Haluros orgánicos

<p>Applications Ethyl 4-Chloroacetoacetate (cas# 638-07-3) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2,4-Dibromophenol is a fundamental starting material for organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ruzo, L., et al.: J. Agric. Food Chem., 24, 291 (1976),<br></p>

<p>Applications Ethyl 4,4-Difluoroacetoacetate is an intermediate used for the synthesis of pharmaceuticals such as potassium channel activators and β-alanine derived GABA-T antagonists.<br>References Qi, J.L., et al.: Euro. J. Medn. Chem., 46, 934 (2011); Schirlin, D., et al.: J. Enzymes. Inhibition., 1, 243 (1987);<br></p>

<p>Applications 2-Chloro-3-formylthiophene is a useful reagent in the discovery and optimization of substituted piperidines as potent, selective, CNS-penetrant α4β2 nAChR potentiators.<br>References Albrecht, B., et al.: Bioorg. Med. Chem. Lett., 18, 5209 (2008);<br></p>

<p>Applications 2-Chloro-α-fluorobenzenepropanoic Acid is a reactant use dint he preparation of thiophene derivatives as modulators of intracellular calcium.<br>References Whitten, J.P., et. al.: U.S. Pat. Appl. Publ., US 20110065724 A1 20110317 (2011)<br></p>

<p>Applications 3,4-Dichlorobenzyl bromide<br></p>

<p>Impurity Mefenamic Acid EP Impurity C<br>Applications 4-Bromo-2-chlorobenzoic Acid (cas# 59748-90-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 3,5-Difluoroisonicotinonitrile (cas# 1214377-09-9) is a useful research chemical.<br></p>

<p>Applications A cell-permeable, selective and irreversible PPARγ antagonist (IC50 = 3.3 nM, 32 nM, and 2 µM for PPARγ, PPARα, and PPARδ, respectively). Reported to covalently modify a cysteine residue in the binding site of PPAR. At a concentration of 10 µM, also acts as an agonist of human pregnane X receptor (PXR) and farnesoid X receptor (FXR). Does not activate liver X receptor-a (LXRa), retinoic acid receptor (RAR), retinoid X receptor-a (RXRa) and thyroid receptors a and b (TRa and TRb<br>References Huang, J.T., et al.: Nature, 400, 378 (1999), Wilson, T.M., et al.: J. Med. Chem., 43, 527 (2000), Leesnitzer, L.M., et al.: Biochemistry, 41, 6640 (2002)<br></p>

<p>Applications 2-Chlorobenzyl cyanide was used in the synthesis of clopidogrel, platelet aggregation inhibitor. It can also be used to synthesize non-peptide CCR1 receptor antagonists.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Huang, Y., et al.: Anhui Med. Pharm. J., 6, 007 (2009); Ng, H., et al.: J. Med. Chem., 42, 4680 (1999)<br></p>

<p>Applications 3-​Bromophenylboronic Acid is a useful synthetic intermediate. It is used in oxidative cross coupling, gold salt catalyzed homocoupling and 1,4-Addition reactions with α,β-unsaturated ketones.<br>References Uchiyama, N., et al.: Chem. Comm., 47, 11671 (2011); Matsuda, T., et al.: tetrahedron Lett., 52, 4779 (2011); Berhal, F., et al.: J. Org. Chem., 76, 6320 (2011)<br></p>

<p>Applications 2-(Dimethylamino)ethanethiol Hydrochloride is a starting material for the synthesis of Echothiophate Iodide (E325800). Echothiophate Iodide is an anticholinesterase drug.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ashani, Y., et al.: Biochem. Pharm., 30, 2593 (1981)<br></p>

<p>Stability Light Sensitive, Volatile<br>Applications 2-​Bromo-​3,​3-​dimethyl-1-​butene is reagent used in synthetic chemistry.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Spaggiari, A. et al.: J. Org. Chem. 72, 2216-2219 (2007)<br></p>