Compuestos deuterados

<p>Applications N2'-Deacetyl-N2'-[3-[(1-ethyl-2,5-dioxo-3-pyrrolidinyl)thio]-1-oxopropyl]-maytansine-d5 is labelled N2'-​Deacetyl-​N2'-​[3-​[(1-​ethyl-​2,​5-​dioxo-​3-​pyrrolidinyl)​thio]​-​1-​oxopropyl]​-maytansine (D199030), a derivative of Mertansine (M257800) which is a cytotoxic agent. It is used as the cytotoxic component in antibody-drug conjugates.<br>References Erickson, H., et al.: Cancer Res., 66, 4426 (2006); Kellogg, B., et al.: Bioconjugate Chem., 22, 717 (2011)<br></p>

<p>Applications A labelled acetylene glycol derivative. It is used in water-based coatings and has both antifoaming and surfactant properties. It is highly toxic and have been found in acrylic adhesives used for food packaging multilayers manufacturing.<br>References Schwartz, J. et al.: J. Coat. Tecnhol., 67, 21 (1995); Chinoy, N.F. et al.: Polym. Paint Colour J., 175, 438 (1985);<br></p>

<p>Applications Isotope labelled Triethyl Phosphate is a useful synthetic intermediate. It was used in the synthesis of mesoporous spheres of metal oxides and phosphates. It was also used to prepare α,β-unsatd. tricyclic enones via an intramolecular Horner-Wadsworth-Emmons cyclization. Phosphorus Flame Retardant.<br>References Dong, A., et al.: J. Am. Chem. Soc., 125, 4976 (2003); Pace, V., et al.: Tetrahedron Lett., 50, 3050 (2009)<br></p>

<p>Applications Isotope labelled 2-Toluidine (T536205) is a carcinogenic and toxic aromatic amine and is a potential bladder cancer risk, surmised from urine assessment and analysis (1). It is contained in hair dye, henna and dyed hair samples (2,3). Possible mutagen (4). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. El-Bayoumy, K. et al.: Cancer Res. 1986 Dec;46(12 Pt 1):6064-7.2. Turesky R. et al.: Chem. Res. Toxicol. 2003 Sep;16(9):1162-73.3. Andrew, A. et al.: Int. J. Cancer. 2004 Apr 20;109(4):581-6.4. Kirkland, D. et al.: Mutat. Res. 2005 Dec 30;588(2):88-105.<br></p>

<p>Applications T-705RTP-13C5 Sodium Salt is a labeled salt derivative of T-705 (F103350) which has activity against the lethal H5N1 influenza A viruses.<br>References Yousuke, F., et al.: Antimicrob Agent Chemother., 49, 981 (2005); Kiso, M., et al.: Proc. Natl. Acad. Sci. U.S.A., 107, 882 (2010)<br></p>

<p>Applications A labelled metabolite of Catecholamines.<br>References Kopin, I.J., et al.: J. Biol. Chem., 236, 2109 (1961), Short, F.W., et al.: J. Med. Pharm. Chem., 5, 642 (1962)<br></p>

<p>Applications 4-Desacetamido-4-chloro Andarine-D4 is a labelled analogue of 4-Desacetamido-4-chloro Andarine (D289535). 4-Desacetamido-4-chloro Andarine is a Selective Androgen Receptor Modulator (SARM) that has potential use for treatment of androgen related diseases such as muscle wasting and osteoporosis. 4-Desacetamido-4-chloro Andarine also a derivative of Andarine (A637470), a non-steroidal SARM that is used by athletes to enhance performance.<br>References Jones, A., et al.: Endocrinology, 150, 385 (2009); Marhefka, C., et al.: J. Med. Chem., 47, 993 (2004); Thomas, A., et al.: Rapid Comm. Mass Spec., 24, 1124 (2010)<br></p>

<p>Applications Isotope labelled penconazole is an conazole based fungicide that works by inhibiting cell membrane ergosterol biosynthesis, thus stopping the development of fungi.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sharma, H., et al.: J. Mycol. Plant. Pathol., 42, 494 (2012); Sen, K., et al.: Food. Chem. Toxicol., 50, 3990 (2012); Pitt, W.M., et al.: Plant Disease., 96, 1303 (2012);<br></p>

<p>Applications Succinic Acid-1,4-13C2 (cas# 79864-95-2) is a compound useful in organic synthesis.<br></p>

<p>Applications L-Alanine-d7 (CAS# 74280-71-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Dibutyldiethyltin is an organotin compound that is an environmental pollutant that is present in sediment and sewage sludge.<br>References Mueller, M.D. et al.: Anal. Chem., 59, 617 (1987);<br></p>

<p>Applications 1-Phenanthrol-d9 has been used as a reactant for the preparation of stable isotope-labeled internal standards of PAH metabolites from urine of smokers and nonsmokers.<br>References Jacob, P. III, et. al.: Anal. Chem., 79, 587 (2007)<br></p>

<p>Applications Isotope labelled N-Iodoacetyltyramine (I685880) is used in iodine-125 labelling of various molecules for chemical analysis.<br>References Lin, C. et al.: Anal. Biochem., 179, 389 (1989);<br></p>

<p>Applications Labelled Methylparaben (M325660). It is used as preservative in foods, beverages and cosmetics.<br>References Goodwin, M., et al.: Science, 203, 559 (1979),<br></p>

<p>Stability Hygroscopic<br>Applications 5-​Methyl-2,​4(1H,​3H)​-​pyrimidinedione-​2-​13C-​1,​3-​15N2 is an intermediate in synthesizing 5-Methyl-2’-deoxy Cytidine-13C,15N2 (M295904). It is an isotopic analog of 5-Methyl-2’-deoxy Cytidine (M295900), a Cytidine (C998300) analog and also an isostere of Thymidine (T412000).<br>References Sabini, E., et al.: J. Med. Chem., 51, 4219 (2008), Sabini, E., et al.: J. Mol. Biol., 378, 607 (2008)<br></p>

<p>Applications Isotope labelled Acetamide (A133060) which is often used as plasticizer and as industrial solvent (1). It can also be used for the transamidation of carboxamides in 1,4-dioxane in the absence of a catalyst (2) . Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br>References 1. Ma, X. et al.: Carb. Polym. 2004 Aug:57(2):197-2032. Vanjari, R. et al.: Tetrahedron. Lett. 2013 MayL54(20):2553-5<br></p>

<p>Applications Diphenyl Methyl Phosphate-d3 is the deuterated form of Diphenyl Methyl Phosphate (D492423), which is a phosphorus flame retardant additive.<br>References Stapleton, H. M., et al.: Environ. Sci. Technol., 46, 13432(2012)<br></p>

<p>Applications Isotope labelled Aminoacetonitrile Hydrochloride (A580055), a useful synthetic intermediate. It is a reagent used to synthesize dipeptide nitriles as reversible and potent cathepsin S inhibitors. It can also used to prepare substituted cyclic ureas as possible HIV protease inhibitors.<br>References Ward, Y., et al.: J. Med. Chem., 45, 5471 (2002); Wilkerson, W., et al.: J. Med. Chem., 40, 4079 (1997)<br></p>

<p>Applications N-Butylbenzenesulfonamide, is the labeled analogue of N-Butylbenzenesulfonamide, which is a plasticizer used commercially in the polymerization of polyamide compounds.<br>References Strong M.J., et al.: Acta Neuropathologica, 81(3), 235-241 (1991);<br></p>

<p>Applications Isotope Labelled 2-Bromopyridine is a 2-halogenated pyridine used in the preparation of a variety of biologically active compounds such as antimalarial agents and beta-adrenoceptor agonist.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References LaMontagne, M.P. et al.: J. Med. Chem., 17, 519 (1974); Yoshizaki, S. et al.: Chem. Pharm. Bull., 37, 3430 (1989);<br></p>

<p>Applications Labelled Dimethyl Phosphate (D477600). Used in the synthesis of L,L- and L,D-di-myo-inositolphosphates.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Stieglitz, K., et al.: J. Biol. Chem., 277, 22863 (2002),<br></p>

<p>Stability Light Sensitive, Possibly Shock Sensitive<br>Applications Labelled 2,4-Dinitrophenol It is a precursor to other chemicals and is biochemically active, inhibiting energy (adenosine triphosphate, ATP) production in cells with mitochondria. It is also used in the synthesis of coumarins.<br> E0<br>References Harper, J. et al.: Obesity Rev., 2, 255 (2001; Yavari, I. et al.: Tetra. Lett., 39, 2391 (1998);<br></p>

<p>Applications Isovaleryl L-Carnitine-d3 Chloride is labelled Isovaleryl L-Carnitine Chloride (I917580) which is used to prepare carnitine benzyl esters as neuroprotectant prodrugs.<br>References Gong, X., et al.: J. Chem. Res., 6, 327 (2008)<br></p>

<p>Applications Labelled Aldicarb Sulfoxide (A514665). Aldicarb Sulfoxide is an analog of Aldicarb (A514650) detected in agricultural products as pesticide residue.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ashby, J., et al.: Environ. Mutagen., 7, 919 (1985), Ashby, J., et al.: Mutat. Res., 257, 229 (1991), Kazius, J., et al.: J. Med. Chem., 48, 312 (2005), Benigni, R., et al.: Mutagenesis, 25, 335 (2010),<br></p>

<p>Applications Isotope labelled 2-Bromoethanol is an widely used intermediate in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tian, Z., et al.: Int. J. Quant. Chem., 111, 631 (2011); Thayer, F.K., et al.: Org. Syntheses., 6, (1926);<br></p>

<p>Applications Octadecanoic-18,18,18-d3 Acid (CAS# 62163-39-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled Melamine (M208703), which forms synthetic resins with formaldehyde. It remains largely non-metabolized in male Wistar rats with 90% of the administered dose excreted in the urine (1,2) and thus acts as a non-protein nitrogen food additive found in milk (3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br>References 1. Mast, R. et al.: Food Chem Toxicol. 1983 Dec;21(6):807-10.2. Smith, J. et al.: Toxicol Appl Pharmacol. 1994 Apr;125(2):296-308.3. Anirudhan, T. et al.: Food Chem. 2017 Jul 15;227:85-92.<br></p>

<p>Applications Isotope labelled Hexadecyltrimethylammonium Bromide (CTAB) (H293860), is a cationic surfactant used as a template in the synthesis of Mesoporous γ-Fe2O3.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yu, H.-h., et al.: Gongneng Cailiao, 42, 2005 (2011),<br></p>

<p>Applications Palmitoyl-16,16,16-d3-L-carnitine Hydrochloride is the isotope labelled analog of Palmitoyl-L-carnitine Hydrochloride (P155050); a long-chain fatty ester of carnitine which is accumulated and released into the circulation in fatty-acid oxidation defects.<br>References Ventura, F., et al.: Clinica Chimica Acta, 281, 1 (1999); Pourfarzam, M., et al.: Clinical Chem,, 40, 2267 (1994); Schaefer, J., et al.: Pediatric Res., 37, 354 (1995)<br></p>

<p>Applications 4-tert-Butylphenol-D9 is the labelled analogue of 4-tert-Butylphenol (B694105). 4-tert-Butylphenol is a reactant in the preparation of (2-bromocyclopent-2-en-1-yl)phenols.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Speck, K., et. al.: Org. Lett., 17, 1982 (2015)<br></p>

<p>Applications Labelled Sodium Formate is used in various organic reactions and syntheses. It is used in the preparation of [3,2b]pyridines as well as the palladium-catalyzed coupling of vinyl triflates with organostannanes.<br>References Mathes, B. et al.: Tetra., 44, 725 (2003); Scott, W. et al.: J. Am. Chem. Soc., 108, 3033 (1986);<br></p>

<p>Applications 3-Fluoro-6-nitroanisole-d3 is a compound useful in organic synthesis.<br></p>

<p>Applications 1-Naphthalenemethanol-d7 (cas# 1189876-86-5) is a compound useful in organic synthesis.<br></p>

<p>Applications One of the vitamins of the B6 complex; present in many foodstuffs (yeast, liver and cereals). It has a role in transporting protein Bsu1, contributes to thiamine uptake; characterization of thiamine (vitamin B1) transporter Thi9 from Schizosaccharomyces pombe.<br>References Williams, R., et al.: J. Biol. Chem., 87, 581 (1930), Rodionov, D., et al.: J. Biol. Chem., 277, 48949 (2002),Nosaka, K., et al.: Mol. Microbiol., 58, 467 (2005),<br></p>

<p>Applications Isotope labelled Methanol (M276585), which is a common chemical reagent in organic synthesis participating in a variety of reactions. Used to prepare novel triazole-polyphenol hybrid compounds as FabG4 (Rv0242c) enzyme inhibitors for the treatment of Mycobacterium Tuberculosis (1). Also used in the synthesis of prodelphinidin B1/B2/B4 which display antitumor activities against prostate cancer cells.Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Banerjee, D. et al.: Org. Biomol. Chem. 2014 Jan 7;12(1):73-85.<br></p>

<p>Applications Labelled Sulfanilic acid (S689095). Sulfanilic acid is a toxic metabolite of Tartrazine (T007700). Used as Ehrlich’s reagent, for detecting of nitrites. Antibacterial.<br>References Collins, T., et al.: Food Chem. Toxic., 28, 821 (1990), Levine, W., et al.: Drug Metab. Rev., 23, 235 (1991), Sasaki, Y., et al.: Mutat. .Res., 519, 103 (2002),<br></p>

<p>Applications (R)-10-Monohydroxy-10,11-dihydro Carbamazepine-d3 is labelled (R)-10-Monohydroxy-10,11-dihydro Carbamazepine which is the metabolite of Oxcarbazepine (OXC) and Eslicarbazepine acetate, (BIA 2-093, ESL), novel central nervous system drugs.<br>References Duncan, J., et al.: Br. J. Clin. Pharmacol., 53, 123 (2002), Almeida, L., et al.: J. Clin. Pharmacol., 45, 1062 (2005), Coppola, G., et al.: CNS Drugs, 18, 133 (2004),<br></p>

<p>Applications n-Octadecane-d38 (CAS# 16416-31-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications A bactericide detected in rivers and lakes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lindstrom, A., et al.: Environ. Sci. Technol., 36, 2322 (2002)<br></p>

<p>Applications Labelled Succinic Anhydride is used in the synthesis of propanoyloxy derivatives used as drug absorption modifiers. In addition it is a reagent for novel non-carboxylate inhibitors of AKR1C3<br>References Coufalova, L. et al.: Steroids, 78, 435 (2013); Heinrich, D. et al.: Eur. J. Med. Chem., 62, 738 (2013);<br></p>

<p>Applications 4-Toluidine-d7 (Major) (cas# 68693-08-3) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Labelled Glycidol. Stabilizer in manufacturing of vinyl polymers; intermediate in synthesis of glycerol, glycidyl ethers, and amines; additive for oil and synthetic hydraulic fluids; epoxy resin diluent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hiles, R.A., et al.: Food Cosmet. Toxicol., 19, 347 (1981), Thompson, E.D., et al.: Food Chem. Toxicol., 22, 665 (1984),<br></p>

<p>Applications Isotope labelled Hydrazine Sulfate, is a reagent used in the heterocyclization of primary amines and may be cyclized itself. It is also used in the synthesis of novel triazole corrosion inhibitors for mild steel.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bentiss, F. et al.: J. App. Electrochem., 29, 1073 (1999); Ju, Y. et al.: J. Org. Chem., 71, 135 (2006);<br></p>

<p>Applications sotope labelled m-Cresol (C781915) is one of the components that make up liquid rice hull smoke, and may contribute to its anti-inflammatory effects in mice.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications N,N-Dimethylformamide-13-C is the isotope labelled analog of N,N-Dimethylformamide. N,N-Dimethylformamide-d7 is used as a cofactor for enzymic oxidation of brassinin, which allows the transformation of dithiocarbamate group into an aldehyde equivalent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pedras, M., et al.: Bioorg. Med. Chem., 19, 1390 (2011);<br></p>

<p>Applications Labelled Fenfluramine. Anorexic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pinder, et al.: Drugs, 10, 241 (1975), Caccia, S., et al.: Eur. J. Clin. Pharmacol., 29, 221 (1985), Finner, N., et al.: Curr. Ther. Res., 38, 847 (1985),<br></p>

<p>Applications n-Butyl 4-Hydroxybenzoate-2,3,5,6-d4 is the labelled analogue of butyl 4-​hydroxybenzoate (B693600), which is an antimicrobial agent used in cosmetic products.<br>References Gilliland, D., et al.: J. Appl. Bacteriol., 72, 258 (1992), Routledge, E., et al.: Toxicol. Appl. Pharmacol., 153, 12 (1998), Miller, C., et al.: J. Biol. Chem., 272, 32824 (1997), Nakagawa, Y., et al.: Biochem. Pharmacol., 55, 1907 (1998),<br></p>

<p>Applications 1,2,4-Trichlorobenzene-d3 (CAS# 2199-72-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications A labelled metabolite of Theophylline.<br>References ottrup, A., et al.: Pharmacol. Toxicol., 67, 340 (1990), El-Kadi, A., et al.: Drug Metab. Dispos., 28, 1112 (2000), Kim, S., et al.: J. Med. Chem., 45, 2131 ( 2002), Hansel, T., et al.: Drugs Today, 40, 55 (2004),<br></p>

<p>Applications tert-Butyl Methyl-d3 Ether (CAS# 29366-08-3) is a useful isotopically labeled research compound.<br></p>