Haluros orgánicos

<p>Applications Formamidine Hydrobromide is used as a reactant in the synthesis of organometal halide perovskites (OHPs).<br>References Shi, Yifei, et al.: ACS App. Mat. &amp; Interfaces, 10(11), 9849-9857 (2018)<br></p>

<p>Applications 2-Fluoro-4-(methylsulfonyl)benzoic acid<br></p>

<p>Applications 2-Ethoxy-N,N,N-trimethylethanaminium chloride is being used for the study of antigibberellin activity and the role quaternary ammonium salts play.<br>References Gafurov, R.G., et al.: Doklady Biological Sciences, 394, 66-70 (2004); Gafurov, R.G., et al.: Doklady Biological Sciences, 421 (2004);<br></p>

<p>Applications Chlorsulfaquinoxaline is used to prepare carbonic anhydrase inhibitors 1,3,4-thiadiazole-2-sulfonamide derivatives as antitumor agents.<br>References Supuran, C., et al.: Eur. J. Med. Chem., 35, 867 (2000)<br></p>

<p>Applications [(1-Fluoroethenyl)sulfinyl]benzene is an intermediate used in the synthesis of 13-Fluorodibenzo[a,i]pyrene (F588440), which is a polycyclic aromatic hydrocarbon (PAH) thus potentially exhibiting carcinogenic properties through activation of P450 mono-oxygenase enzymes. Also, it has unique electrical and optical properties due to being a conjugated macromolecule.<br>References Zhang, F. et al.: J. Org. Chem., 65, 3952 (2000); Amaladass, P. et al.: Tetra., 64, 7992 (2008);<br></p>

<p>Applications 2,4-Dibromophenol Acetate (cas# 36914-79-1) is a compound useful in organic synthesis.<br></p>

<p>Stability Store FROZEN<br>Applications Material that was assayed to be approximately 80% pure was diluted to 5% in benzene.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications (S)-2-Bromobutyric Acid is a key intermediate for the introduction of a particular stereogenic unit into the structure of chiral active pharmaceutical compounds,<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Brenna, E. et al.: Org. Proc. Res. Dev., 16, 262 (2012);<br></p>

<p>Applications 3-Bromopentane-2,4-dione (cas# 3043-28-5) is a useful research chemical.<br></p>

<p>Applications 2-Bromo-6-chlorobenzoic acid is used in the syntheis of Diclofenac Monobromo Sodium Salt Impurity (D436490).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Moser, P., et al.: J. Med. Chem., 33, 2358 (1990),<br></p>

<p>Applications 6-chloro-2,4-dimethylnicotinonitrile (cas# 101251-72-3) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-Chloro-p-xylene is a toxic compound found in algae.<br>References Tsai, K.; et al.: Environ. Toxicol. Chem., 26, 1931 (2007).<br></p>

<p>Applications 3-Bromo-4-isopropylbenzoic acid<br></p>

<p>Stability Hygroscopic<br>Applications (2R)-Tetrahydro-2-furanmethanamine is a stereoisomer of Tetrahydro-2-furanmethanamine (T293545) which is used in the synthesis of novel topoisomerase I targeting anti-cancer agents with mild to potent cytotoxic activity. Tetrahydro-2-furanmethanamine (T293545) is also used in the discovery and synthesis of orally bioavailable stearoyl-CoA desaturase 1 inhibitors.<br>References Lopez-Rodriguez, M. et al.: 44, 4504 (2001); Liu, G. et al.: J. Med. Chem., 50, 3086 (2007);<br></p>

<p>Applications 2-Bromoethyl Methyl Ether was used as a reactant for the preparation of alkyl ethers of β-alkylcholine salts.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Major, R.T., Cline, J.K.: J. Am. Chem. Soc., 55, 2504 (1933)<br></p>

<p>Applications 2-Bromophenetole<br></p>

<p>Applications 1-Bromo-2,3-dimethyl-benzene is a useful synthetic intermediate. It is used as a reagent to synthesize vaniprevir. It can also be used to synthesize various piperidine derivatives, e.g., 4-arylpiperidines and cinnamoylpiperidine, which are 5-HT2C agonist and PAR1 antagonist, respectively.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Song, Z., et a;.: J. Org. Chem., 76, 9553 (2011); Conway, R., et al.: Bioorg. Med. Chem. Lett., 22, 2560 (2012); Planty, B., et al.: Bioorg. Med. Chem. Lett., 20, 1735 (2010)<br></p>

<p>Applications 2,2-Dimethylbutanoyl chloride is a reagent that is used in the synthesis of 4α,5-Dihydro Simvastatin (D450010). 4α,5-Dihydro Simvastatin is an impurity in the synthesis of Simvastatin (S485000), a synthetic derivative of a fermentation product of Aspergillus terreus. A competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic. Simvastatin, the drug, is sold under the trade name Zocor.<br>References Hoffman, W.F., et al.: J. Med. Chem., 29, 849 (1986), Mol, M.J., et al.: Lancet, 2, 936 (1986),<br></p>

<p>Applications tert-Butyl Bromoacetate is a halogenated t-butyl acetate commonly used as an alkylating agent. tert-Butyl Bromoacetate is used in the synthesis of collagenase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Steinman, D.H. et al.: Bioorg. Med. Chem. Lett., 8, 2087 (1998); Fray, M.J. et al.: J. Med. Chem., 46, 3514 (2003): Neri, P. et al.: J. Org. Chem., 59, 3880 (1994);<br></p>

<p>Applications 6-Chloronicotinic Acid, is an organic building block used for the synthesis of various biologically active compounds, including inhibitors. It is an intermediate for the synthesis of N-(thiophen-2-yl) benzamide derivatives as BRAFV600E inhibitors, and novel DNA-gyrase B inhibitors.<br>References Xie, Y., et al.: Bioorg. Med. Chem. Lett., 23, 2306 (2013); Shiroya, U., et al.: Med. Chem. Res., 22, 5227 (2013);<br></p>

<p>Stability Moisture Sensitive<br>Applications 2,3-Dichloropropionyl Chloride is used as a reagent in the synthesis of 6-chloro-5-cyclohexyl-1-indancarboxylic acid, a potent analgesic, antipyretic, and antiinflammatory agent, and its related compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sawa, Y., et al.: Yakugaku Zasshi, 96, 653 (1976)<br></p>

<p>Applications 2,6-Dichlorobenzonitrile (DCBN or dichlobenil) is a herbicide and is slightly toxic for humans. It is metabolized in the liver by the enzyme CYP2A6.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, H., et al.: Soil Sci. Soc. Am. J., 67, 122 (2003); Shedletzky, E., et al.: Plant Physiol., 94, 980 (1990)<br></p>

<p>Applications 3-Bromo-benzenebutanoic Acid is a reactant used in the preparation of pyrrolo-(di)-benzazocinones via an intramolecular cyclization of N-acyliminium ions formed from 4,4-diethyoxybutyl amides (Erratum)<br>References King, F.D., et al.: Org. Biomol. Chem., 7, 5271 (2009); King, F.D., et al.: Org. Biomol. Chem., 7, 167 (2009)<br></p>

<p>Applications (S)-4-Chlorostyrene oxide is used in the biosynthetic preparation though epoxidation of styrene and substituted styrenes by whole cells of Mycobacterium.<br>References Rigby, S. R., et al.: Bioorg. Med. Chem. 2, 553 (1994);<br></p>

<p>Applications 4,5-Dichloro-phenylenediamine (cas# 5348-42-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-(4-Chlorophenyl)but-3-en-2-one (cas# 3160-40-5) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications Oleyl Chloride is used as a chemical reagent in the preparation of Vitamin E analogs as well as antiviral nucleoside phosphoramidate prodrugs used in the treatment of HIV and HBV.<br>References Cho, J. et al.: Bioorg. Med. Chem., 22, 6665 (2014); Iwata, R. et al.: Bioorg. Med. CHem. Lett., 25, 815 (2015);<br></p>

<p>Applications 2-[(2-fluorophenyl)sulfanyl]acetic acid (cas# 705-02-2) is used in the preparation of phenylsulfanylalkylcarboxylic acid compositions, useful for the delivery of active agents.<br>References Wang, N. F., et al.: PCT Int. Appl. 118 pp. (2008)<br></p>

<p>Applications o-Chloramine T (cas# 110076-44-3) is a useful research chemical.<br></p>

<p>Applications 5-​Bromopentyl Acetate is used to model the toxicity of haloesters on marine bacterium such as Vibrio fischeri.<br>References Cornin, M.T.D, et. al.: SAR QSAR Environ. Res., 11, 301 (2000)<br></p>

<p>Applications 1-Bromo-3,4-dichlorobenzene<br></p>

<p>Applications 2,5-Bis(trifluoromethyl)aniline is a haloalkul substituted aniline used in the preparation of anti-benign prostatic hyperplasia drug, Dutasteride (D735000).<br>References Liang, Y. et al.: Jil. Dax. Xueb. Lixeub., 45, 1035 (2007);<br></p>

<p>Applications Cyclopropylhydrazine Dihydrochloride, is a building block used in preparation of more complex compound.<br></p>

<p>Applications (1,3-Dioxolan-2-ylmethyl)triphenylphosphonium Bromide is used as a reactant in the synthesis of ketolides methyloxoerythromycins with antibacterial activity as highly potent against macrolide-resistant and susceptible respiratory pathogens.<br>References Agouridas, C., et al.: J. Med. Chem., 41, 4080 (1998);<br></p>

<p>Applications 2-(2,4-Difluorophenyl)-1,2,3-propanetriol is used as a reagent in the synthesis of glycerol derivatives as intermediates for antifungal phenyltriazolylpropanediol derivatives. Also an impurity of the antifungal agent Fluconazole (F421000).<br>References Richard, K. et al.: Antimicrob. Ag. Chemother., 27, 832 (1985); Yasohara, Y., et al.: PCT Int. Appl. WO 9528374 A1 19951026. Oct 26, 1995<br></p>

<p>Applications 3-Bromomethylphenylboronic acid, pinacol ester<br></p>

<p>Stability Hygroscopic<br>Applications 2-Chloroethyl benzoate (cas# 939-55-9) is a useful research chemical.<br></p>

<p>Applications (1S,3R)-3-(4-Bromophenyl)cyclopentanamine is a stereoisomer of (1R,3S)-3-(4-Bromophenyl)cyclopentanamine, used in the synthesis of pharmaceutical agents.<br></p>

<p>Applications 2-Fluoroiodobenzene is used as a reagent in various organic reactions. It is used in the synthesis of spirocyclic [1,2,3]-triazolooxazine nucleosides which have antiviral properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dell'Isola, A., et al.: Chem-Eur. J., 20, 11685 (2014)<br></p>

<p>Applications Intermediate in the synthesis of Fulvestrant (F862500) impurity C.<br></p>

<p>Applications 3-Bromonitrobenzene (cas# 585-79-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Tetraethyl Fluoromethylenebisphosphonate is a reagent in the synthesis and design of T6PP inhibitors. T6PP catalyzes the hydrolysis of trehalose 6-​phosphate to form trehaloseand is important in many fungal, bacterial pathogens.<br>References Liu, C. et al.: Tetrahedron., 73, 1324 (2017);<br></p>

<p>Applications Ethyl trans-2-(4-aminocyclohexyl)acetate, HCl<br></p>

<p>Applications 1H-1,3-benzodiazole-5-sulfonyl chloride hydrochloride (cas# 1956321-85-9) is a useful research chemical.<br></p>

<p>Applications 3-Bromophthalic anhydride<br></p>

<p>Applications 2,2,2-Trifluoroacetamide (cas# 354-38-1) is a useful research chemical.<br></p>

<p>Applications Tetrachlorothiophene is chlorinated derivative of Thiophene (T368080), which is used as a building block of various organic molecules and pharmaceuticals providing functional properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Prasad, B. et al.: Chem. Comm., 48, 10434 (2012); Freitas, V. et al.: Struct. Chem., 24, 661 (2013);<br></p>

<p>Applications N-​Methylaniline Trifluoroacetate is regent used in organic synthesis, functioning as an α-methylating agent for ketones and activates internucleodecoupling upon removal.<br>References Nikolaev, V. et al.: E-Eros. Encyc. Reag. Org. Synth, 1, (2001); Wallace, D. et al.: Tetrahedron Lett., 54, 4425 (2013);<br></p>

<p>Applications 2-Chloro-4'-nitrobenzanilide (cas# 55501-45-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Amino-2-chlorobenzeneacetic Acid can be used as reactant/reagent in starting material in preparation of phenylacetamides as protein kinase inhibitors useful in treatment of various proliferative diseases.<br>References Bold, G., et al.: PCT Int. Appl., WO 2006108640 A1 20061019 (2006);<br></p>

<p>Applications 2-Bromo-1-(2-hydroxy-5-(2-hydroxyethyl)phenyl)ethanone is an intermediate in the synthesis of 3-Hydroxy Darifenacin (Mixture of Diastereomers) (H825190), the hydroxylated metabolite of Darifenacin (D193400).<br>References Soudijn, W., et al.: Eur. J. Pharmacol., 1, 47 (1967), John, B., et al.: Xenobiotica, 22, 1339 (1992), Franz, P., et al.: Drug Metab. Dispos., 21, 249 (1993),<br></p>

<p>Applications (5-Carboxypentyl)triphenylphosphonium Bromide (cas# 50889-29-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,5-Bis(Trifluoromethyl)Nitrobenzene (cas# 320-88-7) is a useful research chemical.<br></p>

<p>Stability Unstable in solution. Small amounts of precipitate should have no effect on use.<br>Applications 1-Chloro-N,N-2-trimethylpropenylamine acts as a reagent in the synthesis and antitumor activity of (-)-bassianolide in human cancer cells through cell cycle arrest. Enantioselective total synthesis of nannocystins A and A0 as elongation factor 1 inhibitors. Total synthesis of (-)-caprazamycin A with antibacterial activity against Mycobacterium tuberculosis (TB) via diastereoselective aldol reaction.<br>References Mun, B., et al.: Bioorg. Chem., 69, 64 (2016); Huang, J., et al.: Org. Lett., 18, 4702 (2016); Nakamura, H., et al.: Angew. Chem., Int. Ed., 54, 3136 (2015)<br></p>

<p>Applications 9,9-Dihexylfluorene (cas# 123863-97-8) is a useful research chemical.<br></p>

<p>Applications 3-chloro-N-(3-hydroxyphenyl)propanamide (cas# 50297-40-0) is a useful research chemical.<br></p>

<p>Applications 4-(4-Bromo-3-formylphenoxy)benzonitrile (cas# 906673-54-9) is a useful research chemical.<br></p>

<p>Stability Light Sensitive<br>Applications Ethyl 2,3-dibromo-3-phenylpropionate<br></p>

<p>Applications 4-Amino-2,6-dichlorophenol (cas# 5930-28-9) is a useful research chemical.<br></p>

<p>Applications 2,5-Dibromothiophene (cas# 3141-27-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Chloro-1-butanol is a reagent used in the preparation of pharmaceutical compounds such as canthine analogues for their activity against HeLa cervical cells. Also used in the preparation of novel and highly potent Bryostatin, another anti-cancer agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Naik, P. et al.: Tetrahedron, 69, 6545 (2013); Wender, P. et al.: J. Am. Chem. Soc., 124,13648 (2002);<br></p>

<p>Applications 5-Chlorohexanoic acid CAS#: 112176-22-4 is a building block used in organic synthesis.<br>References Liang, S., et al., Green Chemistry., 20, 680 (2018)<br></p>

<p>Stability Air Sensitive, Moisture Sensitive<br>Applications 3-Hexyl Chloroformate is a potential impurity in the synthesis of Dabigatran Etexilate Mesylate (D100150); a nonpeptide and direct thrombin inhibitor. Antithrombotic.<br>References Zheng, Y., et al.: Org. Process Res. Dev., 18, 744 (2014); Hauel, N., et al.: J. Med. Chem., 45, 1757 (2002); Mungall, D., et al.: Curr. Opin. Invest. Drugs, 3, 095 (2002); Stangier, J., et al.: J. Clin. Pharmacol., 45, 555 (2005)<br></p>