Compuestos deuterados

Applications Labelled acetylsalicylic acid impurity B.
References Walter, M., et al.: Eur. J. Biochem., 1996, 239, 281 (1996), Bantignies, B., et al.: Plant Mol. Biol., 42, 871 (2000), Bais, H., et al.: J. Biol. Chem., 278, 32413 ( 2003), Finkler, C., et al.: Genetica, 124, 117 (2005),

Applications Labelled 2-(1-Piperazinyl)pyrimidine, the major metabolite of Tandospirone (T006430).
References Goa, K., et al.: Drugs, 32, 114 (1986); Lamberg, T., et al.: Clin. Pharmacol. Ther., 63, 640 (1998); Niwa, T., et al.: Biol. Pharm. Bull 28, 1711 (2005); Natsui, K., et al.: Eur. J. Drug Metab. Pharmacokinet., 32, 233 (2007);

Applications Cyclopentanone-2,2,5,5-d4 (CAS# 3997-89-5) is a useful isotopically labeled research compound.

Applications The toxicity of halogenated benzoic acids was found to be directly related to the compound's hydrophobicity. Toxicity and quantitative structure-activity relationships of benzoic acids to Pseudokirchneriella subcapitata. This is the labelled analog.
References Moore, D., et al.: Environ. Toxicol. Chem., 16, 794 (1997), Zhao, Y., et al.: Sci. Total Environ., 216, 205 (1998), Fiorentino, A., et al.: J. Agric.Food Chem., 51, 1005 (2003),

Applications Emamectin-d3 is deuterium labeled emamectin, a soluble derivative of avermectin and used as parasiticide and insecticide. Emamectin activates glutamate-gated chloride channels.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Xu X., et al.: Biochem Biophys Res Commun 473, 795 (2016); Lumaret, J. P., et al.: Curr Pharm Biotechnol. 13, 1004 (2012)

Applications Isotope labelled Tripropyl phosphate is an organophosphorus flame retardant and plasticizer. Phosphorus Flame Retardant
References Bacaloni, A., et al.: Environ. Sci. Technol., 42, 1898 (2008)

Applications Benzyl-alpha,alpha-d2 Alcohol (CAS# 21175-64-4) is a useful isotopically labeled research compound.

Applications Cefepime-D8 sulfate is a labelled analogue of Cefepine sulfate, a cephalosporin that has antibacterial effects against Gram-positive and Gram-negative bacteria. Cefepime sulfate is used to treat mild to severe bacterial infections.
References Neu, H.: Am. J. Med., 100, 68S (1996); Sanders, C.: Clin. Infect. Dis., 17, 369 (1993); Sanders, W., et al.: Clin. Infect. Dis., 23, 454 (1996); Yahav, D., et al.: Lancet Infect. Dis., 7, 338 (2007)

Applications N-Methyl-N’-nitrosopiperazine-d4 is the isotope labelled analog of N-Methyl-N’-nitrosopiperazine (M325800), which is used as a reagent in the organic synthesis of several compounds including that of (4-methoxyphenoxy)acetic and (3,4,5-trimethoxyphenoxy)acetic acid amides and hydrazides which display antimicrobial and anthelmintic properties and may act as potential neurotropic and cardiovascular agents. N-Methyl-N’-nitrosopiperazine also diplayed strong nasal carcinogenity and genotoxicity toward nasal cells.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Valenta, V., et al.: Collect. Czech. Chem. C., 52, 3013 (1987); Klein, R., et al.: Carcinogenesis, 20, 1629 (1999);

Applications Labelled 2,3-Butanedione (B690030). 2,3-Butanedione (Diacetyl), the molecule implicated in the disease known as popcorn lung, has now been implicated in amyloid-β peptide toxicity associated with Alzheimer’s disease. Diacetyl accelerates amyloid-β aggregation-a hallmark of Alzheimer’s disease. These preliminary finding raise the possibility of long-term neurological toxicity mediated by DA.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wang, J., et al.: Exp. Neurol., 158, 328 (1999); Brown, M., et al.: Cell, 100, 391 (2000); Heinitz, K., et al.: J. Neurochem., 98, 1930 (2006); Brody, D., et al.: Science, 321, 1221 (2008); More, S., et al.: J. Med. Chem., 52, 4650 (2009);

Applications Product of smoking tobacco
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Benigni, R., et al.: Env. Mol. Mutagen., 48, 754 (2007), Shin, H., et al.: Food Chem. Toxicol., 47, 192 (2009),

Applications Oxaloacetic Acid-13C4 is labelled form of Oxaloacetic Acid (O845030) which is a four carbon dicarboxylic acid that is an intermediate in the citric acid cycle and glucogenesis. It has been shown to inhibit succinate dehydrogenase.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Zeylemaker, W.P. et al.: Biochim. Biophys. Acta Enzymol., 132, 210 (1967); Dalla-Betta, P. et al.: Int. J. Mol. Sci., 10, 2809 (2009);

Applications 2,7-Diisopropyl-9,9-dimethyl-9,10-dihydroacridine-d6 (Major) is a labeled analogue of 2,7-Diisopropyl-9,9-dimethyl-9,10-dihydroacridine (D455760), a useful chemical reagent. Also, it is derived from 9,9-Dimethyl-9,10-dihydroacridine (D474300), which are currently being used in the development of thermally activated delayed fluorescence (TADF) molecules which are being researched for their possible efficient deep-​blue TADF emitting potential.
References Kwon, D.Y., et al.: J. Nanosci. Nanotechnol., 15, 7828-31 (2015); Wada, Y., et al.: Adv. Mater., 30 (2018).

Applications Verapamil-d3 Hydrochloride is the labeled analogue of Verapamil Hydrochloride (V125000), which is a calcium channel blocker, antihypertensive, antianginal, and antiarrhythmic (class IV).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Atlas, D, and Adler, M.: Proc. Natl. Acad. Sci. USA, 78, 1237 (1981); Janis, R., et al.: Adv. Drug. Res., 16, 309 (1987)

Applications 1-Octanol-d17, is the labeled analogue of 1-Octanol (O237900), which is an fatty acid alcohol that is used industrially to form various synthetic intermediate and pharmaceuticals.
References Nagaraja, N., et al.: J. Entomol. Res., 37, 29 (2013); Luang, S., et al.: J. Biol. Chem., 288, 10111 (2013);

Applications Isotope labelled 9-Bromophenanthrene (B687200), a halogenated polycyclic aromatic hydrocarbon that has been seen to have a room temperature phosphorescence that can be induced by β-cyclodextrin (β-CD) in the presence of cyclohexane; however, trace Fe(III) causes a decrease of the RTP emission.

Applications DL-Histidine-alpha,beta,beta-d3 (CAS# 344299-50-9) is a useful isotopically labeled research compound.

Applications Labelled Butylparaben. An antimicrobial agent used in cosmetic products.
References Gilliland, D., et al.: J. Appl. Bacteriol., 72, 258 (1992), Routledge, E., et al.: Toxicol. Appl. Pharmacol., 153, 12 (1998), Miller, C., et al.: J. Biol. Chem., 272, 32824 (1997), Nakagawa, Y., et al.: Biochem. Pharmacol., 55, 1907 (1998),

Stability Volatile
Applications 1,2-Dichloroethane-D4 is a labelled analogue of 1,2-Dichloroethane (D434325). 1,2-Dichloroethane is one of the major waste products of the Vinyl Chloride industries, and has also been classified as a potential human carcinogen.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hung, W., et al.: Appl. Surf. Sci., 255, 2205 (2008); Rannug, U., et al.: Chem.-Biol. Int., 20, 1 (1978)