Toxicología

<p>Applications Aminoacetonitrile is a useful synthetic intermediate. It is a reagent used to synthesize dipeptide nitriles as reversible and potent cathepsin S inhibitors. It can also used to prepare substituted cyclic ureas as possible HIV protease inhibitors.<br>References Ward, Y., et al.: J. Med. Chem., 45, 5471 (2002); Wilkerson, W., et al.: J. Med. Chem., 40, 4079 (1997)<br></p>

<p>Applications Emtricitabine Isopropyl Carbamate is a derivative of Emtricitabine (E525000). Emtricitabine is a reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner.<br>References FASEB J., 13, 1511 (1999), Molina, J.-M., et al.: J. InfecSchinazi, R.F., et al.: Antimicrob. Ag. Chemother., 36, 2423 (1992), Shockeor, J.P., et al.: Xenobioica, 26, 189 (1996), Feng, J.Y., et al.: . Dis., 182, 599 (2000)<br></p>

<p>Applications Eicosapentaenoyl Ethanolamide inhibits dietary-restriction-induced lifespan extension in wild type and TOR pathway mutant nematodes.<br>References Lucanic, M., et al.: Nature, 473, 226 (2011)<br></p>

<p>Applications N-(6-Bromo-4-hydroxyquinazolin-2-yl)guanidine (CAS# 74189-10-9) is a useful research chemical compound.<br></p>

<p>Applications Emtricitabine Amadori Rearrangement Product is an impurity of Emtricitabine(E525000) which is a reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. A nucleoside analog structurally related to Lamivudine (L172500).<br>References FASEB J., 13, 1511 (1999), Molina, J.-M., et al.: J. InfecSchinazi, R.F., et al.: Antimicrob. Ag. Chemother., 36, 2423 (1992), Shockeor, J.P., et al.: Xenobioica, 26, 189 (1996), Feng, J.Y., et al.: . Dis., 182, 599 (2000)<br></p>

<p>Applications 2,3,4,6-Tetra-O-acetyl-a-D-galactopyranosyl azide (CAS# 94427-00-6) is a useful research chemical compound.<br></p>

<p>Applications Ethyl-2,2,2-d3 Alcohol: Most ethyl alcohols are used in alcoholic beverages in suitable dilutions. Other uses are as solvents in laboratory and industry , in the manufacture of denatured alcohol, pharmaceuticals, in perfumery, in organic synthesis. Used as antiseptic.<br>References Wiberg, G.S., et al.: Toxicol. Appl. Pharmacol., 16, 718 (1970), Brown, N.A., et al.: Science, 206, 573 (1979),<br></p>

<p>Stability Moisture Sensitive, Toxic<br>Applications Benzyl Chloromethyl Ether is a reagent in the preparation of benzoyl-hydroxypyrimidine-diones, which are dual inhibitors of HIV reverse transcriptase and integrase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tang, J., et al.: Bioorg. Med. Chem. Lett., 21, 2400 (2011); Berkley, S., et al.; Nat. Med. 16, 981 (2010)<br></p>

<p>Applications N-Desdecanoyl, N-(dodeca-2,6,9-trienoyl) Daptomycin Trifluoroacetic Acid Salt is an impurity of Daptomycin (D193350), cyclic lipopeptide antibiotic derived from a fermentation product of Streptomyces roseosporus; disrupts plasma membrane function in gram-positive bacteria. Antibacterial.<br>References Allen, N.E., et al.: Antimicrob. Agents Chemother., 31, 1093 (1987), Tully, F.P., et al.: Expert Opin. Invest. Drugs, 8, 1223 (1999),<br></p>

<p>Applications 2,5-Thiazolylmethyl Diacarbonate is an impurity of Ritonavir (R535000), a selective HIV protease inhibitor.<br>References Daluge, S., et al.: Antimicrob. Agents Chemother., 38, 1590 (1994); Ammaranond, P., et al.: J. Clin. Virol., 26, 153 (2003); Harrigan, P., et al.: J. Infect. Dis., 191, 339 (2005); Miller, J., et al.: Bioorg. Med. Chem. Lett., 16, 1788 (2006); Koppala, S., et al.: J. Chromatogr. Sci., 53, 662 (2015);<br></p>

<p>Stability Temperature Sensitive<br>Applications Antibiotic A21 is a new polyene macrolide Amphotericin amide antibiotic with antimycotic effectiveness.<br>References Flores-Romero, J. D., et al.: Org. Process Res. Dev., 20, 1529 (2016), Antillon, A., et al.: PLoS One, 11, 9 (2016)<br></p>

<p>Applications: Imidazole derivative with antifungal properties.<br>References Walker, K.A.M., et al.: J. Med. Chem., 21, 840 (1978), Odds, F.C., et al.: J. Antimicrob. Chemother., 14, 105 (1984),<br></p>

<p>Applications N-Hydroxy-methyl Methoxy Tenofovir Alfenamide is an impurity of Tenofovir (T018500) which is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);<br></p>

<p>Applications A hydrated form of trisodium glycyrrhizinate, a bioactive compound used in conjunction with glutamyl-​tryptophan to treat acute infections caused by influenza (H3H2) virus.<br>References Smirnov, V. S.; Voprosy Virusologii, 57, 23 (2012).<br></p>

<p>Applications 2-(Benzyloxy)-1-propanol is used to prepare amino diol HIV-protease inhibitors. It is also used to synthesize diphenyl-substituted amino alcohols as protease inhibitors.<br>References Chen, P., et al.: J. Med. Chem., 39, 1991 (1996); Gordon, E., et al.: Eur. Pat. Appl. (1994), EP 580402 A2 19940126<br></p>

<p>Applications 2-Fluoro-3-methoxyaniline is a reagent that is used in the structure-activity relationship studies on a series of cyclopentane-containing macrocyclic inhibitors of hepatitis C virus NS3/4A protease leading to the discovery of TMC435350.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Raboisson, R., et al.: Bioorg. Med. Chem. Lett., 18, 4853 (2008)<br></p>

<p>Applications 1-(2,2-Dihydroxyethyl)-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic Acid is an intermediate in the synthesis of Bictegravir-15N, d2 (B382096), which is the labeled version of Bictegravir, which is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.<br>References Tsiang M. et al.: Antimicrob Agents Chemother. 2016 Nov 21;60(12):7086-7097;<br></p>

<p>Applications Hexaflumuron-D3 is an isotope labeled compound of Hexaflumuron (H293885). Hexaflumuron is an benzoylphenylurea based chitin synthesis inhibitor used against Ephestia figulilella.<br>References Sun, C.X., et al.: Bull. Environ. Contamin. Toxicol., 89, 868 (2012); Khajepour, S., et al.: J. Insect. Sci., 12, 102 (2012);<br></p>

<p>Applications Ethidium bromide (EtBr) is the most commonly used nucleic acid stain for PAGE or agarose gel electrophoresis. The fluorescence of EtBr increases 21-fold upon binding to double-stranded RNA and 25-fold on binding double-stranded DNA so that destaining the background is not necessary with a low stain concentration (10 μg/ml). Ethidium bromide has been used in a number of fluorimetric assays for nucleic acids. It has been shown to bind to single-stranded DNA (although not as strongly) and triple-stranded DNA. Because of its ability to bind to DNA, EtBr is an inhibitor of DNA polymerase. Antiprotozoal (Trypanosoma). Dyes and metabolites.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Waring, M.J., et al.: J. Mol. Biol., 13, 269 (1965), Probst, G.S., et al.: Environ. Mutagen., 3, 11 (1981),<br></p>

<p>Applications α-[2-[Methyl(1-naphthalenylmethyl)amino]ethyl]-Benzenemethanol is an impurity of naftifine (N213100) an antifungal.<br>References Stuetz, A., et al.: Journal of Medicinal Chemistry, 29, 112 (1986)<br></p>