Señalización citoesquelética
Los inhibidores de la señalización del citoesqueleto son compuestos que interrumpen las vías de señalización que regulan el citoesqueleto, crucial para la forma celular, la motilidad, la división y el transporte intracelular. Estos inhibidores se utilizan para estudiar la dinámica de las proteínas del citoesqueleto, como la actina y la tubulina, y su papel en procesos como la migración celular, la adhesión y la metástasis del cáncer. Los inhibidores de la señalización del citoesqueleto son valiosos en la investigación sobre biología celular, cáncer y neurobiología. En CymitQuimica, ofrecemos una amplia gama de inhibidores de la señalización del citoesqueleto de alta calidad para apoyar su investigación en estas áreas.
Se han encontrado 1382 productos de "Señalización citoesquelética"
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SNIPER(ABL)-024
CAS:<p>SNIPER(ABL)-024, a compound that conjugates GNF5 (ABL inhibitor) to an LCL161 derivative (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels,</p>Fórmula:C52H61F3N8O9SPureza:98%Forma y color:SolidPeso molecular:1031.15MS143
CAS:<p>MS143: potent AKT degrader, DC50=46 nM, GI50=0.8 µM in PC3 cells, degrades AKT via ubiquitin-proteasome, suppresses cancer growth.</p>Fórmula:C59H81ClN12O6SForma y color:SolidPeso molecular:1121.87Tyrosine Kinase Inhibitor Library
<p>A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related</p>Forma y color:Odour SolidAlvespimycin TFA
<p>Alvespimycin (17-DMAG) TFA is a potent inhibitor of Hsp90, binding with an EC50 of 62 ± 29 nM.</p>Fórmula:C34H49F3N4O10Forma y color:SolidPeso molecular:730.34008ML-B01
<p>ML-B01 is an orally active inhibitor targeting Akt and PKA, with IC50 values of 2 nM and 136 nM, respectively. It demonstrates good blood-brain barrier (BBB) permeability in mice.</p>Fórmula:C24H31Cl2N5OForma y color:SolidPeso molecular:476.44KIF2C-IN-1
<p>KIF2C-IN-1 (Compound 7S9) is a selective and potent small molecule inhibitor of KIF2C. It stabilizes the interaction between KIF2C and microtubule proteins, preventing the depolymerization of polyglutamylated microtubules. KIF2C-IN-1 enhances the cytotoxicity of Paclitaxel in Paclitaxel-resistant triple-negative breast cancer (TNBC) cells and, when combined with Paclitaxel, significantly reduces tumor growth in mouse models.</p>Fórmula:C36H39ClN4O9SForma y color:SolidPeso molecular:738.21263TNIK-IN-7
CAS:<p>TNIK-IN-7 is a Traf2 and Nck interacting kinase (TNIK) inhibitor with antitumor activity for the study of signaling and proliferation in colorectal cancer cells</p>Fórmula:C23H22N4O2Pureza:99.87%Forma y color:SoildPeso molecular:386.45AT-1002
CAS:<p>AT-1002 is a tight junction regulator and absorption enhancer. It is a 6-mer synthetic peptide.</p>Fórmula:C32H53N9O7SPureza:98%Forma y color:SolidPeso molecular:707.88TAT-Gap19
CAS:<p>Cx43 blocker, IC50 ~7μM; doesn't affect gap junctions/Panx1. TAT motif enhances effect; works in vivo, brain-penetrant.</p>Fórmula:C119H212N46O26Pureza:98%Forma y color:SolidPeso molecular:2703.28SMS 121
CAS:<p>SMS 121 is a novel CD36 inhibitor that impairs fatty acid uptake and cell viability in acute myeloid leukaemia (AML) cells.</p>Fórmula:C20H21NO5Pureza:98.29%Forma y color:SoildPeso molecular:355.38INY-03-041 trihydrochloride
<p>INY-03-041 trihydrochloride: potent, selective PROTAC AKT degrader; combines Ipatasertib and Lenalidomide; IC50s: AKT1 (2.0 nM), AKT2 (6.8 nM), AKT3 (3.5 nM).</p>Fórmula:C44H59Cl4N7O5Forma y color:SolidPeso molecular:907.8AS-605240 potassium
<p>AS-605240 (potassium) is an orally active PI3Kγ inhibitor with an IC50 of 8 nM and a Ki of 7.8 nM. It inhibits MCP-1 and CSF1-induced PKB phosphorylation with IC50 values of 0.181 µM and 0.550 µM, respectively. In mouse models of peritonitis induced by RANTES (CCL5) and thioglycolate, AS-605240 (potassium) reduces neutrophil recruitment, showing EC50 values of 9.1 mg/kg and 10 mg/kg. Additionally, AS-605240 (potassium) ameliorates arthritis induced by αCII-IA in mice.</p>Fórmula:C12H6KN3O2SForma y color:SolidPeso molecular:294.98178PM050489
CAS:<p>PM050489, a polyketone inhibitor from Lithoplocamia lithistoides, halts mitosis at 26.4 nM IC50 and aids cancer research.</p>Fórmula:C31H44ClN3O7Forma y color:SolidPeso molecular:606.15Cyclo(RGDfC) TFA
<p>Zelminemab (AMG-301) is a humanized monoclonal antibody targeting ADCYAP1R1 for use in neurological disorders.</p>Fórmula:C26H35F3N8O9SPureza:98.59%Forma y color:SolidPeso molecular:692.67Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Forma y color:Odour Solidc(phg-isoDGR-(NMe)k) TFA
<p>C(phg-isoDGR-(NMe)k) TFA is a selective and potent ligand for α5β1-integrin, exhibiting an IC50 of 2.9 nM [1].</p>Fórmula:C29H42F3N9O9Forma y color:SolidPeso molecular:717.69Tubulin polymerization-IN-78
<p>Tubulin polymerization-IN-78 (compound 10a) is an inhibitor of tubulin polymerization, with an IC50 value of 2.69 μM. It exhibits antiproliferative activity.</p>Forma y color:Odour Solidpara-amino-Blebbistatin
CAS:<p>para-amino-Blebbistatin is a water-soluble, stable, non-phototoxic inhibitor of non-muscle myosin II, with enhanced properties over blebbistatin.</p>Fórmula:C18H17N3O2Forma y color:SolidPeso molecular:307.353Solidagonic acid
CAS:<p>Solidagonic acid inhibits HSET, prevents fission yeast cell death, and hinders L. sativa and L. multiflorum seedling growth.</p>Fórmula:C22H34O4Forma y color:SolidPeso molecular:362.5K34c hydrochloride
CAS:<p>K34c hydrochloride is an alpha5β1 integrin antagonist for glioblastoma study.</p>Fórmula:C26H30ClN3O4Pureza:99.76% - 99.89%Forma y color:SoildPeso molecular:483.99
