Señalización citoesquelética
Los inhibidores de la señalización del citoesqueleto son compuestos que interrumpen las vías de señalización que regulan el citoesqueleto, crucial para la forma celular, la motilidad, la división y el transporte intracelular. Estos inhibidores se utilizan para estudiar la dinámica de las proteínas del citoesqueleto, como la actina y la tubulina, y su papel en procesos como la migración celular, la adhesión y la metástasis del cáncer. Los inhibidores de la señalización del citoesqueleto son valiosos en la investigación sobre biología celular, cáncer y neurobiología. En CymitQuimica, ofrecemos una amplia gama de inhibidores de la señalización del citoesqueleto de alta calidad para apoyar su investigación en estas áreas.
Se han encontrado 1537 productos para "Señalización citoesquelética".
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Paprotrain
CAS:Paprotrain ((alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile) inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM.Fórmula:C16H11N3Pureza:99.91%Forma y color:SolidPeso molecular:245.28Ref: TM-T12359
5mg46,00€1mL*10mM (DMSO)49,00€10mg58,00€25mg92,00€50mg160,00€100mg236,00€200mg353,00€500mg580,00€CWP232228
CAS:CWP232228 is a selective Wnt/β-catenin pathway inhibitor targeting β-catenin/TCF binding, halting breast/liver CSC growth and metastasis safely.Fórmula:C33H34N7Na2O7PPureza:98.87%Forma y color:SolidPeso molecular:717.63Fuzapladib
CAS:Fuzapladib (IS-741) is a PLA2 inhibitor that reduces Mac-1 expression to prevent inflammation and pancreatitis.Fórmula:C15H20F3N3O3SPureza:99.87%Forma y color:SolidPeso molecular:379.4Ref: TM-T67749
1mg60,00€5mg138,00€1mL*10mM (DMSO)177,00€10mg200,00€25mg424,00€50mg618,00€100mg802,00€Larazotide acetate
CAS:Larazotide acetate is a synthetic peptide. It functions as a tight junction regulator and reverses leaky junctions to their normally closed state.Fórmula:C34H59N9O12Pureza:95.53% - 99.42%Forma y color:Purple LiquidPeso molecular:785.89GNE 2861
CAS:GNE 2861 inhibits PAK4, PAK5, and PAK6 (IC50s: 7.5, 36, 126 nM, respectively). GNE 2861 is a PAK inhibitor that shows group II selectivity.Fórmula:C22H26N6O2Pureza:97.03%Forma y color:SolidPeso molecular:406.48Ref: TM-T16429
1mg40,00€2mg52,00€5mg82,00€1mL*10mM (DMSO)87,00€10mg124,00€25mg245,00€50mg409,00€100mg605,00€Nefopam hydrochloride
CAS:Nefopam hydrochloride (Nefopam HCl) is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity.Fórmula:C17H20ClNOPureza:99.32% - 99.85%Forma y color:White SolidPeso molecular:289.8Danicamtiv
CAS:Danicamtiv (MYK-491) is an inotropic agent and it also is a selective allosteric activator of cardiac myosin.Fórmula:C16H20F3N5O4SPureza:99.38%Forma y color:SolidPeso molecular:435.42Ref: TM-T15050
1mg129,00€5mg260,00€1mL*10mM (DMSO)286,00€10mg430,00€25mg710,00€50mg973,00€100mg1.333,00€Fluocinolone (Acetonide)
CAS:Fluocinolone Acetonide (Flucort-N) is a glucocorticoid derivative used topically in the treatment of various skin disorders.Fórmula:C24H30F2O6Pureza:99.29% - 99.82%Forma y color:SolidPeso molecular:452.49N-Desmethyltamoxifen hydrochloride
CAS:N-Desmethyltamoxifen hydrochloride is the major tamoxifen metabolite in humans.Fórmula:C25H28ClNOPureza:99.15%Forma y color:SolidPeso molecular:393.95Tubulin inhibitor 6
CAS:Tubulin inhibitor 6 (iHAP1) is an inhibitor of tubulin and a potent inhibitor of multiple cancer cell lines.Fórmula:C20H14ClNO2SPureza:99.05%Forma y color:SolidPeso molecular:367.85SGC-AAK1-1
CAS:SGC-AAK1-1 is a potent and selective inhibitor of AAK1 (AP2 associated kinase 1) (IC50 of 270 nM and a Ki of 9 nM),and is a chemical probe.Fórmula:C21H25N5O3SPureza:99.68%Forma y color:SolidPeso molecular:427.52Ref: TM-T12885
5mg43,00€1mL*10mM (DMSO)47,00€10mg75,00€25mg138,00€50mg261,00€100mg374,00€200mg537,00€CK-666
CAS:CK-666 inhibits Arp2/3 complex, blocking Arp2/3 activation and actin filament formation.Fórmula:C18H17FN2OPureza:99.93%Forma y color:White SolidPeso molecular:296.34Ref: TM-T10826
1mg38,00€5mg82,00€1mL*10mM (DMSO)90,00€10mg133,00€25mg266,00€50mg515,00€100mg715,00€200mg895,00€7-Aminocephalosporanic acid
CAS:7-Aminocephalosporanic acid (7-ACA) is used for synthesis of cephalosporin antibiotics and intermediates.Fórmula:C10H12N2O5SPureza:91.05% - 99.33%Forma y color:White SolidPeso molecular:272.28ML-9
CAS:ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 μM, respectively.Fórmula:C15H18Cl2N2O2SPureza:99.69%Forma y color:SolidPeso molecular:361.29Abciximab
CAS:Abciximab: chimeric antibody, anti-platelet, blocks glycoprotein IIb/IIIa, vitronectin, Mac-1.Pureza:SDS-PAGE:95.2%;SEC-HPLC:95.9%Forma y color:Transparent LiquidPeso molecular:95.18 kDaCC-99677
CAS:CC-99677 (Gamcemetinib) is a MK2 inhibitor targeting autoimmune diseases; potent in rat assays with IC50=156.3 nM & EC50=89 nM.Fórmula:C22H20ClN5O3SPureza:99.59%Forma y color:SolidPeso molecular:469.94AS1949490
CAS:AS1949490, a selective SHIP-2 inhibitor with IC50 of 620 nM, boosts glucose metabolism by upregulating GLUT1 in L6 myotubes.Fórmula:C20H18ClNO2SPureza:99.94%Forma y color:SolidPeso molecular:371.88Ref: TM-T14327
1mg38,00€2mg50,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg119,00€25mg236,00€50mg380,00€100mg555,00€Teplizumab
CAS:Teplizumab (MGA-031) is a humanized monoclonal antibody against CD3 that slows the loss of beta cell function.Teplizumab is used to treat type 1 diabetes.Pureza:SDS-PAGE:95.8%;SEC-HPLC:99.7%Forma y color:LiquidPeso molecular:145.79 kDaAdropin (34-76) (human, mouse, rat)
CAS:Adropin (34-76) (human, mouse, rat) is a peptide that attenuates liver fibrosis and insulin resistance. Cost-effective and quality-assured.Fórmula:C190H293N55O68S2Pureza:94.23% - 99.95%Forma y color:White SolidPeso molecular:4499.82K34c hydrochloride
CAS:K34c hydrochloride is an alpha5β1 integrin antagonist for glioblastoma study.Fórmula:C26H30ClN3O4Pureza:99.76% - 99.89%Forma y color:White SolidPeso molecular:483.99Otelixizumab
CAS:Otelixizumab (ChAglyCD3) is a chimeric monoclonal antibody targeting CD3, used in research on Type 1 diabetes and autoimmune diseases.Pureza:>95%Forma y color:Transparent LiquidPeso molecular:144.58 kDaOrbofiban TFA
CAS:Orbofiban TFA is an orally active GPIIb/IIIa platelet receptor antagonist with inhibitory effects on platelet aggregation for the study of unstable coronaryFórmula:C19H24F3N5O6Pureza:97.21% - 99.23%Forma y color:SolidPeso molecular:475.42TTBK1-IN-2
CAS:TTBK1-IN-2, a TTBK1 inhibitor with IC50s of 0.24/4.22 µM, lowers TDP-43 phosphorylation in vitro and in mice.Fórmula:C18H13ClN4OPureza:99.83%Forma y color:SolidPeso molecular:336.77Ref: TM-T60086
1mg77,00€5mg159,00€1mL*10mM (DMSO)167,00€10mg226,00€25mg378,00€50mg537,00€100mg718,00€200mg964,00€Darifenacin hydrobromide
CAS:Darifenacin hydrobromide (UK-88525) is a selective muscarinic receptor antagonist used to treat urinary incontinence and overactive bladder syndrome.Fórmula:C28H31BrN2O2Pureza:99.75% - >99.99%Forma y color:SolidPeso molecular:505.45Mps1-IN-3
CAS:Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).Fórmula:C26H31N7O4SPureza:99.25%Forma y color:SolidPeso molecular:537.63Ref: TM-T16130
2mg34,00€5mg54,00€1mL*10mM (DMSO)64,00€10mg87,00€25mg149,00€50mg255,00€100mg384,00€200mg538,00€Spiperone
CAS:Spiperone (Spiropitan) is a spiro butyrophenone analog similar to HALOPERIDOL and other related compounds.Fórmula:C23H26FN3O2Pureza:99.34% - 99.91%Forma y color:SolidPeso molecular:395.47RWJ 50271
CAS:RWJ 50271 inhibits LFA-1/ICAM-1 interaction with IC50 5.0 μM in HL60 cells.Fórmula:C18H17F3N4O2SPureza:99.09%Forma y color:White SolidPeso molecular:410.41Ref: TM-T12783
1mg120,00€5mg295,00€1mL*10mM (DMSO)326,00€10mg447,00€25mg707,00€50mg964,00€100mg1.243,00€200mg1.693,00€Bisindolylmaleimide VIII acetate
CAS:Bisindolylmaleimide VIII acetate is a selective PKC inhibitor with an IC50 of 158 nM in rat brain and varying IC50s for different PKC isoforms.Fórmula:C26H26N4O4Pureza:99.27%Forma y color:Red SolidPeso molecular:458.51NMS-P715
CAS:NMS-P715 is a highly selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).Fórmula:C35H39F3N8O3Pureza:99.84%Forma y color:SolidPeso molecular:676.73Verubulin hydrochloride
CAS:Verubulin hydrochloride (MPC-6827 hydrochloride) is an agent of blood brain barrier permeable microtubule-disrupting, with potent and broad-spectrum cytotoxicFórmula:C17H18ClN3OPureza:98.29% - 99.77%Forma y color:SolidPeso molecular:315.8Ref: TM-T13298
5mg52,00€1mL*10mM (DMSO)52,00€10mg73,00€25mg138,00€50mg200,00€100mg284,00€200mg411,00€PKC β pseudosubstrate acetate
PKC β pseudosubstrate acetate (PKC β pseudosubstrate acetate (172308-76-8 Free base)) is a selective cell-permeable inhibitor of PKC.Pureza:95.42%Forma y color:SoildA-3 hydrochloride
CAS:A-3 hydrochloride: potent, reversible kinase antagonist; permeable; inhibits PKC, CKI, PKA, CKII, MLCK; Ki: 4.3-80 μM.Fórmula:C12H14Cl2N2O2SPureza:99.32%Forma y color:SolidPeso molecular:321.22Ref: TM-T14069
1mg34,00€5mg63,00€10mg90,00€1mL*10mM (DMSO)95,00€25mg161,00€50mg260,00€100mg416,00€500mg888,00€ADH-1 trifluoroacetate
CAS:ADH-1 trifluoroacetate (Exherin trifluoroacetate) is a cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities.Fórmula:C24H35F3N8O8S2Pureza:90.08% - 99.98%Forma y color:White SolidPeso molecular:684.71Ref: TM-T1608
2mg42,00€5mg62,00€10mg89,00€1mL*10mM (DMSO)89,00€25mg167,00€50mg227,00€100mg339,00€200mg482,00€Imatinib Mesylate
CAS:Imatinib Mesylate (STI-571) is a tyrosine kinase receptor inhibitor with antineoplastic activity (IC50s: 0.6 μM, 0.1 μM and 0.1 μM for v-Abl, c-Kit and PDGFR,Fórmula:C29H31N7O·CH4SO3Pureza:98% - >99.99%Forma y color:White SolidPeso molecular:589.71CMPD101
CAS:CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM).Fórmula:C24H21F3N6OPureza:99.01% - 99.04%Forma y color:SolidPeso molecular:466.46ATN-161 acetate
CAS:ATN-161 acetate, a pentapeptide compound derived from the synergistic region of fibronectin, is an integrin-alpha5 antagonist with antitumor activity.Fórmula:C25H39N9O10SPureza:98.27%Forma y color:White SolidPeso molecular:657.7Delcasertib
CAS:Delcasertib (KAI-9803) is a potent and selective inhibitor of δ-protein kinase C (δPKC).Fórmula:C120H199N45O34S2Pureza:99.96%Forma y color:SolidPeso molecular:2880.28Ref: TM-T11740
1mg192,00€5mg485,00€10mg700,00€25mg1.063,00€50mg1.459,00€1mL*10mM (DMSO)1.603,00€100mg1.963,00€TINK-IN-1
CAS:TINK-IN-1 is a selective and potent TNIK inhibitor (IC50: 8 nM).TINK-IN-1 inhibits colorectal cancer cell viability and can be used to study mental retardation.Fórmula:C24H24N4O3Pureza:99.8%Forma y color:SolidPeso molecular:416.47Ref: TM-T77660
1mg39,00€2mg50,00€5mg82,00€10mg120,00€25mg236,00€50mg353,00€100mg517,00€500mg1.099,00€(+)-Blebbistatin
CAS:(+)-Blebbistatin is the inactive enantiomer of (–)-Blebbistatin. (–)-Blebbistatin is a selective myosin II ATPase inhibitor.Fórmula:C18H16N2O2Pureza:99.88%Forma y color:Yellow SolidPeso molecular:292.33Ref: TM-T12503
2mg40,00€5mg60,00€1mL*10mM (DMSO)62,00€10mg92,00€25mg170,00€50mg268,00€100mg432,00€200mg618,00€ATN-161 trifluoroacetate salt
CAS:ATN-161 TFA salt, a new integrin α5β1 inhibitor, curbs angiogenesis, liver metastases growth, enhances survival in mice.Fórmula:C25H36F3N9O10SPureza:98% - 99.98%Forma y color:White SolidPeso molecular:711.67BNC105
CAS:BNC105 is a tubulin polymerization inhibitor. It has potent antiproliferative and tumor vascular disrupting properties.Fórmula:C20H20O7Pureza:96.57%Forma y color:SolidPeso molecular:372.37Ref: TM-T14694
1mg79,00€5mg152,00€1mL*10mM (DMSO)167,00€10mg215,00€25mg351,00€50mg494,00€100mg665,00€200mg893,00€Cibisatamab
CAS:Cibisatamab, a T-cell bispecific antibody, targets CEA on cancer cells and CD3 on T-cells, inducing T-cell-mediated tumor cell killing.Pureza:SDS-PAGE:99.1%;SEC-HPLC:96.5%Forma y color:Transparent LiquidPeso molecular:191.1 kDaDasatinib
CAS:Dasatinib (BMS-354825) is a tyrosine kinase inhibitor that inhibits Src and Bcr-Abl (Ki=16/30 pM) and is orally active and ATP-competitive.Fórmula:C22H26ClN7O2SPureza:99.59% - 99.86%Forma y color:Pale-Yellow SolidPeso molecular:488.01Dasatinib monohydrate
CAS:Dasatinib monohydrate, an oral SRC-kinase inhibitor, counters imatinib-resistant chronic myeloid leukemia.Fórmula:C22H28ClN7O3SPureza:99.68% - >99.99%Forma y color:White SolidPeso molecular:506.03Entasobulin
CAS:Entasobulin is an inhibitor of β-tubulin polymerization. It has a potential anticancer activity.Fórmula:C26H18ClN3O2Pureza:98.40%Forma y color:SolidPeso molecular:439.89Meclofenamic acid sodium
CAS:Meclofenamic acid sodium (Movens), a non-steroidal anti-inflammatory agent, has properties of antipyretic and antigranulation activities.Fórmula:C14H10Cl2NNaO2Pureza:98% - 98.96%Forma y color:SolidPeso molecular:318.14Bosutinib
CAS:Bosutinib (SKI-606) is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl (IC50: 1 nM) and Src (IC50: 1.2 nM) kinases.Fórmula:C26H29Cl2N5O3Pureza:98.98% - 99.9%Forma y color:Yellow SolidPeso molecular:530.45CCT251545
CAS:CCT251545 is an potent and oral-bioavailable WNT signaling inhibitor(IC50 of 5 nM in 7dF3 cells).Fórmula:C23H24ClN5OPureza:98.29% - 98.69%Forma y color:White SolidPeso molecular:421.92Pamidronate Disodium
CAS:Pamidronate Disodium (CGP 23339A), a nitrogen-containing bisphosphonate, can help to strengthen bones.Fórmula:C3H9NNa2O7P2Pureza:99.86% - 99.93%Forma y color:White CrystalsPeso molecular:279.03NVS-PAK1-1
CAS:NVS-PAK1-1 is an effective and selective allosteric PAK1 inhibitor (IC50: 5 nM).Fórmula:C23H25ClF3N5OPureza:99.35%Forma y color:SolidPeso molecular:479.93
