Haluros orgánicos

<p>Applications (3-Phenoxyphenyl)methyl Ester 3-[(1Z)-2-chloro-3,3,3-trifluoro-1-propen-1-yl]-2,2-dimethyl-cyclopropanecarboxylic Acid is used in the preparation of agricultural chemicals.<br>References Thompson, W,. et al.: PCT Int. Appl., 2013<br></p>

<p>Applications 1-Iodo-3-nitrobenzene is a reactant used int he synthesis of Vismodegib (V674700), an, antineoplastic drug that targets the Hedgehog (Hh) pathway. Inhibition of the Hh signaling may be effective in the treatment and prevention of many types of human cancers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cao, M., et. al.: Chem. Papers, 68, 1408 (2014); Gupta, S. et al.: Ther. Advances in Med. Oncology 2,237(2010)<br></p>

<p>Applications 6-Chloro-7-deazaguanine (cas# 84955-31-7) is a compound useful in organic synthesis.<br></p>

<p>Stability Moisture Sensitive<br>Applications 2-Chloroethylphosphoryl Dichloride (cas# 1455-05-6) is a useful research chemical.<br></p>

<p>Applications 1,2-Difluorobenzene is used in electrochemical analysis of transition metal complexes. 1,2-difluorobenzene is also a potent inhibitor of NMDA receptor.<br>References O'toole, T.R. et al.: Inorg. Chem., 28, 3923 (1989); Eger, E.I. et al.: Anesth. Analg., 102, 1397 (2006);<br></p>

<p>Applications 3-Bromo-2,6-dihydroxybenzoic Acid (cas# 26792-49-4) is a compound useful in organic synthesis.<br>References Norman, M., et al.: J. Med. Chem., 39, 1172 (1996),<br></p>

<p>Applications 2-Fluoro-4-hydroxyphenylboronic acid<br></p>

<p>Applications 4-Borono-2-(trifluoromethyl)benzoic acid<br></p>

<p>Applications 2-Chloroethyl Ethyl Sulfide is used as a reagent in the synthesis of furfuryl xanthines as adenosine receptor antagonists. It is also used as a reagent in the synthesis of methoxypropyl xanthines as putative A2B receptor antagonists.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Balo, M.C., et al.: Bioorg. Med. Chem., 17, 6755 (2009); Nieto, M.I., et al.: Bioorg. Med. Chem., 17, 3426 (2009)<br></p>

<p>Applications 1,2-Dichloro-4-nitrobenzene is an intermediate in the synthesis of agrochemicals. Studies have been conducted to use 1,2-Dichloro-4-nitrobenzene as an organic intermediate for the synthetic preparation of ciprofloxacin (C482500).<br>References Lu, C.S., et al.: Adv. Mater. Res., 396, 2379 (2012); Suzuki, H., et al.: Synthesis., 841 (1994); Wang, P.C., et al.: Cataly. Commun., 14, 42 (2011);<br></p>

<p>Applications 2-(2,2,2-Trifluoroethoxy)phenol is a reactant used for the preparation of phenyl acetate compounds with short sedative and hypnotic effect.<br></p>

<p>Applications N-Fluorobenzenesulfonimide is a mild electrophilic fluorinating reagent<br></p>

<p>Applications 2-(Diethylamino)ethyl 3-Nitro-4-propoxybenzoate Hydrochloride is a useful intermediate used in the preparation of proxymetacaine.<br>References Monguzzi, R., et al.: Eur. J. Med. Chem., 9, 214 (1974)<br></p>

<p>Applications 9-chloro-1,2,3,4-tetrahydroacridine (cas# 5396-30-5) is a useful research chemical.<br></p>

<p>Stability Hygroscopic, Water Sensitive<br>Applications A useful synthetic intermediate.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-Nitro-5-(trifluoromethyl)aniline is a reagent in the synthesis of benzo[d]imidazole derivatives which has vasorelaxant activity and antihypertensive effects.<br>References Navarrete-Vazquez, G., et al.: Bioorg. Med. Chem., 18, 3985 (2010);<br></p>

<p>Applications 4,5-Dichlorothiophene-2-carboxylic Acid is used in the preparation of compounds that have therapeutic BACE1 and BACE2 inhibitors which are used for the treatment of Alzheimer’s disease, type 2 diabetes and other metabolic disorders.<br>References Banner, D., et al.: PCT Int. Appl., 2011:1438553 (2013)<br></p>

<p>Applications 2,2,2-Trifluoroethyl Formate acts as a reagent for the preparation of HCV NS5B inhibitor MK-3281, an inhibitor of hepatitis C virus.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Colarusso, S., et al.: Synlett, 11, 1527 (2011)<br></p>

<p>Applications α,α,α-Trifluorotoluene, is used as a specialty solvent in organic synthesis and an intermediate in the production of pesticides and pharmaceuticals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Skelly, P. D., et al.: Handbook for Critical Cleaning, 1, 191 (2011);<br></p>

<p>Applications Methyl 4-(Chloroformyl)butyrate is used in the synthesis of Leukotriene B4, a proinflammatory agent produced from leukocytes.<br>References Crooks, S. et al.: Int. J. Biochem. Cell. Biol., 30, 173 (1998); Wenkert, E. et al.: J. Org. Chem., 55, 6203 (1990);<br></p>

<p>Applications 1-Bromo-4-chlorobutane is used as a reagent in the synthesis of a novel spirohydantoin derivative as a potent multireceptor-active antipsychotic and antidepressant agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Czopek, A., et al.: Bioorg. Med. Chem., 23, 3436 (2015)<br></p>

<p>Applications (Z)-Ethyl 4-(2-(tert-butoxy)-2-oxoethoxy)-2-(2-chlorobenzylidene)-3-oxobutanoate is an intermediate for the synthesis of O-Des[2-aminoethyl]-O-carboxymethyl dehydroamlodipine (D289480), which is the metablolite of Amlodipine (A633495), a long-acting calcium channel blocker that is commonly used as an anti-hypertensive in the treatment of cardiovascular conditions.<br>References Arrowsmith, J.E., et al.: J. Med. Chem., 29, 1696 (1986), Burges, R.A., et al.: J. Cardiovasc. Pharmacol., 9, 110 (1987), Haria, M., et al.: Drugs, 50, 560 (1995)<br></p>

<p>Stability Hygroscopic<br>Applications 5-Chloro-2-Thiophenecarbonyl Chloride is a reagent in the synthesis of indolinyl-thiazole based inhibitors of cellular lipid uptake. Also used in the preparation of anticoagulants and such related promising drug candidates.<br>References Dockendorff, C. et al.: ACS Med. Chem. Lett.., 6, 375 (2015);<br></p>

<p>Applications Isobutyryl chloride is a useful intermediate commonly used in synthetic chemistry. Isobutyryl chloride is also a potential inducer of pulmonary adenomas in strain A mice.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Theiss, J., et al.: Cancer Res., 39, 391 (1979)<br></p>

<p>Applications o-Tolylhydrazine Hydrochloride is a reagent used in the organic syntheses such as opioid receptor antagonists as well as adenosine receptor antagonists as well as adenosine receptor antagonists.<br>References Colotta, V. et al.: J. Med. Chem., 43, 3118 (2000); Portoghese, P. et al.: J. Med. Chem., 33, 1714 (1990);<br></p>

<p>Impurity Anastrozole 1,3-Dibromomethyl Impurity<br>Applications 1,​3-​Bis(bromomethyl)​-​5-​methylbenzene is a reagent used in the synthesis of sphingosine kinase 2 inhibitors. Anastrozole 1,3-Dibromomethyl Impurity<br>References Congdon, M. et al.: Bioorg. Med. Chem. Lett., 25, 4956 (2015);<br></p>

<p>Applications Used for production of peptide thioester. This compound often contains some of the analogous alkyl bromide.<br></p>

<p>Applications 2-Chloro-4,6-dimethoxyaniline Hydrochloride (cas# 82485-84-5) is a compound useful in organic synthesis.<br></p>

<p>Stability Moisture Sensitive<br>Applications N-Phenylbis(trifluoromethanesulfonamide) is used in the enantioselective synthesis of β-amino acids via the Mannich reaction. Used in the synthesis of sphingosine 1-phosphate-1 receptor agonists useful in pharmaceutical application.<br>References Asano, M. et al.: Tetra. Asymm., 24, 449 (2013);<br></p>

<p>Applications A 3-aryl substituted Azetidine (A813000).<br></p>

<p>Applications 2-Chloro-1-(2-((3-chloropropyl)amino)-2-oxido-1,3,2-oxazaphosphinan-3-yl)ethanone is an intermediate used in the synthesis of Ifosfamide Impurity A (I265005), which is an impurity of Ifosfamide (I265000), a cytostatic agent related structurally to cyclophosphamide.<br>References Creaven, P. J., et al.: Cancer Treat. Rep., 60, 445(1976), Schoenike, S. E., Clin. Pharm., 9, 179(1990), Skinner, R., et al.: J. Clin. Oncol., 11, 173 (1993).<br></p>

<p>Applications Bis(Dichloromethyl) Ether an important reagent used in chemical research.<br>References Hsu, F. L., et al.: ACS Med. Chem. Lett., 10, 761-766 (2019)<br></p>

<p>Applications 3,3,3-trifluoro-2-oxopropanoic acid (cas# 431-72-1) is a useful reagent in the biotransformation of pentafluoropropane in rat and humans.<br>References Bayer, T., et al.: Chem. Res. Toxicol., 15, 723 (2002)<br></p>

<p>Applications A metabolite of halogenated aniline.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cnubben, N.H.P., et al.: Biochem. Pharmacol., 49, 1235 (1995),<br></p>

<p>Applications Oxydiethylene Bis(chloroformate) is a useful research intermediate for organic synthesis.<br>References Qian, W., et al.: Zhejiang Yike Daxue Xuebao, 25, 252 (1996); Alekseev, N. N., et al.: Kinetika i Kataliz, 29, 471 (1988); Alekseev, N. N., et al.: Plast. Massy, 5, 52 (1984)<br></p>

<p>Applications p-Trifluoroacetyltoluene is used as a reagent in the synthesis of 5-methylene-2-(trifluoromethyl)morpholin-3-one derivatives which have fungicidal activity.<br>References Tian, L., et al.: RSC Adv., 5, 100418 (2015)<br></p>

<p>Applications 6-Chloro-2,1,3-benzoselenadiazole (cas# 6343-86-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Bromo-N-(3-chloropropyl)benzenesulfonamide<br></p>

<p>Applications Trimethylsilylethynyl(phenyl)iodonium Tetrafluoroborate is used in synthesis of 1-Alkynyl(triphenyl)arsonium Tetrafluoroborates by onium transfer reaction of 1-Alkynyl(phenyl)iodonium Tetrafluoroborates with Triphenylarsine. Also, used in preparation of Furan- and Thiophene-substituted alkynes and alkynyl ketones by Copper Iodide-catalyzed coupling and carbonylation of Heterocyclic Boronic Acids with Alkynyliodonium salts.<br>References Nagaoka, T., et al.: Tetrah. Lett., 36, 261-4 (1995); Yu, Chan-Mo, et al.: Synlett, 2631-2634 (2005);<br></p>

<p>Applications 2-AMINOETHANOL HYDROCHLORIDE (cas# 2002-24-6) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications 1-Chloroethyl ethyl carbonate (cas# 50893-36-2) is a useful research chemical.<br></p>

<p>Applications Tetrachlorocyclopropene is a useful compound in organic synthesis.<br>References Belding, Lee, et al.: J. of Org. Chem., 83(12), 6489-6497 (2018); Sanchez Garcia, Jessica J., et al.: Pure and App. Chem., 88(12), 1129-1142; (2016)<br></p>

<p>Applications 2-Amino-1-(4-trifluoromethoxyphenyl)ethanone Hydrochloride is a reagent for the preparation of 4-phenylimidazole-2-thiones as tyrosinase inhibitors, their pharmaceutical and cosmetics compositions for the treatment or the prevention of the pigmentary disorders.<br>References Boiteau, J. G., et al.: From Fr. Demande (2008), FR 2917087 A1 20081212<br></p>

<p>Impurity Amiodarone EP Impurity H / Amiodarone USP Related Compound H<br>Stability Moisture Sensitive, Hygroscopic<br>Applications 2-Chloro-N,N-diethylethylamine Hydrochloride (Amiodarone EP Impurity H) is a related compound of Amiodarone, a non-selective ion channel blocker.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bonati, M., et al.: J. Pharm. Sci., 73, 829 (1984), Plomp, T.A., Anal. Profiles Drug Subs., 20, 1 (1991), Chow, M., et al.: Ann. Pharmacother., 30, 637 (1996), Singh, B.N., et al.: Clin. Cardiol., 20, 608 (1997)<br></p>

<p>Applications (2,6-Dichlorophenyl)methanamine was one of the reactants used in making a library of highly selective and potent G protein-coupled receptor kinase 2 inhibitors.<br>References Waldschmidt, Helen V, et al.: J. of Med. Chem., 59(8), 3793-3807 (2016).<br></p>

<p>Applications 3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-propionyl chloride, rech grade<br></p>

<p>Applications (2-((tert-Butyldiphenylsilyl)oxy)-4-fluorophenyl)boronic Acid is an intermediate used in the synthesis of Bicyclo Risperidone (B382800), which is an impurity of Risperidone (R525000); a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.<br>References Jannssen, P.A.J., et al.: J. Pharmacol. Exp. Ther., 244, 685 (1988); Gelders, Y.G., et al.: Pharmacopsychiatry, 23, 206 (1990); Green, B.: Curr. Med. Res. Opin., 16, 57 (2000)<br></p>

<p>Applications Fumaryl Chloride is a reagent used in the synthesis of thermosetting resins which are widely used in industrial fields.<br>References Kudo, K. et al.: J. App. Polym. Sci., 133 (2016);<br></p>

<p>Applications 2-(2-chloroethoxy)benzenesulfonamide (cas# 82097-01-6) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications 4-(Trifluoromethylthio)benzoyl Chloride is a reactant in the preparation of anthranilic acids as selective and dual PPAR/FXR ligands.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Merk, D., et. al.: Bioorg. Med. Chem., 23, 499 (2015)<br></p>

<p>Applications 3-Bromo-5-hydroxybenzyl Alcohol is an intermediate used to prepare (isoxazolylphenyl)arylmethanols as inhibitors of the BET bromodomain family member BRD4(1) for potential use as antitumor agents.<br>References Hewings, D., et al.: J. Med. Chem., 56, 3217 (2013)<br></p>

<p>Applications 2-chloro-5-(dimethylsulfamoyl)benzoic acid (cas# 37088-27-0) is a useful research chemical.<br></p>

<p>Applications 3,5-Difluorobenzoic Acid can be used as reactant/reagent in Rh(III)-catalyzed regioselective heterocyclization of benzoic acids with acrylates to give phthalides with water as the solvent<br>References Zhu, Y., et al.: Eur J Org Chem, 2017, 806 (2017)<br></p>

<p>Applications 3-Chloro-4-fluorophenylacetic Acid is a useful intermediate for organic synthesis.<br>References Baltzly, R., et al.: J. Org. Chem., 26, 2353 (1961); Feng, Q., et al.: Adv. Synth. Catal., 356, 1697 (2014)<br></p>

<p>Applications 7-Chloro-6-sulfamoylisatoic Anhydride is an intermediate in the synthesis of 2-Amino-4-chloro-5-sulfamoyl-o-benzotoluidide (A604420) and in the synthesis of 3-Aryl- and 3-​aralkyl-​1,​2,​3,​4-​tetrahydro-​4-​oxo-​6-​quinazolinesulfonamides.<br>References Shetty, B., et al.: J. Med. Chem., 13, 886 (1970);<br></p>

<p>Applications 3-(Dibenzo[b,e]oxepin-11(6H)-ylidene)-N,N-diethylpropan-1-amine Hydrochloride (E/Z Mixture) is an intermediate in synthesizing N-Diethylnordoxepin Salt (D468115), a compound useful in organic synthesis.<br></p>

<p>Applications 2,4,5-Tribromotoluene (cas# 3278-88-4) is a useful research chemical.<br></p>

<p>Applications 2-(Bromomethyl)-5-(trifluoromethyl)furan is an intermediate used to prepare tertiary sulfonamides as liver X receptor antagonists. It is also used to synthesize hydantoin based inhibitors of MMP13 with potential use in osteoarthritis.<br>References Zuercher, W., et al.: J. Med. Chem., 53, 3412 (2010); De Savi, C., et al.: Bioorg. Med. Chem. Lett., 23, 4705 (2013)<br></p>

<p>Applications (Ethoxycarbonylmethyl)triphenylphosphonium bromide is an intermediate in the synthesis of 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone-13C5, which is an isotope labelled Mutagen X (MX) is a chlorinated furanone that accounts for more of the mutagenic activity of drinking water than any other disinfection byproduct. DNA damages provoked by the six mutagens (furylframide, MX, 4-nitroquinoline N-oxide, sodium azide, 1-nitropyrene, and captan) used in the present study have been known to subject to the nucleotide excision repair system.<br>References Hakulinen, P., et al.: Toxicol. Lett., 151, 439 (2004), Richardson, S., et al.: Mutat. Res., 636, 178 (2007), Kim, J., et al.: Environ. Toxicol., 23, 319 (2008),<br></p>

<p>Applications 3,5-Dichloro-4-Hydroxybenzenesulfonic Acid (cas# 25319-98-6) is a useful research chemical.<br></p>

<p>Applications 4,6-​Dibromo-thieno[3,​4-​c]​[1,​2,​5]​thiadiazole-​2-​SIV is used as a reactant in the preparation of TCNQ analogs composed of heterocyclic rings.<br>References Suzuki, K., et al.: Synth. Met., 102, 1480 (1999)<br></p>

<p>Applications 2-Ethoxy-N,N,N-trimethylethanaminium chloride is being used for the study of antigibberellin activity and the role quaternary ammonium salts play.<br>References Gafurov, R.G., et al.: Doklady Biological Sciences, 394, 66-70 (2004); Gafurov, R.G., et al.: Doklady Biological Sciences, 421 (2004);<br></p>

<p>Applications 2-Chloro-4-fluorobenzoic Acid s a useful synthetic intermediate. It can be used to prepare aryl aminopyrazole benzamides as oral non-steroidal selective glucocorticoid receptor agonists. It can also be used to synthesize (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetamide derivatives as arginine vasopressin V2 receptor agonists.<br>References Barnett, H., et al.: Bioorg. Med. Chem. Lett., 19, 158 (2009); Tsukamoto, I., et al.: Bioog. Med. Chem., 16, 9524 (2008)<br></p>

<p>Applications Bis(2,4,5-tribromophenyl)iodonium Hydrogen Sulfate is an intermediate in the synthesis of 2,2',4,4',5,6'-Hexabromodiphenyl ether (H290745), which is a hepatotoxic polybrominated diphenyl ester (PBDE) that is commonly used as a flame retardant. 2,2',4,4',5,6'-Hexabromodiphenyl ether is also sometimes found in food and meats as well, posing a significant risk to humans (especially during pregnancy) and/or animals that consume it. One of the new POPs under the Stockholm Convention<br>References Johnson, P., et al.: Sci. Total Environ., No vol. given, 445 (2013); Scott, L., et al.: Organo. Comp., 74, 1109 (2012); Zhao, Y., et al.: Env. Sci. Tech., 47, 5939 (2013)<br></p>

<p>Applications 4-(4-Chlorophenyl)-4-hydroxycyclohexanone (cas# 36716-71-9) is a compound useful in organic synthesis.<br></p>

<p>Applications 1,2-Diamino-4,5-dimethoxybenzene Hydrochloride is the salt form of 1,2-Diamino-4,5-dimethoxybenzene (D416425), which reacts with aldehydes to produce highly fluorescent benzimidazole derivatives. It can be used for the detection of aldehydes as well as DTAN.<br>References Iwata, T., et al.: Chem. Pharm. Bull., 33, 3499 (1985); Hara, S., et al.: J. Chromatography, 377, 111 (1986); Masui, H., et al: Inorg. Chem., 32, 258 (1993)<br></p>