Señalización citoesquelética
Los inhibidores de la señalización del citoesqueleto son compuestos que interrumpen las vías de señalización que regulan el citoesqueleto, crucial para la forma celular, la motilidad, la división y el transporte intracelular. Estos inhibidores se utilizan para estudiar la dinámica de las proteínas del citoesqueleto, como la actina y la tubulina, y su papel en procesos como la migración celular, la adhesión y la metástasis del cáncer. Los inhibidores de la señalización del citoesqueleto son valiosos en la investigación sobre biología celular, cáncer y neurobiología. En CymitQuimica, ofrecemos una amplia gama de inhibidores de la señalización del citoesqueleto de alta calidad para apoyar su investigación en estas áreas.
Se han encontrado 1382 productos de "Señalización citoesquelética"
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Carotegrast
CAS:<p>Carotegrast, an orally available α4 integrin receptor inhibitor, has anti-inflammatories activities.</p>Fórmula:C27H24Cl2N4O5Forma y color:SolidPeso molecular:555.41Synstatin (92-119)
CAS:<p>Synstatin (92-119) serves as an anti-tumor agent by suppressing angiogenesis and cancer cell invasion, chiefly through the down-regulation of integrin αvβ3 and</p>Fórmula:C133H207N35O46Pureza:98%Forma y color:SolidPeso molecular:3032.27THK-5105
CAS:<p>THK-5105, a tau-binding arylquinoline, could be an 18F-PET imaging probe for Alzheimer's disease.</p>Fórmula:C20H21FN2O2Forma y color:SolidPeso molecular:340.39EG-011
CAS:<p>EG-011, a potent first-in-class WASP activator, enhances actin polymerization, showing selective anti-tumor effects in lymphomas.</p>Fórmula:C28H26N4O4Forma y color:SolidPeso molecular:482.53Gly-Arg-Gly-Asp-Ser TFA
CAS:<p>Gly-Arg-Gly-Asp-Ser (TFA), osteopontin domain, binds αvβ3 and αvβ5 integrins; IC50s: ~5 μM, ~6.5 μM.</p>Fórmula:C19H31F3N8O11Forma y color:SolidPeso molecular:604.49Pin1 modulator 1
CAS:<p>Pin1 modulator 1 (compound IIb-219) is a specific β-Catenin targeting agent that inhibits the Wnt pathway and is applicable in researching Wnt-mediated diseases, including cancer [1].</p>Fórmula:C18H15NO3S2Forma y color:SolidPeso molecular:357.44β-Catenin modulator-3
CAS:<p>β-Catenin modulator-3 (compound IIa-112), an oxazole and thiazole-based chemical entity, serves as a potent and selective modulator of β-Catenin [1].</p>Fórmula:C21H22N2O3SForma y color:SolidPeso molecular:382.483CAI
CAS:<p>3CAI inhibits AKT1/2, reduces mTOR/GSK3β, and triggers apoptosis in colon cancer cells.</p>Fórmula:C10H8ClNOPureza:98.13%Forma y color:SolidPeso molecular:193.63Pterostilbene-isothiocyanate
CAS:<p>Pterostilbene-isothiocyanate (PTER-ITC) demonstrates strong anticancer properties in vitro, particularly disrupting the interaction between β-catenin and TCF-4</p>Fórmula:C18H19N3O3SForma y color:SolidPeso molecular:357.43AT7867 hydrochloride
CAS:<p>AT7867 hydrochloride is a potent inhibitor of AKT and p70 S6 kinase, displaying oral activity and demonstrating an anticancer effect [1].</p>Fórmula:C20H21Cl2N3Forma y color:SolidPeso molecular:374.31α7β1 integrin modulator-1
CAS:<p>α7β1 Integrin Modulator-1 is a potent modulator with research potential for muscular dystrophy [1].</p>Fórmula:C23H29N3O6SPureza:98%Forma y color:SolidPeso molecular:475.56Lotrafiban
CAS:<p>Lotrafiban: Oral GP IIb/IIIa inhibitor for treating coronary and cerebrovascular disease.</p>Fórmula:C23H32N4O4Forma y color:SolidPeso molecular:428.52L-739758
CAS:<p>L-739758 is a glycoprotein IIb/IIIa inhibitor.</p>Fórmula:C22H26N4O5S3Forma y color:SolidPeso molecular:522.66PVZB1194
CAS:<p>PVZB1194, a biphenyl-type inhibitor of Kinesin spindle protein Eg5 (KIF11), exhibits anticancer potential by inducing cell cycle arrest and apoptosis through</p>Fórmula:C13H9F4NO2SPureza:98%Forma y color:SolidPeso molecular:319.28BCR-ABL-IN-4
CAS:<p>BCR-ABL-IN-4: Anticancer BCR-ABL inhibitor; stops K562 cells (IC50: 0.67 nM), targets T315I Ba/F3 cells (IC50: 16 nM).</p>Fórmula:C27H24ClF2N5O4Forma y color:SolidPeso molecular:555.96β-catenin-IN-4
CAS:<p>β-Catenin-IN-4 is a β-catenin inhibitor characterized by a K_i value of 0.64 μM.</p>Fórmula:C38H33ClF3N5O9Forma y color:SolidPeso molecular:796.14SB-743921 free base
CAS:<p>SB-743921, a kinesin spindle protein (KSP) inhibitor, is used potentially for the treatment of non-Hodgkin's lymphoma (NHL).</p>Fórmula:C31H33ClN2O3Pureza:98%Forma y color:SolidPeso molecular:517.06SEN461
CAS:<p>SEN461 is a wnt inhibitor.</p>Fórmula:C25H34N4O6Pureza:98%Forma y color:SolidPeso molecular:486.56Heclin
CAS:<p>Heclin is an inhibitor of HECT E3 ubiquitin ligase that acts by inhibiting Smurf2, Nedd4, and WWP1 with IC50 values of 6.8, 6.3, and 6.9 μM, respectively.</p>Fórmula:C17H17NO3Pureza:95.79%Forma y color:SolidPeso molecular:283.32(-)-Indolactam V
CAS:<p>(-)-Indolactam V: PKC activator, antitumor, Ki 3.36 nM/1.03 μM for η/γ-CRD2, Kd 5.5-213 nM for C1 domains.</p>Fórmula:C17H23N3O2Pureza:98%Forma y color:SolidPeso molecular:301.38Antitumor agent-86
CAS:<p>Antitumor agent-86 targets MCF-7 cells with 2.62 µM IC50, induces apoptosis, and disrupts RAS/PI3K/Akt/JNK pathways.</p>Fórmula:C29H31N5O2SPureza:98%Forma y color:SolidPeso molecular:513.65Demethylasterriquinone B1
CAS:<p>insulin receptor (IR) activator</p>Fórmula:C32H30N2O4Pureza:98%Forma y color:SolidPeso molecular:506.59HSP90-IN-19
CAS:<p>HSP90-IN-19: potent Hsp90 inhibitor, IC50 = 0.27 μM, used in research on viral diseases, neurodegeneration, inflammation.</p>Fórmula:C29H38O7Pureza:98%Forma y color:SolidPeso molecular:498.61Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2
CAS:<p>Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2 demonstrates serum stability and non-toxicity to neuronal cells, while selectively inhibiting the fibrilization of tau in</p>Fórmula:C38H65N11O9Forma y color:SolidPeso molecular:819.9922-(4′-py)-JA
CAS:<p>22-(4′-py)-JA, a semisynthetic derivative of junamycin A isolated from the Thai blue sponge (Xestospongia sp.), exhibits antimetastatic properties by inhibiting</p>Fórmula:C32H30N4O8Pureza:98%Forma y color:SolidPeso molecular:598.6PBB3
CAS:<p>PBB3 is a tau-specific PET tracer.</p>Fórmula:C17H15N3OSForma y color:SolidPeso molecular:309.39PKC-θ inhibitor 1
CAS:<p>PKC-theta inhibitor 1 is an inhibitor of PKCθ (Ki of 6 nM)</p>Fórmula:C17H15F3N4OPureza:98%Forma y color:SolidPeso molecular:348.32L 738167
CAS:<p>L 738167 is a potent antagonist of the long-acting fibrinogen receptor.</p>Fórmula:C25H34N6O6SForma y color:SolidPeso molecular:546.64TC-I 15
CAS:<p>α2β1 integrin inhibitor</p>Fórmula:C23H28N4O6S2Pureza:98%Forma y color:SolidPeso molecular:520.62SC-52012
CAS:<p>SC-52012 is a novel and potent fibrinogen receptor antagonist, an RGD mimetic, which inhibits platelet aggregation.</p>Fórmula:C25H30N4O6Pureza:97.20%Forma y color:SolidPeso molecular:482.53Lamifiban
CAS:<p>Lamifiban is a nonpeptide glycoprotein IIb/IIIa antagonist. It prevents platelet loss during experimental cardiopulmonary bypass.</p>Fórmula:C24H28N4O6Pureza:98%Forma y color:SolidPeso molecular:468.5KU-177
CAS:<p>KU-177 is an Aha1 inhibitor that disrupts the interaction between Hsp90 and Aha1, eliminating cell proliferation and PI resistance induced by elevated AHSA1.</p>Fórmula:C27H23NO8Pureza:96.92% - 98.54%Forma y color:SolidPeso molecular:489.47IWP 12
CAS:<p>IWP 12 is a potent inhibitor of porcupine (Porcn), blocking Wnt signaling and inhibiting fin regeneration in adult and juvenile fish.</p>Fórmula:C18H18N4O2S3Pureza:98.88%Forma y color:SolidPeso molecular:418.56BIO-7662
CAS:<p>BIO-7662 is an effective and highly selective antagonist of α4β1 integrin.</p>Fórmula:C38H48N6O8SPureza:98%Forma y color:SolidPeso molecular:748.89Solenopsin
CAS:<p>Solenopsin is an ATP-competitive inhibitor of AKT(IC50 : 10 μM) .</p>Fórmula:C17H35NPureza:98%Forma y color:SolidPeso molecular:253.47Palmitic acid calcium
CAS:<p>Calcium palmitate, a long-chain saturated fatty acid prevalent in animals and plants, induces the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in mouse granulosa cells. It is employed to establish a cell steatosis model [1] [2].</p>Fórmula:C16H32O2CaForma y color:SolidPeso molecular:275.463-Hydroxyxanthone
CAS:<p>3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one), a xanthone derivative, exhibits inhibitory effects on NADPH-catalyzed lipid peroxidation in human umbilical vein</p>Fórmula:C13H8O3Pureza:98%Forma y color:SolidPeso molecular:212.2MK-6240
CAS:<p>MK-6240: A tau PET tracer with high specificity for NFTs binding.</p>Fórmula:C16H11FN4Pureza:98%Forma y color:SolidPeso molecular:278.28NTRC 0066-0
CAS:<p>NTRC 0066-0 is a TTK inhibitor that can be used in cancer research.</p>Fórmula:C33H39N7O2Pureza:98.30%Forma y color:SolidPeso molecular:565.71HDAC-IN-55
CAS:<p>HDAC-IN-55(8j) is a small-molecule inhibitor that enhances E-cadherin expression and suppresses cancer cell proliferation [1].</p>Fórmula:C17H17N3O3Pureza:98%Forma y color:SolidPeso molecular:311.34Levocabastine hydrochloride
CAS:<p>Levocabastine HCl is an agent with antihistaminic activity.</p>Fórmula:C26H30ClFN2O2Forma y color:SolidPeso molecular:456.98TRV-1387
CAS:<p>TRV-1387, a benzofurazan derivative, inhibits the aggregation of tau and amyloid-β [1].</p>Fórmula:C23H25F3N4O2Forma y color:SolidPeso molecular:446.47Kif15-IN-2
CAS:<p>Kif15-IN-2 is a kinesin Kif15 inhibitor with potential anticancer activity and can be used in prostate cancer research.</p>Fórmula:C20H20N6O4SPureza:98.17%Forma y color:SolidPeso molecular:440.48CT-721
CAS:<p>CT-721: potent, time-bound Bcr-Abl inhibitor, IC50 21.3 nM, effective against CML.</p>Fórmula:C30H29ClN6OPureza:98%Forma y color:SolidPeso molecular:525.04TCS 21311
CAS:<p>TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.</p>Fórmula:C27H25F3N4O4Pureza:99.39% - ≥98%Forma y color:SolidPeso molecular:526.51HSP90-IN-27
CAS:<p>HSP90-IN-27, also known as compound 19, is an inhibitor of HSP90 [1].</p>Fórmula:C18H21N3O2SPureza:98%Forma y color:SolidPeso molecular:343.44Ifebemtinib
CAS:<p>Ifebemtinib (BI-853520) is an adhesion plaque kinase inhibitor with anti-tumour activity for the study of breast cancer.</p>Fórmula:C28H28F4N6O4Pureza:98.84% - 99.85%Forma y color:SolidPeso molecular:588.55UCL-TRO-1938
CAS:<p>UCL-TRO-1938 is a subtype-selective PI3Kα allosteric activator with cardioprotective and neuroregenerative effects.</p>Fórmula:C27H32N6OPureza:99.95%Forma y color:SolidPeso molecular:456.58αvβ1 integrin-IN-1
CAS:<p>αvβ1 integrin-IN-1 is a potent and selective inhibitor of αvβ1 integrin (IC50 of 0.63 nM) with antifibrotic effects.</p>Fórmula:C26H34N6O6SPureza:99.74% - >99.99%Forma y color:SolidPeso molecular:558.65CFI-402257
CAS:<p>CFI-402257 is a selective inhibitor of Mps1/TTK kinase (Mps1 Ki = 0.09 nM; EC50 = 6.5 nM)and can be used in studies about hepatocellular carcinoma diseases.</p>Fórmula:C28H30N6O3Pureza:96.66% - 99.51%Forma y color:SolidPeso molecular:498.58
