Señalización citoesquelética
Los inhibidores de la señalización del citoesqueleto son compuestos que interrumpen las vías de señalización que regulan el citoesqueleto, crucial para la forma celular, la motilidad, la división y el transporte intracelular. Estos inhibidores se utilizan para estudiar la dinámica de las proteínas del citoesqueleto, como la actina y la tubulina, y su papel en procesos como la migración celular, la adhesión y la metástasis del cáncer. Los inhibidores de la señalización del citoesqueleto son valiosos en la investigación sobre biología celular, cáncer y neurobiología. En CymitQuimica, ofrecemos una amplia gama de inhibidores de la señalización del citoesqueleto de alta calidad para apoyar su investigación en estas áreas.
Se han encontrado 1382 productos de "Señalización citoesquelética"
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Chromeceptin
CAS:<p>Chromeceptin is an inhibitor of the IGF signaling pathway, decreases the numbers of tumorsphere, and inhibits the AKT/mTOR pathway.</p>Fórmula:C19H16F3N3OPureza:99.85%Forma y color:SoildPeso molecular:359.35SMART1
<p>SMART1 is a CRBN-dependent PROTAC with high specificity that effectively degrades Smurf1. It inhibits tumor growth in xenograft models of colorectal cancer (CRC) with KRAS mutations and blocks the PDK1-Akt signaling pathway in KRAS-mutated colorectal cancer.</p>Fórmula:C40H35N9O7Forma y color:SolidPeso molecular:753.76DSPE-PEG1000-iRGD
<p>DSPE-PEG1000-iRGD is a PEG compound made from DSPE and the αv-integrin-targeting peptide (iRGD). The iRGD peptide initially binds to αv-integrins and undergoes proteolytic cleavage within tumors to produce CRGDK/R, which interacts with neuropilin-1, thereby facilitating tumor targeting and penetration. DSPE-PEG1000-iRGD is useful for drug delivery applications.</p>Forma y color:Odour SolidHypoglycemic agent 3
<p>Compound H26, a derivative of corosolic acid, functions as Hypoglycemic agent 3. It exhibits lipid-lowering and significant blood glucose-reducing properties, making it a potential hypoglycemic drug. Hypoglycemic agent 3 targets MCCC1 to mitigate insulin resistance, and may be useful in researching type 2 diabetes.</p>Fórmula:C32H51NO5Forma y color:SolidPeso molecular:529.751NMS-E973
CAS:<p>NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.</p>Fórmula:C22H22N4O7Pureza:99.84%Forma y color:SolidPeso molecular:454.43Orbofiban acetate
CAS:<p>Orbofiban Acetate is a compound that serves as an antagonist to the platelet GPIIb/IIIa receptor, effectively inhibiting platelet aggregation when administered</p>Fórmula:C19H27N5O6Forma y color:SolidPeso molecular:421.45PDK-IN-1
CAS:<p>PDK-IN-1, a PDK inhibitor, IC50: 0.03μM (PDK1), 0.1μM (HSP90), reduces tumor mass.</p>Fórmula:C20H16BrN7OForma y color:SolidPeso molecular:450.29AKT1-IN-9
<p>AKT1-IN-9 (4) is a selective inhibitor of the AKT1(E17K) mutation, exhibiting EC50 values of 9 nM in LAPC4-CR cells and 995 nM in SkBr3 cells.</p>Fórmula:C33H25FN6O4Forma y color:SolidPeso molecular:588.588Davunetide
CAS:<p>Davunetide: neuroprotective 8-amino acid peptide, improves daily function in schizophrenia, boosts memory in mild cognitive impairment.</p>Fórmula:C36H60N10O12Pureza:98%Forma y color:SolidPeso molecular:824.92Akt1-IN-1
<p>Akt1-IN-1: Potent, selective Akt1 inhibitor, IC50 18.79 nM, non-teratogenic/hepatotoxic/cardiotoxic, useful in cancer research.</p>Fórmula:C31H34FN5O5S2Forma y color:SolidPeso molecular:639.76Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Forma y color:Odour SolidR-BC154 acetate
<p>R-BC154 acetate: selective α9β1 antagonist, high-affinity integrin probe for α9β1/α4β1 activity study.</p>Fórmula:C56H65N9O14S3Forma y color:SolidPeso molecular:1184.362119738-71-3
CAS:<p>Compound 2119738-71-3 interacts with the FAK receptor.</p>Fórmula:C25H29ClFN7O2Pureza:98%Forma y color:SolidPeso molecular:513.99SNIPER(ABL)-050
<p>SNIPER(ABL)-050 is a chemical compound that combines Imatinib, an ABL inhibitor, with MV-1, an IAP ligand, using a linker.</p>Fórmula:C68H84N12O9Pureza:98%Forma y color:SolidPeso molecular:1213.47FDA-Approved Kinase Inhibitor Library
<p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>Forma y color:LiquidSIAIS100
<p>SIAIS100, a potent BCR-ABL PROTAC degrader, demonstrates a DC50 value of 2.7 nM, highlighting its efficacy.</p>Fórmula:C44H50ClF2N9O5SForma y color:SolidPeso molecular:890.44Besufetamig
CAS:<p>Besufetamig is a bispecific antibody targeting programmed cell death protein 1 (PD-1) and the CD3ε chain. It modulates immune cell activity, exerting both immunosuppressive and antitumor effects. Besufetamig holds promise for cancer research.</p>Forma y color:LiquidCeratamine A
CAS:<p>Ceratamine A, from Pseudoceratina sponge, is a cytotoxic, microtubule-stabilizing antimitotic alkaloid.</p>Fórmula:C17H16Br2N4O2Pureza:98%Forma y color:SolidPeso molecular:468.14AKTide-2T
CAS:<p>Peptide substrate for Akt/PKB</p>Fórmula:C74H114N28O20Pureza:98%Forma y color:SolidPeso molecular:1715.87BCR-ABL-IN-3
CAS:<p>BCR-ABL-IN-3 irreversibly inhibits Bcr-Abl with <100 nM IC50, showing significant anti-cancer effects.</p>Fórmula:C20H17ClF2N4O3SForma y color:SolidPeso molecular:466.89MS15 TFA
<p>MS15 TFA is a potent, selective AKT PROTAC degrader, effectively inhibiting AKT1, AKT2, and AKT3 with IC50 values of 798 nM, 90 nM, and 544 nM, respectively [1</p>Fórmula:C66H80F3N11O7SPureza:98%Forma y color:SolidPeso molecular:1228.47Tubulin inhibitor 38
<p>Tubulin Inhibitor 38 (Compound 14), a tetrazole-based agent, demonstrates significant antiproliferative effects by inducing mitotic arrest and blocking the cell</p>Fórmula:C17H13ClN6OSForma y color:SolidPeso molecular:384.84EMD527040
CAS:<p>EMD527040 is a potent αvβ6 antagonist with antifibrotic effects, used in carcinoma and liver fibrosis research.</p>Fórmula:C29H32Cl2N4O5Forma y color:SolidPeso molecular:587.5p5 Ligand for Dnak and DnaJ
CAS:<p>P5 is a nonapeptide ligand for DnaK/DnaJ, mimicking the key sites of mitochondrial aspartate aminotransferase presequence.</p>Fórmula:C44H81N15O11SPureza:98%Forma y color:SolidPeso molecular:1028.27Box5 TFA
<p>Box5 TFA, a potent Wnt5a antagonist, impedes Wnt5a signaling, restricts Wnt5a-initiated Ca2+ release, and hampers cell migration, showing promise for melanoma</p>Fórmula:C32H51F3N6O15S2Forma y color:SolidPeso molecular:880.9Filanesib TFA
CAS:<p>Filanesib (ARRY-520) inhibits KSP, triggering mitotic arrest and cell death in dividing tumor cells.</p>Fórmula:C22H23F5N4O4SPureza:98%Forma y color:SolidPeso molecular:534.5MS21
CAS:<p>MS21 is a unique AKT degrader that selectively hampers the proliferation of cancers with mutations in the PI3K/PTEN pathway, alongside wild-type KRAS and BRAF.</p>Fórmula:C58H79ClN12O6SForma y color:SolidPeso molecular:1107.86Anticancer agent 139
<p>Compound 6h (Anticancer Agent 139) exhibits potent anticancer activity, engaging in a π-cationic interaction with Lys352 of Tubulin and demonstrating high</p>Fórmula:C16H12F3N3OForma y color:SolidPeso molecular:319.28MS143
CAS:<p>MS143: potent AKT degrader, DC50=46 nM, GI50=0.8 µM in PC3 cells, degrades AKT via ubiquitin-proteasome, suppresses cancer growth.</p>Fórmula:C59H81ClN12O6SForma y color:SolidPeso molecular:1121.87Echistatin
CAS:<p>Potent αVβ3 integrin blocker, stops osteoclast binding & bone loss, hinders platelet aggregation. Ki=0.27 nM, IC50s: 0.1 nM (bone), 30 nM (platelets).</p>Fórmula:C217H341N71O74S9Pureza:98%Forma y color:SolidPeso molecular:5417.111H-Benzo[a]carbazole
CAS:<p>11H-Benzo[a]carbazole is a kinesin-like protein KIF11 inhibitor that can inhibit the viability of HeLa cells.</p>Fórmula:C16H11NPureza:99.14%Forma y color:SolidPeso molecular:217.27Combretastatin A-1 phosphate tetrasodium
CAS:<p>OXi-4503, a prodrug of Combretastatin A-1, disrupts tubulin, inhibits Wnt/β-catenin and AKT, and has anti-tumor/vascular effects.</p>Fórmula:C18H18Na4O12P2Forma y color:SolidPeso molecular:580.24BMP agonist 1
<p>BMP Agonist 1 (compound 2 b) is a small-molecule stimulator of bone morphogenic protein (BMP) signaling, crucial for the differentiation of C2C12 cells.</p>Fórmula:C21H16N2O6Forma y color:SolidPeso molecular:392.36trans-Dehydrocurvularin
CAS:<p>trans-Dehydrocurvularin is a useful organic compound for research related to life sciences. The catalog number is T125357 and the CAS number is 21178-57-4.</p>Fórmula:C16H18O5Forma y color:SolidPeso molecular:290.315SNIPER(ABL)-020
<p>SNIPER(ABL)-020, a Dasatinib-Bestatin conjugate via linker, inhibits ABL and targets IAP, reducing BCR-ABL protein.</p>Fórmula:C44H59ClN10O8SPureza:98%Forma y color:SolidPeso molecular:923.52Myrtucommulone
CAS:<p>Myrtucommulone is an inhibitor of the chaperonin activity of HSP60, correlating to LRP130 and LONP aggregation.</p>Fórmula:C38H52O10Pureza:98%Forma y color:SolidPeso molecular:668.81Phosphatidylserines (bovine)
CAS:<p>Phosphatidylserine: a natural phospholipid, 2-10% in mammals, CNS-rich, synthesized in ER, involved in cell signaling, apoptosis marker.</p>Fórmula:C42H78NO10P(foroleoyl)Forma y color:SolidPeso molecular:788.1Echistatin TFA
<p>Echistatin TFA: a minimal RGD protein from snake venom; inhibits platelet aggregation and bone resorption; targets αIIbβ3, αvβ3, α5β1.</p>Forma y color:Odour SolidTubulin polymerization-IN-46
<p>Tubulin polymerization-IN-46 (compound 9q) is a microtubule/tubulin inhibitor that impedes tubulin polymerization, induces apoptosis, and arrests MCF-7 breast</p>Fórmula:C22H25NO6Forma y color:SolidPeso molecular:399.44PU-H71 HCl
CAS:<p>PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT.</p>Fórmula:C18H22ClIN6O2SPureza:98.95%Forma y color:SoildPeso molecular:548.83Anti-inflammatory agent 60
<p>Anti-inflammatory agent 60 (compound 21) inhibits nitric oxide production, presenting an IC50 of 12.95 μM, and reduces iNOS, phosphorylated p65, and β-catenin</p>Pureza:98%Forma y color:Odour Solid10-Oxo Docetaxel
CAS:<p>10-Oxo Docetaxel is a Docetaxel intermediate having remarkable antitumor properties.</p>Fórmula:C43H51NO14Pureza:98%Forma y color:SolidPeso molecular:805.874SNIPER(ABL)-019
<p>SNIPER(ABL)-019, a compound that links Dasatinib (ABL inhibitor) to MV-1 (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels, exhibiting a</p>Fórmula:C60H77ClN12O9SPureza:98%Forma y color:SolidPeso molecular:1177.853-Phenyltoxoflavin
CAS:<p>3-Phenyltoxoflavin (Phenyltoxoflavin) is an inhibitor of HSP90 (Kd = 585 nM) with anti-cancer activity.</p>Fórmula:C13H11N5O2Pureza:99.88%Forma y color:SolidPeso molecular:269.26Coronaridine
CAS:<p>Coronaridine is a useful organic compound for research related to life sciences. The catalog number is T124824 and the CAS number is 467-77-6.</p>Fórmula:C21H26N2O2Forma y color:SolidPeso molecular:338.451MK2-IN-5
CAS:<p>MK2-IN-5, a pseudosubstrate of Mk2 with an inhibition constant (K_i) of 8 μM, selectively targets the protein interaction domain of the MAPK pathway and</p>Fórmula:C61H113N21O16Pureza:98%Forma y color:SolidPeso molecular:1396.68DynaMin inhibitory peptide, myristoylated
CAS:<p>Cell-permeable dynamin inhibitor; blocks its binding to amphiphysin, hindering endocytosis; curbs NMDA receptor internalization.</p>Fórmula:C61H107N19O14Pureza:98%Forma y color:SolidPeso molecular:1330.64Blosozumab
CAS:<p>Blosozumab (LY2541546) is a monoclonal antibody targeting sclerostin that promotes bone formation, used in the research of osteoporosis.</p>Pureza:98.7% (SEC-HPLC) - 99.53% (SEC-HPLC)Forma y color:LiquidGamitrinib TPP
CAS:<p>Gamitrinib TPP targets mitochondrial HSP90, inhibiting cancer, and blocks mitochondrial matrix.</p>Fórmula:C52H65N3O8PPureza:98%Forma y color:SolidPeso molecular:891.078Catumaxomab
CAS:<p>Catumaxomab is a rat-mouse hybrid lgG2 monoclonal and bispecific antibody that binds to the antigens CD3 and EpCAM for malignant ascites in cancer patients.</p>Pureza:95%Forma y color:Liquid
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