Haluros orgánicos

<p>Applications 1,3-Bis(2-hydroxyhexafluoroisopropyl)benzene (cas# 802-93-7) is a useful research chemical.<br></p>

<p>Applications 3-Fluoropyruvic Acid is a useful building block and has been proposed to have a mechanistic effect on the inactivation of mandelate racemase.<br>References Nagar, M.; et al.: Biochemistry, 54, 2747 (2015).<br></p>

<p>Applications 2-Chloro-3-hydroxybenzoic acid (cas# 51786-10-8) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications 2-Chloroethylphosphoryl Dichloride (cas# 1455-05-6) is a useful research chemical.<br></p>

<p>Applications 2-Bromo-6-chlorobenzoic acid is used in the syntheis of Diclofenac Monobromo Sodium Salt Impurity (D436490).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Moser, P., et al.: J. Med. Chem., 33, 2358 (1990),<br></p>

<p>Stability Light Sensitive<br>Applications 1,2,4,5-Tetrabromobenzene is a useful synthetic intermediate. It is used as a building block to prepare various aryl containing compounds such as tetrabenzanthracene, substituted pentacenes [pentacene (P237770)], n-stacking tetracene (N377650) derivatives and so on.<br>References Hilton, C., et al.: J. Am. Chem. Soc., 128, 14824 (2006); Zhao, Y., et al.: J. Org. Chem., 73, 5506 (2008); Chem, Z., et al.: Org. Lett., 8, 273 (2006)<br></p>

<p>Applications 4-Fluoro-2-iodoaniline is a useful reactant for the synthesis of cyclohepta[b]indole scaffold via annulative two-carbon ring-expansion.<br>References Tymann, D. C., et al.: Chem. Eur. J, 26, 11974 (2020)<br></p>

<p>Applications 4-(4-Chlorophenyl)-2-butanone has been used as a reactant in the preparation of diarylheptanoids as tumor necrosis factor-α (TNF-α) inhibitors.<br>References Dhuru, S., et. al.: Bioorg. Med. Chem. Lett., 21, 3784 (2011)<br></p>

<p>Applications 3,4-Dichlorobenzyl bromide<br></p>

<p>Applications 6-Chloro-7-deazaguanine (cas# 84955-31-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,4,5-Tribromotoluene (cas# 3278-88-4) is a useful research chemical.<br></p>

<p>Applications 3-(4-FLUOROPHENYL)CYCLOPENTANONE (cas# 165591-10-6) is a useful research chemical.<br></p>

<p>Applications Ethyl 4-bromoacetoacetate<br></p>

<p>Applications 9-Fluorenone is a polycyclic aromatic ketone that has photosensitizing properties and also has the ability to undergo electrochemical polymerization. 9-Fluorenone is used in industry as an initiator in visible-light cured resin systems. 9-Fluorenone has potentially toxic effects on humans, as exposure can cause DNA mutations.<br>References Cihaner, A., et al.: J. Elec. Chem., 568, 151 (2004); Li, Y., et al.: J. Biomed. Mater. Res. Part B-A, 84, 58 (2008); Okamoto, H., et al.: Org. Lett., 13, 2758 (2011)<br></p>

<p>Applications 2-(Bromomethyl)-5-(trifluoromethyl)furan is an intermediate used to prepare tertiary sulfonamides as liver X receptor antagonists. It is also used to synthesize hydantoin based inhibitors of MMP13 with potential use in osteoarthritis.<br>References Zuercher, W., et al.: J. Med. Chem., 53, 3412 (2010); De Savi, C., et al.: Bioorg. Med. Chem. Lett., 23, 4705 (2013)<br></p>

<p>Applications 1-Iodohexane (cas# 638-45-9) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Acetoxy-3-chloro-2-pentanone (cas# 13051-49-5) is a compound useful in organic synthesis.<br></p>

<p>Applications (Ethoxycarbonylmethyl)triphenylphosphonium bromide is an intermediate in the synthesis of 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone-13C5, which is an isotope labelled Mutagen X (MX) is a chlorinated furanone that accounts for more of the mutagenic activity of drinking water than any other disinfection byproduct. DNA damages provoked by the six mutagens (furylframide, MX, 4-nitroquinoline N-oxide, sodium azide, 1-nitropyrene, and captan) used in the present study have been known to subject to the nucleotide excision repair system.<br>References Hakulinen, P., et al.: Toxicol. Lett., 151, 439 (2004), Richardson, S., et al.: Mutat. Res., 636, 178 (2007), Kim, J., et al.: Environ. Toxicol., 23, 319 (2008),<br></p>

<p>Applications 2-[[[(9H-Fluoren-9-ylmethoxy)Carbonyl]Amino]Methoxy]-Acetic acid is a useful reagent in organic synthesis.<br></p>

<p>Applications Methyl 5-chloropentanoate (cas# 14273-86-0) is a useful research chemical.<br></p>

<p>Applications 1,​1,​1,​2-​Tetrachloroethane is a chlorinated hydrocarbon and used as a solvent for cellulose, acetate, fat, waxes, greases, rubber, and sulfur. It is a contaminant in groundwater. 1,​1,​1,​2-​Tetrachloroethane can also induce heptotoxicity.Environmental contaminants; food contaminants.<br>References Lorah, M. M., and Olsen, L. D. Environ. Sci. Technol. 33, 227 (1999); Zheng, R. D., et al.: J Dig Dis. 13, 321 (2012)<br></p>

<p>Applications 2-Acetamido-4-fluorophenylboronic acid, pinacol ester<br></p>

<p>Applications 2,5-Difluoro-1,4-phenylenediboronic acid, pinacol ester<br></p>

<p>Applications 2,3,4,5-Tetrafluorobenzoic Acid is used in the synthesis of diterpenoid analogs as antitumor compounds. Also used in the synthesis of novel quinoline lactones.<br>References Li, D. et al.: Eur. J. Med. Chem., 64, 215 (2013); Zheng, H. et al.: Lett. Org. Chem., 10, 252 (2013);<br></p>

<p>Stability Light Sensitive<br>Applications Cis-1-Bromo-2-ethoxyethylene<br></p>

<p>Applications 4-Fluoro-1,2-phenylenediamine has shown anticancer activity in human prostate adenocarcinoma cell.<br>References Ahmed, H.A.: Bull. Faculty Pharmacy, 49, 25 (2011)<br></p>

<p>Applications 4-Fluoro-2-formylphenylboronic acid<br></p>

<p>Applications 4-bromo-2-ethyl-1-fluorobenzene (cas# 627463-25-6) is a useful research chemical.<br></p>

<p>Applications 3-Chloro-4-fluorophenylacetic Acid is a useful intermediate for organic synthesis.<br>References Baltzly, R., et al.: J. Org. Chem., 26, 2353 (1961); Feng, Q., et al.: Adv. Synth. Catal., 356, 1697 (2014)<br></p>

<p>Applications 3,5-Dichloro-4-Hydroxybenzenesulfonic Acid (cas# 25319-98-6) is a useful research chemical.<br></p>

<p>Applications 5-Amino-2-bromobenzoic acid (cas# 2840-02-0) is a useful research chemical.<br></p>

<p>Applications methyl 3-chloro-4-hydroxyphenylacetate (cas# 57017-95-5) is a useful research chemical.<br></p>

<p>Applications A cell-permeable, selective and irreversible PPARγ antagonist (IC50 = 3.3 nM, 32 nM, and 2 µM for PPARγ, PPARα, and PPARδ, respectively). Reported to covalently modify a cysteine residue in the binding site of PPAR. At a concentration of 10 µM, also acts as an agonist of human pregnane X receptor (PXR) and farnesoid X receptor (FXR). Does not activate liver X receptor-a (LXRa), retinoic acid receptor (RAR), retinoid X receptor-a (RXRa) and thyroid receptors a and b (TRa and TRb<br>References Huang, J.T., et al.: Nature, 400, 378 (1999), Wilson, T.M., et al.: J. Med. Chem., 43, 527 (2000), Leesnitzer, L.M., et al.: Biochemistry, 41, 6640 (2002)<br></p>

<p>Stability Moisture Sensitive<br>Applications Used in the production of antimicrobial agents.<br>References Selvin, J. et al.: App. Microbio. Biotech., 83, 439 (2009);<br></p>

<p>Applications Chloromethanesulfonyl Chloride is a very useful intermediate for organic synthesis. It enhances citric acid production by Aspergillus niger NCIM-1696 and increases the yield of citric acid. It also functions as a useful intermediate for pharmaceutical synthesis.<br>References Mahato, J., et al.: J. Chemtracks, 16, 245 (2014); Shealy, Y. F., et al.: J. Med. Chem., 26, 1168 (1983); Johnson, J. K., et al.: ACS Med. Chem. Lett., 7, 785 (2016)<br></p>

<p>Applications Trimethyl (2-N-t-Butoxycarbonylamino)ethylammonium Bromide is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Chloro-5-(2,3-dichlorophenoxy)-1,2-benzenediamine is an intermediate in the synthesis of 5-Chloro-6-(2,3-dichlorophenoxy)-1,3-dihydro-2H-benzimidazol-2-one (C365505), which is a metabolite of Triclabendazole (T774175), the only anthelmintic drug, which is active against immature, mature and adult stages of fluke.<br>References Whelan, M., et al.: J. Chromato., 1275, 41 (2013); Barrera, S., et al.; Antimicrob. Agent. Chemother., 56, 3535 (2012);<br></p>

<p>Applications 2-(chloromethyl)thiophene (cas# 765-50-4) is a useful research chemical.<br></p>

<p>Applications Methyl 2-Chloro-1-cyclopentenecarboxylate is a versatile reactant that can be synthesized from Methyl 2-Cyclopentanonecarboxylate (M294705), which is used in the preparation of functionalized ketones.<br>References Mashima, K. et al.: J. Org. Chem., 59, 3064 (1994); Hamashima, Y. et al.: J. Am. Chem. Soc., 124, 11240 (2002);<br></p>

<p>Applications tert-Butyl-(3-iodo-1,1-dimethyl-propoxy)-dimethyl-silane (cas# 105262-85-9) is used as a reagent in the preparation of Methyl Acetoacetate.<br>References Heslin, J. C., et al.: J. Chem. Soc. [Perkin 1]. 6, 1417 (1988)<br></p>

<p>Applications Coupling reagent for peptide synthesis and starting material for preparing other coupling reagents.<br></p>

<p>Applications 1-Bromo-2-chloro-3-nitrobenzene is a reagent used in pharmaceutical synthesis. Used in the synthesis of benzodiazepinone bromodomain inhibitor CPI-​637 which may be applicable to cancer therapies.<br>References Taylor, A. et al.: ACS. Med. Chem. Lett., 7, 531 (2016);<br></p>

<p>Applications Methyl 3,5-dichlorobenzoate (cas# 2905-67-1) is a useful research chemical.<br></p>

<p>Stability Light Sensitive, Volatile<br>Applications 1-Bromo-3,3-dimethyl-1-butene is used as a reagent in the preparation of bromo(dimethyl)butenes via elimination of dibromo(dimethyl)butane in the preparation of alkynes.<br>References Sydnes, L. K., et al.: Monatsh. Chem., 136, 1737 (2005)<br></p>

<p>Applications N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-oxopropanamide (cas# 87310-69-8) is a compound useful in organic synthesis.<br></p>

<p>Applications Oxydiethylene Bis(chloroformate) is a useful research intermediate for organic synthesis.<br>References Qian, W., et al.: Zhejiang Yike Daxue Xuebao, 25, 252 (1996); Alekseev, N. N., et al.: Kinetika i Kataliz, 29, 471 (1988); Alekseev, N. N., et al.: Plast. Massy, 5, 52 (1984)<br></p>

<p>Applications 6-Destrifluoromethyl-5-trifluoromethyl Bendoflumethiazide is an impurity of Bendroflumethiazide (B133500), a thiazide diuretic that is used to treat patients with Arterial Hypertensive Disease. Bendroflumethiazide works by blocking sodium reabsorption in the distal tubules within the kidneys.<br>References Borgström, L., et al.: J. Pharmacokinet. Biop., 8,431 (1981); Castillo, A., et al.: FASEB J., 23, 805 (2009); Greible, H., et al.: Arch. Intern. Med., 110, 34 (1962); Hallin, L. &amp; Hansson, L.: J. Cardiovasc. Pharm., 5, 1083 (1983)<br></p>

<p>Applications 2-(3-Bromo-4-(trifluoromethoxy)phenyl)-2,2-difluoroacetic acid<br></p>

<p>Applications 1,3-Dibenzyl-5-fluorouracil (cas# 75500-02-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Used in the preparation of vancomycin-related antibacterial agents.<br>References Leadbetter, M. et al.: J. Antibiot. 57, 326 (2004)<br></p>

<p>Applications 3,4-Dichloro-6-aminotoluene is an building block reagent used in the synthesis of various drug analogues and pharmaceutical goods.<br>References PCT Int. Appl. (2013), WO 2013030138 A1 20130307.; Shimada, I., et al.: Bioorg. Med, Chem., 16, 1966 (2008);<br></p>

<p>Applications Ethyl 8-bromooctanoate is a useful research reagent for organic synthesis and other chemical processes.<br>References Shao, M., et al.: Bioorg. Med. Chem. Lett., 27, 4051 (2017); Wang, L., et al.: Chin. J. Chem., 32, 157 (2014)<br></p>

<p>Applications Heptadecanoyl Chloride is an aliphatic reagent used in organic synthesis such as thiazole based amides for gelation study. Chloride derivative of Heptadecanoic Acid (H281030), a saturated fatty acid and occurs as a trace component of the fat in ruminants.<br>References Yadav, P. et al.: New J. Chem., 39, 721 (2015); Beare-Rogers., et al.: Pure. Applied. Chem., 73, 685 (2001);<br></p>

<p>Impurity Amiodarone EP Impurity H / Amiodarone USP Related Compound H<br>Stability Moisture Sensitive, Hygroscopic<br>Applications 2-Chloro-N,N-diethylethylamine Hydrochloride (Amiodarone EP Impurity H) is a related compound of Amiodarone, a non-selective ion channel blocker.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bonati, M., et al.: J. Pharm. Sci., 73, 829 (1984), Plomp, T.A., Anal. Profiles Drug Subs., 20, 1 (1991), Chow, M., et al.: Ann. Pharmacother., 30, 637 (1996), Singh, B.N., et al.: Clin. Cardiol., 20, 608 (1997)<br></p>

<p>Applications 2,2-difluoroacetamide is a useful research chemical for the preparation of dihydroperfluoroalkyl amines and other fluoro derivatives.<br>References Vyazkov, V. A., et al.: Fluorine Notes, 65 (2009); Gontar, A. F., et al.: Fluorine Notes, 64 (2009); Englin, M. A., et al.: Zhurnal Obshchei Khimii, 33, 2963 (1963)<br></p>

<p>Applications 4,4,4-Trifluorobutyryl Chloride can be used in the preparation of hydrazide compounds with pyriproxyfen useful for pest control.<br>References Ikari, K.: Can. Pat. Appl., CA 2747600 A1 20120203 (2012)<br></p>

<p>Applications 2-(1,3-Dioxolan-2-yl)ethyltriphenylphosphonium Bromide (cas# 86608-70-0) is a useful research chemical.<br></p>

<p>Applications 4-​Chloro-​3-​sulfobenzoic acid is a useful chemical for the preparation of pyridinylbiphenylcarboxamide derivatives for the use as nervous system agents.<br>References Wei, Z.L., et al.: PCT Int. Appl. 199pp. Patent 2009 CODEN:PIXXD2;<br></p>

<p>Applications Methyl 4-Bromophenylacetate (cas# 41841-16-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Bromo-3-thiophenesulfonyl Chloride, Technical grade (cas# 111283-90-0) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>