Compuestos deuterados

Applications 5-[2-[(3-Chloro-2-hydroxypropyl)thio]-4-thiazolyl]-2-thiophenecarboxamide-d5 is an intermediate in synthesizing Arotinolol-D5 Hydrochloride (A771502), which is a labelled analogue of Arotinolol (A771500). Arotinolol is both and alpha- and beta-adrenoceptor antagonist and is used to treat essential tremors and hypertension.
References Kuroda, Y., et al.: Neurology, 38, 650 (1988); Miyagishi, A., et al.: Arch. Pharmacodyn. Ther., 271, 249 (1984); Wu, H., et al.: Hypertens. Res.: Off. J. Jpn. Soc. Hypertens., 24, 605 (2001);

Applications An intermediate in the preparation of deuterated cytidine derivatives
References Chamorro, C., et al.: Bioorg. Med. Chem. Lett., 11, 3085 (2001), Bornemann, B., et al.: Bioorg. Med. Chem., 14, 6235 (2006), Desbouis, D., et al.: J. Med. Chem., 51, 6689 (2008),

Applications Labelled Nitisinone intermediate.

Applications 2-Pyridineacetic Acid-d6 Ethyl Ester is an labelled analogue of 2-Pyridineacetic Acid (P991750), a compound used often in nucleophilic substitution.
References Genicot, C., et al.: Bioorg. Med. Chem. Lett., 13, 437 (2003),

Applications 2-Amino-5-chlorobenzophenone Oxime-d5 is an intermediate in synthesizing N-Demethyl Chlordiazepoxide-d5 (D230827), a deuterium labelled analogue of N-Demethyl Chlordiazepoxide (D230825), which is the main metabolite of anxiolytic drug Chlordiazepoxide (C327050).
References MacDonald, A., et al.: Anal. Profiles Drug Subs., 1, 15 (1972); Greenblatt, D.J., et al.: Clin. Pharmacokinet., 3, 381 (1978); Barbone, F., et al.: Lancet, 352, 1331 (1998); Miki, A., et al.: J. Anal. Toxicol., 26, 87 (2002)

Applications 2-(tert-Butylamino)-4-chloro-6-cyclopropylamino-1,3,5-triazine-d9 (cas# 1189419-70-2) is a compound useful in organic synthesis.

Applications Propylene Glycol β-D-Glucopyranosiduronic Acid Benzyl Ester 2,3,4-Triacetate-d6 s an intermediate in the synthesis of Isotope labelled Propylene Glycol 2-Glucuronide which is a metabolite of propylene glycol, used in the synthesis of N-terminal kinase inhibitors with cellular activity. Acts as a solvent for various pharmaceutical compounds.
References Szczepankiewicz, B. et al.: J. Med. Chem., 49, 3563 (2006); Mateus, R. et al.: Int. J. Pharm., 444, 106 (2013);

Applications 2-Cyano-acetic Acid Sodium Salt-13C2 (cas# 1346598-51-3) is a compound useful in organic synthesis.

Applications 6-Amino-3-methyluracil-d3 (cas# 1246820-43-8) is a compound useful in organic synthesis.
References Grant, D.M., et al.: Clin. Pharm. and Ther., 33, 591 (1983)

Applications (Z)-2-(Methoxyimino)-3-oxobutanoic Acid-d3 Methyl Ester (cas# 1331636-65-7) is a compound useful in organic synthesis.

Applications Can be used in the preparation of substances for treatment of dermatological conditions and skin protection.

Applications 1,1,2-Trimethyl-1H-benzo[e]indole-d6 is a labelled analogue of 1,1,2-Trimethyl-1H-benzo[e]indole (T896032). It is a useful research chemical.

Applications 5,6-Diamino-2,4-dihydroxypyrimidine-13C2, Hydrochloride Salt (cas# 1346605-20-6) is a compound useful in organic synthesis.

Applications Toluene-4-d1 (CAS# 4409-83-0) is a useful isotopically labeled research compound. It is an efficient and recyclable nano-catalyst for selective oxidation.
References Wanna, W., et.al., J.Cataly., 370, 332-346,(2019);

Applications Toluene-3-d1 (CAS# 4409-85-2) is a useful isotopically labeled research compound. This compound can be used for spectroscopic studies on toluene and deuterated derivatives.
References Balfour, W., et.al., Can. J. Phys., 72, 1225-1235,(1994);

Applications Toluene-2-d1 (CAS# 4409-84-1) is a useful isotopically labeled research compound. This compound can be used in preparation for various organic synthesis applications, and for determining deuterium isotopic effects in 13C NMR spectra of benzene derivatives.
References Zaidlewicz, M.,et.al., Sci. Synth, 6,921-943,(2004); Novak, P.,et.al., Magn.Reson.Chem., 34,610-615,(1996);

Applications Ethanolamine-d7 (CAS# 1219802-89-7) is a useful isotopically labeled research compound.

Applications Phenoxy-d5-acetic Acid Ethyl Ester (cas# 1189442-18-9) is a compound useful in organic synthesis.

Applications Isotope labelled 2-Ethyl-1-hexanol is used in the preparation of succinate-based plasticizers for replacing phthalate plasticizers. Also used in the preparation of polymeric plasticizers.
References Stuart, A. et al.: Eur. Polym. J. 49, 2785 (2013); Braslau, R. et al.: J. Polym. Sci. Part. A. Polym. Chem., 51, 1175 (2013);

Applications 3,5-O-Dibenzyl Metaproterenol-d7 is an intermediate used in the synthesis of Metaproterenol-d7 Hemisulfate Salt (M225837), which is labelled Metaproterenol (M225835). Bronchodilator.
References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971),