Haluros orgánicos

<p>Applications α,α'-Dichloro-o-xylene is a useful building block, and has been used in the preparation of nanocomposite copper metal.<br>References Nejadshafiee, V.; et al.: Turkish Journal of Chemistry, 41, 700 (2017).<br></p>

<p>Applications 4-Chloro-1,1’-biphenyl (cas# 2051-62-9) is a compound useful in organic synthesis.<br></p>

<p>Applications PERFLUORO(METHYLCYCLOHEXANE) (cas# 355-02-2) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications Tris(1-chloro-2-propyl) Phosphate is a flame retardant of low hydrolytic stability, used in polyurethane (PU) rigid and flexible foam, PVC, EVA, phenolics and epoxy resin.<br>References Grump, D., et al.: Toxicol. Sci., 126, 140 (2012); Paciorek, S.J., et al.: J. Porous. Mater., 19, 161 (2012);<br></p>

<p>Stability Moisture Sensitive<br>Applications Trichloromethyl chloroformate is used as a reagent to prepare diisocyanates (e.g. Tolylene 2,4-Diisocyanate [T536710]) with benzene or Furan (F863650) rings. Trichloromethyl chloroformate is also used as a dehydrating agent in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mai, K. &amp; Patil, G.: Tetrahedron Lett., 27, 2203 (1986); Nowakowski, J.: Prak. Chem.-Chem. Ztg., 334, 187 (1992)<br></p>

<p>Applications Bromothalonil can be used in biological study of comparison and validation of an in vitro skin sensitization strategy using a data set of 33 chemical references.Environmental toxin on US EPA Toxic Release Inventory list (TRI) list.<br>References Clouet, E., et al.: Toxicology In Vitro, (2017)<br></p>

<p>Stability Hygroscopic<br>Applications A phosphonic acid derivative for development of biologically active compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ma, Q.F., et al.: Biochemistry, 29, 1412 (1990), Soti, C., et al.: Eur. J. Biochem., 270, 2421 (2003), Barabas, O., et al.: J. Biol. Chem., 279, 42907 (2004),<br></p>

<p>Stability Volatile<br>Applications Trichloroethylene-d (CAS# 13291-68-4) was useful in an isotope exchange column study to understand the slow desorption of organic compounds in soils and sediments.<br>References Werth, C. J., et al.: ACS Division Environ. Chem., 37, 174 (1997)<br></p>

<p>Stability Light Sensitive<br>Applications 3-Chlorocyclohexene (cas# 2441-97-6) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 1H,1H,2H,2H-Perfluorodecyltriethoxysilane is used in making thin film transistors, polyethersulfone membranes, and a superwettable Janus membrane.<br>References Zhu, Zhigao, et al.: J. of Membrane Sci., 563, 602-609 (2018); Khan, Aftab A., et al.: Separation and Purification Tech., 210, 20-28 (2019); Shih, Andy, et al.: MRS Adv., 3(33), 1877-1882 (2018)<br></p>

<p>Applications Octachlorocyclopentene (cas# 706-78-5) is a useful research chemical.<br></p>

<p>Applications 1,2,5,6,9,10-Hexabromocyclododecane is a flame retardant used in foamed polystyrene. One of the new POPs under the Stockholm Convention<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Larsen, E.R. et al.: J. Fire Sci., 4, 261 (1986);<br></p>

<p>Applications 1,3-Dibromoadamantane (cas# 876-53-9) is a compound useful in organic synthesis.<br></p>

<p>Applications Difluoroacetic acid<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 3-Chloropropionic Acid (cas# 107-94-8) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Methyl 3-bromo-4-hydroxybenzoate<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Impurity Phenylephrine EP Impurity A<br>Applications rac Norphenylephrine Hydrochloride is an Impurity A of phenylephrine. A phenylephrine derivative as leukotriene D4 antagonists.<br>References Musser, J.H., et al.: J. Med. Chem., 30, 2087 (1987),<br></p>

<p>Applications Methyl 2-Bromomethylbenzoate is a reactant in the preparation of Methyl 2-((4-(2-(2-methylphenoxy)acetyl)piperazin-1-yl)methyl)benzoate with neuroprotective activity.<br>References Zhong, Y., et. al.: Chin. J. Struct. Chem., 33, 1096 (2014)<br></p>

<p>Stability Mositure Sensitive<br>Applications Used for the preparation of substituted glycoside sulfamates as anticonvulsant agents for the treatment of epilepsy.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Asano, N., et al.: J. Antibiot., 40, 526 (1987), Ikeuchi, H., et al.: Bioorg. Med. Chem., 17, 6641 (2009),<br></p>

<p>Impurity Leflunomide EP Impurity H<br>Stability Hygroscopic<br>Applications 2-Cyano-N-[4-(trifluoromethyl)phenyl]acetamide (Leflunomide EP Impurity H) is used to prepare aminothiophene carboxylates and carboxamides as adenosine A1 receptor allosteric enhancers. It is also used to synthesize (1,2,3-triazol-4-yl)benzenamines as inhibitors against VEGF receptors 1 and 2.<br>References Nikolakopoulos, G., et al.: Bioorg. Med. Chem., 14, 2358 (2006); Kiselyov, A., et al.: Bioorg. Med. Chem. Lett., 19, 1344 (2009)<br></p>

<p>Stability Volatile<br>Applications Perfluorohexane (cas# 355-42-0) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications N-Phenoxyisopropyl-N-benzylaziridinium Perchlorate is a useful intermediate in the synthesis of aziridinium ions and analogs that functions as α-adrenergic blockades.<br>References Henkel, J. G., et al.: J. Med. Chem., 19, 6 (1976)<br></p>

<p>Applications 1,2,4-Tribromobenzene is a compound commonly used in organic synthesis reactions. 1,2,4-Tribromobenzene is hepatotoxic to rats, and is also toxic to humans.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dodd, D., et al.: Int. J. Toxicol., 31, 250 (2012); Szymanska, J.: Arch Toxicol., 72, 97 (1998)<br></p>

<p>Applications 1-Chloropentane is used for studies on the antimicrobial activity of some halogenated hydrocarbons and their derivatives, effect of chlorinated hydrocarbons on the myelin sheath of peripheral nerve tissues.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kalatskaya, L. M., et al.: Fiziologicheski Aktivnye Veshchestva; 20, 77 (1988); Rumsby, M. G., et al.: J. Neurochem., 13, 1513 (1966)<br></p>

<p>Applications 4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chang, Y.A., et al.: Bioconjugate Chem., 3, 200 (1992); Liao, T.H., et al.: Anal. Biochem., 148, 365 (1985)<br></p>

<p>Stability Very Volatile<br>Applications 1,1-Dichloroethane is used as a chemical solvent in the preparation of precursors of quinolizine, isoquinoline and indole alkaloids(1). Groundwater contaminant, DDT biodegredation product(2,3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Butler, E. et al.: Env. Sci. Tech. 2000, 34 (3), pp 422–429.2. Ren, L. et al.: Chemosphere. 2017 Feb;168:244-253.3. Grewal, J. et al.: J. Environ. Sci. Health. B. 2016 Dec;51(12):809-816.<br></p>

<p>Stability Moisture Sensitive<br>Applications Ethyl Trifluoroacetate is an intermediate used in the synthesis of various pharmaceutically active molecules and agricultural products. Ethyl Trifluoroacetate is also useful for the preparation of trifluoroacylated compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References HugenBerg, V., J. Fluorine. Chem., 131, 942 (2010); Belyakova, Z.V., et al.: Russ. J. Gen. Chem., 79, 2634 (2009); Wu, J.L., et al.: Jingxi. Huagong. Zhongjianti., 40, 64 (2010);<br></p>

<p>Stability Very Hygroscopic<br>Applications (S)-Isopropyl-2-aminopropanoate Hydrochloride, is a chemical reagent used in the synthesis of anti-HCV prodrugs based on imidazotriazine and pyrrolotriazine molecules.<br>References Tyndall, E. Bioorg. Med. Chem. Lett., 25, 869 (2015);<br></p>

<p>Applications 1,5-Dibromo-1-(2-fluorophenyl)-2-pentanone is used as a reagent in the synthesis of Prasugrel (P701150) and its intermediates.<br>References Nyulasi, B., et al. PCT Int. Appl. WO 2012052788 A1 20120426. Apr 26, 2012<br></p>

<p>Applications A chemical additive to control bacterial contamination in ethanol fermentation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Vaisanen, O., et al.: J. Ind. Microbio., 4, 419 (1989), Costerton, J., et al.: J. Bacteriol., 176, 2137 (1994), Pirttijarvi, T., et al.: J. Appl. Bacteriol., 81, 445 (1996),<br></p>

<p>Applications Nonanoyl Chloride is used in the synthesis of immunosuppressants involving 2-aminoethanols and aminopropane-1,2-diols. Also used in the synthesis of Vanilloids with antinociceptive and antiinflammatory compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kiuchi, M. et al.: J. Med. Chem., 43, 2946 (2000); Janusz, J. et al.: J. Med. Chem., 36, 2595 (1993);<br></p>

<p>Applications Hexyl chloroformate is used as a derivatizing agent in organic synthesis, and is also used as a reagent to synthesize Dabigatran (D100090), an oral thrombin inhibitor used to prevent venous thromboembolism.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Eerenberg, E., et al.: Circulation, 124, 1573 (2011); Eriksson, B., et al.: Lancet, 370, 949 (2007); Maurino, V., et al.: J. Am. Soc. Mass Spec., 10, 1328 (1999); Simpson, J., et al.: J. Am. Soc. Mass Spec., 6, 525 (1995); van Ryn, J., et al.: Thromb. &amp; Haemo., 103, 1116 (2010)<br></p>

<p>Applications 3,5-Dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline (cas# 104147-32-2) is a useful research chemical.<br></p>

<p>Applications Di-tert-butyldichlorosilane (cas# 18395-90-9) is a useful research chemical.<br></p>

<p>Applications 4-Chlorophenylamine is an organic chemical reagent and precursor in the synthesis of various drugs and dyestuffs. It is a building block and a degredation product of Chlorhexidine (C335045), an antiseptic as well as azo dyes and pigments in printing and textiles.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Leucea, D. et al.: Ind. Text., 61, 304 (2010); Below, H. et al.: Microchim. Acta 146, 129 (2004);<br></p>

<p>Applications 3-(Trifluoromethyl)benzenepropanol (cas# 78573-45-2_x000D_) is a compound useful in organic synthesis.<br></p>

<p>Stability Moisture Sensitive<br>Applications 3,5-Dinitrobenzoyl Chloride was used as a derivatization agent for high performance liquid chromatographic analysis of several compounds including polyamines and acteylated derivatives, taurine and hypotaurine and biogenic amines in fermented foods. It was also used in the synthesis of several organic compounds including that of a novel starch derivative which has adsorption property for creatinine and may therefore be useful in treatment of renal failure.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kirschbaum, J., et al.: J. Chromatogr A., 881, 517 (2000); Wongyai, S., et al.: Biomed. Chromatogr., 2, 254 (1988); Masuoka, N., et al.: J. Chromatogr B., 660, 31 (1994); Jiu-gao, Y., et al.: Acta Pharm. Sin., 38, 191 (2003);<br></p>

<p>Stability Very Very Moisture Sensitive<br>Applications Difluoromethanesulfonyl Chloride is a reactant used in the synthesis of ketoconazole sulfonamide analogs as antifungal agents.<br>References Blass, B. et al.: Bioorg. Med Chem. Lett., 26, 5825 (2016);<br></p>

<p>Applications 2-Chlorobenzyl Chloride is a reagent in the synthesis of piperidine derivatives which are used as human heat shock protein 70 inhibitors for treatment of drug-resistant tumors. 2-Chlorobenzyl Chloride is also used as a reagent in the synthesis of benzothiazole derivatives bearing indole-based moiety which can exhibit anticancer activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zeng, Y., et al.: Eur. J. Med. Chem., 97, 19 (2015); Ma, J., et al.: Eur. J. Med. Chem., 96, 173 (2015)<br></p>

<p>Applications Fadrozole hydrochloride is a very potent and selective inhibitory effect of the aromatase enzyme system.<br></p>

<p>Applications Octafluorocyclopentene (cas# 559-40-0) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications 4,4'-Oxybis[p-(phenylsulfonylaniline)] Hydrochloride is used in the preparation of polyamido polysulfone thermoplastics.<br>References Cho, I., et al.: U.S. (1975), US 3859252 A 19750107<br></p>

<p>Applications Fluoranthene is a commonly occurring environmental pollutant and can be classified as either a tumour initiator or a cocarcinogen in humans. Fluoranthene is widely used as an intermediate to synthesize fluorescent dyes. This compound is a contaminant of emerging concern (CECs).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hecht, S., et al.: Carcinogenesis, 16, 1433 (1995); Storer, J., et al.: Arch. Dermatol., 120, 874 (1984); Ma, X., et al.: Dyes Pigments, 82, 353 (2009)<br></p>

<p>Applications 1-fluoro-3,3-dimethyl-1$l^{3},2-benziodoxole (cas# 1391728-13-4) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications N-(2-Chloroethyl)-1,2-ethanediamine Dihydrochloride is an analog of 2-(2-Aminoethylamino)ethanol (A608990); a reagent used in the synthesis of various pharmacologically active compounds and functional groups. Also used in the synthesis of antitumor anthracene-diones and antitumor DNA intercalators. More recently used in the synthesis of ionic liquids with various thermal, dielectric and catalytic properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bair, K. et al.: J. Med. Chem., 33, 2385 (1990); Krapcho, A. et al.: J. Med. Chem., 37, 828 (1994); Karadag, A. et al.: J. Mol. Liq., 177, 369 (2013)<br></p>

<p>Applications Chlorendic Anhydride is a chlorinated hydrocarbon used in the synthesis of unsaturated polyester resins. It is also an environmental pollutant. Chlorinated Reactive flame retardant Intermediate<br>References Bongiovanni, R., et al.: J. Appl. Polym. Sci., 75, 651 (2000); Brown, T., Wania, F.: Environ. Sci. Technol., 42, 5202 (2008); Howard, P., Muir, D.: Environ. Sci. Technol., 44, 2277 (2010);<br></p>

<p>Applications 3-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol<br></p>

<p>Applications Bromonitromethane is used in the preparaton of [2,3-d]pyrimidines as inhibitors of Lck which can be used in the treatment of diseases where T-cell proliferation is unwanted. It is also used in the synthesis of isoxazoline N-oxides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References DiMauro, E. et al.: Bioorg. Med. Chem. 17, 2305 (2007); Kunetsky, R. et al.: Org. Lett., 5, 4907 (2003);<br></p>

<p>Applications Intermediate in the preparation of imidazole antifungal agents.<br>References Albet, C. et al.; J. Pharmaceut. Biomed. 10, 205 (1992); Raga, M. et al.; Eur. J. Med. Chem. 21, 329 (1986)<br></p>