Otros inhibidores

<p>2-(butan-2-yldisulfanyl)butane is a compound containing a disulfide bond that is used in organic synthesis and biochemical experiments.</p>

<p>1-Hexadecanoylpyrrolidine is an long-chain ketone that can be used in organic synthesis and biological experiments.</p>

<p>1,2-Butanedithiol（1,2-Dimercaptobutane） is an organosulfur compound used in organic synthesis and biochemical experiments.</p>

<p>2-Methoxy-6-methylpyrazine is a pyrazine that is used in organic synthesis and biological experiments.</p>

<p>Thieno[2,3-b]thiophene is a thiophene that can be used in organic optoelectronic materials and biochemical experiments.</p>

<p>2-Propylfuran is a furan commonly used in flavor preparation, organic synthesis and biochemical experiments.</p>

<p>(Propan-2-yl)cyclohexane is a cyclohexane that is used in organic synthesis and biochemical experiments.</p>

<p>UV-1164 is an aromatic ether commonly used as an ultraviolet absorber.</p>

<p>Fluc-IN-1 is a inhibitor of firefly luciferase (Fluc) and further inhibits WNT/β-catenin through Fluc without acting through Frizzled 7 or signaling amplifier.</p>

<p>3-Amino-hexanoic acid is a β-amino acid used in organic synthesis and biochemical experiments.</p>

<p>Anetumab ravtansine is an antibody-drug conjugate (ADC) that can be used in life science related research. The CAS number is 1375258-01-7.</p>

<p>Mal-PEG12-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.</p>

<p>Araloside C is a natural product from plants</p>

<p>Bromo-PEG2-phosphonic acid diethyl ester is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis targeting chimeras (PROTACs)[1].</p>

Boc-Pip-alkyne-Ph-COOH: PROTAC linker for ARD-266, degrades AR in prostate cancer cells; DC50: 0.2-1 nM.

<p>Ergosterol peroxide is anti-cancer and has multiple inhibitory effects including hACAT-1, Lp-PLA2, and osteoclastogenesis with low toxicity.</p>

<p>Crustacean Cardioactive Peptide (CCAP) is a conserved modified cyclic nonapeptide primary structure of PFCNAFTGC-NH2, a disulfide bridge between Cys3 and Cys9.</p>

<p>Amino-PEG24-CH2-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.</p>

<p>Geoside is a natural compound isolated from stevia rebaudiana.</p>

<p>3-Hydroxychimaphilin is a natural product for research related to life sciences. The catalog number is TN5796 and the CAS number is 33253-99-5.</p>

<p>Lysipressin: contracts rabbit bladder, stimulates adenylate cyclase, antidiuretic hormone in pigs/marsupials.</p>

<p>Antibiotic MA144 K1 is an anthracycline glycoside that functions as a chemotherapeutic agent, inhibiting the growth of malignant tumors and treating infections caused by Gram-positive bacteria.</p>

<p>RGD-PEG-Cy3 is a fluorescent labeling reagent that combines the Cy3 fluorescent dye, peptide (RGD), and polyethylene glycol (PEG). The Cy3 fluorophore is commonly employed in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry, with a peak emission wavelength of approximately 562-570 nm. RGD is a peptide sequence (CRGDKGPDCiRGD) that targets tumor tissues specifically by binding to αvβ3 and αvβ5 integrin receptors, which are involved in tumor neovascularization.</p>

<p>3-Oxo-C8-HSL (N-(3-Oxooctanoyl)-l-homoserine lactone) is an autoinducer molecule. It acts as a promoter regulated by TraR and significantly enhances the expression of tra genes.</p>

<p>Azido-PEG36-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.</p>

<p>Dextran-CY3 is a fluorescent labeling reagent combining the Cy3 fluorescent dye with Dextran. The Cy3 fluorophore is commonly utilized in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has a maximum emission wavelength of approximately 562-570 nm. Dextran inhibits platelet aggregation and clotting factors, and is used as a plasma volume expander.</p>

<p>Triptorelin is a GnRH agaonist shown to inhibit estradiol-induced cancer cell proliferationIn vivo: (1) Triptorelin can improve the pregnancy rate by 12% to 15% in ewes6 and downregulate ovarian GnRHR-I expression of female rats, especially in late-growing follicles.(2) Triptorelin immunity blocked EET and UWT, inhibited uterine growth and development and enhance the expression levels s of ESR1, LHR, and FSHR proteins.<br>[1]. Wei S et al. Triptorelin and cetrorelix induce immune responses and affect uterine development and expressions of genes and proteins of ESR1, LHR, and FSHR of mice. Immunopharmacol Immunotoxicol. 2016 Jun;38(3):197-204.</p>

<p>4”-O-Glucosylvitexin is a naturally derived compound that inhibits TPO activity. It is extracted and purified from the fruit of hawthorn (Crataegus pinnatifida).</p>

<p>Megalomicin is a macrocyclic lactone antibiotic complex produced by Micromonospora.</p>

<p>Target Protein Ligand-Linker Conjugates 4 is a compound formed by connecting a target protein ligand with a linker. It is used in the synthesis of PROTACs, such as PROTAC SMARCA2 degrader-21.</p>

<p>PACE4 Inhibitory peptide C23 (Compound C23) is an effective peptidomimetic inhibitor known to act against PACE4. It exhibits antiproliferative effects on PCa cell lines, with a Ki of 5 nM, and IC50 values of 25 μM and 40 μM for DU145 and LNCaP cells, respectively. Additionally, PACE4 Inhibitory peptide C23 suppresses tumor growth in LNCaP xenograft mice.</p>

<p>Phytochelatin 4 (PC 4) a heavy metal detoxifier/chelator consisting of 4 units of glu - cys , tolerant to Cd (cadmium), ultimately sequestered in the vesicle.</p>

<p>Sclerotigenin is a benzodiazepine compound with insecticidal properties, discovered in Penicillium sclerotigenum (NRRL 3461). It exhibits significant insecticidal activity against the crop pest Helicoverpa zea.</p>

<p>DEAE-dex-Cy5 is a fluorescent labeling reagent that combines the Cy5 fluorescent dye with Dextran (dex) and diethylaminoethyl (DEAE). Cy5, a cyanine dye, has a wavelength of approximately 662 nm and is used for molecular labeling and microscopic imaging. Dextran inhibits platelet aggregation and coagulation factors, serving as a plasma volume expander.</p>

<p>Etamivan (Ethamivan) (INN) or ethamivan (USAN), is a respiratory stimulant drug concerned with nikethamide. Its trade name is Analepticon, and no longer used in the US.</p>

<p>PCEEA hydrochloride is a psychoactive compound structurally similar to eticyclidine, ketamine, and phencyclidine.</p>

<p>Methoxyadiantifoline is a natural product for research related to life sciences. The catalog number is TN6104 and the CAS number is 115452-09-0.</p>

<p>Swertianin 2-O-α-L-rhamnopyranosyl-(1→2)-β-D-xylopyranoside is a natural product for research related to life sciences.</p>

<p>Amino-PEG4-hydrazide-Boc is a PEGylation-based linker employed for the synthesis of PROTACs[1].</p>

<p>MI-2 (Menin-MLL Inhibitor) is an effective menin-MLL interaction inhibitor (IC50: 446 ± 28 nM).</p>

<p>Propargyl-PEG4-tetra-Ac-beta-D-galactose is a PEGylated proteolysis-targeting chimera (PROTAC) linker utilized for PROTAC synthesis[1].</p>

<p>5-Acetyl-2-(1-hydroxy-1-methylethyl)benzofuran is a phytoalexin.</p>

<p>7-Methoxy-1-naphthaleneacetic acid blocks auxin transport/action in plants, affecting Arabidopsis and maize.</p>

<p>Mal-amido-PEG24-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.</p>

<p>RXFP3/4 agonist 1 is a relaxin family peptide 3/4 receptor (RXFP3/4) agonist(EC50s of 82/2 nM, respectivley).</p>

<p>Azide-PEG4-Tos is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.</p>

<p>Methyl retinoate triggers inflammation, alters blood cells, may cause leukemia, and treats vitamin A deficiency issues.</p>

<p>6-Hydroxyisosativan is a natural product for research related to life sciences. The catalog number is TN5455 and the CAS number is 2172624-69-8.</p>

<p>Acerinol, from Chinese herbs, may reverse cancer drug resistance, boosting ABCB1 ATPase, not altering its mRNA/protein expression.</p>

<p>C-NH-Boc-C-Bis-(C-PEG1-Boc) is a versatile alkyl/ether-based PROTAC linker for synthesizing PROTACs[1].</p>