Compuestos deuterados

Applications A labelled metabolite of Dichloropropanols.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Velisek, J., et al.: J. Agric. Food Chem., 28, 1142 (1980), Johnson, J., et al.: Anal. Chem., 62, 2162 (1990),

Applications Bis(4-hydroxyphenyl) Sulfone-d4 is the isotope labelled compound commonly used as a reactant in epoxy reactions and is also used as a latent thermal catalyst for epoxy resin.
References Fu, J.W., et al.: Adv. Mat. Rsch., 266, 1022 (2011); Li, J.X., et al.: Polymers. Adv. Tech., 23, 803 (2012);

Applications Glutaric Acid (2,2,4,4-D4, 98%) (cas# 19136-99-3) is a useful research chemical.

Applications A labelled derivative of Dibarbituric acid.
References Hitchings, G.H., et al.: J. Biol. Chem., 177, 357 (1949),

Stability Air Sensitive
Applications 2,4-Xylidine-d6 is labelled 2,4-Xylidine (X749690) which is an aniline derived chemical reagent used in the synthesis of antiarrhythmic compounds. It is also used as a reactant in the synthesis of anticonvulsants.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kalinin, D. et al.: Eur. J. Med. Chem., 63, 144 (2013); Ragavendran, J. et al.: Eur. J. Med. Chem., 42, 146 (2007);

Applications o-Anisidine is a highly toxic environmental pollutant and digestive system carcinogen. It is also a toxin that has been identified to be present in cigarettes.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Coggins, C.R.E. et al.: Inhal. Toxicol., 23, 41 (2011); Dracinska, H. et al.: Neuroendorinol. Lett., 27, 9 (2006); Naiman, K. et al.: Neuroendocrinol. Lett., 31, 36 (2010);

Applications 1,4-Butane-2,2,3,3-d4-diamine 2HCl (CAS# 88972-24-1) is a useful isotopically labeled research compound.

Applications 4-Nitrophenol-13C6 is an intermediate in the synthesis of labelled 4-Aminophenol (A618920). It is also a nephrotoxic metabolite of Acetaminophen (A161220) and Phenacetin (P294580) (1,2).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References (1) Watanabe, et al.: Drug Metab. Dispos., 38, 1532 (2010)(2) Batuta, S. and Begum, N. A. Synth. Commun. 47, 137-147 (2017)

Applications Indole-4,5,6,7-d4 is a labelled analogue of Indole (I577320), which can be used in perfumes and in the synthesis of tryptophan. It is also an intermediate in synthesizing Indoleacetic Acid-13C6 (I577343), which has the potential to be used in anti-cancer therapy in conjunction with horseradish peroxidase (HRP).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kawano, T. et al.: Gen. Hypo. 60, 664 (2003);

Applications DL-Indole-3-lactic Acid Methyl Ester-D5 is an intermediate used in the synthesis of DL-Indole-3-lactic Acid-d5 (I627102), which is the isotope labelled analog of DL-Indole-3-lactic Acid (I627100); a reagent in the synthesis of 2-hydroxy-1-(1H-indol-3-yl)-4-methylpentan-3-one which has weak antibacterial activity against 16 bacterial strains, including Escherichia coli, Bacillus subtilis and Staphylococcus aureus. DL-Indole-3-lactic Acid is also used in the preparation of Monatin, a natural sweet peptidomimetic.
References Nguyen, S.T., et al.: Bioorg. Med. Chem. Lett., 20, 5739 (2010); Nakamura, K., et al.: Peptide Sci., 40, 61 (2003)

Applications Isotope Labelled 1-Nitrosopyrrolidine (N545950), which is one of the N-nitroso compounds (NOCs) implicated in human colon carcinogenesis, but the toxicological mechanisms involved have not been elucidated. Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.
References 1. Singer, S. et al.: J. Med. Chem. 1985 Aug;28(8):1088-93.2. Tomatis, L. et al.: Carcinogenesis. 1997 Jan;18(1):97-105.3. Helguera, A. et al.: Toxicol Appl Pharmacol. 2007 Jun 1;221(2):189-202.

Applications Labelled Sulfamonomethoxine. Protein binding. Inhibitor of enzyme. Sulfamonomethoxine and Trimethoprim are used for treating porcine unknown hyperpyrexia.
References Bridges, et al.: Biochem. J., et al.: 96, 829 (1965), Hong, Y.-L., et al.: Antimicrob. Agents Chemother., 39, 1756 (1995)

Applications D-Tyrosine-d2 is deuterium labelled D-Tyrosine (T899970). D-Tyrosine, the stereoisomer to L-Tyrosine (T899975), is an amino acid used in various organic syntheses for antibiotics. It is used in the synthesis of (-)-anisomycin, as well as BATSI (boronic acid transition state inhibitors) which act on β-lactamases. It has also been studied as an inhibitor of microbial growth on surfaces, reducing microbial attachment to hydrophillic glass and hydrophobic polypropylene surfaces.
References Li, Ji. et al.: Chin. Chem. Lett., 23, 647 (2012); Xu, H. et al.: Water Res., 45, 5796 (2011); Ke, W. et al.: Antimicrob. Agents Chemother., 55, 174 (2011)

Applications 1,4-Dichlorobutane-d8 (CAS# 83547-96-0) is a useful isotopically labeled research compound.

Applications 5-Hydroxy Propafenone Hydrochloride-d5 is a labeled analogue of 5-Hydroxy Propafenone Hydrochloride (H952450), a metabolite of Propafenone (P757500), a sodium channel blocker. Antiarrhythmic (class IC).
References Hege, H.G., et al.: Eur. J. Drug Metab. Pharmacokinet., 9, 41 (1984); Hollmann, M., et al.: Arzneim.-Forsch., 33, 763 (1983); Bryson, H. M., et al.:Drugs, 45, 85 (1993); Rae, A. P., et al.: Am. J. Cardiol., 82, 59N (1998)

Stability Very Hygroscopic
Applications Metolachlor ESA-d6 Sodium Salt is deuterium labelled salt form of Metolachlor ESA (M338860) which is a synthetic herbicide.
References Mai, H., et al.: Aquat. Toxicol. 147, 48 (2014); McCarty, G. W., et al.: Sci Total Environ 473-474, 473 (2014);

Applications Labelled O,O-Diethyl Dithiophosphate (D444265). Used in the synthesis of novel phosphorothioates and phosphorodithioates as cholinesterase inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Millard, C., et al.: J. Neurochem., 64, 1909 (1995), Nicolet, Y., et al.: J. Biol. Chem., 278, 41141 (2003), Casida, J., et al.: Chem. Res. Toxicol., 17, 983 (2004),

Applications Acetoin-13C4 is the labeled analogue of the unlabeled (A163775), which is used in food flavoring and fragrances and is also found in some fruits and vegetables.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Dutta, S.M. et al.: Ind. J. Dairy Sci., 24, 107 (1971);