Compuestos deuterados

<p>Stability Hygroscopic<br>Applications Clencyclohexerol-d10 is a labelled analog of Clenbuterol, a β-agonist which can be used as a growth promoter in farm animals.<br>References Maistro, S., et al.: Lancet, 346, 180 (1995); Vanoosthuyze, K., et al.: J. Agric. Food Chem., 45, 3129 (1997); Fiori, M., et al.: Anal. Chim. Acta, 529, 207 (2005); Salquebre, G., et al.: J. Anal. Toxicol., 31, 114 (2007);<br></p>

<p>Applications 4-Phenanthrol-d9 has been used as a reactant for the preparation of stable isotope-labeled internal standards of PAH metabolites from urine of smokers and nonsmokers.<br>References Jacob, P. III, et. al.: Anal. Chem., 79, 587 (2007)<br></p>

<p>Applications Hexanoic-2,2-d2 Acid (CAS# 55320-65-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Aclonifen-d5, is the labeled analogue of Aclonifen, which is used as a pesticide and herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Laini, A., et al.: Sci. Total Environ., 438, 312 (2012); Fantke, P., et al.: Enviorn. Int., 49, 9 (2012);<br></p>

<p>Applications Labelled nitro substituted piperazine.<br></p>

<p>Applications The compund has cytotoxic effects. Labelled Norharmane.<br>References Elfarra, A., et al.: Drug Metab. Dispos., 26, 779 (1998), Da Costa, A., et al.: Biocell, 23, 65 (1999), Janetzky, B., et al.: Drug Dev. Res., 46, 51 (1999), Kutty, R., et al.: Toxicol. Appl. Pharmacol., 107, 377 (1991), Riederer, F., et al.: J. Neurochem., 81, 814 (2002), Schott, Y., et al.: Bioorg. Med. Chem. Lett., 16, 5840 (2006),<br></p>

<p>Stability Hygroscopic<br>Applications N-Acetylneuraminic Acid-13C,d3 is a labelled Neuraminic Acid derivative.<br>References Oetke, C., et al.: J. Biol. Chem., 277, 6688 (2002)<br></p>

<p>Applications Verapamil-d3 Hydrochloride is the labeled analogue of Verapamil Hydrochloride (V125000), which is a calcium channel blocker, antihypertensive, antianginal, and antiarrhythmic (class IV).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Atlas, D, and Adler, M.: Proc. Natl. Acad. Sci. USA, 78, 1237 (1981); Janis, R., et al.: Adv. Drug. Res., 16, 309 (1987)<br></p>

<p>Applications A labelled metabolite of Theophylline.<br>References ottrup, A., et al.: Pharmacol. Toxicol., 67, 340 (1990), El-Kadi, A., et al.: Drug Metab. Dispos., 28, 1112 (2000), Kim, S., et al.: J. Med. Chem., 45, 2131 ( 2002), Hansel, T., et al.: Drugs Today, 40, 55 (2004),<br></p>

<p>Applications 1,10-Decanedioic-d16 Acid (CAS# 73351-71-0) is a useful isotopically labelled compound for studying saturated fatty acids.<br>References Yamada, T., et al.: Adv. Synth. Catal., 358, 3277 (2016)<br></p>

<p>Applications 2,7-Diisopropyl-9,9-dimethyl-9,10-dihydroacridine-d6 (Major) is a labeled analogue of 2,7-Diisopropyl-9,9-dimethyl-9,10-dihydroacridine (D455760), a useful chemical reagent. Also, it is derived from 9,9-Dimethyl-9,10-dihydroacridine (D474300), which are currently being used in the development of thermally activated delayed fluorescence (TADF) molecules which are being researched for their possible efficient deep-​blue TADF emitting potential.<br>References Kwon, D.Y., et al.: J. Nanosci. Nanotechnol., 15, 7828-31 (2015); Wada, Y., et al.: Adv. Mater., 30 (2018).<br></p>

<p>Applications Isotope labelled 9-Bromophenanthrene (B687200), a halogenated polycyclic aromatic hydrocarbon that has been seen to have a room temperature phosphorescence that can be induced by β-cyclodextrin (β-CD) in the presence of cyclohexane; however, trace Fe(III) causes a decrease of the RTP emission.<br></p>

<p>Applications Isotope labelled Tripropyl phosphate is an organophosphorus flame retardant and plasticizer. Phosphorus Flame Retardant<br>References Bacaloni, A., et al.: Environ. Sci. Technol., 42, 1898 (2008)<br></p>

<p>Applications Ademethionine-d3 1,4-Butanedisulfonate, is a labeled analogue of Ademethionine 1,4-Butanedisulfonate (A280355), used in the synthesis of sulfonio-adenosyl-L-methionine (SAMe) salts.<br></p>

<p>Applications Labelled 2-acetylthioethanesulfonic acid. Mesna (M225750) impurity.<br></p>

<p>Stability Unstable in Solution, Hygroscopic<br>Applications Used in nucleophilic substitution.<br>References Genicot, C., et al.: Bioorg. Med. Chem. Lett., 13, 437 (2003),<br></p>

<p>Applications Labelled Fumaric Acid (F500380). Occurs in many plants. Essential to vegetable and tissue respiration. Used as an antioxidant.<br>References Jelitto, T., et al.: Planta, 188, 238 (1992), Son, H., et al.: J. Agric. Food Chem., 56, 8007 ( 2008),<br></p>

<p>Applications Isotope labelled 4-Chlorobenzoic Acid is a benzoic acid analogue that showed antifungal activity against strains of Aspergillus flavus, Aspergillus fumigatus and Aspergillus terreus, causative agents of human aspergillosis, in in vitro bioassays. It is used as a preservative.<br>References Rep, M., et al.: J. Biol. Chem., 275, 8290 (2000), Jaeger, T., et al.: Biofactors, 27, 109 (2006), Kim, J., et al.: Fungal Biology, 114, 817 (2010),<br></p>

<p>Applications Wittig Reagent<br></p>

<p>Applications The precursor of the ubiquitous natural compound malondialdehyde.<br>References Basu, A.K., et al.: J. of Labelled Compounds &amp; Radiopharmaceuticals, XX11, 11, 1175 (1985)<br></p>

<p>Applications A bactericide detected in rivers and lakes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lindstrom, A., et al.: Environ. Sci. Technol., 36, 2322 (2002)<br></p>

<p>Applications Hexamethylbenzene-d18 (cas# 4342-40-9) is a useful research chemical.<br></p>

<p>Applications 1-Amino Hydantoin Hydrochloride (A611090), a metabolite of Nitrofuran.Environmental contaminants<br>References Tribalat, L., et al.: Anal. Bioanal. Chem., 386, 2168 (2006), Chu, P., et al.: J. Agric. Food Chem., 55, 2129 (2007),<br></p>

<p>Applications Labelled Butylparaben. An antimicrobial agent used in cosmetic products.<br>References Gilliland, D. et al.: J. Appl. Bacteriol., 72, 258 (1992); Routledge, E. et al.: Toxicol. Appl. Pharmacol., 153, 12 (1998); Miller, C. et al.: J. Biol. Chem., 272, 32824 (1997); Nakagawa, Y. et al.: Biochem. Pharmacol., 55, 1907 (1998);<br></p>

<p>Applications Nonanal-d18, is the labeled analogue of Nonanal (N649330), a component of essential oils. Nonanal possesses a strong fruity odor. Essential oils have varying effects from antibacterial activity to hypolipidemic activity.<br>References Zorrilla-Fontanesi, Yet al.: Plant. Phys., 159, 851 (2012): Taherkhani, M. et al.: Asian. J. Chem., 24, 1461 (2012); Ahmadvand, H. et al.: Iran. J. Pharm. Res., 11, 1219 (2012);<br></p>

<p>Applications N,N-Dimethyldodecylamine-d6 is the isotope labelled analog of N,N-Dimethyldodecylamine. N,N-Dimethyldodecylamine is used as a reagent in the synthesis of epoxy quaternary ammonium salt surfactants which exhibit potential antibacterial activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liu, Y., et al.: J. Disper. Sci. Technol., 35, 1460 (2014)<br></p>

<p>Applications Isotope labelled Oxacillin Sodium Salt is a semi-synthetic antibiotic related to Penicillin. Antibacterial.<br>References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971),<br></p>

<p>Applications Oxaloacetic Acid-13C4 is labelled form of Oxaloacetic Acid (O845030) which is a four carbon dicarboxylic acid that is an intermediate in the citric acid cycle and glucogenesis. It has been shown to inhibit succinate dehydrogenase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zeylemaker, W.P. et al.: Biochim. Biophys. Acta Enzymol., 132, 210 (1967); Dalla-Betta, P. et al.: Int. J. Mol. Sci., 10, 2809 (2009);<br></p>

<p>Applications Aminoguanidine-13C Bicarbonate is a compound useful in organic synthesis.<br></p>

<p>Applications 1-Hexanol-d11 is the labelled analogue of 1-Hexanol (H281220), a perturbing agent on actomyosin ATPase and and was found to modulate the function of actomyosin motor via intermediate-specific structural perturbation.<br>References Komatsu, H., et al.: J. Muscle. Res. Cell. Motil., 25, 77 (2004); Hua, J.F., et al.: J. Insect. Physiol., 59, 690 (2013);<br></p>

<p>Applications 4-Bromophenol-2,3,5,6-d4 is the labelled analogue of 4-Bromophenol (B686405) which is used as a reagent in Stille reactions.<br>References Littke, A.F. et al.: J. Am. Chem. Soc., 124, 6343 (2002);<br></p>

<p>Applications Hexazinone-d6 (dimethyl-d6-amino) (CAS# 1219804-22-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Triethylamine (D15, 98%) (cas# 66688-79-7) is a useful research chemical.<br></p>

<p>Applications Labelled Diglyme. Solvent; it is used as reaction medium for Grignard and similar synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Diethyleneglycol Monoethyl-d5 Ether (CAS# 1219804-11-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Octanoic Acid-13C4 is an isotopic analog of Octanoic Acid (O237880), which is found naturally in the milk of various mammals. Its esters can be used in perfumery and also in the manufacture of dyes. It is also an antimicrobial pesticide used as a food contact surface sanitizer. Caprylic acid is also used in the treatment of some bacterial infections.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lide, D. R., et al.: CRC Handbook chem. Phys., 70th Ed. (1990); Beare-Rogers, J., et al.: Pue Appl. Chem., 73 (4), 685 (2001);<br></p>

<p>Applications Metabolite of oleic and linoleic acids.<br>References Jin, S.J., et al.: Biochem., 29, 8540 (1990).<br></p>

<p>Applications Labelled ε-Aminocaproic Acid. Used in the preparatiom of esters of 6-aminohexanoic acid as antibacterial agents. EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carbo xy peptidase, plasmin, and plasminogen activator.<br>References Dolezal, P., et al.: Pharm. Res., 10, 1015 (1993), Vavrova, K., et al.: Curr. Med. Chem., 12, 2273 (2005), Holas, T., et al.: Bioorg. Med. Chem., 14, 7671 (2006),<br></p>

<p>Applications Methyl-d3 Methanesulfonate (CAS# 91419-94-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2,6-Dimethylphenol-d9 (Major) (cas# 1021325-40-5) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications The main metabolite of Flunixin.<br>References Odensvik, K., et al.: Am. J. Vet. Res., 56, 489 (1995), Ngoh, M.A., et al.: J. Agric. Food Chem., 51, 4701 (2003).<br></p>

<p>Applications Labelled N-Nitroso-N-methyl-N-dodecylamine (N529935). N-Nitroso-N-methyl-N-dodecylamine is a nitroso compound with carcinogenic potency.<br>References Singer, S., et al.: J. Med. Chem., 28, 1088 (1985), Gonzalez-Mancebo, S., et al.: Mutat. Res., 558, 45 (2004), Luan, F., et al.: Chem. Res. Toxicol., 18, 198 (2005),<br></p>

<p>Applications Product of smoking tobacco<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Benigni, R., et al.: Env. Mol. Mutagen., 48, 754 (2007), Shin, H., et al.: Food Chem. Toxicol., 47, 192 (2009),<br></p>

<p>Applications n-Hexatriacontane-d74 (CAS# 16416-34-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled Glycolic Acid (G645600). Constituent of sugar cane juice.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Smyth, H.F., et al.: J. Ind. Hyg. Toxicol., 23, 259 (1941),<br></p>

<p>Applications Hexanoic-5,5-d2 Acid (CAS# 55320-68-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications DL-p-Hydroxyphenyllactic Acid-d3 is the isotope labelled analog of DL-p-Hydroxyphenyllactic Acid (H953665); a reagent in the synthesis of 2-O-(4-coumaroyl)-3-(4-hydroxyphenyl)lactic acid which is an important intermediate of rosmarinic acid biosynthesis.<br>References Matsuno, M., et al.: Chem. Pharm. Bull., 49, 1644 (2001)<br></p>

<p>Applications Isotope labelled Squalane is used as an emollient and moisturizer in cosmetic applications.<br>References Allison, A.: Method, 19, 87 (1999)<br></p>

<p>Applications Labelled Nicotinic acid. It is a precursor of the coenzymes NAD and NADP. Widely distributed in nature; appreciable amounts are found in liver , fish, yeast and cereal grains. Dietary deficiency is associated with pellagra. The term “niacin” has also been applied to nicotinamide or to other derivatives exhibiting the biological activity of nicotinic acid. Vitamin (enzyme cofactor).<br>References Darby, W.J., et al.: Nutr. Rev., 33, 289 (1975), Black, A., et al.: Eur. J. Clin. Nutr., 54, 395 (2000), Cole, T., et al.: Br. Med. J., 320, 1240 (2000), Forshee, R., et al.: J. Nutr., 134, 2733 (2004),<br></p>

<p>Applications N-Methyl-N’-nitrosopiperazine-d4 is the isotope labelled analog of N-Methyl-N’-nitrosopiperazine (M325800), which is used as a reagent in the organic synthesis of several compounds including that of (4-methoxyphenoxy)acetic and (3,4,5-trimethoxyphenoxy)acetic acid amides and hydrazides which display antimicrobial and anthelmintic properties and may act as potential neurotropic and cardiovascular agents. N-Methyl-N’-nitrosopiperazine also diplayed strong nasal carcinogenity and genotoxicity toward nasal cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Valenta, V., et al.: Collect. Czech. Chem. C., 52, 3013 (1987); Klein, R., et al.: Carcinogenesis, 20, 1629 (1999);<br></p>