Toxicología

<p>Stability Hygroscopic<br>Applications Metabolite of Testosterone (T155000).<br>References Shibata, N., et al.: Biochem. J., 368, 783 (2002), Sonneveld, E., et al.: Toxicol. Sci., 83, 136 (2005), Schulze, J., et al.: J. Clin. Endocrinol. Metab., 93, 2500 (2008), Sten, T., et al.: Drug Metab. Disposition, 37, 417 (2009),<br></p>

<p>Applications Chlorimuron-ethyl-d5 is a labeled analogue of Chlorimuron-ethyl (C371273), which is used in weed control method as herbicide.<br>References Sada, Y., et al.: PCT Int. Appl. 45 pp. (2020)<br></p>

<p>Applications Sumatriptan Succinate is a selective 5-HT1B/1D-receptor agonist with anticonvulsant properties (1,2). Sumatriptan Succinate is used for migraine relief (2).<br>References (1) Razzaque, Z., et al.: Br J Clin Pharmacol. 47, 75 (1999) (2) Cady, R. K., et al.: J Headache Pain. 18, 17 (2017)<br></p>

<p>Applications A novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic.<br>References Baudry, M., et al.: Arch. Pharmacol., 308, 231 (1979), Ennis, C., et al.: J. Pharm. Pharmacol., 31, 14 (1979), Brogden, R.N., Drugs, 24, 360 (1982),<br></p>

<p>Applications Isotope labelled flavoprotein responsible for iodide salvage in thyroid glands. A tyrosine hydroxylase inhibitor.<br>References Fitzpatrick, P.F., et al.: Biochemistry, 30, 3658 (1991), Harsing, L.G., et al.: Neuroscience, 77, 419 (1997), Haynes, C., et al.: J. Biol. Chem., 277, 11513 (2002),<br></p>

<p>Applications 2-Isopropyl-6-methyl-4-pyrimidone, is an intermediate used for the synthesis of various benzophenone derivatives, having antifungal and antibacterial activities. It can also be used for the synthesis of Diazinon (D416880), and Diazoxon (D416890), the organophosphate insecticides.<br>References Sun, L., et al.: Molecules, 16, 9739 (2011); Pasti, T. L., J. Environ. Protect. Ecology, 12, 1168 (2011);<br></p>

<p>Stability Light Sensitive<br>Applications Reactive Violet 5 is an azo textile dye used in the textile and fabrics and paper-printing industries.<br>References Kodam, K. et al.: World J. Microbiol.Biotechnol., 21, 367 (2005); Moosvi, S. et al.: World J. Microbiol. Biotechnol., 21, 667 (2005);<br></p>

<p>Applications A structural derivative of Trimethoprim (T795615). A selective dihydrofolate reductase inhibitor; diaminopyridine antibacterial agent.<br>References Thomson, C.J. et al.: J. Chemother., 5, 458 (1993); Hawserl, S. et al.: Biochem. Pharmacol., 71, 941 (2006); Conforti, A. et al.: Br. J. Clin. Pharmacol., 44, 411 (1997);<br></p>

<p>Stability Hygroscopic<br>Applications Diphenylpyraline Hydrochloride is a salt of Diphenylpyraline (D492110), an H1 receptor antagonist (an antihistamine) and is commonly prescribed to treat allergic and vasomotor rhinitis. There is also some research being conducted on diphenylpyraline derivatives to determine their antimycobacterial and antifungal activity.<br>References Kubo, N., et al.: Jpn. J. Pharmacol., 43, 277 (1987); Puhakka, H., et al.: J. Int. Med. Res., 5, 37 (1977); Sokoloff, O.: AMA Arch Derm Syphilol., 64, 754 (1951); Weis, R., et al.: Eur. J. Med. Chem., 43, 872 (2008);<br></p>

<p>Applications 2-Methyl-1,2-benzisothiazolin-3-one (CAS# 2527-66-4) is a useful research chemical compound.<br></p>

<p>Stability Moisture Sensitive<br>Applications Trifloxystrobin is a broad-spectrum foliar fungicide used in plant pritection. Trifloxystrobin functions by inhibiting fungal spore germination. Useful in cannabis testing kits as a component of pesticide mixes (P698235).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Margot, P. et al.: Bright. Crop Prot. Conf. Pest Dis., 2, 375 (1998); Karadimos, D.A. et al.: Crop Prot., 24, 23 (2005); Prom, L.K. et al.: Plant Dis., 87, 252 (2003);<br></p>

<p>Applications An acylamino acid fungicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ravelo-Perez, L., et al.: Food Chem., 111, 764 (2008), Wong, J., et al.: J. Agric. Food Chem., 58, 5897 (2010),<br></p>

<p>Applications A commonly used herbicide/pesticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ait-Aissa, S., et al.: Toxicol., 24, 1979 (2010),<br></p>

<p>Applications Flufenacet is an anilide based herbicide that is applied to the soil surface or incorporated before the crop is emerged. Flufenacet is often used in field corn, corn grown for silage or soybeans to control annual grasses and broadleaf weeds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hulting, A.G., et al.: Weed. Technol., 26, 230 (2012); Bailly, G.C., et al.: Crop Protect., 34, 96 (2012);<br></p>

<p>Applications A neonicotinoid insecticide. Reports show that when exposed to neonicotinid pesticides honeybees have probelms returnign home after foraging and bumblebee colonies grow poorly and produce fewer queens. Useful in cannabis testing kits as a component of pesticide mixes (P698240).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Oliver, J., et al.: J. Environ. Horticult., 28, 135 (2010), Ghosh, A., et al.: J. Entomol. Res., 34, 35 (2010), Chem. and Eng. News 90: 10 (2012)<br></p>

<p>Applications Dicyclopentadiene is used in the preparation of poly(ionic liquid) brushes, used in anti-bacterial and anti-biofouling applications. Also used in the preparation of copolymer structures in the synthesis of nanocapsules.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ye, Q. et al.: J. Mat. Chem., 22, 13123 (2012); Fickert, J. et al.: Macromol., 46, 573 (2013);<br></p>

<p>Applications Labelled Brimonidine. It is an α2 receptor agonist. It is a drug used to treat glaucoma.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Katz, L.J., et al.: Am. J. Ophthalmol., 127, 20 (1999), Cantor, L. B., Expert Opin. Pharmacother., 1, 815 (2000),<br></p>

<p>Applications 4’-Hydroxy Pyrimethanil is a labelled metabolite of the pesticide Pyrimethanil (P997250).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Environmental Protection Agency EPA: Fed. Reg., 69, 52434 (2004);<br></p>

<p>Stability Hygroscopic<br>Applications Antipsychotic.<br>References Schafer, E.W., et al.: Toxicol. Appl. Pharmacol., 21, 315 (1972),<br></p>

<p>Applications Picloram is used as a herbicide. Studies show that Picloram can reduce seed germination rate and vigor as well as seedling growth in Bidens pilosa L.<br>References Freitas, M.R., et al.: RSC Adv., 5, 7547 (2015); Tian, X., et al.: Nongyao, 53, 485 (2014)<br></p>

<p>Applications Mono N-Desmethyl Disperse Polyester Dark Blue is a disperse dye for synthetic polyester fibers. It has good heat and light resistance and is used for thermal transfer recording.<br>References Peters A. T., et al.: J. Soc. Dyers Colour, 108(7-8), 344-8 (1992)<br></p>

<p>Applications Sethoxydim is a neuroplastin isoforms, a member of Ig superfamily. It is expressed and important in stereocilia of outer hair cells function. Also, it is derived from Crotonaldehyde (C818650), which is an αβ-unsaturated aldehyde and an alkylating agent that is commonly found in tobacco smoke and some foods. Crotonaldehyde is also a known mutagen and carcinogen.<br>References Zeng, W., et al.: J. Neurosci., 36, 9201-9216 (2016); Scherer, G., et al.: Hum. Exp. Toxicol., 26, 37 (2007); Zhang, S., et al.: Chem. Res. Toxicol., 19, 1386 (2006)<br></p>

<p>Applications Thifensulfuron is used as a herbicide, a chemical compound that function by inhibiting the action of a plant enzyme, stopping plant growth, and eventually killing the plant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Battaglin, W. A., et al.: Sci. Total Environ., 248, 123(2000)<br></p>

<p>Applications An antimalarial; antirheumatic; lupus erythematosus suppressant. It is a COVID19-related research product.<br>References Yarden, Y., et al.: Nature, 323, 226 (1986), Seifert, R., et al.: J. Biol. Chem., 264, 8771 (1989), Gahl, W., et al.: Mol. Genet. Metab., 76, 234 (2002), Card, J., et al.: Toxicol. Sci., 75, 169 (2003),<br></p>

<p>Applications 17beta-Estradiol-16,16,17-d3 3-Benzoate (CAS# 1192354-74-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Shows antioxidant effects. Antiseptic.<br>References Wong, S., et al.: Clin. Chem., 33, 214 (1987), Daood, H., et al.: Food Chem., 55, 365 (1996), Zainol, M., et al.: Food Chem., 81, 575 (2003),<br></p>

<p>Stability Very Hygroscopic<br>Applications A sulfometabolite of Moxifloxacin (M745000).<br>References Dalhoff, A., et al.: Drugs, 58, 239 (1999), Ahmed, S., et al.: J. Pharm. Pharmacol., 60, 55 (2008),<br></p>

<p>Impurity Amoxicillin EP Impurity C ; Amoxicillin USP Related Compound C<br>Applications Amoxicillin Diketopiperazine (Amoxicillin EP Impurity C) is a major metabolite of Amoxicillin (AMO)(A634235).<br>References Dewdney, J., et al.: Food Chem. Toxic, 29, 477 (1991), Connor, S., et al.: J. Pharm. Pharmacol., 46, 128 (1994), Hernandez, E., et al.: Vet. J., 170, 237 (2005),<br></p>

<p>Applications Chlorexolone is a low-ceiling sulfonamide diuretic.<br>References Goebel, C., et al.: Anal. Chimica Acta, 502, 65 (2004); Smith, E., et al.: J. Chromat., 384, 259 (1987)<br></p>

<p>Applications Hexaconazole is a systematic fungicide of the triazole class. Hexaconazole has a broad spectrum antifungal activity and is commonly used in the control of apple, coffee and peanut diseases.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Brown, M.C. et al.: Bright. Crop Prot. Conf. Pest. Dis., 1, 229 (1988); Gozzo, F. et al.: Pest. Biochem. Physiol., 40, 68 (1991);<br></p>

<p>Applications Labelled Secnidazole (S225000). Analog of Metronidazole. Antiamebic. Antiprotozoal (Trichomonas).<br>References Cosar, C., et al.: Arzneim.-Forsch., 16, 23 (1966), Videau, D., et al.: Br. J. Vener. Dis., 54, 77 (1978), Symonds, J., et al.: J. Antimicrob. Chemother., 5, 484 (1979),<br></p>

<p>Applications Triclabendazole Sulfone-D3 is a stable isotopically labelled metabolite of Triclabendazole (T774175), an anthelmintic.<br>References Wolff, K., et al.: Vet. Parasitol., 13, 145 (1983)<br></p>

<p>Applications Labelled Efavirenz (E42500). A nonnucleoside HIV-1 reverse transcriptase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995),<br></p>

<p>Applications Pyribenzoxim can be used in biological study of production of acetolactate synthase inhibitor herbicide tolerant Brassica napus mutants.<br>References Ruiter, R., et al.: U.S. Pat. Appl. Publ., US 20150089682 A1 20150326 (2015)<br></p>

<p>Applications De-O-ethoxy Tamsulosin is a derivative of Tamulosin (T006350), a specific α1-adrenoceptor antagonist. It is used in the treatment of benign prostatic hypertrophy.<br>References Kawabe, K., et al.: J. Urol., 144, 908 (1990), Abrams, P., et al.: Br. J. Urol., 76, 325 (1995), Michel, M.C., Expert Opin. Pharmacother., 5, 151 (2004),<br></p>

<p>Impurity Abacavir - In House Impurity<br>Applications Abacavir Sulfate (Abacavir - In House Impurity) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.<br>References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)<br></p>

<p>Applications An antimalarial.<br>References Natarajan, L., et al.: Arzneim.-Forsch., 22, 1230 (1972), Kracmer, J., et al.: Pharmazie, 29, 773 (1974), Ahmad, I., et al.: Anal. Profiles Drug Subs., 21, 43 (1992),<br></p>

<p>Applications A fat-metabolism stimulator. Antioxidant.<br>References Plotzker, R., et al.: Am. J. Med. Sci., 283, 79 (1982), Evans, J., et al.: Diabetes Technol. Ther., 2, 401 (2000), Konrad, D., et al.: Diabetes, 50, 1464 (2001), Lockhart, B., et al.: Brain Res., 855, 292 (2000),<br></p>

<p>Applications Epoxiconazole is a fungicide used to inhibit the metabolism and growth of mycelia.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gromadzka, K., et al.: Cereal. Res. Commun., 40, 518 (2012); Chen, Yu,, Plant. Disease., 96, 1495 (2012); Echeverria-Saenz, S., et al.: Sci. Total. Environ., 440, 106 (2012);<br></p>

<p>Applications 3-Desmethyl Trimethoprim is a metabolite of Trimethoprim (T795615); an antibacterial agent that is commonly prescribed in conjunction with Sulfametoxazole (S699086) to treat patients afflicted with urinary tract infections. 3-Desmethyl Trimethoprim gets excreted in the urine of rats, dogs, and man in the form of glucuronides.<br>References Roth, B., et al.: J. Med. Chem., 24, 933 (1981); Liu, Z., et al.: Biomed. Chromatogr., 26, 1101 (2012); Schwartz, D. E., Arzneimittel-Forsch., 20, 1867 (1970)<br></p>

<p>Applications High-ceiling loop diuretic; structurally related to Bumetanide (B689550). Diuretic.<br>References Merkel, W., et al.: Eur. J. Med. Chem., 11, 399 (1976), Pozet, N., et al.: Br. J. Clin. Pharmacol., 9, 577 (1980), Clissold, S.P., et al.: Drugs, 29, 489 (1985),<br></p>

<p>Impurity Doxycycline EP Impurity C<br>Stability Light Sensitive, Unstable in Solution<br>Applications An alternative to doxycycline to control gene expression.<br>References Schiffer, I., et al.: Cancer Res. 63, 7221 (2003) , Eger, K. , et al.: Biochem. Biophys. Res. Comm., 323, 979, (2004).<br></p>

<p>Applications A major metabolite of Zolpidem.<br>References Crestani, F., et al.: Br. J. Pharmacol., 131, 1251 (2000), Li, Q., et al.: Bioorg. Med. Chem. Lett., 12, 465 (2002), Goulle, J., et al.: Ther. Drug Monit., 26, 206 (2004), Ohkanda, J., et al.: J. Med. Chem., 47, 432 (2004), Blackaby, W., et al.: Bioorg. Med. Chem. Lett., 16, 1175 (2006),<br></p>

<p>Impurity Azithromycin EP Impurity L<br>Applications Azithromycin N-Oxide (Azithromycin EP Impurity L) is an Azithromycin (A927000) impurity. A degradation products of Azithromycin.<br>References Anon., et al.: Pharmaeuropa, 13, 750 (2001),<br></p>

<p>Stability Moisture Sensitive<br>Applications Tetramethylphosphorodiamidic Fluoride is a type of pesticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hayat, K., et al.: Afr. J. Environ., 4, 666 (2010)<br></p>

<p>Applications A nootropic drug that produced a significant increase in β-wave activity and stimulated α-wave activity dose-dependently. It has been used in studies to alleviate the effects of memory retrieval deficits in rats.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sara, S.J.: Psychopharmacology, 68, 235 (1980); Wolthuis, O.L.: Pharamacol. Biochem. Behav., 15, 247 (1981); Saletu, B. et al.: Prog. Neuro-Psychopharmacol., 4, 469 (1980);<br></p>

<p>Applications 1,1,3,3,5,5,7,7,9,9,11,11-DODECAMETHYLHEXASILOXANE (cas# 995-82-4) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications A bacteriostatic antibiotic with similar activity and better absorption after oral administration (in animals) than the sodium salt of Fusidic Acid (F865500). Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA.<br>References Findon, G. et al.: Lab. Anim. Sci., 41, 462 (1991); Parsons, R.L. et al.: Curr. Chemother. Proc. Int. Cong. Chemother., 10, 384 (1978);<br></p>

<p>Applications A metabolite of Ofloxacin.<br>References Uematsu, T., et al.: Eur. J. Clin. Pharmacol., 40, 581 (1991), Uematsu, T., et al.: Ther. Drug Monit., 17, 101 (1995), Ballesteros, O., et al.: J. Pharm. Biomed. Anal., 30, 1103 (2002), Kitade, T., et al.: Chem. Pharm. Bull., 51, 53 (2003),<br></p>

<p>Applications An antipsychotic.A representative lot was 92% d8, 8% d7.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Stille, et al: Farnaco, Ed. Prat., 26, 603 (1971), Hane, J.M., et al.: Psychopharmacol. Bull., 24, 62 (1988), Meltzer, H.Y.: J. Clin. Psychiatry, 55, Suppl. B, 47 (1994)<br></p>

<p>Impurity Ondansetron EP Impurity E / Clotrimazole EP Impurity D<br>Applications Imidazole (Ondansetron EP Impurity E) is a versatile heterocycle used in the preparation of various biologically active compounds such as the amino acid histidine and is present in many antifungal medication. It is also used extensively as a corrosion inhibitor on transition metals such as copper.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Arispe, N. et al.: Biophys. J., 95, 4879 (2008); Troesken, E.R. et al.: Endo. Res., 30, 387 (2004); Otmacic Curkovic, H. et al.: Corr. Sci., 51, 2342 (2009);<br></p>

<p>Applications Bis(1-methyl-2-hydroxyethyl) Ether is a metabolite formed during the aerobic degradation of polypropylene glycol by Corynebacterium species. An ether found in smoke condensate from nonfiltered cigarettes.<br>References Kawai, F. et al.: J. Fermentat. Techn., 63, 239 (1985); Schumacher, J. et al.: J. Agr. Food. Chem., 25, 310 (1977)<br></p>

<p>Applications The major labelled metabolite of Thiocolchicoside (TCC), a muscle relaxant drug.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sandouk, P., et al.: Biopharm. Drug Dispos., 15, 87 (1994), Perucca, E., et al.: Eur. J. Drug Metab. Pharmacokinet., 20, 301 (1995), Advokat, C., et al.: Pharmacol. Biochem. Behav., 63, 527 (1999),<br></p>

<p>Impurity Levofloxacin Descarboxy Impurity<br>Applications A degradation product of Levofloxacin (L360000).<br>References Wong, F., et al.: J. Pharm. Biomed. Anal., 15, 765 (1997), Singh, G., et al.: Pharmazie, 43, 134 (1988), Radi, A., et al.: Talanta, 58, 319 (2002),<br></p>

<p>Applications Orally active H1-hystamine receptor antagonist. Antihistaminic.<br>References Tasaka, K., et al.: Arzneim.-Forsch., 29, 488 (1979), Chand, N., et al.: Int. J. Immunopharmacol., 7, 833 (1985),<br></p>

<p>Stability Hygroscopic<br>Applications Deuterated, Memantine (M218000) which is used as an antiparkinsonian and antispasmodic.<br>References Rohde, H., et al.: Fortschr. Med., 100, 2023 (1982), Kornhuber, J., et al.: Eur. J. Pharmacol., 166, 589 (1989), Gortelmeyer, R. and Erbler, H.: Arzneimittel-Forsch., 42, 904 (1992)<br></p>

<p>Stability Moisture Senitive<br>Applications 2,4'-Dichlorodiphenyltrichloroethane is a chlorinated organic pesticide having estrogenic activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Iwata, H., et al.: Environ. Sci. Technol., 27, 1080 (1993), Beyer, A., et al.: Environ. Toxicol. Chem., 21, 941 (2002), Cunningham, S., et al.: Science, 317, 935 (2007),<br></p>

<p>Applications Labelled Azithromycin, a semi-synthetic macrolide antibiotic; related to Erythromycin A. Antibacterial.<br>References Langtry, H.D., et al.: Drugs, 56, 273 (1998),<br></p>

<p>Applications Piroctone Olamine is an anti-dandruff agent used in shampoo formulations.<br>References Georgalas, A. et al.: J. Cosm. Sci., 55, S207 (2004); Mayser, P. et al.: J. Cosm. Sci., 54, 263 (2008);<br></p>

<p>Applications Labelled Zephirol. Quaternary ammonium composition to treat herpes, pseudomonas, staph, hepatitis and other infectious diseases.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Berr, S., et al.: J. Phys. Chem., 91, 4760 (1987), Jones, M., et al.: Eur. J. Pharm. Biopharm., 48, 101 (1999), Okano, L., et al.: Langmuir, 16, 3119 (2000),<br></p>

<p>Stability Hygroscopic<br>Applications Phenethicillin is a semisynthetic penicillin based β-lactam antibiotic and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive bacteria.<br>References Lucien, C., et al.: Can. med. Assoc. J., 84, 535 (1961); Timmers, G.J., et al.: Clin. Microbiol. Infect., 13, 497 (2007);<br></p>

<p>Applications Labelled Sulbactam (S699185). A semi-synthetic β-lactamase inhibitor. It is used in combination with β-lactam antibiotics as antibacterial.<br>References English, A.R., et al.: Antimicrob. Agents Chemother., 14, 414 (1978), Stromberg, B.V., Surg. Gynecol. Obstet., 162, 575 (1986), Mehtar, S., et al.: J. Antimicrob. Chemother., 17, 389 (1986), Campoli-Richards, D.M., et al.: Drugs, 33, 577 (1987),<br></p>

<p>Applications 4-Chlorosalicylic Acid is a metabolite of the herbicide Benthiocarb. 4-Chlorosalicylic Acid shows antifungal activity.<br>References Nakamura, Y. et al.: Agric. Biol. Chem., 41, 1613 (1977); Patel, H.S. et al.: J. Macromol. Sci. Chem., A20, 453 (1983); Amborabe, B.-E. et al.: Plant Physiol. Biochem., 40, 1051 (2002);<br></p>

<p>Applications 3,5-Dimethyl-4-(methylthio)phenol is used as an insecticide and used the synthesis of methiocarb.<br>References Yamada, K. et al.: J. Health Sci., 57, 134 (2011); Keum, Y. et al.: Chromatograph., 52, 237 (2000);<br></p>

<p>Applications Promecarb-d3 is the isotope labelled analog of Promecarb (P756500); a carbamate pesticide.<br>References Knowles, C.O., et al.: B. Environ. Contam. Tox., 27, 529 (1981); Pacioni, N.L., et al.: Anal. Chim. Acta, 583, 63 (2007); Sanchez, F.G., et al.: Analyst, 116, 851 (1991)<br></p>

<p>Impurity Cefotaxime Sodium EP Impurity E<br>Applications 3-Desacetyl Cefotaxime Lactone is an impurity of Cefotaxime sodium (C242950). 3-Desacetyl Cefotaxime Lactone is also a degradation product for other cephalosporin antibiotics such as: Ceftriaxone (C245000), Cefodizime and Ceftiofur (C244700).<br>References Amaker, R., et al.: Antimicrob. Agents Chemother., 40, 1139 (1996), Taylor, P., et al.: Clin. Biochem., 38, 328 (2005),<br></p>

<p>Applications Cyantraniliprole is used as an insecticide and/or acaricide. Also useful in cannabis testing kits as a component of pesticide mixes (P698240).<br>References Abbott, W., et al.: J. Econ. Entomol., 18, 265 (1925), Ali, A., et al.: Environ. Entomol., 19, 1066 (1990),<br></p>

<p>Stability Unstable in Solution<br>Applications Mesosulfuron-methyl can be used in biological study of targeted screening and safety evaluation of 276 agrochemical residues in raisins using buffered ethyl acetate extraction and liquid chromatography-​tandem mass spectrometry analysis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Shabeer, T. P. A., et al.: Chemosphere, 184, 1036 (2017)<br></p>

<p>Applications A highly selective histamine H1-receptor antagonist (with no anticholinergic, antiadrenergic, or antiserotonin activity) for use in the treatment of allergic disorders, especially rhinitis and urticaria.<br>References Simons, F.E.R.: Clin. Alp. Allergy, 29, 3 (1999); Brostoff, J. et al.: Allergy, 51, 251 (1996); Gensthaler, B.M.: Pharm. Zeit., 143, 228 (1998);<br></p>

<p>Applications 3-Hydroxy-4-methoxycinnamic Acid (Isoferulic acid) is a hypoglycemic agent.<br>References Liu, I.-M., et al.: J. Pharmacol. Exp. Ther., 307, 1196 (2003),<br></p>

<p>Applications A metabolite of Atrazine (ATR) (A794600).<br>References Compton, D., et al.: Eur. J. Pharmacol., 110, 157 (1985), Das, P., et al.: Toxicol. Sci., 59, 127 (2001), Das, P., et al.: Life Sci., 73, 3123 (2003), Coban, A., et al.: J. Neurochem., 100, 1177 (2007),<br></p>

<p>Stability Hygroscopic<br>Applications Disodium salt of Mosapride (M731000) derivative.<br>References Yoshida, N., et al.: Arch. Int. Pharmacodyn. Ther., 300, 51 (1989), Yatera, S., et al.: Japan. Pharmacol. Ther., 21, 21 (1993), Ruth, M., et al.: Aliment Pharmacol. Ther., 12, 35 (1998),<br></p>

<p>Applications A metabolite of Metoprolol.<br>References Lennard, M.S., et al.: Br. J. Clin. Pharmacol., 14, 713 (1982), Gengo, F.M., et al.: Clin. Pharmacol. Ther., 36, 320 (1984),<br></p>

<p>Applications Labelled Rapamycin. A triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa’Nui. Used as an immunosuppressant; antirestenotic.This compound contains aproximately 2% d0.<br>References Martel, P.R., et al.: Can. J. Physiol. Pharmacol., 55, 48 (1977), Carlson, R.P., et al.: J. Pharmacol. Exp. Ther., 266, 1125 (1993), Kahan, B.D., et al.: Lancet, 356, 194 (2000), Holmes, D.R., et al.: Circulation, 109, 634 (2004),<br></p>

<p>Stability Hygroscopic<br>Applications A histamine H2-receptor antagonist which inhibits gastric acid secretion. Antiulcerative.<br>References Bradshaw, J., et al.: Brit. J. Pharmacol., 66, 464 (1979), Berstad, A., et al.: Scand. J. Gastroenterol, 15, 637 (1980), Hohnjec, M., et al.: Anal. Profiles Drug Subs., 15, 533 (1986),<br></p>

<p>Applications Acephate acts as a contact and systemic insecticide in agriculture through pesticide formulations. Through perinatal exposure studies, it has been linked to hyperglycemia, changes in lipid metabolism and type 2 diabetes (1). Acephate exposed Drosophila melanogaster potentially display an L-ascorbic acid mediated defense (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. Standard for Pesticide detection. Useful in cannabis testing kits as a component of pesticide mixes (P698240).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Ribeiro, T. et al.: Toxicology. 2016 Nov 30;372:12-21. 2. Rajak, P. et al.: J. Hazard. Mater. 2017 Jan 5;321:690-702.<br></p>

<p>Applications Adamantane-d16 is used in the fast catalytic hydroxylation of hydrocarbons with ruthenium porphyrins. Unlabeled adamantane derivatives have been used to treat influenza, as well as serve as NMDA receptor channel blockers for a wide range of pharmaceutical application.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, C. et al.: Inorg. Chem. 45, 4769 (2012); Thomas. A. et al.: J. Neurosci., 25, 3312 (2005); Deyde, V. et al.: Exp. Rev. Mol. Diag., 9, 493 (2009);<br></p>

<p>Applications Isoprocarb is a non-systematic carbamate insecticide. Isoprocarb functions by reversibly inactivating the enzyme acetylcholinesterase in insects.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Voss, G.: Anzeig. Schaedling., 40, 73 (1967); Metcalf, R.L. et al.: J. Agric. Food Chem., 15, 1022 (1967); Nishioka, T. et al.: Pest. Biochem. Physiol., 6, 320 (1976);<br></p>

<p>Applications Mieshuan is a pesticide. It is effective against house and wild rodents, including rats and mice.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Teng, T., et al.: Zhonghua Yufang Yixue Zazhi, 13, 220 (1979); Deng, Z.: Chinese J. Preventive Medicine, 13, 220 (1979)<br></p>

<p>Applications Ethynyl Estradiol-13C2 is isotope labelled version of Ethynyl Estradiol (E685100) which can be used in biological and analytical studies of simultaneous determination of UV-​filters and estrogens in aquatic invertebrates by modified Quick, Easy, Cheap, Effective, Rugged, and Safe extraction and liquid chromatography tandem mass spectrometry.<br>References 1. Koetsawang, S. et al.: Contraception. 1982 March:25(3) p231-2412. Cuttler, L. et al.: J. Endocrinol. Metab. 1985 Jun;60(6):1087-92.<br></p>

<p>Applications 4-Hydroxy Coumarin is a plant derived antioxidant, protecting against lipid peroxidation, as well as a potential inhibitor of HIV-1 Integrase.<br>References Foti, M. et al.: J. Agric. F., 44, 497 (1996); J. Med. Chem., 40, 242 (1997);<br></p>

<p>Stability Light Sensitive<br>Applications A novel pharmaceutical compound based on PDE IV inhibitors; used in the treatment of respiratory complaints.<br>References Gomez, et al.: Br. J. Anaesth., 74, 549 (1995),<br></p>

<p>Applications A potentially related compound in cephalosporin antibacterial compounds. An isomer of Cefuroxime (C248050).<br>References Chavette, R., et al.: J. Med. Chem., 9, 741 (1966), Miyouchi, M., et al.: J. Chem. Pharm. Bull., 38, 1906 (1990), Sugioka, T., et al.: Chem. Pharm. Bull., 38, 1998 (1990),<br></p>