Compuestos deuterados

Applications Labelled L-α-Dilauroyl Phosphatidylcholine forms robust and versatile membrane bilayers to study the selective and ATP-driven transport ions across membranes into nanoporous carriers using gramicidin A and ATP synthase. It is used in the preparation of other phosphatidylcholines.
References Tomoi, M. et al.: Synth. Comm., 19, 905 (1989); Ichihara, K. et al.: Chem. Phys. Lipids., 137, 94 (2005); Olliynyk, V., et al.: Phys. Chem. Chem. Phys., 15, 2733 (2013); Podloucka, P., et al.: J. Phy. Chem. B., 117, 5043 (2013);

Applications Hexanenitrile-6,6,6-d3 (CAS# 1219805-03-4) is a useful isotopically labeled research compound.

Applications n-Dodecyltrimethylammonium-d34 Bromide (CAS# 2259752-12-8) is a useful isotopically labeled research compound.

Stability Light Sensitive
Applications Acrylonitrile-13C3_x000D_(stabilized with 35-45 ppm 4-hydroxy anisole (H750015)) (cas# 202326-55-4) is a compound useful in organic synthesis.
E0

Applications 3,4-Dichlorobenzoic-d3 Acid (CAS# 350818-53-0) is a useful isotopically labeled research compound.

Applications Amisometradine-d3, is a labeled analogue of Amisometradine (A633600), which is an oral diuretic.
References Papesch, V., et al.: J. Org. Chem., 16, 1879 (1951); Moskalyk, R., et al.: J. Pharma. Sci., 64, 1406 (1975)

Applications N-2-Hydroxy-3-[[2-(methoxyphenoxy)ethyl]amine Carvedilol-d5 is the isotope labelled analog of N-2-Hydroxy-3-[[2-(methoxyphenoxy)ethyl]amine Carvedilol (H946145); the impurity A of Carvedilol (C184625) which is a nonselective β-adrenergic blocker with α1-blocking activity. Carvedilol is also an antihypertensive used in the treatment of congestive heart failure.
References Hirohashi, M., et al.: Arzneim.-Forsch., 40, 735 (1990); Packer, M., et al.: N. Engl. J. Med., 334, 1349 (1996)

Applications 4-Nitrotoluene-2,3,5,6-d4 (CAS# 1276197-16-0) is a useful isotopically labeled research compound.

Applications Suberic Acid-d4, is a labeled analogue of Suberic Acid (S688670), which is used in the preparation of reduction-sensitive micelles affecting their cellular uptake. This has potential application in delivery of anticancer drugs. It is also used in the fluorescent detection of amidinium-carboxylate and amidinium formation.
References Cui, C. et al.: Biomat., 34, 3858 (2013); Kusukawa, T. et al.: Tetra., 68, 9973 (2012);

Applications rac-cis-N-Desmethyl Sertraline-d3 hydrochloride is a labelled metabolite of rac-cis-N-Desmethyl sertraline hydrochloride (D292100). N-Desmethyl sertraline is significantly less active analogue as compared to the methylated compound, sertraline.
References Welch, W.M., et al.: J. Med. Chem. 27, 1508 (1984)

Applications o-Toluic Acid-13C1 (carboxyl-13C) (CAS# 70838-82-3) is a useful isotopically labeled research compound.

Applications Ethyl-2,2,2-d3 Acetate (CAS# 109545-01-9) is a useful isotopically labeled reagent for radiolysis and reactions with radical-cations of esters in freon matrixes.
References Belevskii, V. N., et al.: Khimiya Vysokikh Energii, 21, 209 (1987)

Applications Pyrrolidine-2,2,5,5-d4 Hydrochloride is the salt, labeled analogue of Pyrrolidine (P997950), a heterocyclic compound used as a building block in the synthesis of wide range of pharmaceutical compounds, namely matrix metalloprotein inhibitors (MMPIs) and aminopeptidase N inhibitors (APNIs).
References Li, X. et al.: Mini-Rev. Med. Chem., 10, 794 (2010); Gragutan, I. et al.: Beil. J. Org. Chem., 7, 699 (2011)

Applications Isotope labelled 4-Chlorobenzoic Acid is a benzoic acid analogue that showed antifungal activity against strains of Aspergillus flavus, Aspergillus fumigatus and Aspergillus terreus, causative agents of human aspergillosis, in in vitro bioassays. It is used as a preservative.
References Rep, M., et al.: J. Biol. Chem., 275, 8290 (2000), Jaeger, T., et al.: Biofactors, 27, 109 (2006), Kim, J., et al.: Fungal Biology, 114, 817 (2010),

Applications 3-Hydroxymethyl-(1-oxy-2,2,5,5-tetramethylpyrroline)-15N is an isotope labelled spin-labelling compound.

Applications Trimethyl Orthopropionate-2,2,3,3,3-d5 (CAS# 1219803-49-2) is a useful isotopically labeled research compound.