Haluros orgánicos

<p>Applications 3,5-Diiodothyropropionic acid is an ionotropic analog of L-thyroxine.<br></p>

<p>Applications 5-chloro-2,1,3-benzoxadiazol-4-amine (cas# 80277-04-9) is a useful research chemical.<br></p>

<p>Applications Tetrachlorothiophene is chlorinated derivative of Thiophene (T368080), which is used as a building block of various organic molecules and pharmaceuticals providing functional properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Prasad, B. et al.: Chem. Comm., 48, 10434 (2012); Freitas, V. et al.: Struct. Chem., 24, 661 (2013);<br></p>

<p>Applications N-Trifluoroacetyl-N’-thioformamidohydrazine (cas# 51321-51-8) is a compound useful in organic synthesis.<br></p>

<p>Applications N-​Methylaniline Trifluoroacetate is regent used in organic synthesis, functioning as an α-methylating agent for ketones and activates internucleodecoupling upon removal.<br>References Nikolaev, V. et al.: E-Eros. Encyc. Reag. Org. Synth, 1, (2001); Wallace, D. et al.: Tetrahedron Lett., 54, 4425 (2013);<br></p>

<p>Applications 4-Chlorobutyronitrile (cas# 628-20-6) is a compound useful in organic synthesis.<br></p>

<p>Applications tert-Butyl 2,2,2-trichloroacetimidate is used in the conversion of alcohols and carboxylic acids to their respective ethers and esters.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wessel, H., et al.: J. Chem. Soc., Perkin Trans. 1, 2251 (1985); Armstrong, A., et al.: Tetrahedron Lett., 29, 2483 (1988)<br></p>

<p>Applications 2-Chloro-4'-nitrobenzanilide (cas# 55501-45-6) is a compound useful in organic synthesis.<br></p>

<p>Applications (R)-2,3-Dihydro-N-(phenylmethyl)-1H-Inden-1-amine Hydrochloride, can be used n the synthesis of racemic and optically active 1-aminoindans.<br>References Lidor, R. et al.: Org. Prep. Proc. Int. Vol. 29, Issue 6,P: 701-706 (1997)<br></p>

<p>Applications 2,6-Dimethyl-4-iodoaniline (cas# 138385-59-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Amino-2-chlorobenzeneacetic Acid can be used as reactant/reagent in starting material in preparation of phenylacetamides as protein kinase inhibitors useful in treatment of various proliferative diseases.<br>References Bold, G., et al.: PCT Int. Appl., WO 2006108640 A1 20061019 (2006);<br></p>

<p>Applications 2-Bromo-1-(2-hydroxy-5-(2-hydroxyethyl)phenyl)ethanone is an intermediate in the synthesis of 3-Hydroxy Darifenacin (Mixture of Diastereomers) (H825190), the hydroxylated metabolite of Darifenacin (D193400).<br>References Soudijn, W., et al.: Eur. J. Pharmacol., 1, 47 (1967), John, B., et al.: Xenobiotica, 22, 1339 (1992), Franz, P., et al.: Drug Metab. Dispos., 21, 249 (1993),<br></p>

<p>Applications 5-Cyano-1H-indole-3-butanoyl Chloride is a derivative of Vilazodone (V265000). Vilazodone (V265000) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist which is under clinical evaluation for the treatment of major depression. Antidepressant.<br>References Bartoszyk, G., et al.: Eur. J. Pharmacol., 322, 147 (1997);Heinrich, T., et al.: J. Med. Chem., 47, 4684 (2004);<br></p>

<p>Applications (5-Carboxypentyl)triphenylphosphonium Bromide (cas# 50889-29-7) is a compound useful in organic synthesis.<br></p>

<p>Applications Methyl trans-4-Bromo-2-butenoate is used as a reagent in the synthesis of several organic compounds including that of dimethoxy ketals and ketones via electrochemical oxidative decarboxylation of malonic acids.<br>References Ma, X., et al.: Org. Lett., 17, 4690 (2015);<br></p>

<p>Applications 2-Fluoro-5-iodobenzonitrile is a compound commonly used in synthetic chemistry and is also used as a reagent to synthesize 1-alkyl-1H-indazoles. 2-Fluoro-5-iodobenzonitrile reacts with sodium sulfide to produce mercaptobenzonitriles.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liu, H., et al.: Tetrahedron, 19, 3907 (2013); Taldone, T., et al.: Tetrahedron Lett., 53, 2548 (2012)<br></p>

<p>Applications 2-amino-4-fluoro-5-nitrobenzoic acid (cas# 1194097-41-0) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 5-Bromo-1-pentyne (cas# 28077-72-7) is a useful reagent for the synthesis of spirocyclic compounds.<br>References Cala, L., et al.: Org. Lett., 22, 3846 (2020)<br></p>

<p>Applications 2,2-BIS(3-AMINO-4-HYDROXYPHENYL)HEXAFLUOROPROPANE (cas# 83558-87-6) is a useful research chemical.<br></p>

<p>Applications 1-Iodopropane is used in the synthesis of a new class of cesium selective ionophores. Also used to preparation of secondary amines and diamines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Casnati, A. et al.: J. Am. Chem. Soc., 117, 2767 (1995); Fukuyama, T. et al.: Tetrahedron Lett., 38, 5831 (1997);<br></p>

<p>Applications Terephthaloyl chloride is used as a cross-linking agent to create polymers from various types of monomers.<br> E0<br>References Edwards-Lévy, F., et al.: Int. J. Pharm., 103, 253 (1994); Lee, J., et al.: Biomacromolecules, 7, 1729 (2006); So, Y.: J. Polym. Sci. Pol. Chem., Turska, E., et al.: J. Appl. Polym. Sci., 20, 1849 (1976)<br></p>

<p>Applications 8-chloro-2,3-dihydro-1,4-benzodioxine-5-carboxylic Acid (cas# 66411-24-3) is a useful research chemical.<br></p>

<p>Applications 3-Fluoro-5-trifluoromethylbenzonitrile is a reagent used in the synthesis of cholesteryl ester transfer protein (CETP) inhibitors in the treatment of high cholesterol. Also used in the preparation of substituted pyrimidines with dithioacetals for antimicrobial activity.<br>References Qiao, J. et al.: J. Med. Chem., 58, 9010 (2015); Gami, S. et al.: J. Hetero. Chem., 52, 751 (2015);<br></p>

<p>Applications 3-Bromotetrahydrofuran<br></p>

<p>Applications 4-Fluorobenzamide<br></p>

<p>Applications 2,5-Bis(Trifluoromethyl)Nitrobenzene (cas# 320-88-7) is a useful research chemical.<br></p>

<p>Stability Unstable in solution. Small amounts of precipitate should have no effect on use.<br>Applications 1-Chloro-N,N-2-trimethylpropenylamine acts as a reagent in the synthesis and antitumor activity of (-)-bassianolide in human cancer cells through cell cycle arrest. Enantioselective total synthesis of nannocystins A and A0 as elongation factor 1 inhibitors. Total synthesis of (-)-caprazamycin A with antibacterial activity against Mycobacterium tuberculosis (TB) via diastereoselective aldol reaction.<br>References Mun, B., et al.: Bioorg. Chem., 69, 64 (2016); Huang, J., et al.: Org. Lett., 18, 4702 (2016); Nakamura, H., et al.: Angew. Chem., Int. Ed., 54, 3136 (2015)<br></p>

<p>Applications 3-Phenylpropionyl Chloride is a derivative of phenylpropionic acid used in the preparation of a wide range of pharmaceutical compounds such as antivirals and antitumor agents.<br>References Ermolova, G.I. et al.: Khim.-Farm. Zh., 24, 35 (1990); Bernier, J.L. et al.: J. Med. Chem., 28, 497 (1985); Jung, J.-C. et al.: Bioorg. Med. Chem. Lett., 14, 5527 (2004);<br></p>

<p>Applications 9,9-Dihexylfluorene (cas# 123863-97-8) is a useful research chemical.<br></p>

<p>Applications 3-(Chloromethyl)-2,4,6-trimethylbenzoic Acid (cas# 52411-49-1) is a useful research chemical.<br></p>

<p>Applications 3-chloro-N-(3-hydroxyphenyl)propanamide (cas# 50297-40-0) is a useful research chemical.<br></p>

<p>Applications 4-(4-Bromo-3-formylphenoxy)benzonitrile (cas# 906673-54-9) is a useful research chemical.<br></p>

<p>Stability Light Sensitive<br>Applications Ethyl 2,3-dibromo-3-phenylpropionate<br></p>

<p>Applications 3-Acetylbenzoyl Chloride is used in the synthesis of aminimdes as potential CNS acting agents. Also, it is an intermediate used in the synthesis of 3-[(Dimethylamino)carbonyl]phenol (D461635), which can be used in the synthesis of novel purine and bicyclic pyrimidine, which are factor Xa inhibitors, and also have high selectivity over thrombin and trypsin.<br>References Capuano, B., et al.: Aust. J. Chem., 60, 673-684 (2007); Buckman B. O., et al.: Bio. Med. Chem. Let., 8, 2235 (1998)<br></p>

<p>Applications 4-Bromophthalonitrile is formed from the oxidative ammonolysis of 4-bromo-o-xylene.<br>References Bagirzade, G. A., Russ. J. Gen. Chem., 84, 1085-1090 (2014)<br></p>

<p>Applications 4-Amino-2,6-dichlorophenol (cas# 5930-28-9) is a useful research chemical.<br></p>

<p>Applications 2,5-Dibromothiophene (cas# 3141-27-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Chloro-1-butanol is a reagent used in the preparation of pharmaceutical compounds such as canthine analogues for their activity against HeLa cervical cells. Also used in the preparation of novel and highly potent Bryostatin, another anti-cancer agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Naik, P. et al.: Tetrahedron, 69, 6545 (2013); Wender, P. et al.: J. Am. Chem. Soc., 124,13648 (2002);<br></p>

<p>Applications 4-Bromo-2,6-difluorobenzonitrile<br></p>

<p>Stability Light Sensitive<br>Applications 4-Chlorophenylacetylene (cas# 873-73-4) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications N-(p-Fluorophenyl)-hydroxylamine, is a reactant used in various chemical synthesis, such as in preparation of spiro-isoxazoline and spiro-isoxazolidine derivatives of tomentosin.<br>References Zaki, M., et al.: RSC Advances, Vol. 7, Iss 11, P: 6523-6529 (2017);<br></p>

<p>Stability Hygroscopic<br>Applications Cyclobutylmethylamine Hydrochloride<br></p>

<p>Applications 5-Chlorohexanoic acid CAS#: 112176-22-4 is a building block used in organic synthesis.<br>References Liang, S., et al., Green Chemistry., 20, 680 (2018)<br></p>

<p>Applications CHLOROMETHYL ISOBUTYRATE (cas# 61644-18-6) is a useful research chemical.<br></p>

<p>Applications (Chloromethyl)cyclohexane is a common chemical reagent used in the synthesis of imidazole inhibitors of cytokine release which suppresses the response to tumor necrosis factor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Laufer, S. et al., J. Med. Chem., 45, 1695 (2002); Rabinowitz, M. et al.: J. Med. Chem., 44, 4252 (2001);<br></p>

<p>Applications (3-Bromopropyl)triphenylphosphonium Bromide is used in rearrangement reactions of cyclic organic molecules and in organic synthesis.<br>References Kippo, T. et al.: J. Am. Chem. Soc., 135, 632 (2013); Shi, M. et al.: J. Am. Chem. Soc., 128, 7430 (2006);<br></p>

<p>Applications 2-Bromoethylcyclopropane is used as a reagent to synthesize 22-Hydroxycholesterol (H918010) derivatives, compounds that act as serum cholesterol lowering agents. 2-Bromoethylcyclopropane is also used to prepare pyridazinones, compounds that act as cyclooxygenase 2-inhibitors (they possess anti-inflammatory and antiangiogenic effects).<br>References Chorvat, R., et al.: J. Med. Chem., 28, 194 (1985); Masferrer, J., et al.: Ann. New York Acad. Sci., 889, 84 (1999); Willoughby, D., et al.: Lancet, 355, 646 (2000)<br></p>

<p>Applications 4-Fluoro-a-oxo-benzenepropanoic acid (cas# 7761-30-0) is a useful research chemical.<br></p>

<p>Applications 5-Bromo-2-fluorobenzonitrile<br></p>

<p>Applications 4-Bromobiphenyl is used as a reagent in the synthesis of spirooxindole derivatives for use as AMPK activators. 4-Bromobiphenyl is also used as a reagent in the preparation of indenoindole derivatives as organic electroluminescent device materials.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Madanahalli Ranganath Rao, J., et al.: PCT Int. Appl. WO 2014202580 A1 20141224. Dec 24, 2014; Nagaoka, M., et al.: PCT Int. Appl. WO 2014196556 A1 20141211. Dec 11, 2014<br></p>

<p>Applications 1-(3-Chloropropoxy)-4-fluorobenzene was used as a reagent in the preparation of a library of hydantoin compds which has used to study Aurora kinase A inhibitory activity. It was also used as an alkylation agent in the preparation of tetracyclic quinoxaline butyrophenones as 5-HT2A and postsynaptic D2 antagonists and inhibitors of serotonin transporter for treatment of neuropsychiatric and neurological disorders.<br>References Li, Peng, et al.: J Med. Chem., 57(6), 2670-2682, 2014Bogolubsky, Andrey V., et al.: ACS Comb. Sci., 20(1), 35-43, 2018<br></p>

<p>Applications Nonadecanoyl Chloride is a useful synthetic intermediate. It is used to prepare 5-acyl-2-hydroxymethylpyrroles with P388 cytotoxicities. It is also used to synthesize 3-hydroxy-2-octadecylindole.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nabbs, B., et al.: Bioorg. Med. Chem. Lett., 9, 505 (1999); Clawson, R., et al.: Tetrahedron, 65, 8786 (2009)<br></p>

<p>Applications 3-Fluorobenzoic Acid (cas# 455-38-9) is a compound useful in organic synthesis.<br></p>

<p>Applications Bromo-tert-butyl Alcohol, is an organic building block that can be used in the variety of chemical synthesis. It is used in the synthesis of Monohalogeno-t-butyloxycarbonylamino Acids.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Takanobu, O. et al.: Bull. Chem.Sco. Jap., 45, 2603 (1972);<br></p>

<p>Stability Air Sensitive, Moisture Sensitive<br>Applications 3-Hexyl Chloroformate is a potential impurity in the synthesis of Dabigatran Etexilate Mesylate (D100150); a nonpeptide and direct thrombin inhibitor. Antithrombotic.<br>References Zheng, Y., et al.: Org. Process Res. Dev., 18, 744 (2014); Hauel, N., et al.: J. Med. Chem., 45, 1757 (2002); Mungall, D., et al.: Curr. Opin. Invest. Drugs, 3, 095 (2002); Stangier, J., et al.: J. Clin. Pharmacol., 45, 555 (2005)<br></p>

<p>Applications 1-Bromo-2-(2-propen-1-yloxy)-benzene is used as a reagent to produce high yield (97%) 3-methyl-2,3-dihydrobenzofurans through reductive radical cyclization reactions.<br>References Yoshimi, Y., et al.: Tetrahedron Lett., 54, 2419 (2013); Vaillard, S., et al.: J. Org. Chem., 69, 2037 (2004)<br></p>

<p>Applications 1-(5-Bromo-2-pyridyl)ethanone is a reagent used to synthesize substituted pyridin-3-yl)phenyloxazolidinones as antibacterial agents with reduced activity against monoamine oxidase A.<br>References Reck, F., et al.: J. Med. Chem., 50, 4868 (2007)<br></p>

<p>Applications 2-Iodo-m-xylene is used in the preparation of p-(arylethynyl)arylpropanoic acid derivatives as free fatty acid receptor 1 agonists with low lipophilicity and high oral bioavailability.<br>References Christiansen, E., et al.; J. Med. Chem., 56, 982 (2013);<br></p>

<p>Applications 3,6-Dibromo-9H-carbazole is used as a reagent in the synthesis of P7C3-A20 which is a potent neuroprotective agent.<br>References Naidoo, J., et al.: Tetrahedron Lett., 54, 4429 (2013)<br></p>

<p>Applications 2-Deoxy-2-fluoro-D-mannopyranose Tetraacetate is an intermediate in the synthesis of 2-Deoxy-2-fluoro-D-mannose (D235150). 2-Deoxy-2-fluoro-D-mannopyranose Tetraacetate is used in the synthesis of 2-deoxy-2-fluoroglycoside phosphodiesters as tunable aglycons for fluoro sugar inactivators of β-glycosidases.<br>References Rempel, B. P. &amp; Withers, S. G., Org. &amp; Bio. Chem., 12(16), 2592-2595 (2014)<br></p>

<p>Applications methyl 5-(chloromethyl)-2-furoate (cas# 2144-37-8) is a useful research chemical.<br></p>

<p>Applications 1,5-Dibromopentane is used as an alkylating agent in organic synthesis. 1,5-Dibromopentane is also used as a reagent to synthesize benzo[b]xanthone derivatives, compounds that have potential anticancer activity.<br>References Luo, L., et al.: J. Serb. Chem. Soc., 78, 1301 (2013); Royer, G. &amp; Klotz, I.: J. Am. Chem. Soc., 91, 5885 (1969)<br></p>

<p>Stability Moisture Sensitive<br>Applications Dimorpholinophosphinyl Chloride is an condensing reagent in the synthesis of Dexamethasone Phosphate (D298835), a pro-drug of Dexamethasone (D298800), an anti-inflammatory glucocorticoid.<br>References Stefancich, G., et al.: J. Heterocycle. Chem., 30, 529 (1993);<br></p>

<p>Applications Fluorosulfonyl Isocyanate is an intermediate used in the synthesis of 5-Chloro Acesulfame (C363250), which is an impurity of Acesulfame (A132500), the artificial sweetener, and a new sweet-tasting oxathiazinone dioxides. Acesulfame Potassium Impurity B<br>References Clauss, K., et al.: Liebigs Annalen der Chemie,4, 494 (1980); Armenta, S., et al.: J. Agric. Food Chem., 52, 7798 (2004);<br></p>

<p>Applications Ammonium Bromide is used as a bromide activated chloramine biocide for effective control of volatile fatty acids and catalase and biofilm elimination in paper making industry. Also applied in biopharmaceuticals and dosage form designs.<br>References Bharati, S., et al.: Appita J., 56, 426 92003); Torosian, G., et al.: Am. J. Hosp. Pharm., 30, 716 (1973)<br></p>

<p>Applications (R)-2-Chloro-β-hydroxybenzenepropanoic Acid is<br></p>

<p>Applications 3-Fluoro-4-(trifluoromethoxy)phenylboronic acid<br></p>

<p>Applications p-Phthalamidine Dihydrochloride is a reactant that has been used in the preparation of (phenylene)bis[pyrimidine], benzenedicarboximidamide and benzenetricarboximidamide.<br>References Felix, O., et. al.: New J. Chem., 21, 285 (1997)<br></p>

<p>Applications 1,5-Benzodiazepine Hydrochloride can be used in silver halide emulsion sensitized with a fused diazepine. Its free base form 1,5-Benzodiazepine (CAS 265-02-1) can be used in biological study of interaction of 1,4 and 1,5-benzodiazepines with GABAA receptors of rat cerebellum granule cells in culture.<br>References Nikas, P., et al.: J Mol Neurosci, 56, 768 (2013); Schwalenstocker, H.: U.S., US 4036649 A 19970719 (1997)<br></p>

<p>Stability Moisture Sensitive<br>Applications Methyl (chlorosulfonyl)acetate<br></p>