Señalización citoesquelética
Los inhibidores de la señalización del citoesqueleto son compuestos que interrumpen las vías de señalización que regulan el citoesqueleto, crucial para la forma celular, la motilidad, la división y el transporte intracelular. Estos inhibidores se utilizan para estudiar la dinámica de las proteínas del citoesqueleto, como la actina y la tubulina, y su papel en procesos como la migración celular, la adhesión y la metástasis del cáncer. Los inhibidores de la señalización del citoesqueleto son valiosos en la investigación sobre biología celular, cáncer y neurobiología. En CymitQuimica, ofrecemos una amplia gama de inhibidores de la señalización del citoesqueleto de alta calidad para apoyar su investigación en estas áreas.
Se han encontrado 1381 productos de "Señalización citoesquelética"
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TAK 029
CAS:<p>TAK 029 is a local glycoprotein IIb/IIIa receptor inhibitor.</p>Fórmula:C19H23N5O7Forma y color:SolidPeso molecular:433.42JG-23
CAS:<p>JG-23, a 4-chloro-modified analog, effectively induces t-tau degradation and demonstrates robust metabolic stability, exhibiting an extended half-life (T1/2) of</p>Fórmula:C19H16ClN3OS2Forma y color:SolidPeso molecular:401.93β-Catenin modulator-2
CAS:<p>β-Catenin Modulator-2 (Compound IIa-130), which is an oxazole-thiazole derivative, serves as a potent and selective modulator of β-Catenin [1].</p>Fórmula:C20H18Cl2N2O3SForma y color:SolidPeso molecular:437.34KIF18A-IN-7
CAS:<p>KIF18A-IN-7 is an orally active inhibitor targeting KIF18A, demonstrating potent inhibition with an IC50 value of 9.4 nM against the microtubule-dependent</p>Fórmula:C27H35N3O5S2Forma y color:SoildPeso molecular:545.71Tubulin inhibitor 25
CAS:<p>Potent Tubulin inhibitor 25: IC50 0.98 μM, blocks HT29 cell growth, hinders cell migration & microtubule formation, anti-angiogenic.</p>Fórmula:C26H22O8Forma y color:SolidPeso molecular:462.45Solitomab
CAS:<p>Solitomab (AMG 110) is a bispecific antibody targeting CD3 and EpCAM, used in uterine/ovarian carcinosarcoma research.</p>Forma y color:LiquidRisvodetinib
CAS:<p>Risvodetinib: potent inhibitor of protein tyrosine kinases c-Abl1, c-Abl2, and c-kit.</p>Fórmula:C33H34N8O2Forma y color:SolidPeso molecular:574.68PTK7/β-catenin-IN-1
CAS:<p>PTK7/β-catenin-IN-1 (compound 01065) is a potent inhibitor targeting PTK7/β-catenin and p53/MDM2, with IC50 values of 8.9 μM and 56.5 μM, respectively. This compound shows promise for cancer research applications [1].</p>Fórmula:C22H16N2O2Forma y color:SolidPeso molecular:340.382Synstatin (92-119)
CAS:<p>Synstatin (92-119) serves as an anti-tumor agent by suppressing angiogenesis and cancer cell invasion, chiefly through the down-regulation of integrin αvβ3 and</p>Fórmula:C133H207N35O46Pureza:98%Forma y color:SolidPeso molecular:3032.27BX-2819
CAS:<p>BX-2819 is an Hsp90 inhibitor that exhibits potent antiproliferative activity with an IC50 of 41 nM .</p>Fórmula:C21H24N4O4SPureza:98%Forma y color:SolidPeso molecular:428.51MAO A/HSP90-IN-2
CAS:<p>MAO A/HSP90-IN-2 (compound 4-C), a dual inhibitor of HSP90 and MAO A, exhibits IC50 values of 0.016 μM for MAO A and 4.58 μM for HSP90.</p>Fórmula:C25H31ClN2O4Pureza:98%Forma y color:SolidPeso molecular:458.98HSP90-IN-19
CAS:<p>HSP90-IN-19: potent Hsp90 inhibitor, IC50 = 0.27 μM, used in research on viral diseases, neurodegeneration, inflammation.</p>Fórmula:C29H38O7Pureza:98%Forma y color:SolidPeso molecular:498.61Antitumor agent-86
CAS:<p>Antitumor agent-86 targets MCF-7 cells with 2.62 µM IC50, induces apoptosis, and disrupts RAS/PI3K/Akt/JNK pathways.</p>Fórmula:C29H31N5O2SPureza:98%Forma y color:SolidPeso molecular:513.65UU-T01
CAS:<p>UU-T01 inhibits β-catenin/Tcf4 with Ki of 3.14 µM, binds β-catenin directly with KD of 0.531 µM.</p>Fórmula:C10H10N6OForma y color:SolidPeso molecular:230.23Palmitic acid calcium
CAS:<p>Calcium palmitate, a long-chain saturated fatty acid prevalent in animals and plants, induces the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in mouse granulosa cells. It is employed to establish a cell steatosis model [1] [2].</p>Fórmula:C16H32O2CaForma y color:SolidPeso molecular:275.46SB-743921 free base
CAS:<p>SB-743921, a kinesin spindle protein (KSP) inhibitor, is used potentially for the treatment of non-Hodgkin's lymphoma (NHL).</p>Fórmula:C31H33ClN2O3Pureza:98%Forma y color:SolidPeso molecular:517.06Lotrafiban
CAS:<p>Lotrafiban: Oral GP IIb/IIIa inhibitor for treating coronary and cerebrovascular disease.</p>Fórmula:C23H32N4O4Forma y color:SolidPeso molecular:428.52β-Catenin modulator-5
CAS:<p>β-Catenin Modulator-5 (Compound IIa-84), an oxazole and thiazole-based compound, serves as a potent and selective modulator of β-Catenin [1].</p>Fórmula:C21H22N2O2SForma y color:SolidPeso molecular:366.483CAI
CAS:<p>3CAI inhibits AKT1/2, reduces mTOR/GSK3β, and triggers apoptosis in colon cancer cells.</p>Fórmula:C10H8ClNOPureza:98.13%Forma y color:SolidPeso molecular:193.63α7β1 integrin modulator-1
CAS:<p>α7β1 Integrin Modulator-1 is a potent modulator with research potential for muscular dystrophy [1].</p>Fórmula:C23H29N3O6SPureza:98%Forma y color:SolidPeso molecular:475.56Lotrafiban hydrochloride
CAS:<p>Lotrafiban hydrochloride is an platelet glycoprotein IIb/IIIa blocker with oral activity.</p>Fórmula:C23H33ClN4O4Forma y color:SolidPeso molecular:464.99LY2780301
CAS:<p>LY2780301, an oral Akt (protein kinase B) inhibitor, may hinder cancer cell growth and trigger apoptosis by blocking the PI3K/Akt pathway.</p>Fórmula:C25H27F4N7OForma y color:SolidPeso molecular:517.52MAO A/HSP90-IN-1
CAS:<p>MAO A/HSP90-IN-1 (4-b) is a dual inhibitor of MAO A and HSP90, exhibiting IC50 values of 1.77 μM in glioblastoma (GBM) GL26 cells and 0.019 μM against HSP90α.</p>Fórmula:C24H29ClN2O4Pureza:98%Forma y color:SolidPeso molecular:444.95Iroxanadine sulfate
CAS:<p>Iroxanadine sulfate is a MAPK p38 inhibitor potentially for the treatment of atherosclerosis.</p>Fórmula:C14H22N4O5SForma y color:SolidPeso molecular:358.41GRP78-IN-2
CAS:<p>GRP78-IN-2 inhibits surface GRP78, showing anti-angiogenic and anti-cancer properties, sparing normal cells.</p>Fórmula:C29H29NO6Forma y color:SolidPeso molecular:487.54Phenamacril
CAS:<p>Phenamacril (JS39919) is acyanoacrylate fungicide, has powerful inhibition against Fusarium species, especially to Fusarium graminearum.</p>Fórmula:C12H12N2O2Pureza:99.52%Forma y color:SolidPeso molecular:216.24β-catenin-IN-6
CAS:<p>β-Catenin-IN-6 is an inhibitor of the canonical Wnt/β-catenin signaling pathway, effectively impeding the proliferation of human colorectal cancer cells and</p>Fórmula:C22H19ClN6OForma y color:SolidPeso molecular:418.88TRV-1387
CAS:<p>TRV-1387, a benzofurazan derivative, inhibits the aggregation of tau and amyloid-β [1].</p>Fórmula:C23H25F3N4O2Forma y color:SolidPeso molecular:446.47Levocabastine
CAS:<p>Levocarbastine: 2nd-gen H1 antagonist, treats allergic conjunctivitis, selective NTS2 neurotensin inhibitor.</p>Fórmula:C26H29FN2O2Forma y color:SolidPeso molecular:420.52Teclistamab
CAS:<p>Teclistamab(JNJ-64007957) is a human bispecific monoclonal antibody targeting the CD3 receptor on t-cells and the BCMA for relapsed and refractory multiple myeloma.</p>Pureza:95%Forma y color:LiquidJNJ-26076713
CAS:<p>JNJ-26076713, an oral alpha V integrin blocker, may treat macular edema, AMD, and diabetic retinopathy.</p>Fórmula:C29H38N4O3Pureza:98%Forma y color:SolidPeso molecular:490.64CCT-271850
CAS:<p>CCT-271850 is an inhibitor of the spindle checkpoint function of Monospindle 1.</p>Fórmula:C24H29N7OPureza:98%Forma y color:SolidPeso molecular:431.53TAS0612
CAS:<p>TAS0612, a novel oral inhibitor of RSK, AKT, and S6K, exhibits broad-spectrum antitumor activity by impeding cell growth [1].</p>Fórmula:C27H34F3N9O2Pureza:98%Forma y color:SolidPeso molecular:573.61Dolastatinol
CAS:<p>Dolastatinol, a synthetic analog of Dolastatin 10, serves as a potent low-nanomolar inhibitor of tubulin polymerization.</p>Fórmula:C43H70N6O7SForma y color:SolidPeso molecular:815.12EG-011
CAS:<p>EG-011, a potent first-in-class WASP activator, enhances actin polymerization, showing selective anti-tumor effects in lymphomas.</p>Fórmula:C28H26N4O4Forma y color:SolidPeso molecular:482.53Pivanex
CAS:<p>Pivanex, an oral HDAC inhibitor, targets metastasis, angiogenesis, reduces Bcr-Abl protein, and promotes apoptosis.</p>Fórmula:C10H18O4Pureza:≥98%Forma y color:SolidPeso molecular:202.25PAK1-IN-1
CAS:<p>PAK1-IN-1: PAK1 inhibitor, IC50 9.8 nM, hinders tumor cell migration and invasion dose-dependently.</p>Fórmula:C26H20ClN5O2Forma y color:SolidPeso molecular:469.92G-5555
CAS:<p>G-5555 is a potent inhibitor of p21-activated kinase 1 (PAK1) (Kis: 3.7 nM and 11 nM for PAK1 and PAK2, respectively).</p>Fórmula:C25H25ClN6O3Pureza:99.76% - 99.84%Forma y color:SolidPeso molecular:492.96Luvixasertib hydrochloride
CAS:<p>CFI-402257 hydrochloride, a highly selective and orally bioavailable inhibitor targeting TTK/Mps1, demonstrates an in vitro IC50 value of 1.7 nM against TTK. This compound exhibits anti-cancer activity [1].</p>Fórmula:C28H31ClN6O3Forma y color:SolidPeso molecular:535.04β-Catenin modulator-1
CAS:<p>β-Catenin modulator-1 (IIa-650) is a useful agent in cancer research for modulating β-Catenin [1].</p>Fórmula:C21H28N2O4SForma y color:SolidPeso molecular:404.52ICAM-1-IN-1
CAS:<p>ICAM-1-IN-1 is a potent and selective E-selectin(IC50 = 7 nM) and ICAM-1(IC50 = 5 nM) inhibitor.</p>Fórmula:C15H11BrN2O2SPureza:99.67%Forma y color:SolidPeso molecular:363.23AKT-I-1
CAS:<p>AKT-I-1 is a selective and reversible inhibitor of Akt1.</p>Fórmula:C22H30N6Pureza:99.89%Forma y color:SolidPeso molecular:378.51ALM301
CAS:<p>ALM301: oral AKT inhibitor targeting AKT1, AKT2, AKT3; blocks AKT phosphorylation, curbs cancer cell growth.</p>Fórmula:C25H25N3O3Forma y color:SolidPeso molecular:415.48β-Catenin modulator-4
CAS:<p>β-Catenin modulator-4 (compound IIa-92), encompassing oxazole and thiazole moieties, acts as a potent and selective modulator of β-Catenin [1].</p>Fórmula:C21H21ClN2O2SForma y color:SolidPeso molecular:400.92Flavokawain 1i
CAS:<p>Flavokawain 1i, a derivative of chalcones flavokawain A, flavokawain B, and flavokawain C, exhibits anticancer and antiviral properties.</p>Fórmula:C21H18O4Forma y color:SolidPeso molecular:334.37Gossypolone
CAS:<p>Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.</p>Fórmula:C30H26O10Pureza:96.66%Forma y color:SolidPeso molecular:546.52CFI-402257
CAS:<p>CFI-402257 is a selective inhibitor of Mps1/TTK kinase (Mps1 Ki = 0.09 nM; EC50 = 6.5 nM)and can be used in studies about hepatocellular carcinoma diseases.</p>Fórmula:C28H30N6O3Pureza:96.66% - 99.51%Forma y color:SolidPeso molecular:498.58Roxifiban acetate
CAS:<p>Roxifiban acetate（DMP 754 acetate） is a potent GP IIb / IIIa antagonist that exhibits antiplatelet aggregation activity via immune mediation and can be used in</p>Fórmula:C23H33N5O8Pureza:97.91% - 98.36%Forma y color:SolidPeso molecular:507.54ATM-3507
CAS:<p>ATM-3507 is an inhibitor of tropomyosin. In human melanoma cell lines, the IC50s are from 3.83-6.84 μM.</p>Fórmula:C37H46FN5O2Pureza:96.77% - 98.81%Forma y color:SolidPeso molecular:611.79GNF-6231
CAS:<p>GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.</p>Fórmula:C24H25FN6O2Pureza:99.74% - >99.99%Forma y color:SolidPeso molecular:448.49M2698
CAS:<p>M2698 (MSC2363318A) is an inhibitor of p70S6K, Akt1 and Akt3 with IC50s of 1 nM. M2698 shows anti-cancer activity.</p>Fórmula:C21H19ClF3N5OPureza:99.88%Forma y color:SolidPeso molecular:449.86αvβ1 integrin-IN-1
CAS:<p>αvβ1 integrin-IN-1 is a potent and selective inhibitor of αvβ1 integrin (IC50 of 0.63 nM) with antifibrotic effects.</p>Fórmula:C26H34N6O6SPureza:99.74% - >99.99%Forma y color:SolidPeso molecular:558.65UCL-TRO-1938
CAS:<p>UCL-TRO-1938 is a subtype-selective PI3Kα allosteric activator with cardioprotective and neuroregenerative effects.</p>Fórmula:C27H32N6OPureza:99.95%Forma y color:SolidPeso molecular:456.58Zamaporvint
CAS:<p>Zamaporvint (RXC004) , a Wnt pathway inhibitor with antitumor and antiproliferative activity, blocks Wnt ligand palmitoylation and secretion.</p>Fórmula:C21H16F3N7OPureza:97.5%Forma y color:SolidPeso molecular:439.39Ifebemtinib
CAS:<p>Ifebemtinib (BI-853520) is an adhesion plaque kinase inhibitor with anti-tumour activity for the study of breast cancer.</p>Fórmula:C28H28F4N6O4Pureza:98.84% - 99.85%Forma y color:SolidPeso molecular:588.55PKC-IN-1
CAS:<p>PKC-IN-1 is an ATP-competitive and reversible conventional PKC enzymes inhibitor (PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε with IC50s of 2.3, 8.1, 7.6,</p>Fórmula:C25H37FN8O2Pureza:98% - 98.79%Forma y color:SolidPeso molecular:500.61Quinagolide hydrochloride
CAS:<p>Quinagolide hydrochloride is a selective agonist of dopamine D2 receptor.</p>Fórmula:C20H34ClN3O3SPureza:98%Forma y color:SolidPeso molecular:432.02KY-02327 acetate
<p>KY-02327 acetate inhibits Dvl-CXXC5, stabilizes Wnt/β-catenin signaling, and enhances osteoblast differentiation.</p>Fórmula:C22H31N3O6Forma y color:SolidPeso molecular:433.5Nrf2/HO-1 activator 1
CAS:<p>Compound 24: Potent Nrf2/HO-1 activator with neuroprotective, antioxidant properties; useful in PD research.</p>Fórmula:C21H18O5Forma y color:SolidPeso molecular:350.36SR121566A
CAS:<p>SR121566A is a novel non-peptide antagonist of Glycoprotein IIb/IIIa (GP IIb-IIIa).</p>Fórmula:C20H25N5O4SPureza:98%Forma y color:SolidPeso molecular:431.51Latrunculins A
CAS:<p>Latrunculins A is a novel marine toxin, disrupts microfilament organization in cultured cells.</p>Fórmula:C22H31NO6SForma y color:SolidPeso molecular:437.55Tubulin polymerization-IN-77
CAS:<p>Tubulin polymerization-IN-77 (Compound 15c) is a microtubule polymerization inhibitor that exhibits anti-glioblastoma activity by hindering microtubule polymerization. It demonstrates significant blood-brain barrier permeability, effectively induces G2/M phase arrest in GBM cells, and triggers apoptosis, while also markedly inhibiting tumor cell migration.</p>Fórmula:C22H19BrF3NO7Forma y color:SolidPeso molecular:546.288HG-7-86-01
CAS:<p>HG-7-86-01 is a selective type II tyrosine kinase inhibitor with antiproliferative activity against mutant T315I- Bcr-Abl for chronic myeloid leukemia (CML).</p>Fórmula:C28H21F3N6O2SPureza:99.07%Forma y color:SolidPeso molecular:562.57PI3K-IN-29
CAS:<p>PI3K-IN-29: Strong PI3K block, inhibits Akt phosphorylation. IC50: U87MG 0.264µM, HeLa 2.04µM, HL60 1.14µM.</p>Fórmula:C27H22ClN7O3SForma y color:SolidPeso molecular:560.03FAK inhibitor 7
CAS:<p>FAK inhibitor7, a potent FAK inhibitor, demonstrates an IC50 of 3.58 nM. This compound effectively inhibits downstream signaling cascades of FAK (such as Src and AKT), which leads to cell cycle arrest at the G0/G1 phase and induces cytotoxic autophagy in ovarian cancer cells. Additionally, FAK inhibitor7 has been shown to suppress tumor metastasis and growth in ovarian cancer mouse models.</p>Fórmula:C32H37N7O3Forma y color:SolidPeso molecular:567.68Tubulin inhibitor 16
<p>Tubulin inhibitor 16 is a potent tubulin inhibitor with antiproliferative activity. Tubulin inhibitor 16 exhibits cytotoxicity in HepG2 cells [1].</p>Fórmula:C16H12FNO2Forma y color:SolidPeso molecular:269.27Hsp90-IN-37
CAS:<p>Hsp90-IN-37 (Z-2) is an inhibitor of heat shock protein 90 (Hsp90), demonstrating a 69% inhibition rate on Hsp90 enzyme activity. It exhibits antitumor properties.</p>Fórmula:C12H15N3O2Forma y color:SolidPeso molecular:233.266HSP90-IN-32
CAS:<p>HSP90-IN-32, a carboxy-terminus inhibitor of Hsp90C, exhibits antiproliferative activity in various cell lines including SKMel173, SKMel103, SKMel19, and A375, with IC50 values of 1.01 μM, 0.782 μM, 0.607 μM, and 1.413 μM, respectively. This compound holds potential for research in anticancer agents.</p>Fórmula:C33H40N2O4Forma y color:SolidPeso molecular:528.68ZLY06
CAS:<p>ZLY06 is a dual agonist of peroxisome proliferator-activated receptors (PPAR) δ and γ with oral activity (PPAR δ: EC50=341 nM; PPARγ: EC50=237 nM). It mediates the upregulation of CD36 and induces hepatic lipid accumulation by inhibiting the phosphorylation of AKT1. Moreover, ZLY06 significantly improves glucose and lipid metabolism without increasing body weight, primarily by enhancing the β-oxidation of fatty acids and reducing hepatic lipid synthesis, thereby alleviating fatty liver disease.</p>Fórmula:C25H26O6Forma y color:SolidPeso molecular:422.47Tau ligand-1
CAS:<p>Tau ligand-1 (Compound 75) is a ligand of aggregated tau protein that can penetrate the blood-brain barrier. In tissues affected by Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, and Pick's disease, Tau ligand-1 shows high affinity for aggregated tau protein, with equilibrium dissociation constants (KD) ranging from 1 to 3.8 nM. It holds potential as a positron emission tomography (PET) tracer for imaging studies of tau-related diseases within the central nervous system.</p>Fórmula:C17H16FN3OForma y color:SolidPeso molecular:297.327GSK3335103
CAS:<p>GSK3335103 is a non-peptide, orally active inhibitor of αvβ6 integrin (pIC50=8), employed in the study of pulmonary fibrosis.</p>Fórmula:C27H36FN3O4Forma y color:SolidPeso molecular:485.59POSH-IN-2
CAS:<p>POSH-IN-2 (MIDI) is a mitochondrial fission inhibitor and a DRP1 inhibitor that effectively prevents mitochondrial fragmentation caused by cellular stress and genetic mitochondrial damage. It covalently interacts with DRP1-C367 to target the interaction of DRP1 with multiple receptors.</p>Fórmula:C22H16N2O2Forma y color:SolidPeso molecular:340.37PM-060184
CAS:<p>PM-060184, a tubulin polymerisation inhibitor, is used potentially for the treatment of solid tumours and breast cancer.</p>Fórmula:C31H45N3O7Pureza:98%Forma y color:SolidPeso molecular:571.7C086
CAS:<p>C086 is a novel and potent Hsp90 inhibitor that suppresses cell cycle progression, induces apoptosis, and exhibits anti-metastatic properties by modulating various mechanisms in different cell types.</p>Fórmula:C29H28O8Forma y color:SolidPeso molecular:504.53KUNG65
CAS:<p>KUNG65 acts as a selective Grp94 inhibitor, demonstrating a target dissociation constant (K_d) of 540 nM. It exhibits a minimum selectivity of 73-fold compared to other Hsp90 isoforms.</p>Fórmula:C23H20ClFO4Forma y color:SolidPeso molecular:414.85XD23
CAS:<p>XD23 is a potent osteosarcoma inhibitor that functions by downregulating DKK1 and activating the WNT/β-catenin signaling pathway.</p>Fórmula:C22H26ClN7O3Forma y color:SolidPeso molecular:471.94Nic-15
CAS:<p>Nic-15 (compound 4n) serves as an anti-constrictive agent targeting the low vascular characteristics of pancreatic tumors. These characteristics enable cancer cells to adapt to the nutrient-deficient tumor microenvironment and develop resistance to treatment. Nic-15 modulates the PI3K/Akt/mTOR pathway and alleviates ER stress induced by Gemcitabine. It significantly inhibits migration and colony formation in MIA PaCa-2 and PANC-1 pancreatic cancer cells. When used in combination with Gemcitabine, Nic-15 effectively addresses resistance issues in pancreatic tumors. In xenograft models in vivo, Nic-15 notably enhances the efficacy of Gemcitabine.</p>Fórmula:C25H26F2O3Forma y color:SolidPeso molecular:412.47Si306
CAS:<p>Si306, an Src inhibitor, exhibits antitumor activity by reducing the phosphorylation of focal adhesion kinase (FAK) and the expression of epidermal growth factor receptor (EGFR), thereby inhibiting the invasion of human glioblastoma (GBM).</p>Fórmula:C25H26BrClN6OSForma y color:SolidPeso molecular:573.94SF0166
CAS:<p>SF0166: potent αvβ3 antagonist, IC50: 0.6 nM. Blocks cell adhesion, IC50: 7.6 pM-76 nM. Reduces neovascularization in mice.</p>Fórmula:C23H27F2N5O4Forma y color:SolidPeso molecular:475.49NAP1051
CAS:<p>NAP1051, a biomimetic analog of Lipoxin A4, serves an anti-tumor role by targeting the inflammatory tumor microenvironment. It inhibits the chemotaxis of neutrophils to fMLP and stimulates macrophage efferocytosis by activating AKT. NAP1051 is utilized in research on colorectal cancer.</p>Fórmula:C23H34O5Forma y color:SolidPeso molecular:390.51Alfalone
CAS:<p>Alfalone (compound 9ia) is an antimitotic agent. It induces cleavage arrest and initiates the formation of tubercular eggs.</p>Fórmula:C17H14O5Forma y color:SolidPeso molecular:298.29TPI-287
CAS:<p>TPI 287: synthetic taxane; may halt cancer by stabilizing microtubules, blocking cell division, inducing apoptosis.</p>Fórmula:C46H63NO15Forma y color:SolidPeso molecular:869.99PKCTheta-IN-2
CAS:PKCTheta-IN-2 (compound 14) is a potent and selective inhibitor of PKCθ, with an IC50 value of 0.25 nM. It demonstrates good selectivity across a broad range of kinases, including the PKC subfamily (30 kinases). Additionally, PKCTheta-IN-2 effectively inhibits the production of IL-2 in mice, where it exhibits an IC50 of 682 nM.Fórmula:C24H23N5O2Forma y color:SolidPeso molecular:413.47Uprosertib hydrochloride
CAS:<p>Uprosertib hydrochloride is a potent and selective inhibitor of pan-Akt (IC50: 180/328/38 nM for Akt1/Akt2/Akt3, respectively).</p>Fórmula:C18H17Cl3F2N4O2Pureza:98%Forma y color:SolidPeso molecular:465.71DCEM1
CAS:<p>DCEM1 binds to heat shock protein 60 (HSP60) and inhibits the interaction between HSP60 and ClpP, thereby blocking the mitochondrial unfolded protein response. Additionally, DCEM1 suppresses the expression of β-catenin and reduces ATP production in PC-3 and TKO cells. It is utilized in research related to prostate cancer.</p>Fórmula:C22H23N3O2SForma y color:SolidPeso molecular:393.5016,16-Dimethyl prostaglandin E2
CAS:<p>16,16-Dimethyl prostaglandin E2 regulates hematopoietic stem cells via EP2/EP4 and Wnt, taken orally.</p>Fórmula:C22H36O5Pureza:98%Forma y color:SolidPeso molecular:380.52Cemdomespib
CAS:<p>Cemdomespib (KU-596) is a potent Hsp90 modulator with neuroprotective effects and can improve diabetic neuropathy.</p>Fórmula:C24H30FNO6Forma y color:SolidPeso molecular:447.5GSK3β-IN-2
CAS:<p>GSK3β-IN-2 (Compound S01) is an inhibitor of GSK3β with an IC50 of 0.35 nM. It activates the Wnt/β-catenin signaling pathway, promoting neurogenesis and neurite outgrowth. GSK3β-IN-2 reduces tau protein phosphorylation induced by Aβ at the Ser396 site, thereby decreasing neurofibrillary tangles. Furthermore, GSK3β-IN-2 improves Alzheimer's disease symptoms in a zebrafish model.</p>Fórmula:C25H18N4OForma y color:SolidPeso molecular:390.437Antitubulin agent 1
<p>Antitubulin agents-1 disrupts microtubules, ups α-tubulin acetylation, and has anticancer properties.</p>Fórmula:C21H19N3O3Forma y color:SolidPeso molecular:361.39OXA-11
CAS:<p>OXA-11 (FAK-IN-16) is a FAK inhibitor with anti-tumor activity, useful for cancer research.</p>Fórmula:C37H49F3N7O5PPureza:98.70% - 99.20%Forma y color:SolidPeso molecular:759.8GR 83895
CAS:<p>GR 83895 is an antagonist of prototype fibrinogen receptor.</p>Fórmula:C29H39N9O8SPureza:98%Forma y color:SolidPeso molecular:673.74HSN748
CAS:<p>HSN748 is an analog of ponatinib and acts as a multi-kinase inhibitor. It exhibits inhibitory activity against kinases such as FLT3, ABL1, RET, PDGFRα/β, MNK1, and MNK2. HSN748 can suppress the growth of chronic myeloid leukemia and acute myeloid leukemia cell lines, making it a useful compound in leukemia research.</p>Fórmula:C27H24F3N7OForma y color:SolidPeso molecular:519.521TTBK1/2-IN-1
CAS:<p>TTBK1/2-IN-1 (compound 3) is a potent inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 816 nM and 384 nM, respectively.</p>Fórmula:C17H16N4OForma y color:SolidPeso molecular:292.335HSP90-IN-11
<p>HSP90-IN-11: potent HSP90 inhibitor, akin to AUY-922; hinders CRC/NSCLC cell proliferation; degrades EGFR, Akt proteins.</p>Fórmula:C27H30FN3O6Forma y color:SolidPeso molecular:511.54Myoseverin B
CAS:<p>Myoseverin B is a microtubule assembly inhibitor that impedes tubulin polymerization (IC50 = 2 μM) and generally exhibits low cytotoxicity across most cell types. It is utilized in antitumor agent research.</p>Fórmula:C27H32N6O2Forma y color:SolidPeso molecular:472.582AKT-IN-11
<p>AKT-IN-11 is one of the most potent antibacterial agents against human hepatocellular carcinoma Bel-7402 cell line (IC50: 1.15 μM).</p>Fórmula:C27H27ClF3NO4Forma y color:SolidPeso molecular:521.96APN/AKT-IN-1
<p>APN/AKT-IN-1, a dual APN (IC50=0.21μM) & AKT (IC50=0.27μM) inhibitor, hinders GSK3β phosphorylation.</p>Fórmula:C18H27N7O3Forma y color:SolidPeso molecular:389.45FO-4-15
CAS:<p>FO-4-15 is an activator of mGluR1/CaMKIIα. It exhibits protective effects against H2O2 in human neuroblastoma (SH-SY5Y) cells. In mice with Alzheimer's disease, FO-4-15 enhances cognitive function by activating the mGluR1/CaMKIIα pathway, reducing Aβ accumulation, Tau hyperphosphorylation, and synaptic damage.</p>Fórmula:C18H20N4O4SForma y color:SolidPeso molecular:388.44JC168
CAS:<p>JC168 is a phenyl analog of peloruside and functions as a microtubule inhibitor with antiproliferative and anticancer properties. It enhances tubulin polymerization, thereby disrupting microtubule dynamics, making it a useful agent in the study of microtubule-associated diseases.</p>Fórmula:C26H40O7Forma y color:SolidPeso molecular:464.592Hsp110-STAT3 interaction-IN-1
CAS:<p>Row174336 (compound 29) serves as an efficient inhibitor of the Hsp110-STAT3 interaction, exhibiting antiproliferative activity in the HPAEC cell line with an IC50 of 22.67 μM.</p>Fórmula:C23H31N3O4SForma y color:SolidPeso molecular:445.58AMXI-5001 hydrochloride
<p>AMXI-5001 hydrochloride, an oral inhibitor of PARP1/2 and microtubules, shows greater potency and selective anti-cancer effects.</p>Fórmula:C25H21ClFN5O3Forma y color:SolidPeso molecular:493.92AS2521780
CAS:<p>AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).</p>Fórmula:C30H41N7OSPureza:98%Forma y color:SolidPeso molecular:547.76L 734217
CAS:<p>L 734217 is an antagonist of the fibrinogen receptor.</p>Fórmula:C18H31N3O4Pureza:98%Forma y color:SolidPeso molecular:353.46NRX-2663
CAS:<p>NRX-2663 boosts β-catenin binding to E3 ligase SCFβ-TrCP (Kd: 54.8 nM, EC50: 22.9 nM).</p>Fórmula:C20H13F3N2O5Forma y color:SolidPeso molecular:418.32PROTAC α-synuclein degrader 6
CAS:<p>PROTACα-synuclein degrader 6 (compound T3) is a PROTAC degrader of α-synuclein and tau, with an EC50 of 1.57 μM and 4.09 μM, respectively. This compound plays a significant role in neurodegenerative disease (ND) research.</p>Fórmula:C37H39N5O9SPeso molecular:729.80ETB
CAS:<p>ETB is a potent inhibitor of Hsp60 chaperone activity. It can impede the chaperone function of both wild-type proteins and the C237A and C447A mutant proteins. ETB binds to Hsp60 at Cys442, and the C442A mutant demonstrates resistance to ETB inhibition.</p>Fórmula:C24H33NO6Peso molecular:431.52SPA0355
CAS:<p>SPA0355 is a thiourea derivative with antioxidant and anti-inflammatory properties. It inhibits RANKL (receptor activator of nuclear factor κB ligand)-induced osteoclastogenesis in primary bone marrow-derived macrophages and suppresses the activation of MAPKs, Akt, and NF-κB pathways. Furthermore, SPA0355 enhances osteoblast differentiation by increasing alkaline phosphatase activity and mineralized nodule formation. It protects ovariectomized mice from bone loss by stimulating osteoblast differentiation and inhibiting osteoclast resorption, making it a potential candidate for studying postmenopausal osteoporosis.</p>Fórmula:C22H21N3O2SForma y color:SolidPeso molecular:391.486Hsp90-IN-38
CAS:<p>Hsp90-IN-38 (compound 20m) is an inhibitor of HSP90 (heat shock protein). It demonstrates a strong binding affinity to HSP90 with a Kd of 87 nM. The compound inhibits ATPase activity with an IC50 of 0.13 μM. Hsp90-IN-38 also shows inhibitory effects on HCT116, MCF-7, SKBr3, K562, and A549 cells with IC50 values of 0.187, 0.072, 0.105, 0.403, and 0.031 μM, respectively.</p>Fórmula:C28H35N3O5Forma y color:SolidPeso molecular:493.595Terpendole E
CAS:<p>Terpendole E is an atypical L5 site inhibitor.</p>Fórmula:C28H39NO3Forma y color:SolidPeso molecular:437.61AMG28
CAS:<p>AMG28 is an inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 805 nM and 988 nM, respectively. Additionally, AMG28 suppresses the phosphorylation of tau protein at the Ser422 site, with an IC50 of 1.85 μM.</p>Fórmula:C20H20N4OForma y color:SolidPeso molecular:332.399Tubulin polymerization-IN-32
<p>Tubulin polymerization-IN-32: a cancer cell growth inhibitor used for research in cancers like lymphoma.</p>Fórmula:C29H30N2O7Forma y color:SolidPeso molecular:518.56Mps1-IN-8
CAS:<p>Mps1-IN-8, a Mps1 inhibitor, can be utilized in the study of various tumors [1].</p>Fórmula:C35H47N8O6PForma y color:SolidPeso molecular:706.77Tubulin polymerization-IN-33
<p>Tubulin-IN-33, an oxazoloisoindole, hinders microtubule assembly; effective against NCI cancer cells.</p>Fórmula:C27H28N2O6Forma y color:SolidPeso molecular:476.52PP487
CAS:<p>PP487 is a dual tyrosine kinase/PI(3)K inhibitor, exhibiting IC50 values of 0.017 μM, 0.072 μM, 0.004 μM, 0.01 μM, 0.55 μM, 0.22 μM, and < 0.01 μM against DNA-PK, mTOR, Hck, Src, EGFR, EphB4, and PDGFR, respectively. It is applicable in cancer research [1].</p>Fórmula:C14H14BrN5OForma y color:SolidPeso molecular:348.2Dictyostatin
CAS:<p>Dictyostatin: potent microtubule stabilizer & anticancer agent with antiproliferative effects; researched for tauopathies.</p>Fórmula:C32H52O6Forma y color:SolidPeso molecular:532.75Tubulin polymerization-IN-8
CAS:<p>Compound IIc inhibits tubulin polymerization, arrests cell cycle at G2/M in HCT116 cells, IC50 12.7 μM, potential for cancer research.</p>Fórmula:C21H24N4O4SForma y color:SolidPeso molecular:428.5AKT-IN-10
CAS:<p>AKT-IN-10, a potent AKT inhibitor, has potential for breast and prostate cancer research, impacting cell growth and survival pathways.</p>Fórmula:C26H34ClN5O2Forma y color:SolidPeso molecular:484.03MT-134
<p>MT-134 is a SkMII -specific inhibitor and has excellent exposure in muscles.</p>Fórmula:C19H16N4O3Forma y color:SolidPeso molecular:348.36GSD-11
<p>GSD-11: Potent, selective anti-austerity agent; blocks Akt/mTOR pathway, hinders PANC-1 cell migration & colony growth. Promising for pancreatic cancer study.</p>Fórmula:C20H28O2Forma y color:SolidPeso molecular:300.44Tubulin polymerization-IN-63
CAS:<p>Tubulin polymerization-IN-63 (compound 6) is an inhibitor of tubulin polymerization. It exhibits an IC50 value of 0.29 μM against MES-SA cells, making it suitable for use in cancer research.</p>Fórmula:C20H24ClCuN5O2SForma y color:SolidPeso molecular:497.5Epothilone E
CAS:<p>Epothilone E, a derivative of epothilone, functions by inhibiting microtubule protein activity, thereby halting cell division and exhibiting anti-tumor</p>Fórmula:C26H39NO7SForma y color:SolidPeso molecular:509.66Kolavenic acid analog
CAS:<p>KAA, an anticancer compound, inhibits centrosome clustering and targets HSET+ yeast and cancer cells.</p>Fórmula:C25H38O4Forma y color:SolidPeso molecular:402.57FPDT
<p>FPDT combats glioblastoma by inhibiting the AKT pathway; IC50: >100 μM (astrocytes), 45-68 μM (GBM cells).</p>Fórmula:C16H12FNO2SForma y color:SolidPeso molecular:301.34Tubulin inhibitor 22
<p>Compound 4c: Strong tubulin inhibitor with anti-cancer & anti-angiogenic effects; halts MGC-803 cells in G2/M, triggers Caspase-mediated apoptosis.</p>Fórmula:C20H17BrFNO4Forma y color:SolidPeso molecular:434.26G-9791
CAS:<p>G-9791 is an effective and selective inhibitor of group-I PAK.</p>Fórmula:C26H26ClFN6O2Pureza:98%Forma y color:SolidPeso molecular:508.98Icafolin-methyl
CAS:<p>Icafolin-methyl is a plant-specific herbicide that acts as an inhibitor of tubulin polymerization. In plants, it metabolizes into the carboxylic acid icafolin, potentially inhibiting plant tubulin polymerization by binding to β-tubulin.</p>Fórmula:C18H18F2N2O5Forma y color:SolidPeso molecular:380.343Nrf2/HO-1 activator 2
<p>Compound 13m, a difluoro derivative, activates Nrf2/HO-1, showing neuroprotective and antioxidant effects, useful in PD research.</p>Fórmula:C20H16F2O5Forma y color:SolidPeso molecular:374.33EV206
CAS:<p>EV206 is an effective inhibitor of Hsp70, exhibiting antiproliferative properties. This compound induces cell apoptosis (apoptosis) and enhances the protein expression of cleaved PARP and caspase-3. Additionally, EV206 demonstrates antitumor activity.</p>Fórmula:C21H19N3OForma y color:SolidPeso molecular:329.40HSP90α-IN-1
CAS:<p>HSP90α-IN-1 is an HSP90α inhibitor (IC50= 111 nM) that demonstrates anti-aging activity across various cellular senescence models. Belonging to the xanthine family, HSP90α-IN-1 is involved in research focused on combating age-related inflammation, senescence, and diseases (including cancer), and it may contribute to extending healthy lifespan.</p>Fórmula:C19H16N4O2Forma y color:SolidPeso molecular:332.356Dioleyl phosphatidylserine
CAS:<p>Dioleyl phosphatidylserine is a phospholipid that can activate PKC-γ (Protein Kinase C-gamma) when the Ca2+ concentration is below 0.5 μM, specifically at a concentration of 100 μM.</p>Fórmula:C42H78NO10PForma y color:SolidPeso molecular:788.04FAK-IN-21
CAS:<p>FAK-IN-21 (compound 9) is a FAK inhibitor with an IC50 value of 37.52 nM. It inhibits cell growth and the phosphorylation of FAK, making it useful for research into diffuse gastric cancer.</p>Fórmula:C22H22F2N8O3SForma y color:SolidPeso molecular:516.52Tubulin inhibitor 19
<p>Tubulin inhibitor 19 (9b), a potent indole chalcone, strongly blocks tubulin, valuable in cancer studies.</p>Fórmula:C21H23NO5Forma y color:SolidPeso molecular:369.41Fradafiban
CAS:<p>Fradafiban binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM. Fradafiban is a non-polypeptide platelet glycoprotein IIb/IIIa antagonist.</p>Fórmula:C20H21N3O4Pureza:98%Forma y color:SolidPeso molecular:367.40Monomethyl auristatin E intermediate-17
CAS:<p>MonomethylauristatinE intermediate-17 is an intermediate compound used in the synthesis of MonomethylauristatinE. MonomethylauristatinE (MMAE) functions as a microtubule/tubulin inhibitor with anticancer properties. It is widely utilized as the cytotoxic component in antibody-drug conjugates (ADCs).</p>Fórmula:C27H35NO7SPeso molecular:517.636-B345TTQ
CAS:<p>6-B345TTQ is an α4 integrin inhibitor that can impede the interaction between α4 and Leupaxin. This compound is applicable for studies focused on inflammation research.</p>Fórmula:C22H20BrNO4Forma y color:SolidPeso molecular:442.303β-Catenin modulator-8
CAS:<p>β-Catenin modulator-8 (Compound Ⅸa) is a specific β-catenin modulator for use in cancer research.</p>Fórmula:C17H20N2O2SPureza:99.97%Forma y color:SolidPeso molecular:316.42Des-ethyl-carafiban
CAS:<p>Des-ethyl-carafiban (Compound 44) is an antagonist of the fibrinogen receptor, effectively inhibiting platelet aggregation induced by various agonists. It is useful for research in thrombotic diseases.</p>Fórmula:C22H23N5O5Forma y color:SolidPeso molecular:437.448Lisavanbulin
CAS:<p>Lisavanbulin (BAL-101553) is a prodrug of Avanbulin (BAL 27862), a microtubule-targeting agent. It exhibits antitumor activity, particularly effective against tumors with high expression of end-binding protein 1.</p>Fórmula:C26H29N9O3Forma y color:SolidPeso molecular:515.57Hsp90-IN-34
CAS:<p>Hsp90-IN-34 (compound HAM-1) is a chemical inhibitor that targets the Aha1-Hsp90 chaperone complex with high affinity (KDapp=23.5 µM). It modulates the ATPase activity of Hsp90 by affecting the interaction between Hsp90 and Aha1.</p>Fórmula:C22H14F2N6OForma y color:SolidPeso molecular:416.38KU-32
CAS:<p>KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.</p>Fórmula:C20H25NO8Pureza:98%Forma y color:SolidPeso molecular:407.41EX05
CAS:<p>EX05, an effective KIF18A inhibitor, exhibits an IC50 of 8.2 nM and holds potential for cancer research applications.</p>Fórmula:C26H30F2N4O5SForma y color:SolidPeso molecular:548.60AChE/GSK-3β-IN-1
CAS:<p>AChE/GSK-3β-IN-1 is a potent dual AChE/GSK-3β inhibitor that crosses the blood-brain barrier and acts on hAChE (IC50: 1.2 nM), hBChE (IC50: 149.8 nM) and hGSK-</p>Fórmula:C31H35N7O3SForma y color:SolidPeso molecular:585.72AM-9022
CAS:<p>AM-9022 is a potent and selective KIF18A inhibitor, orally active and suitable for cancer research [1].</p>Fórmula:C27H36F2N6O4SForma y color:SolidPeso molecular:578.67Zalunfiban dihydrochloride
<p>Zalunfiban (RUC-4) is a potent αIIbβ3 platelet antagonist, IC50 45 nM, used in myocardial infarction research.</p>Fórmula:C16H20Cl2N8O2SForma y color:SolidPeso molecular:459.35α5β1 integrin agonist-1
CAS:<p>α5β1 integrin agonist-1 is an α5β1 integrin agonist that selectively delivers 5-FU to tumour cells and induces tumour cell death.</p>Fórmula:C24H26FN5O9Forma y color:SolidPeso molecular:547.49HSP90-IN-9
<p>HSP90-IN-9: potent HSP90 inhibitor, dose-dependent fungicide, impedes biofilm/morphology with FLC, reverses FLC resistance.</p>Forma y color:SolidTyrosine kinase-IN-9
CAS:<p>Tyrosine kinase-IN-9 (Compound B) is an inhibitor of c-Abl. It is useful for studying neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.</p>Fórmula:C20H14ClN3O3Forma y color:SolidPeso molecular:379.796MKLP2-IN-1
CAS:<p>MKLP2-IN-1 (compound 12a) is an inhibitor of MKLP2 that demonstrates excellent oral bioactivity. In vitro, MKLP2-IN-1 inhibits the ATPase activity stimulated by recombinant MKLP2 microtubules and, in a mouse Calu-6 lung cancer model, it effectively suppresses tumor growth.</p>Fórmula:C23H19BrFN3O2Forma y color:SolidPeso molecular:468.318Antitumor agent-200
CAS:<p>Antitumor agent-200 (Compound 2g) is a microtubule synthesis inhibitor that binds to the colchicine site on tubulin, causing G2/M cell cycle arrest and inducing reactive oxygen species (ROS) production. It demonstrates significant inhibitory activity against P-glycoprotein (P-gp) overexpressing cell lines MCF7/ADR and KBV200, with resistance indices (DRI) of 0.83 and 0.58, respectively. In an MCF-7 xenograft model, Antitumor agent-200 (at 25 mg/kg, administered intraperitoneally) achieves a 57.2% tumor growth inhibition rate. This compound is applicable for research in the field of cancer therapy.</p>Fórmula:C19H21FN2O3SeForma y color:SolidPeso molecular:423.34DDO-6691
CAS:<p>DDO-6691 is an inhibitor of heat shock protein 90 (HSP90). It exhibits antiproliferative effects against various tumor cells, with the highest sensitivity observed in HCT-116 colon cancer cells (IC50: 1.08 μM). DDO-6691 also demonstrates potent tumor growth inhibition in HCT-116 xenograft mouse models.</p>Fórmula:C22H17N3O2SForma y color:SolidPeso molecular:387.45Tubulin polymerization-IN-35
<p>Tubulin-IN-35 inhibits oxazolylisoindole microtubule formation, targeting VL51 marginal zone lymphoma.</p>Fórmula:C31H35N3O5Forma y color:SolidPeso molecular:529.63Tubulin inhibitor 15
<p>Tubulin inhibitor 15 is a potent tubulin inhibitor with antiproliferative activity. Tubulin inhibitor 15 exhibits cytotoxicity in HepG2 cells [1].</p>Fórmula:C16H12FNO2Forma y color:SolidPeso molecular:269.27Ethaboxam
CAS:<p>Ethaboxam is a β-tubulin inhibitor and antifungal agent used against oomycete pathogens.</p>Fórmula:C14H16N4OS2Pureza:99.37%Forma y color:SolidPeso molecular:320.43AKT-IN-26
CAS:<p>AKT-IN-26 (Compound 453) is an AKT inhibitor that binds to the Pleckstrin Homology (PH) domain of AKT. It is useful for research related to cell proliferation and cancer involving the AKT pathway.</p>Fórmula:C21H17N5O4SForma y color:SolidPeso molecular:435.456Tubulin inhibitor 49
CAS:<p>Tubulin inhibitor 49 (Compound 18) is an inhibitor of tubulin polymerization with an IC50 of 48 μM. It disrupts the microtubule network of cells, causing cell cycle arrest in the G2 phase, and exhibits cytotoxicity with an IC50 of 8.8 μM in HeLa cells.</p>Fórmula:C18H14F3N3OSForma y color:SolidPeso molecular:377.383Onalespib lactate
CAS:<p>Onalespib lactate is a second-generation, potent and selective HSP90 Inhibitor with antitumor activity.</p>Fórmula:C27H37N3O6Forma y color:SolidPeso molecular:499.6Tasidotin hydrochloride
CAS:<p>Tasidotin hydrochloride, a dolastatin 15 analog, inhibits microtubule assembly and dynamics.</p>Fórmula:C32H59ClN6O5Pureza:98%Forma y color:SolidPeso molecular:643.30TACC3 inhibitor 2
CAS:<p>TACC3 inhibitor 2 (Compound 13b) is a TACC3 inhibitor with an IC50 of 200 nM. It induces mitotic arrest, apoptosis (Apoptosis), and DNA damage. TACC3 inhibitor 2 is applicable for research in the field of cancer.</p>Fórmula:C20H22FN5O2Forma y color:SolidPeso molecular:383.419Wikstrol A
CAS:<p>Wikstrol A: antifungal, anti-mitotic, anti-HIV agent with various IC50/MDC values (67.8-131 µM) and deforms P. oryzae mycelia.</p>Fórmula:C30H22O10Forma y color:SolidPeso molecular:542.49Tubulin polymerization-IN-75
CAS:<p>Tubulin polymerization-IN-75 (Compound 6) is an inhibitor of tubulin polymerization, with an IC50 value of 30 μM. It effectively suppresses the proliferation of cancer cells Huh7 and 293T, demonstrating IC50 values of 14.3 μM and 13.8 μM, respectively.</p>Fórmula:C14H11NOForma y color:SolidPeso molecular:209.243TTBK1/2-IN-3
CAS:<p>TTBK1/2-IN-3 (compound 10) is a potent inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 579 nM and 258 nM, respectively. TTBK1/2-IN-3 can reduce the expression of primary cilia on the surface of human induced pluripotent stem cells (iPSC).</p>Fórmula:C21H22N4OForma y color:SolidPeso molecular:346.426Ack1 inhibitor 1
CAS:<p>Ack1 inhibitor 1 is a potent and selective orally active inhibitor of ACK1 kinase, with an IC50 value of 2.1 nM. It effectively inhibits the phosphorylation of ACK1 and the activation of downstream AKT, demonstrating anti-tumor activity [1].</p>Fórmula:C39H40F3N7O4Forma y color:SolidPeso molecular:727.77RMS-07
CAS:<p>RMS-07, a covalent MPS1/TTK inhibitor, has an IC50 of 13.1 nM, targeting a kinase hinge cysteine.</p>Fórmula:C35H40N8O2Forma y color:SolidPeso molecular:604.74Macbecin I
CAS:<p>Hsp90 inhibitor</p>Fórmula:C30H42N2O8Pureza:98%Forma y color:SolidPeso molecular:558.66Tubulin polymerization-IN-74
CAS:<p>Tubulin polymerization-IN-74 (compound 11) is an inhibitor of tubulin polymerization, with an IC50 value of 15 μM. It is applicable to cancer research.</p>Fórmula:C14H11NSForma y color:SolidPeso molecular:225.309Tubulin polymerization-IN-34
<p>"Tubulin-IN-34 inhibits oxazolylisoindole microtubule assembly, selective for VL51 lymphoma."</p>Fórmula:C31H35N3O6Forma y color:SolidPeso molecular:545.63NRX-103094
CAS:<p>NRX-103094 boosts β-catenin binding to SCFβ-TrCP ligase with EC50 62 nM and Kd 0.6 nM.</p>Fórmula:C20H11Cl2F3N2O4SPureza:99.13%Forma y color:SolidPeso molecular:503.28NRX-252114
CAS:<p>NRX-252114 promotes mutant β-catenin degradation, binding it to E3 ligase SCFβ-TrCP (EC50: 6.5 nM; Kd: 0.4 nM).</p>Fórmula:C22H12Cl2F3N3O2SPureza:99.70%Forma y color:SolidPeso molecular:510.32AKT Kinase Inhibitor
CAS:<p>AKT Kinase Inhibitor is an Akt inhibitor with antitumor activity that selectively inhibits cell proliferation in a dose-dependent manner.Cost-effective and quality-assured.</p>Fórmula:C16H19N7O3Pureza:97.83% - 99.13%Forma y color:SolidPeso molecular:357.37Ombrabulin
CAS:<p>Ombrabulin is a derivative of CA-4 phosphate. It is known to show antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells.</p>Fórmula:C21H26N2O6Pureza:98%Forma y color:SolidPeso molecular:402.44Tau tracer 2
CAS:<p>Tau tracer 2 (Pl-2620) is a specific imaging agent designed to detect and visualize Tau protein aggregates, primarily used for diagnosing neurodegenerative diseases [1].</p>Fórmula:C15H9FN4Forma y color:SolidPeso molecular:264.26324-Methylenecycloartanyl ferulate
CAS:<p>24-Methylenecycloartanyl ferulate, a compound belonging to the γ-oryzanol family, demonstrates the ability to enhance parvin-beta expression within human breast cancer cells. Furthermore, it exhibits potential as an ATP-competitive Akt1 inhibitor, with an EC 50 value of 33.3 μM.</p>Fórmula:C41H60O4Forma y color:SolidPeso molecular:616.927ZW4864
CAS:<p>ZW4864 is a selective inhibitor of the β-catenin/B-Cell Lymphoma 9 protein (β-catenin/BCL9 PPI) interaction, demonstrating oral activity. It inhibits β-catenin/BCL9 PPI with a K_i value of 0.76 μM and an IC_50 value of 0.87 μM.</p>Fórmula:C33H43ClN6O3Forma y color:SolidPeso molecular:607.2Cercosporin
CAS:<p>Cercosporin, produced by the plant pathogen Cercospora kikuchii and the elsinochromes, is a potent photosensitizer with a short activation wavelength. Cercosporin contains perylene quinone structural features essential for PKC activity (IC50: 0.6-1.3 μM).</p>Fórmula:C29H26O10Pureza:98%Forma y color:SolidPeso molecular:534.5120-HETE
CAS:<p>20-HETE is a CYP450 product, vasoconstrictor, modulates K+ channels, affects NADPH, ROS, NF-κB, NO synthase, and cell apoptosis/proliferation.</p>Fórmula:C20H32O3Pureza:99.79%Forma y color:SolidPeso molecular:320.47Sevasemten
CAS:<p>Sevasemten is an allosteric inhibitor that targets skeletal muscle myosin. It displays selectivity in its inhibition, demonstrated by IC50 values of ≤10 μM for skeletal muscle myosin and >100 μM for cardiac myosin, respectively.</p>Fórmula:C16H11F4N5O2Forma y color:SolidPeso molecular:381.28PF-03814735
CAS:<p>PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.</p>Fórmula:C23H25F3N6O2Pureza:98%Forma y color:SolidPeso molecular:474.48Cevipabulin fumarate
CAS:<p>Cevipabulin (TTI-237) fumarate is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40 nM in the human tumor cell line).</p>Fórmula:C22H22ClF5N6O5Pureza:98%Forma y color:SolidPeso molecular:580.89CMX-2043
CAS:<p>CMX-2043 is a drug potentially to block oxidative damage and activate cell survival pathways.</p>Fórmula:C16H26N2O6S2Pureza:98%Forma y color:SolidPeso molecular:406.52BCR-ABL-IN-8
CAS:<p>BCR-ABL-IN-8 (compound 26f) is a BCR-ABL inhibitor featuring a trimethoxy group [1].</p>Fórmula:C30H33N7O5Pureza:98%Forma y color:SolidPeso molecular:571.63
