furil Dioxime (cas# 23789-34-6) is a useful research chemical.

Applications Tert-Butyl 4-(Aminomethyl)Indoline-1-Carboxylate (cas# 1086392-32-6) is a useful research chemical.

Applications Indole-3-acetonitrile is an indole derivative involved in the biosynthesis of the plant hormone indole acetic acid (I577340) via the indole-3-acetaldoxime pathway.
References Kong, W., et al.: Plant Cell Physiol, 56, 715-726 (2015)

Applications 1-Benzylindole-5-boronic Acid Pinacol Ester acts as a reagent in the synthesis of 3,3-difluoro-2-oxindoles via electrophilic fluorination of indoles using N-fluorobenzenesulfonimide. Preparation of triazolopyridine compounds as JAK kinase inhibitors useful in the treatment of neurodegenerative and inflammatory diseases.
References : Lim, Y., et al.: Org. Lett., 14, 5676; Menet, C., et al.: PCT Int. Appl. (2010), WO 2010010190 A1 20100128.

Applications (2R,3aS,7aS)-Octahydroindole-2-carboxylic Acid Hydrochloride is an intermediate in the synthesis of Perindoprilat (P287530), an angiotensin-converting enzyme (ACE) inhibitor. Antihypertensive.
References Vincent, M., et al.: Drug Design Disc., 9, 11 (1992), Pascard, C., et al.: J. Med. Chem., 34, 663 (1991)

Applications 5-Nitro-1H-quinolin-2-one is used in the synthetic preparation of novel antileishmanial agents for Leishmania donovani promastigotes.
References Paloque, L., et al.: Europ. J. Med. Chem., 54, 75 (2012);

Applications 5-Aminotricyclo[3.3.1.13,7]decane-1,3-diol is an intermediate used in the synthesis of Hydroxy Vildagliptin (V305035), which is an impurity of Vildagliptin (V305000). Vildagliptin is a DPP-​4 enzyme inhibitor, has anti-oxidant properties and used as an apoptotic agent on pancreatic cancer . Vildagliptin is used to treat type 2 diabetes mellitus (T2DM) and improve the endothelial function of patients.
References Amritha, C.A., et al.: J. Clin. Diagn. Res., 9, FC14 (2015); Cosenso-Martin, L.N., et al.: Diabetol. Metab. Syndr., 7, 70/1 (2015)

Stability Hygroscopic
Applications 2,4-Dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride (cas# 1187830-76-7) is a useful research chemical.

Applications Bicyclo[4.1.0]Heptane-7-Carboxylic Acid (cas# 41894-76-2) is a useful reagent for the heteroatom-​directed C-​H borylation of cyclopropanes and cyclobutanes.
References Murakami, R., et al.: Chem. Eur. J., 20, 13127 (2014)

Applications 3-(ETHOXYCARBONYL)BICYCLO[1.1.1]PENTANE-1-CARBOXYLIC ACID (cas# 1823373-90-5) is a useful research chemical.

Applications 6-Fluoroquinolin-2(1H)-one

Applications 2-tert-Butyl-1H-indole (cas# 1805-65-8) is a useful research chemical.

Applications 7-Deazapurine (cas# 18549-65-0) is a compound useful in organic synthesis.

Applications 5-Chloroindole-2-carboxylic Acid is used in the synthesis of 4-(3-aminomethylphenyl)piperidine-1-carboxamides as potent, selective, and orally bioavailable inhibitors of βII tryptase. It is also a reagent used to prepare indole amides with possible antihistaminic activities.
References Levell, J., et al.: Bioorg. Med. Chem., 13, 2859 (2005); Battaglia, S., et al.: Eur. J. Med. Chem., 34, 93 (1999)

Applications 4,7-Dimethylquinolin-2(1H)-one is a reagent in the preparartion of citralidene hydrazido quinolinones which has antibacterial activity.
References Piste, P. B., et al.: J. Chem. Biol. Phy. Sci., 3, 1746 (2013);

8-Bromoisoquinoline is a bifunctional alkylating agent that is used to synthesize esters and amides. It is commonly used for the synthesis of amino acids, peptides, and other biologically active molecules. 8-Bromoisoquinoline has been shown to have a synergistic effect with hydroxyalkyl carbamates, which may be due to its ability to form an ionic bond with the carboxylic acid in these compounds. This chemical can also react with nitro groups and serve as a chlorinating agent, as well as react with anions such as phosphate and acetate. 8-Bromoisoquinoline can be synthesized by reacting ethyl bromoacetate with tetrahydroisoquinolinium chloride in hydrochloric acid or isopropyl alcohol.

Pangelin is a novel biochemical agent, which is meticulously derived from a unique microbial source with advanced bioconversion techniques. This product functions primarily through a targeted enzymatic mechanism that modulates specific biochemical pathways, ensuring high specificity and efficacy in its action. The enzymatic process engages with targeted substrates to yield predictable and controlled outcomes, making it a potentially valuable tool in biochemical research and applications.

Please enquire for more information about 4,7-Diazaspiro[2.5]octane dihydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

4-Hydroxy-3-nitro-2(1H)-quinolinone is a quinoline derivative that has been shown to have anticancer activity against cancer cells. It can be used for the treatment of various types of cancer, including lung cancer, breast cancer, and colon cancer. This drug inhibits the growth of cancer cells by blocking the cycle at the G1 phase and inducing apoptosis. It also disrupts mitochondrial membrane potential, leading to an increase in reactive oxygen species and DNA damage. 4-Hydroxy-3-nitro-2(1H)-quinolinone is an epidermal growth factor receptor (EGFR) antagonist and blocks epidermal growth factor signaling through its inhibition of EGFR tyrosine kinase activity. It also downregulates TNFα expression in tumor cells by inhibiting NFκB activation.