Toxicología

<p>Stability Hygroscopic<br>Applications Ethanolamine-13C2 Hydrochloride is the labeled analogue of Ethanolamine (E676500), which is used in the preparation of various pharmaceutical compounds and inhibitors. Ethanolamine-13C2, is also a 13C-labeled lipid precursor, used for the detection of phospholipid metabolism and the synthesis of phosphatidylethanolamine in T47D human breast cancer cells.<br>References Ronen, S. M., et al.: Magnetic Resonance Med., 25, 384 (1992); Lombardo, L. et al.: J. Med. Chem., 47, 6658 (2004); Egan, T.: J. Med. Chem., 43, 283 (2000);<br></p>

<p>Stability Hygroscopic<br>Applications An impurity in the synthesis of Erythromycin (E649950). An antibacterial.<br>References Zhang, L. et al.: J. Antibio., 64, 243 (2011); Koch, W.L., et al.: Anal. Profiles Drug Subs., 8, 157 (1979),<br></p>

<p>Applications Stereoisomer to Darunavir (D193500), a second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral. It is a COVID19-related research product.<br>References Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003), Arasteh, K., et al.: AIDS, 19, 943 (2005), Surleraux, D.L.N.G., et al.: J. Med. Chem., 48, 1813 (2005),<br></p>

<p>Impurity Abacavir API<br>Applications Abacavir (Abacavir API) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.<br>References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)<br></p>

<p>Stability Hygroscopic<br>Applications The main metabolite of Omeprazole.<br>References Renberg, L., et al.: Drug Metab. Dispos., 17, 69 (1989), Calabresi, L., et al.: Pharmacol. Res., 49, 493 (2004), Yin, O., et al.: J. Clin. Pharmacol., 44, 582 (2004),<br></p>

<p>Applications Tedizolid, known as TR-700, is an oral and i.v administered intracellular antibacterial drug.<br>References Schaadt, R. et al.: Antimicrob. Agents Chemother., 53, 3236 (2009); Lemaire, S. et al.: J. Antimicrob. Chemother., 64, 1035 (2009)<br></p>

<p>Applications 2-Phenoxyethanol is a preservative used in cosmetics and is also used as an anesthetic in aquaculture and fisheries.<br>References Pillai, R., et. al.: Cosmet. Technol., 16, 25 (2013); Ghanawi, J., et. al.: Aquac. Res., 44, 359 (2013)<br></p>

<p>Applications Niclosamide is used as an anthelmintic drug (Cestodes).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Loftsson, T., et al.: J. Pharm. Sci., 85, 1017 (1996), Malik, N., et al.: Anti. Cancer Drugs, 10, 767 (1999), El-Sayed, M., et al.: Pharm. Res., 18, 23 (2001),<br></p>

<p>Impurity Lamivudine EP Impurity A<br>Stability Hygroscopic<br>Applications Lamivudine Acid (Lamivudine EP Impurity A) is an impurity of Lamivudine (L172500). Impurity A per European Pharmacopoeia.<br>References Dwyer, O., et al.: Synlett, 11, 1163 (1995),<br></p>

<p>Applications Adenine metabolite, which can be used as a plant growth regulator.<br>References Borrmann, T., et al.: J. Med. Chem., 52, 5974 (2009), Gokce, G., et al.: Biochem., 48, 4980 (2009), Castillo-Garit, J., et al.: Eur. J. Pharm. Sci., 39, 30 (2010),<br></p>

<p>Stability Hygroscopic<br>Applications Semisynthetic aminoglycoside antibiotic derived from Kanamycin A. Antibacterial.<br>References Cabana, T., et al.: Antimicrob. Agents Chemother., 3, 478 (1973), Cappelletti, L.M., et al.: J. Antibiot., 36, 328 (1983), Monteleone, P.M., et al.: Anal. Profiles Drug Subs., 12, 37 (1983),<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of (-)-Emtricitabine (E525000).<br>References Paff, M. et al.; Antimicrob. Agents Ch. 38, 1230 (1994)<br></p>

<p>Applications An active insecticidal constituent of pyrethrum flowers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Okey, A., et al.: Pharmacol. Ther., 45, 241 (1990), Barter, R., et al.: Toxicol. Appl. Pharmacol., 113, 36 (1992), Hood, A., et al.: Toxicol. Sci., 49, 263 (1999),<br></p>

<p>Applications Controlled substance (opiate). Used in treatment of opioid dependence.<br>References Bishara, R.H., et al.: Anal. Profiles Drug Subs., 3, 365 (1974), Senay, E.C., et al.: Int. J. Addict., 20, 803 (1985), Inturrisi, C.E., et al.: Clin. Pharmacol. Ther., 41, 392 (1987), Sees, K.L., et al.: J. Am. Med. Assoc., 283, 1303 (2000),<br></p>

<p>Applications Cyhalodiamide is a diamide insecticide and an agrochemical compound.<br>References Zhang, Y., et al.: Int. J. Agric. Biol., 19, 1421 (2017); Xing, J., et al.: Nongyao, 54, 842 (2015)<br></p>

<p>Applications Alendronic Acid-d6 Sodium Salt is a labelled salt analogue of Alendronic Acid (A521250), a bisphosphonate used as a bone reabsoption inhibitor.<br>References Wang, X.M., et al.: Clin. J. Dent. Res., 3, 26 (2000); Woo, T., et al.: Best Pract. Res. Clin. Rheumatol., 15, 469 (2001); Benford, H.L., et al.: Bone, 28, 465 (2001)<br></p>

<p>Applications Labelled Pentylenetetrazole (P227500). Non-specific CNS stimulant; convulsant; narcotic antagonist.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Goldenthal, et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971),<br></p>

<p>Applications Pemoline-d5 is a CNS stimulant. Controlled Substance.<br>References Connors, C.K., et al.: Psychopharacolgia, 26, 321 (1972), Schafer, E.W., et al.: Toxicol. Appl. Pharmacol., 21, 315 (1972),<br></p>

<p>Applications The labelled enatiomeric analogue of the antimicrobial agent Thiamphenicol (T344160).<br>References Gal, J. et al.: J. Pharmac. Sci., 77, 1062 (1988); Martin, J. et al.: Anal. Biochem., 96, 215 (1979);<br></p>

<p>Applications Isotope labelled analog of Gamithromycin (G195000), a macrolide compound which is known to have antibacterial activity, and is useful in the therapy of bacterial infections in mammals. Antibiotic.<br>References Broto, P., et al.: Eur. J. Med. Chem., 19, 71 (1984), Farrar, V., et al.: J. Med. Chem., 36, 3517 (1993), Clark, D., et al.: J. Pharm. Sci., 88, 807 (1999),<br></p>

<p>Applications Xiaochongliulin is used in methods and formulations for preventing downward migration of agricultural materials.<br>References Essig, Kenneth J., et al.: PCT Int. Appl.,(2020);<br></p>

<p>Applications An orally active, antimycotic allylamine related to naftifine. A specfic inhibitor of squalene epoxidase, a key enzyme in fungal ergosterol biosynthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Petranyi, G., et al.: Science, 224, 1239 (1984), Ryder, N.S., et al.: Antimicrob. Agents Chemother., 27, 252 (1985), Evans, E.G.V., et al.: Br. Med. J., 318, 1031 (1999),<br></p>

<p>Applications Used as an anticholelithogenic. Epimer with Chenodiol with respect to the hydroxyl group at C7.<br>References Tint, G.S., et al.: Gastroenterology, 91, 1007 (1986), Poupon, R.E, et al.: N. Engl. J. Med., 324, 1548 (1991), MacKenzie, P., et al.: J. Biol. Chem., 283, 36205 (2008),<br></p>

<p>Applications Labelled Linezolid. Prototype of the oxazolidinone antimicrobials; inhibits bacterial mRNA translation.<br>References Brickner, S.J., et al.: J. Med. Chem., 39, 673 (1996), Ford, C.W., et al.: Antimicrob. Agents Chemother., 40, 1508 (1996), Rybak, M.J., et al.: Pharmacotherapy, 18, 456 (1998), Stevens, D.L., et al.: Clin. Infect. Dis., 34, 1481 (2002),<br></p>

<p>Applications Diofenolan is a pesticide, an insect growth regulator. Diofenolan has been developed as a Juvenile hormone agonist for insect pest control<br>References Fan, C., et al.: J. AOAC Int., 98, 130 (2015); Abe, R., et al.: Aquat. Toxicol., 159, 44 (2015)<br></p>

<p>Applications The (R,R)-enantiomer of Voriconazole. An antifungal (systemic). An ergosterol biosynthesis inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sanati, H., et al.: Antimicrob. Ag. Chemother., 41, 2492 (1997),<br></p>

<p>Applications 7-Hydroxy-furo[3,4-b]pyrazin-5-one is a derivative of 6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one (C379925) which is an impurity of Eszopiclone (E889150), a nonbenzodiazepine hypnotic agent used as a treatment for insomnia.<br>References Gottesmann, C., et al.: Eur. J. Neurosci., 10, 409 (1998), Yoshimoto, M., et al.: Eur. Neuropsychopharmacol., 9, 29 (1999),<br></p>

<p>Applications Labelled Diclofenamide, a potent carbonic anhydrase inhibitor. Diclofenamide may provide a therapeutic strategy in the inhibition of the human cytosolic isoforms I and II and transmembrane tumor-associated isoenzymes IX and XII. Diclofenamide has been shown to be is effective in the prevention of episodic weakness in both hypokalemic periodic paralysis (HypoPP) and potassium-sensitive periodic paralysis (PSPP).<br>References Brzozowski, Z. et al.: Eur. J. Med. Chem., 46, 3656 (2010); Tawil, R. et al.: Ann. Neurol., 47, 46 (2000); Casey, J. et al.: J. Med. Chem., 47, 2337 (2004);<br></p>

<p>Applications Artemether- 13C, d3, is the labeled analogue of Artemether (A777400), which is a derivative of Artemisinin (A777500). Antimalarial, used to treat strains of malaria which are multi-drug resistant.<br>References Hombhanje, F., et al.: Pharma., 3, 3581 (2010), Michael, O., et al.: Malaria J., 9, 335 (2010), Cesar, I., et al.: J. Pharm. Biomed. Anal., 54, 114 (2011),<br></p>

<p>Applications Novel intermediate of Azithromycin that acts as antibiotic.<br>References Krajacic, M.B., et al.: J. Antibiot., 58, 380 (2005),<br></p>

<p>Impurity Cefuroxime Axetil EP Impurity A<br>Applications Δ2-Cefuroxime Axetil (Cefuroxime Axetil EP Impurity A) is an oral prodrug of Cefuroxime (C248060), an injectable second generation cephalosporin with an excellent antibacterial activity. This ester is applied in therapy as a mixture of the R and S diastereoisomers.<br>References Nguyen, N., et al.: Pharm. Res., 8, 893 (1991), Stoeckel, K., et al.: Antimicrob. Agents Chemother., 42, 2602 (1998), Scott, L., et al.: Drugs, 61, 1455 (2001),<br></p>

<p>Stability Light Sensitive<br>Applications Labelled N-Demethyl Rifampicin (D231250). N-Demethyl Rifampicin is a metabolite of Rifampicin (R508000).<br>References Marsili, L., et al.: J. Antibiot., 37, 1209 (1984), Nikaido, H., et al.: Antimicrob. Ag. Chemother., 37, 1393 (1993), Piddock, L., et al.: J. Antimicrob. Chemother., 45, 159 (2000),<br></p>

<p>Applications Dimethyl phosphorodithiolate derivatives used as insecticides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Isotope labelled o-Cresol is a compound used as a disinfectant and have also been used as antiseptic in surgery.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Razavi, S.M., et al.: Nat. Prod. Res., 26, 2148 (2012); Asadollahi-B. M., et al.: Environ. Toxicol. Pharmacol., 34, 826 (2012);<br></p>

<p>Impurity Atorvastatin EP Impurity D<br>Applications O-Methyl Atovaquone (Atorvastatin EP Impurity D) is a Atovaquone derivative that shows protozoacidal activity against Plasmodium falciparum.<br>References Danoun, S., et. al.: Heterocycl. Commun., 5, 343 (1999)<br></p>

<p>Applications Fenobuccarb is a carbamate insecticide used as an agricultural insecticide on rice and cotton.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Strempel, S., et al.: Envrion. Toxicol. Chem., 32, 1187 (2013); Xu, X.M., et al.: Food. Chem., 135, 161 (2012);<br></p>

<p>Applications An organophosphate pesticide that is an inhibitor of acetylcholinesterase (AChE).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yan, D. et al.: Zhong. Huan. Kex., 26, 364 (2006); Wood, S.J. et al.: Pest. Sci., 32, 485 (1991);<br></p>

<p>Applications Glyphosate-13C,15N is an isotopic analog of Glyphosate (G765000) which is used as a herbicide.<br>References Davis, V., et al.: Weed Sci., 57, 494 (2009), Bellaloui, N., et al.: J. Agric. Food Chem., 57, 9050 (2009),<br></p>

<p>Applications A metabolite of Caffeic acid.<br>References Zhu, B., et al.: J. Biol. Chem., 269, 292 (1994), Azuma, K., et al.: J. Agric. Food Chem., 48, 5496 (2000), Stark, T., et al.: J. Agric. Food Chem., 54, 5530 (2006), Hensel, A., et al.: Planta Med., 73, 142 (2007),<br></p>

<p>Applications Pigment Violet 23 is an organic pigment found in various colourings such as tattoo inks, visual art and archeological objects. Pigment Violet 23 is also used in the preparation of nano silica-filled color resists.<br>References Persechino, S.; et al.: Spectrochim. Acta, Part A, 206, 547 (2019); Domenech-Carbo, M. T.; et al.: ChemTexts, 2, 1 (2016); Lee, C.; et al.: Adv. Polym. Tech., 31, 163 (2012).<br></p>

<p>Applications Xanthohumol is found in the hop plant Humulus Lupulus. Xanthohumol decreases inflammation, oxidative stress, and angiogenesis during the healing of skin wounds in type 1 diabetic rats.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Costa, R., et. al.: J. Nat. Prod., 76, 2047 (2013) Yuan, Y., et. al.: Eur. J. Pharmaceut. Sci., 53, 55 (2014)<br></p>

<p>Applications N-Ethyl-N-(2-hydroxyethyl)perfluorooctylsulphonamide is a perfluorinated alkyl sulfonamide (PFAS) used in a variety of consumer products for surface protection. It is a pollutant found in the air.<br>References Shoeib, M., et al.: Environ. Sci. Technol., 39, 6599 (2005); Martin, J., et al.: Anal. Chem., 74, 584 (2002)<br></p>

<p>Applications Labelled analogue of Flucloxacillin, a semisynthetic penicillin.<br>References Markovich, M. et al.: Antibiot. Med. Biotekhnol., 31, 603 (1986); Rahman, M. et al.: Biochem. Pharmacol., 46, 1721 (1993); Silva, D. et al.: Med. Biol. Res., 37, 963 (2004);<br></p>

<p>Applications The trans-isomer of the third generation synthetic pyrethroid insecticide, Bifenthrin (B383000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Moisture Sensitive<br>Applications (Z)-Metominostrobin (cas# 133408-51-2) is a compound useful in organic synthesis.<br></p>

<p>Applications Bromoxynil is a nitrile herbicide. Bromoxynil is effective in post-emergent control of broad leaf weeds in cereal, corn, sorghum, onions, flax, mint, turf, and on non-cropland.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bhattacharya, S.P. et al.: Pesticides, 22, 7 (1988); Culpepper, A.S. et al.: Weed Technol., 12, 554 (1998); Rosales-Robles, E. et al.: Weed Technol., 19, 385 (2005);<br></p>

<p>Applications Trinexapac-ethyl<br></p>

<p>Applications Clomazone is used in herbicidal combinations.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zagar, C., et al.: PCT Int. Appl. 53pp. (2020)<br></p>

<p>Applications A microorganism based antimicrobial with high efficiency, low toxicity and good environmental compatibility. A key effective component of the pesticide M18.<br>References Chen, Y. et al.: Sci China, Ser. C Life Sci., 51, 174 (2008); Xu, Y. et al.: Jin. Yu Zhuan. Huax., 12, 8 (2004); Badria, F.A. et al.: Scient. Pharmac., 62, 355 (1994);<br></p>

<p>Applications Labelled Triclocarban. Used as bacteriostat and antiseptic in soaps and other cleansing compositions. Antiseptic, disinfectant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rastogi, S., et al.: Contact Derm., 32, 28 (1995), Thomassin, M., et al.: J. Pharm. Biomed. Anal., 15, 831 (1997), Heath, R., et al.: J. Biol. Chem., 274, 11110 (1999), Dayan, A., et al.: Food Chem. Toxicol., 45, 125 (2007),<br></p>

<p>Stability Hygroscopic<br>Applications (R,R)-Ethambutol-d4 Dihydrochloride is the isotope labelled analog of (R,R)-Ethambutol Dihydrochloride (E889805); a compound that shows antitumor properties when complexed with platinum. Also an isomer of Ethambutol (E889800) which is an antibacterial (tuberculostatic).<br>References Coluccia, M. et al.: Anticanc. Res., 11, 281 (1991); Wilkinson, et al.: J. Med. Chem., 5, 835 (1962); Kulig, et al.: Diss. Pharm. Pharmacol., 23, 463 (1971); Lee, C.S., et al.: Anal. Profiles Drug Subs., 7, 231 (1978)<br></p>

<p>Impurity Ritonavir EP Impurity E<br>Applications Hydroxy Ritonavir (Ritonavir EP Impurity E) is a metabolite of Ritonavir (R535000), HIV-1 protease inhibitor. It is a COVID19-related research product.<br>References Eagling, V., et al.: Br. J. Clin. Pharmacol., 48, 543 (1999), Eagling, V., et al.: Xenobiotica, 32, 1 (2002), Meaden, E., et al.: J. Antimicrob. Chemother., 50, 583 (2002), Treijtel, N., et al.: Drug Metab. Dispos., 33, 1325 (2005),<br></p>

<p>Applications Cyhalothrin solution is a synthetic insecticidal solution. Also, it is one of 124 pesticide residues in Chinese liquor-making raw materials (sorghum and rice hull).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Han, Y., et al.: Food Chem., 241, 258-267 (2018)<br></p>

<p>Applications Melatonin MT1/MT2 receptor agonist. Sedative, hypnotic.<br>References Yukuhiro, N., et al.: Brain Res., 59, 1027 (2004), Cajochen, C., et al.: Curr. Opin. Invest. Drugs, 6, 114 (2005), Kato, K., et al.: Neuropharmacology, 48, 301 (2005),<br></p>

<p>Applications Labelled rac-Nicotine (N412420). Nicotine is an alkaloid isolated from plants. Nicotine is an active stimulant, having both addictive and carcinogenic properties. Nicotine can be absorbed through the alimentary canal, respiratory tract and intact skin. Nicotine is used in the treatment of smoking withdrawal syndrome. Nicotine has been used as an anthelmintic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Guillen, M., et al.: J. Agric. Food Chem., 53, 1093 (2005), Alburges, M., et al.: Eur. J. Pharmacol., 573, 124 (2007), Roy, K., et al.: Eur. J. Med. Chem., 44, 1941 (2009),<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Azelastine (A808250).<br>References Heinemann, U. et al.: J. Chrom. B Anal. Tech. Biomed. Life Sci., 793, 389 (2003); Tasaka, K., et al.: Arzneim.-Forsch., 29, 488 (1979);<br></p>

<p>Applications Sulfoxaflor-d3 is the isotope analog of Sulfoxaflor. Sulfoxaflor, is a new insecticide which acts as an insect neurotoxin, and is the only member of class of chemicals called the sulfoximines which act on the central nervous system of insects with much lower toxicity to mammals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anon, IP.com J., 12, 19 (2011)<br></p>

<p>Stability Hygroscopic<br>Applications Lupulone is a hop plant (Humulus lupulus L.) acid that inhibits tumorigenicity of hepatocellular carcinoma cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Saugspier, M. et al.: Onc. Rep., 28, 1423 (2012); Kavalier, A. et al.: J. Agri. Food Chem., 59, 4783 (2011);<br></p>

<p>Applications Flumetralin is a pesticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fillion, J., et al.:J. AOAC Int., 83, 698(2000); Judson, R., et al.: Environ. Health Perspectives, 118, 485 (2010)<br></p>

<p>Applications A bactericide detected in rivers and lakes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lindstrom, A., et al.: Environ. Sci. Technol., 36, 2322 (2002)<br></p>

<p>Applications A GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects.<br>References Gelmi, M., et al.: J. Med. Chem., 50, 2245 (2007), Mascia, M., et al.: Eur. J. Pharmacol., 558, 37 (2007), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),<br></p>

<p>Applications Labelled Thiamphenicol (T344160). Thiamphenicol is an antibiotic. Thiamphenicol is the methyl-sulfonyl analogue of chloramphenicol and has a similar spectrum of activity, but is 2.5 to 5 times as potent. Thiamphenicol is used particularly for the treatment of sexually transmitted infections and pelvic inflammatory disease.<br>References Tikhonova, E., et al.: J. Biol. Chem., 279, 32116 (2004), Baucheron, S., et al.: J. Antimicrob. Chemother., 55, 707 (2005), Pages, J., et al.: Trends. Mol. Med., 11, 382 (2005), Lomovskaya, O., et al.: Biochem. Pharmacol., 71, 910 (2006), Samosorn, S., et al.: Bioorg. Med. Chem., 14, 857 (2006),<br></p>

<p>Applications Methylene Dithiocyanate emulsion is used as bactericide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Butler, E., et al.: Toxicol. Appl. Pharmacol., 93, 72 (1988), Dix, D., et al.: Toxicol. Sci., 95, 5 (2007), Abbott, B., et al.: Reprod. Toxicol., 27, 246 (2008),<br></p>

<p>Stability Hygroscopic<br>Applications Limaprost is an analog of Prostaglandin E1 with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is used as an antianginal.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tsuboi, T., et al.: Arch. Int. Pharmacodyn., 247, 89 (1980), Adaikan, P.G., et al.: Prostaglandins Med., 6, 449 (1981), Kottegoda, S.R., et al.: Prostaglandins Leukotrienes Med., 8, 343 (1982), Ishizaki, T., et al.: Chest, 85, 382 (1984),<br></p>

<p>Applications (8Z)-8-Dodecen-1-ol is a component of various insect sex pheromones.<br>References Kim, S.H., et al: Repub. Korean Kongkae Taeho Kongbo, KR 2015046436 A 20150430 (2015); Ma, R., et al.: Faming Zhuanli Shenqing, CN 104177256 A 20141203 (2014)<br></p>

<p>Applications A labelled selective serotonin reuptake inhibitor (SSRI). Used as an antidepressant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wong, D.T., et al.: Life Sci., 15, 471 (1974), Goldstein, D.J., et al.: Br. J. Psychiat., 166, 660 (1995), Ni, Y.G., et al.: Proc. Nat. Acad. Sci. USA, 94, 2036 (1997)<br></p>

<p>Applications Fluazifop-P-butyl<br></p>

<p>Applications N,N-Dimethylformamide Di-tert-butyl Acetal is used as a reagent in the synthesis of fused bicyclic ethers which act as herbicides on broad-leaved weeds. It is also used as a reagent in the preparation and biological evaluation of cystobactamide 507 which is bacterial topoisomerase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Schaetzer, J., et al.: Bioorg. Med. Chem. Lett., 24, 4643 (2014); Casalini, F., et al.: Moreno, M., et al.: Synlett, 26, 1175 (2015)<br></p>

<p>Applications N,N-Diethyl-3-(mesitylsulphonyl)-1H-1,2,4-triazole-1-carboximidamide (Cafenstrole) (cas# 125306-83-4) is a useful research chemical.<br></p>

<p>Stability Light Sensitive, Temperature Sensitive<br>Applications A metabolite of vitamin A (Retinol) (R252000).<br>References Allo, S., et al.: J. Biol. Chem., 266, 22003 (1991), Brancolini, C., et al.: J. Cell Biol., 139, 759 (1997), Bubb, M., et al.: J. Biol .Chem., 269, 14869 (1994),<br></p>