Haluros orgánicos

<p>Applications 2-Fluoro-5-nitroanisole<br></p>

<p>Stability Hygrscopic<br>Applications N-(2,6-Dimethylphenyl)-2,2-dichloroacetamide is an intermediate used to prepare Ranolazine (R122500), an antianginal agent.<br>References Aalla, S., et al.: Org. Proc. Res. Dev.,16, 748 (2012)<br></p>

<p>Applications 4-bromo-2-ethyl-1-fluorobenzene (cas# 627463-25-6) is a useful research chemical.<br></p>

<p>Applications This compound is an impurity in the synthesis of Etoricoxib (E934100), a specific inhibitor of COX-2. It is also used in the synthesis of selective GlyT1 inhibitors.<br>References Pinard, E. et al.: J. Med. Chem., 53, 4603 (2010); McGeer, P.L., et al.: Exp. Gerontol., 37, 925 (2002), Chenevard, R., et al.: Circulation, 107, 405 (2003);<br></p>

<p>Applications (1R,3S)-3-(4-Bromophenyl)cyclopentanamine is used in the synthesis of pharmaceutical agents.<br></p>

<p>Applications 5-[1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione is an impurity of the DPP-IV inhibitor Sitagliptin (S491000).<br>References Ye, F. et al.: Hech. Huax., 18, 767 (2010); Ahn, J.H, et al.: Bioorg. Med. Chem. Lett., 17, 2622 (2007);<br></p>

<p>Applications 4-Fluorobenzophenone is a Wittig reagent.<br>References Buschauer, A., J. Med. Chem., 32, 1963 (1989); Yamataka, H., et al.: J. Org. Chem., 53, 3877 (1988)<br></p>

<p>Applications 3-(Aminomethyl)-4-fluorophenol Hydrobromide is derived from 2-Fluoro-5-methoxybenzaldehyde, which is versatile reactant used in the solid-phase synthesis of BODIPY dyes and development of an immunoglobulin fluorescent sensor.<br>References Vendrell, M., et al.: Chem. Commun., 47, 8424 (2011);<br></p>

<p>Applications 2,2-Difluoro-1,3-benzodioxole is used in the synthesis of Kv3 inhibitors as well as in the preparation of renin inhibitors.<br></p>

<p>Applications 1-Bromo-2-chloro-3-fluoro-4-(trifluoromethyl)-benzene is a useful synthetic intermediate.<br></p>

<p>Applications 2-Fluorophenyl cyclopentyl ketone (cas# 111982-45-7) is a useful research chemical.<br></p>

<p>Applications 3-Fluoropicolinonitrile<br></p>

<p>Applications 3-​[2-​(Trifluoromethyl)​phenyl]​propionic Acid is a reactant used in the synthesis of small molecule inhibitors of anthrax toxin.<br>References Williams, J. et al.: Bioorg. Med. Chem., 22, 419 (2014);<br></p>

<p>Applications 2,2-Diiodopropane is used in studying the Raman effect (isomerism rotation) and is used as a reagent in some synthetic preparations.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kahovec, L., et al: Z. Physik. Chem., B47, 48 (1940); Charette, A., et al: Synlett, 1, 176 (2002)<br></p>

<p>Applications 3-(trifluoromethyl)oxetan-3-ol (cas# 1403676-72-1) is a useful research chemical.<br></p>

<p>Applications Triethylamine Hydrochloride is a hydrochloride salt of triethyllamine (T775740). Triethylamine is used as a competing base for the separation of acidic basic and neutral drugs by reverse-phased high-performance liquid chromatography (HPLC). Triethylamine induces visual disturbances (such as foggy vision) in humans, and is also used in industry as a quenching agent in the ozonolysis of alkenes (e.g. (E)-2-Pentene [P227315]). Triethylamine is used in the purification of drugs which are pharmacologically or chemically similar through separation in reverse-phase HPLC (2).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br>References 1. Akesson B. et al.: Int Arch Occup Environ Health. 1986;57(4):297-302. 2. Roos RW. et al.: J Chromatogr. 1986 Dec 24;370(3):403-18.<br></p>

<p>Applications (1S,2S,3R,5S)-3-Amino-5-(2-hydroxyethoxy)cyclopentane-1,2-diol Hydrochloride is used in the synthesis of Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004); Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007); Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007)<br></p>

<p>Applications 9-Fluorenylmethyl tosylate is a useful reagent in the synthesis of Se-​(9-​Fluorenylmethyl) selenoesters and amino thioacids.<br>References Crich, D., et al.: Org. Lett., 9, 4423-26 (2007); Fecourt, F., et al.: Org. Lett., 15, 3758-61 (2013);<br></p>

<p>Applications N,N'-Diaminoguanidine Monohydrochloride is an analyte for HPLC. It also functions as an intermediate for the synthesis of energetic salts or materials based on dinitroguanidine.<br>References Shen, K., et al.: Huaxue Gongye Yu Gongcheng Jishu, 35, 74 (2014); Hu, B., et al.: Aust. J. Chem., 67, 1037 (2014); Zhang, Y., et al.: Chem. - A Eur. J., 18, 987 (2012)<br></p>

<p>Applications 4-(4-Carboxy-3-fluorophenyl)-2-fluorobenzoic acid<br></p>

<p>Applications 1,7-Dichloro-octamethyltetrasiloxane 95% (cas# 2474-02-4) is a useful research chemical.<br></p>

<p>Impurity Nizatidine EP Impurity H<br>Applications 2-(Dimethylamino)thioacetamide (Nizatidine EP Impurity H) is used in the preparation of thiazole derivatives. 2-(Dimethylamino)thioacetamide is an impurity of the histamine H2-receptor antagonist Nizatidine (N598500).<br>References Johnson, R.A. et al.: J. Org. Chem., 57, 2869 (1992):<br></p>

<p>Applications 6-Bromohexene is used as a reagent in the synthesis of carbendazim dithioate analogs which can exhibit antibacterial, antifungal, and soil dehydrogenase activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zahran, M.A H., et al.: Res. J. Pharm., Biol. Chem. Sci., 6, 1084 (2015)<br></p>

<p>Applications 4-Fluorobenzal chloride (cas# 456-19-9) is a useful research chemical.<br></p>

<p>Applications Bis[2-​(1-​methylethyl)​phenyl] Ester Phosphorochloridic Acid is an intermediate in the synthesis of Bis(2-isopropylphenyl) Phenyl Phosphate (B451445), which is a triaryl phosphate used as plasticizers in polyvinyl chloride (PVC) as well as a flame retardant. Studies show that Bis(2-isopropylphenyl) Phenyl Phosphate inhibits the human androgen receptor.<br>References Duke, A.J.: Chimia, 32, 457 (1978); Honkakoski, P. et al.: Biochem. Pharmacol., 67, 97 (2004); Nobile, E.R. et al.: Bull. Environ. Contam. Toxicol., 25, 755 (1980);<br></p>

<p>Applications 2,3,5,6-Tetrachloro-p-xylene is a derivative of 2,3,5,6-Tetrachloro-4-methyl benzonitrile used as intermediates of pesticide with fluorine.<br>References Oliver, B.G., et al.: Environ. Sci. Technol., 19, 842 (1985), Boden, N., et al.: Tetrahedron Lett., 47, 8685 (1995),<br></p>

<p>Stability Very unstable to water and protic solvents.<br>Applications N,N-Dimethylmethyleneiminium chloride (cas# 30354-18-8) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Very Hygroscopic<br>Applications Magnesium Bromide is an inorganic salt used in the synthesis of superconductors and nanowires. Also present in polymer nanocomposites to improve conductivity.<br>References Alam, M. et al.: Polym. Int., 63, 1465 (2014); McDonald, T. et al.: J. Am. Chem. Soc., 135, 7056 (2012);<br></p>

<p>Applications 1-Bromo-3-phenylpropane is used in the synthesis of MraY natural inhibitors as antibacterial agents. Also used in the preparation of quinolinone derivatives as potent and selective MAO-B inhibitors.<br>References Fer, M. et al.: J. Org. Chem., 78, 10088 (2013); Meiring, L. et al.: Bioorg. Med. Chem. Lett., 23, 5498 (2013);<br></p>

<p>Applications Tigoloyl Chloride is used in the polymerization of propylene as well as through a Freidel-Crafts reaction for the preparation of permethylindenyl complexes of transition metals. As well, it is primarily used as a reagent in the enantioselective synthesis of dihydropyrans.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References O'Hare, D. et al.: Organometallics, 11, 48 (1992); Kaminsky, W. et al.: J. Organomet. Chem., 487, 181 (1995); Evans, D. A. et al.: J. Am. Chem. Soc., 122, 1635 (2000);<br></p>

<p>Applications (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran can be used as reactant/reagent in preparation of C-​aryl D-​glurofuranoside compounds useful as reference compounds in the quality control of gliflozin type medicine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Xu, Z., et al.: Faming Zhuanli Shenqing, CN 106279072 A 20170104 (2017);<br></p>

<p>Applications tert-Butyl 4-Iodobutyrate is a versatile reactant used in the preparation of phosphorylated 3-heteroarylcoumarins that are employed in fluorescence microscopy and nanoscopy. It is also used in the preparation of α-Me α-carboxyalkyl amino acids that can be incorporated into phosphotyrosine-free peptides as Grb2 SH2-inhibitors and potential anticancer agents.<br>References Long, Y., et al.: J. Med. Chem., 51, 6371 (2008); Nizamov, S., et al.: Chem. Eur. J., 18, 16339 (2012);<br></p>

<p>Applications 4-Chloroiodobenzene is used as a reagent in the synthesis of Clothiapine (C588550); an atypical antipsychotic of the dibenzothiazepine chemical class that has shown efficacy in treatment-resistant schizophrenic patients.<br>References Schmutz, J., et al.: Helvetica Chimica Acta 50, 245 (1967); Geller, V., et al.: Schizophrenia Research 80 (2-3), 343 (2005)<br></p>

<p>Applications 3-(2-Aminoethyl)indolin-2-one Hydrochloride (cas# 4993-84-4) is a useful research chemical.<br></p>

<p>Applications (2-Chloroethyl)(3-chloropropyl)amine is used in the preparation of quaternary ammonium salt of cyclophosphamide and its derivatives as antitumor agents.<br></p>

<p>Applications Bromodifluoromethyl Phenyl Sulfone can be used to prepare difluoromethyl ethers via difluoromethylation of alcohols.<br>References Xie, Q., et.al.:Angew. Chem. Int., 56, 3206-3210, (2017);<br></p>

<p>Applications 2-(2-Chloro-6-fluorobenzylthio)aniline<br></p>

<p>Applications Methyl 4-(trifluoromethyl)benzoate<br></p>

<p>Applications NE-100 is a potent and selective σ1 receptor antagonist.<br>References Sabino, V., et al.: Psychopharmacology, 205, 327 (2009); Kunitachi, S., et al.: Brain Res., 1279, 189 (2009)<br></p>

<p>Applications 3-(Bromomethyl)benzoic Acid is a compound useful in organic synthesis and other pharmacological processes.<br>References Mahajan, P., et al.: Phosphorus Sulfur Silicon Relat. Elem., 190, 1803 (2015); Wilson, J. E., et al.: ACS Med. Chem. Lett., 7, 261 (2016)<br></p>

<p>Applications 2-Aminobenzylcyanide, Hydrochloride (cas# 40943-70-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,4,5-Trichlorophenoxyacetic Acid Isobutyl Ester is a component in herbicide formulation used in the protection of crops.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Noble, A. et al.: Pest. Sci., 28, 203 (1990);<br></p>

<p>Applications 2-Chloroisonicotinic Acid is a derivative of Isonicotinic Acid (I821760) and is used as a reagent in the synthesis of (phenylmorpholinyl)pyrimidinones as selective and orally active glycogen synthase kinase-3β inhibitors.<br>References Fukunaga, K., et al.: Bioorg. Med. Chem. Lett., 23, 6933 (2013)<br></p>

<p>Impurity Mefenamic Acid EP Impurity C<br>Applications 4-Bromo-2-chlorobenzoic Acid (cas# 59748-90-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 3,5-Difluoroisonicotinonitrile (cas# 1214377-09-9) is a useful research chemical.<br></p>

<p>Applications 4-Fluoro-2-formylphenylboronic acid<br></p>

<p>Applications 4-{[(p-Fluorophenyl)imino]methyl}phenol is used in the preparation of benzylacetones which promote anti-fungal activity.<br>References Sandhar, R. et al.: J. Ind. Council Chem., 22, 32 (2005);<br></p>

<p>Applications (R)-(+)-2-Chloropropionic Acid (cas# 7474-05-7) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 3-Chloro-5-Hydroxy-2-pentanone is used to prepare thiothiamine.<br>References Li, L. et al.: Faming Zhuanli Shenqing (2014), CN 104140420 A<br></p>

<p>Applications A phenylhydrazone derivative with fungicidal activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 5-Bromo-2-ethoxy-benzenesulfonyl chloride<br></p>

<p>Applications (S)​-2-​Aminohexanedioic Acid 6-​Methyl Ester Hydrochloride is used to prepare amino acid containing thiophene derivatives as agonists for enhancing binding of integrin-expressing cells to integrin receptors.<br>References Biediger, R., et al.: PCT Int. Appl., WO 2012068251 A2 20120524 (2012)<br></p>

<p>Applications 4-Hydroxy-L-homoserine is a derivative of L-Homoserine (H615010), an intermediate in the biosynthesis of essential amino acids.<br>References Tudor, D.W., et al.: Synthesis., 11, 1061 (1993); Roberts, S.J., et al.: Bioorg. Med. Chem. Lett., 13, 265 (2003);<br></p>

<p>Stability Unstable in Aqueous Solution<br>Applications 4-Bromomethylphenylboronic acid<br></p>

<p>Applications α-Ethyl-benzeneacetyl Chloride is used in the synthesis of mild and neutral system for selective reduction of organic functional groups. Also used in the preparation of phenothiazine derivatives for the reversible inhibition of human butyrylcholinesterase.<br>References Sarmah, B. et al.: Tetrahedron, 47, 8587 (1991); Darvesh, S. et al.: Bioorg. Med. Chem., 15, 6367 (2007);<br></p>

<p>Applications 4,5-Dichloroveratrole (cas# 2772-46-5) is a useful research chemical.<br></p>

<p>Applications 3-Aminophthalic Acid Hydrochloride Dihydrate (cas# 1852533-96-0) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications 3-Bromo-1-(trimethylsilyl)-1-propyne is a reactant used in the preparation of a novel lipid mediator with anti-inflammatory activity. Also used in the preparation of (+)-Rubriflordilactone A, a natural nortriterpenoid.<br>References Goto, T. et al.: Tetrahedron., 71, 8320 (2015); Goh, S. et al.: Angew. Chem. Int. Ed., 54, 12618 (2015);<br></p>

<p>Stability Moisture Sensitive<br>Applications Oxalyl Bromide, is an acid halide that can be used in organic synthesis and in preparation of Carbon-substituted iminium salts. It is also used as a reactant for synthesis of aromatic and hydroaromatic angucyclinone via the Diels-Alder reaction, and in cyclization to produce CRF1 receptor antagonists.<br> E0<br>References Nelson, S. G. Science of Synthesis, Volume20a, ages15-52,Journal; General Review 2006; Joerg M.:Department of Organic ChemistryUniversity of Paderborn, Warburger Str. 100, Paderborn, Germany.<br></p>

<p>Applications 1,5-Difluoro-2,4-dinitrobenzene acts as an oleanolic acid NO-releasing derivative used towards the treatment of colon cancer. Also used in the synthesis of beta blockers used as bronchodialators.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fu, J. et al.: RSC. Adv., 5,19445 (2015); Bhushan, R. et al.: Anal. Lett., 47, 202 (2014);<br></p>

<p>Applications 3-Oxo-N-(4-trifluoromethylphenyl)butyramide (cas# 351-87-1) is a useful research chemical.<br></p>

<p>Applications (1R)-4-Bromo-2,3-dihydro-1H-inden-1-amine is used to prepare sphingosine 1 phosphate receptor modulators useful in treatment of S1P1-associated diseases.<br>References Boehm, M., et al.: PCT Int. Appl., WO 2012158550 A2 20121122 (2012)<br></p>

<p>Applications 2-Acetoxyisobutyryl Bromide is used as a reagent in the preparation of didehydro-dideoxyinosine phosphoramidate produgs which have anticancer activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Borek, W., et al.: Nucleos. Nucleot. Nucl., 33, 507 (2014)<br></p>

<p>Applications 4-(Dimethylamino)benzoyl chloride (cas# 4755-50-4) is a useful research chemical.<br></p>

<p>Applications 1,5-Diiodo-3-oxopentane (cas# 34270-90-1) is a compound useful in organic synthesis.<br></p>