Haluros orgánicos

<p>Applications Iodosobenzene (cas# 536-80-1) is a useful research chemical.<br></p>

<p>Impurity Furosemide EP Impurity E<br>Applications 2,4-Dichlorobenzoic Acid (Furosemide EP Impurity E) is a di-halogenated benzoic acid derivative and an intermediate in the synthesis of spirodiclofen (S682990), a tetronic acid acaricide fungicide used in controlling red mites.<br>References Cho, Y.C., et al.: FEMS. MIcrobiol. Ecol., 42, 51 (2002); Corbella, M.E., et al.: Biodegradation., 12, 149 (2001);<br></p>

<p>Applications 1-Amino-2,4-dibromo-anthraquinone is a useful compound to study the uPAR·uPA protein-protein interaction (PPI) involved in signaling and proteolytic events that lead to tumor invasion and metastasis. It is also used to evaluate potential renal toxicants based on a relationship between chemical-induced kidney weight gain and kidney histopathology in rats. 1-Amino-2,4-dibromo-anthraquinone is a reagent utilized in copper-catalyzed Ullmann condensation to synthesize anthraquinone derivatives as novel dyes.<br>References Malik, E. M., et al.: Dyes Pigm. 131, 33 (2016); Craig, E. A., et al.: J. Appl. Toxicol. 35, 729 (2015); Mani, T., et al.: Bioorg. Med. Chem 21, 2145 (2013)<br></p>

<p>Applications An Acetanilide and Anisole derivative metabolite by liver.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pesenti, C., et al.: ChemBioChem., 5, 590 (2004), Sandford, G., et al.: J. Fluorine Chem., 128, 90 (2007),<br></p>

<p>Stability Light Sensitive<br>Applications 1,2-Dichloroethylene (Mixture of cis and trans) is a chlorinated solvent used in organic synthesis. Environmental pollutant found in river ecosystems contributing to habitat degradation.Environmental toxin on US EPA Toxic Release Inventory list (TRI) list.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Schaefer, R. et al.: Freshwater Biol., 61, 2116 (2016);<br></p>

<p>Stability Volatile<br>Applications 2,2,3,3,4,4-Hexafluoro-1-butanol has been used in phase-​transfer catalysis as a reactant in the synthesis process of fluorinated allylic ethers and thio ethers.<br>References Boutevin, B., et al.: J. Fluorine. Chem., 35, 399-410 (1987).<br></p>

<p>Applications Reagent used in the preparation of carbonic anhydrase inhibitors.<br></p>

<p>Applications 3-Acetyl-3-chlorodihydrofuranone (cas# 2986-00-7) is a compound useful in organic synthesis.<br>References Litvak, M., et al.: Pharm. Chem. J., 39, 500 (2005), Thomas, A., et al.: Bioorg. Med. Chem. Lett., 18, 2206 (2008),<br></p>

<p>Applications 4-Chlorobenzonitrile<br></p>

<p>Stability Moisture Sensitive<br>Applications Pentachloroacetone is a disinfection byproduct.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jeong, C., et al.: Environ. Sci. Technol., 46, 12120 (2012); Colman, J., et al.: Toxicol. Appl. Pharm., 254, 100 (2011)<br></p>

<p>Applications 2,4,6-Tribromophenol a reagent used in industrial synthesis of compounds and pharmaceuticals. It is used in the synthesis of anti-HIV candidates. Identified as a metabolic impurity of industrial chemical runoff in humans and wildlife.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ludovici, D. et al.: Bioorg. Med. Chem. Lett., 11, 2229, (2001); Hovander, L. et al.: Arch. Env. Cont. Toxicol., 42, 105 (2002);<br></p>

<p>Applications 2,3-Dibromopropionamide (cas# 15102-42-8) is a useful research chemical.<br></p>

<p>Applications 4-CHLORO-3-FLUOROPHENYLACETONITRILE (cas# 251570-03-3) is a useful research chemical.<br></p>

<p>Applications 3-(4-Bromophenyl)-2-propen-1-ol (cas# 105515-33-1) is a useful reagent for the preparation of aryltetralin cyclic ether lignans.<br>References Xiang, J. C., et al.: Angew. Chem. Int. Ed., 59, 21195 (2020)<br></p>

<p>Applications 2,2,2-trichloroethanol (TCE) is an active metabolite of Trichloroacetaldehyde monohydrate [chloral hydrate (CH)] (T774055), a sedative/hypnotic that increases cerebral blood flow (CBF).<br>References Parelkar, N., et al.: J. Pharma. Exper. Ther., 332, 803 (2010); Merdink, J., et al.: Toxicol, 245, 130 (2008)<br></p>

<p>Applications 1-Chlorododecane is used as a reagent in the chemical modification of zein to reduce the brittleness of zein films.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Shi, K., et al.: J. Agr. Food Chem., 59, 56 (2011)<br></p>

<p>Applications 4-(2-Chlorophenyl)-cyclohexanone is used in the synthetic preparation of cyclohexyl pyridylpiperazines as Δ8-Δ7 sterol isomerase ligands with antiproliferative activity.<br>References Berardi, F., et al.: J. Med. Chem., 51, 7523 (2008)<br></p>

<p>Applications Phenyl N-​(2-​Chloro-​4-​hydroxyphenyl)​carbamate is a reagent used in the prepartion of quinoline-carboxamide compounds including Lenvatinib (L329400), an orally active inhibitor of multiple receptor tyrosine kinases including VEGF, FGF and SCF receptors.<br>References Wang, N. et al.: Faming Zhuanli Shenqing (2017), CN 106632033 A 20170510.<br></p>

<p>Applications 1-Chloro-4-(chlorophenylmethyl)benzene is used in the synthesis of novel benzhydrylpiperazine derivatives as cytotoxic compounds in the treatment of various cancers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gurdal, E. et al.: Drug Res., 63, 121 (2013); Yarim, M. et al.: Int. J. Mol. Sci., 13, 8071 (2013);<br></p>

<p>Applications 2-(2-Chloroethoxy)acetyl Chloride (cas# 39229-33-9) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications A metabolite of Bis(2-chloroethyl) Ether.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lingg, R.D. et al., Arch. Environ. Con. Tox., 11, 173 (1982)<br></p>

<p>Stability Hygroscopic<br>Applications Semicarbazide Hydrochloride is a metabolite of Nitrofuran (N493840), a minor antimicrobial used in veterinary medicine affecting semicarbazide-sensitive amine oxidase (SSAO) activity (1). Semicarbazide may be found in from nitrofuran residues in honey extracts (2) as well as milk from dairy cows (3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.Environmental contaminants; Food contaminants; Heat processing contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Elliott J. et al.: J Pharm Pharmacol. 1989 Jan;41(1):37-41. 2. Tribalat L. et al.: Anal Bioanal Chem. 2006 Dec;386(7-8):2161-8. 3. Chu, P. et al.: J. Agric. Food Chem. 2007 Feb:55(6);2129-2135<br></p>

<p>Applications 5-Bromo-2-picoline is a halogenated pyridine derivative used is a building block in the preparation of nitrogen containing heterocyclic compounds.<br>References Gallant, M. et al.: Bioorg. Med. Chem. Lett., 18, 1407 (2008);<br></p>

<p>Applications Nonanoyl Chloride is used in the synthesis of immunosuppressants involving 2-aminoethanols and aminopropane-1,2-diols. Also used in the synthesis of Vanilloids with antinociceptive and antiinflammatory compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kiuchi, M. et al.: J. Med. Chem., 43, 2946 (2000); Janusz, J. et al.: J. Med. Chem., 36, 2595 (1993);<br></p>

<p>Applications (2-Carboxyethyl)dimethylsulfonium Chloride is the hydrochloride salt of Dimethylsulfoniopropionate (D479360), a metabolite produced primarily by marine phytoplankton and is the main precursor to the climatically important gas dimethylsulfide (DMS).<br>References Reisch, C.R. et al.: Front. Microb. Physiol. Metab., 1, 172 (2011); Groene, T. et al.: J. Plant Physiol., 138, 85 (1991); Tocher, C.S. et al.: Can. J. Biochem. Physiol., 44, 519 (1966);<br></p>

<p>Applications 4-(Trifluoromethyl)benzyl Bromide is a useful building block. It is used in the synthesis of 1-(Substituted benzyl)-2-substituted-5,6-dichlorobenzimidazoles with antiviral activities.It is also used to prepare 2-[(4-diarylmethoxy)phenyl]benzimidazoles as potent inhibitors of hepatitis C virus NS5B polymerase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Porcari, A., et al.: J. Med. Chem., 41, 1252 (1998); Ishida, T., et al.: Bioorg. Med. Chem. Lett., 16, 1859 (2006)<br></p>

<p>Stability Hygroscopic, Moisture Sensitive, Volatile<br>Applications Oxalyl Chloride is used in the preparation of cardiolipin analogs which induce peroxidase activity by Cytochrome C. It is also used in the preparation of fluorescent indicators for cytosolic calcium.<br> E0<br>References Abe, M. et al.: Biochem., 50, 8383 (2011); Minta, A. et al.: J. Biol. Chem., 264, 8171 (1989);<br></p>

<p>Applications Fluorinert FC 40 is a colorless, thermally stable, fully- fluorinated liquid. A useful modifier for the design of soft porous polymers.<br>References Turani-i-Belloto, A., et al.: Polymers (Basel, Switzerland), 12, 1008 (2020)<br></p>

<p>Applications 1-[4-(2-Chloroethoxy)phenyl]-2-phenylethanone (cas# 19561-95-6) is a compound useful in organic synthesis.<br></p>

<p>Impurity Tizanidine EP Impurity E<br>Applications (Tizanidine EP Impurity E)<br></p>

<p>Applications 2-Chlorobenzyl Chloride is a reagent in the synthesis of piperidine derivatives which are used as human heat shock protein 70 inhibitors for treatment of drug-resistant tumors. 2-Chlorobenzyl Chloride is also used as a reagent in the synthesis of benzothiazole derivatives bearing indole-based moiety which can exhibit anticancer activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zeng, Y., et al.: Eur. J. Med. Chem., 97, 19 (2015); Ma, J., et al.: Eur. J. Med. Chem., 96, 173 (2015)<br></p>

<p>Applications Fadrozole hydrochloride is a very potent and selective inhibitory effect of the aromatase enzyme system.<br></p>

<p>Applications Bromoacetic Acid is a relatively strong alkylating agent as well as a versatile building block used very commonly in organic synthesis. Bromoacetic acid has been shown to reversibly inhibit human erythrocyte carbonic anhydrase B.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Song, C. et al.: J. Org. Synth., 74, 8980 (2009); Kramer, S.P. et al.: J. Nat. Cancer Inst., 31, 297 (1963); Whitney, P.L. et al.: Eur. J. Biochem., 16, 126 (1970);<br></p>

<p>Stability Form Trimer in solution<br>Applications 2-Fluoro-6-hydroxyphenylboronic Acid is a synthetic reagent used in the preparation of alkylene-bridged [(3,4-dihydro-2H-benzo[b][1,4]oxazinyl) or (piperidinyl)(biphenyl-3-yl)pyrazolo[1,5-a]pyrimidinyl](tert-butoxy)acetic acid derivatives as HIV integrase inhibitors for treating HIV infection.<br>References Naidu, N., et al.: PCT Int. Appl. (2014), WO 2014028384 A1 20140220;<br></p>

<p>Applications Chlorthiamid<br></p>