Toxicología

<p>Applications Thiamine hydrochloride phosphate-d3 was used as a reagent in the redn. of cytochrome c in its reaction with thiamine and its structural analogs.<br>References Vovk, A. I, et al.: Russian J. of Gen. Chem. 72(11), 1808-1812. (2002)<br></p>

<p>Applications A hydroxylated analogue of Tamoxifen (T006000) with anti-estrogenic properties.<br>References Ruenitz, P.C. et al.: J. Med. Chem., 25, 1056 (1982)<br></p>

<p>Applications cis-trans-Nepetalactone, is an organic compound, isolated from the plant catnip,which acts as a cat attractant. Nepetalactone can also be effective on some insects. It repels cockroaches and mosquitos.<br>References Kingsley, D, ABC Science Online, Feb 14, 2009; McElvain, S.M., et al.: J. Am.Chem.Soc, 63, 1558 (1941);<br></p>

<p>Applications Potent, non-competitive CCR5 receptor antagonist; inhibits binding of HIV viral coat protein gp120. Antiviral.<br>References Fumero, E., et al.: Clin. Microbiol. Infect., 9, 1077 (2003), Walker, D.K., et al.: Drug Metab. Dispos., 33, 587 (2005), Wood, A., et al.: Prog. Med. Chem., 43, 239 (2005),<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Dopamine.<br>References Johnson, G., et al.: Life Sci., 26, 1591 (1980), Eisenhofer, G., et al.: J. Clin. Endocrinol. Metab., 82, 3864 (1997), Strassburg, C., et al.: Biochem. J., 338, 489 (1999), Alonen, A., et al.: Drug Metab. Dispos., 33, 657 (2005),<br></p>

<p>Applications Androsterone glucuronide (ADT-G) is one of the major circulating C19-steroid metabolites in humans. Exaggerated Androsterone (A637535) metabolism is observed in hyper-androgenic as well as in some normo-androgenic women with acne and androsterone glucuronide could be a marker in differentiating acne and hirsutism in hyperandrogenic women.<br>References Thompson, D.L. et al.: Clin. Endocrinol., 32, 283 (1990); Stener-Victorin, E. et al.: J. Clin. Endocrinol. Metab., 95, 810 (2010);<br></p>

<p>Applications Dicamba is a herbicide. Dicamba functions by increasing plant growth rate. At sufficient concentrations, the plant outgrows its nutrient supplies and dies. Dicamba has been approved by the EPA for use on genetically modified soybeans and cotton.Environmental toxin on US EPA Toxic Release Inventory list (TRI) list.<br>References Oehler, D.D., et al.: J. Agric. Food Chem., 28, 685 (1980); Griffin, J., et al.: Weed Techno., 27, 696 (2013); Chem. and Eng. News, Nov. 14, 2016, p. 17<br></p>

<p>Applications Antitussive. Chain between 6 and 17 units of ethylene glycol with the major product containing 10 units.<br>References Scholtissek, C., et al.: Antiviral Res., 38, 213 (1998), McGovern, S., et al.: J. Med. Chem., 45, 1712 (2002), Regenthal, R., et al.: Hum. Exp. Toxicol., 21, 343 (2002),<br></p>

<p>Applications 1,1’-Diphenyl-D10 is a labelled analogue of 1,1’-Diphenyl (D486980).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Labelled Pyruvic acid (P998900). Intermediate in sugar metabolism and in enzymatic carbohydrate degradation (alcoholic fermentation) where it is converted to acetaldehyde and CO2 by carboxylase. In muscle, Pyruvic acid (derived from glycogen) is reduced to lactic acid during exertion, which is reoxidized and partially retransformed to glycogen during rest. The liver can convert Pyruvic acid to alanine by amination. A diagnostic agent for Parkinson disease.<br>References Wenzel, A., et al.: J. Neurosci., 21, 53 (2001), Martinez., et al.: Development, 6, 851 (2002), Nakayama, K., et al.: J. Biochem., 146, 757 (2009), Tanaka, T., et al.: J. Pharmacol. Sci., 109, 24 (2009),<br></p>

<p>Applications Labelled racemic analogue of Ruxolitinib (R702000). Ruxolitinib is a selective Janus tyrosine kinase (JAK1 and JAK2) inhibitor used in the treatment of myeloproliferative neoplasms and psoriasis.<br>References Shilling, A.D. et al.: Drug Metab. Disp., 38, 2023 (2010); Mesa, R.A.: IDrugs, 13, 394 (2010); Campas-Moya, C.: Drugs Fut., 35, 457 (2010);<br></p>

<p>Applications Lapatinib-d7 Dihydrochloride is a labeled Lapatinib (L175800), a reversible dual inhibitor of ErbB1 and ErbB2 tyrosine kinases. Antineoplastic.<br>References Kim, T.E., et al.: Drugs, 6, 886 (2003); Wood, E.R., et al.: Cancer Res., 64, 6652 (2004); Spector, N.L., et al.: J. Clin. Oncol., 23, 2502 (2005)<br></p>

<p>Applications Chenodeoxycholic Acid 24-Acyl-β-D-glucuronide is a glucuronide metabolite of Chenodeoxycholic Acid (CDCA) (C291900).<br>References Alme, B., et al.: J. Steroid Biochem., 13, 907 (1980), Goto, J., et al.: Steroids, 63, 186 (1998), Barbier, O., et al.: J. Steroid Biochem. Mol. Biol., 85, 235 (2003),<br></p>

<p>Applications A neuroprotective agent. Modulates glutamatergic transmission. A glutamate release inhibitor. An anticonvulsant. Neuroprotective agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mizoule, J., et al.: Neuropharmacology, 24, 767 (1985), Wahl, F., et al.: Eur. J. Pharmacol., 230, 209 (1993) Bensimon, G., et al.: N. Engl. J. Med., 330, 585 (1994)<br></p>

<p>Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.<br>References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),<br></p>

<p>Applications Labelled Psilocybin. The major of two hallucinogenic components of Teonanacatl, the sacred mushroom of Mexico, the other component being Psilocin. Psychomimetic.Controlled substance (hallucinogen).<br>References Hofmann, et al.: Experientia, 14, 397 (1958), Callahan, P., et al.: J. Pharmacol. Exp. Ther., 246, 866 (1988), Appel, J., et al.: Eur. J. Pharmacol., 159, 41 (1989), Blair, J., et al.: J. Med. Chem., 43, 4701 (2000),<br></p>

<p>Applications A metabolite of Aniline. Arylamines are predominantly conjugated by constitutive enzyme forms in the liver.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Axelrod, J., et al.: J. Biol. Chem., 232 835 (1958), Lilienblum, W., et al.: Biochem. Pharmacol., 33, 2041 (1984),<br></p>

<p>Applications Combined dopamine (D2) and serotonin (5HT2) receptor antagonist. Antipsychotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sainati, S.M., et al.: J. Clin. Pharmacol., 35, 713 (1995), Szewczak, M.R., et al.: J. Pharmacol. Exp. Ther., 274, 1404 (1995), Kongsamut, S., et al.: Eur. J. Pharmacol., 317, 417 (1996),<br></p>

<p>Stability Hygroscopic<br>Applications Tenofovir Alafenamide is a prodrug of Tenofovir (T018500), which is a reverse transcriptase inhibitor used to treat HIV and Hepatitis B. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),<br></p>

<p>Applications KU-0058948 is a poly (ADP-ribose) polymerase (PARP) inhibitor. Studies show that KU-0058948 is a potent agonist that activates transfected extracellular signal-regulated kinase 8 (ERK8) in cells. KU-0058948 induces cell cycle arrest and apoptosis of primary myeloid leukemic cells and myeloid leukemic cell lines in vitro<br>References Klevernic, I.V. et al.: FEBS Lett., 583, 680 (2009); Gaymes, T.J. et al.: Haematologica, 94, 638 (2009);<br></p>

<p>Applications Rolitetracycline is a tetracycline antibiotic that may be given intravenously or intramuscularly in serious bacterial infections when oral administration is not practicable.<br>References Choudhary, S., et al.: Chem. Biol. Drug. Des., 80, 693 (2012); Ejim, L., et al.: Nature. Chem. Biol., 7, 348 (2011); Giorgetti, S., et al.: J. Biol. Chem., 286, 2121 (2011);<br></p>

<p>Applications (2S,3S)-Hydroxybupropion hydrochloride (CAS# 106083-71-0) is a useful research chemical compound.<br></p>

<p>Applications Vortioxetine Hydrobromide is a multimodal serotonergic agent that inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT (1,2,3).<br>References (1) Bang-Andersen, B., et al.: J. Med. Chem., 54, 3206 (2011)(2) Mørk, A., et al.: J. Pharmacol. Exp. Ther., 340, 666 (2012) (3) Mørk, A., et al.: Pharmacol. Biochem. Behav. 105C, 41 (2013)<br></p>

<p>Impurity Albendazole Impurity 6 Calcium<br>Applications Cyanamide is used in the synthesis of H2 receptor histamine antagonists. Also use in the synthesis of oxadiazoles and 1,2,4-thiaziazoles as dual 5-lipoxygenase and cyclooxygenase inhibitors. (Albendazole Impurity 6)<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Young, R. et al.: J. Med. CHem., 31, 656 (1988); Unangst, P. et al.: J. Med. CHem., 35, 3691 (1992);<br></p>

<p>Applications Labelled Dacarbazine (D101400). Dacarbazine is used as an antineoplastic for treatment of malignant melanoma and sarcomas.<br>References Shealy, et al.: Biochem. Pharmacol., 11, 674 (1962), Carter, et al.: Eur. J. Cancer, 8, 85 (1972),<br></p>

<p>Applications Perampanel is a novel, noncompetitive AMPA receptor antagonist for the treatment of epilepsy. Also in the treatment of primary generalized tonic-clonic seizures in idiopathic generalized epilepsy. Perampanel is a selective non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor antagonist that reduces neuronal excitation (1,2,3,4).<br>References (1) Shih, J., et al.: Therap. Clinical Risk Management, 9, 285 (2013)(2) Rogawski, M. A., et al.: Epilepsy Curr., 11, 56 (2011)(3) Franco, V., et al.: Ther Drug Monit. 38, 744 (2016) (4) Rudzinski, L. A., et al.: J Investig Med. 64, 1087 (2016)<br></p>

<p>Applications Carbocisteine is a mucolytic agent used in the treatment of respiratory disorders ranging from the influenza virus infection to chronic obstructive pulmonary disease (COPD).<br>References Stevenson, G.B. et al.: Eur. Resp. J., 27, 865 (2006); Suer, E. et al.: J. Infect. Chemother., 14, 333 (2008); Yamaya, M. et al.: Am. J. Physiol., 299, L160 (2010);<br></p>

<p>Applications Cephalosporin Antibiotic.<br>References Murata, H., et al.: J. Hepatol., 38, 573 (2003), Osawa, M., et al.: Legal Med., 10, 143 (2008), Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009),<br></p>

<p>Stability Moisture Sensitive<br>Applications Chlorpyrifos Oxon is a metabolite of Chlorpyrifos (C425300) in human.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Atterberry, T., et al.: Toxicol. Appl. Pharmacol., 147, 411 (1997), Karanth, S., et al.: Toxicol. Sci., 58, 282 (2000), Barter, Z., et al.: Drug Metab. Dispos., 36, 2405 (2008),<br></p>

<p>Applications A synthetic progestin largely used in hormone therapy, on the central nervous system by studying two markers of the neuroendocrine function: the neurosteroid allopregnanolone and the opioid .beta.-endorphin. Progestogen.<br>References Bernardi, F., et al.: Eur. J. Endocrinol., 138, 316 (1998), Rupprecht, R., et al.: Steroids, 64, 83 (1999), Uzunova, V., et al.: Brain Res., 976, 1 (2003), Pluchino, N., et al.: J. Steroid Biochem. Mol. Biol., 102, 205 (2006),<br></p>

<p>Applications Eszopiclone is the active stereoizomer of Zopiclone and belongs to the class of drug known as cyclopyrrones. It is a nonbenzodiazepine hypnotic agent used as a treatment for insomnia.This is a controlled substance (depressant) in the US but not in Canada.<br>References Gottesmann, C., et al.: Eur. J. Neurosci., 10, 409 (1998), Yoshimoto, M., et al.: Eur. Neuropsychopharmacol., 9, 29 (1999),<br></p>

<p>Applications An antibiotic produced by Streptomyces lincolnensis. Lincomycin is a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of the 23S rRNA. Inhibits bacterial protein synthesis. Antibacterial.<br>References Mason, D.J., et al.: Antimicrob. Agents Chemother., 555 (1962), Gray, et al.: Toxicol. Appl. Pharmacol., 6, 476 (1964), Muti, H.Y., et al.: Anal. Profiles Drug Subs. Excip., 23, 269 (1994),<br></p>

<p>Applications Labelled Tryptamine (T894600). Occurs in plants.<br></p>

<p>Applications Tripamide is a diuretic.<br>References Ogihara, T., et al.: Hypert. Res., 32, 163 (2009)<br></p>

<p>Applications Apixaban-13C, d3 is labelled Apixaban (A726700) which is a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.<br>References Luettgen, J.M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011);<br></p>

<p>Applications Dichlorodipropyltin is a diorganotin dihalide which has broad applications in both laboratory and industry. The Dichlorodipropyltin class of compounds can be used as a poly(vinyl chloride) stabilizers, fungicides and insecticides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chandrasekaran, R.K. et al.: J. Organometallic Chem. 3, 215 (1981);<br></p>

<p>Applications Diuretic and antihypertensive.<br>References Twagirumukiza, M., et al.: Trop. Med. Int. Health, 15, 350 (2010), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010), Peters, R., et al.: Anal. Bioanal. Chem., 396, 2583 (2010),<br></p>

<p>Applications Pentachlorophenol Sodium Salt can be used in biological study of evaluation of interaction between pesticides and a cell membrane model by surface plasmon resonance spectroscopy analysis. One of the new POPs under the Stockholm Convention.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Moriwaki, H., et al.: J Agr Food Chem, 65, 5390 (2017)<br></p>

<p>Applications The labeled version of Meclizine (M202700(P)), which is an antiemetic.<br>References Cohen, B., et al.: Arch. Neurol., 27, 129 (1972),<br></p>

<p>Applications Raltegravir (MK-0518) is a potent integrase (IN) inhibitor for WT and S217Q PFV IN.<br>References Hare, S., et al.: Proc. Natl. Acad. Sci. U. S. A., 107, 20057 (2010); Hicks, C., et al.: Clin. Infect. Dis., 48, 931 (2009); Moss, D., et al.: Antimicrob. Agents Chemother., 56, 3020 (2012); Hare, S., et al.: Mol. Pharmacol., 80, 565 (2011)<br></p>

<p>Applications Antimetabolite antiviral dosing regimen for hepatitis C virus or flaviviridae therapy.<br>References Teh, A.-H., et al.: Biochemistry, 45, 7825 (2006),<br></p>

<p>Applications Zolmitriptan is a serotonin 5HTID-receptor agonist and used to treat migraine (1,2,3).<br>References (1) Glen, R.C., et al.: J. Med. Chem., 38, 3566 (1995)(2) Seaber, E., et al.: Brit. J. Clin. Pharmacol., 41, 141 (1996)(3) Tepper, S.J., et al.: Curr. Med. Res. Opin., 15, 254 (1999)<br></p>

<p>Applications 4-(Trifluoromethyl)nicotinoyl Glycine-13C2,15N is the isotope labelled analog of 4-(Trifluoromethyl)nicotinoyl Glycine (T791375); a metabolite of Flonicamid (F405710), which is a novel insecticide with rapid inhibitory effect against aphid feeding.<br>References Lee, Sung Woo., et al.: J. Chrom. A., 1218(28), 4366-4377 (2011); Hengel, Matt J., et al.: J. Agr. Food Chem., 55(20), 8033-8039 (2007); Morita, M., et al.: Pest. Manag. Sci.,63, 969 (2007); Sabatino, L., et al.: Food. Additive. Contamin., 6, 11 (2013);<br></p>

<p>Applications Verapamil-d3 Hydrochloride is the labeled analogue of Verapamil Hydrochloride (V125000), which is a calcium channel blocker, antihypertensive, antianginal, and antiarrhythmic (class IV).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Atlas, D, and Adler, M.: Proc. Natl. Acad. Sci. USA, 78, 1237 (1981); Janis, R., et al.: Adv. Drug. Res., 16, 309 (1987)<br></p>

<p>Applications An intermediate of SCH 51048, an antifungal agent.<br>References Lovey, R.G., et al.: Bioorg. Med. Chem. Lett., 12, 1739 (2002), Lovey, R., et al.: J. Med. Chem., 35, 4221 (1992),<br></p>

<p>Applications Novaluron is an insect growth regulator and shows killing effect against various larvae of genus Lepidoptera, Coleoptera, Hemiptera and Diptera. Useful in cannabis testing kits as a component of pesticide mixes (P698240).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lefebvre, M., et al.: J. Econmic. Entomol., 105, 866 (2012); Brock, T.C.M., et al.: Environ. Sci. Pollu. Res., 19 3610 (2012);<br></p>

<p>Applications Taurine-d4 is the isotope labelled analog of Taurine (T007850), an organic acid found in animal tissues and is a major constituent of bile. Taurine has many biological roles such as conjugation of bile acids, antioxidation, osmoregulation, membrane stabilization and modulation of calcium signaling.<br>References Brosnan J. et al.: J. Nutrit., 136, 1636S (2006); Birdsall, T.C. et al.: Alt. Med. Rev., 3, 128 (1998); Foos, T.M. et al.: Neurochem. Res., 27, 21 (2002); Das, J. et al.: Pathophysiology, 15, 181 (2008);<br></p>

<p>Stability Hygroscopic<br>Applications Labelled dimethyl phosphorodithiolate derivatives used as insecticides.<br></p>

<p>Applications 2-Hydroxy-5-(trifluoromethyl)pyridine (cas# 33252-63-0) is a compound useful in organic synthesis.<br></p>

<p>Applications A synthetic opioid similar in structure to Methadone (M225865). It acts as a μ-opioid receptor agonist and evokes heroin-like discriminative stimulus effects.<br>References Newman, J.L. et al.: Psychopharmacol., 164, 108 (2002); Brase, D.A. et al.: Biochem. Pharmacol., 25, 1684 (1976);<br></p>

<p>Applications 4-Amino-N-(1,1-dimethylethyl)-4,5-dihydro-3-(1-methylethyl)-5-oxo-1H-1,2,4-triazole-1-carboxamide is a triazolinone herbicide with a broad spectrum of weed control.<br>References Dayan, F., et al.: Weed Science, 57, 579 (2009); Elmore, M., et al.: Weed Technol., 27, 596 (2013)<br></p>

<p>Applications RTI-113 is a 3-phenyltropane analogue that acts as a potent and selective dopamine uptake inhibitor. RTI-113 has been shown to reduce cocaine self-administration at high occupancy of dopamine transporter. Studies suggest that RTI-113 and its analogs may be useful tools for developing potential agonist therapies for cocaine dependence.<br>References Dworkin, S. et al.: Synapse, 30, 49 (1998); Negus, S.S. et al.: Pharmacol. Biochem. Behav., 91, 333 (2009); Cook, C. et al.: Eur. J. Pharmacol., 442, 93 (2002);<br></p>

<p>Applications O,O,S-Trimethyl Dithiophosphate is a metabolite resulting from the degradation of Dimethoate (D460505), isolated from treatment wastewater.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, R., et al.: Int Biodeterior Biodegradation, 64, 51 (2010);<br></p>

<p>Applications Isotope labelled Fenbuconazole is a conazole based fungicide used as a spray for the control of leaf spot, yellow and brown rust, powdery mildew and net blotch on wheat and barley and apple scab, pear scab and apple powdery mildew on apples and pears.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Reiss, R., et al.: Food. Chem. Toxicol., 50, 4421 (2012); Loos, M. et al.: Environ. Sci. Technol., 46, 9830 (2012);<br></p>

<p>Applications Anesthetic (local).<br>References Cederholm. I., et al.: Reg. Anesth., 19, 18 (1994), Johansson, B., et al.: Anesth. Analg., 78, 210 (1994), Oda, Y., et al.: Anesthesiology, 82, 214 (1995),<br></p>

<p>Applications Labelled Bendamustine (B132502). Bendamustine is an antineoplastic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bremer, K., et al.: Tumordiagn. Ther., 17, 1 (1996), Barman Balfour, J.A., et al.: Drugs, 61, 631 (2001),<br></p>

<p>Impurity Cefixime EP Impurity D<br>Applications (E)-Cefixime is an isomeric impurity of the third generation cephalosporin antibiotic, Cefixime (C242800).<br>References Bian, L. et al.: Yao. Fen. Zaz., 30, 872 (2010); Rajadurai, R. et al.: Anal. Chem. Ind. J., 9, 265 (2010);<br></p>

<p>Applications A novel labelled intermediate of Fexofenadine (F322470).<br>References McTavish, D., et al.: Drugs, 39, 552 (1990), Honig, P., et al.: Clin. Pharmacol. Ther., 52, 231 (1992), Yun, C., et al.: Drug Metab. Dispos., 21 403 (1993),<br></p>

<p>Applications Quaternary ammonium composition to treat herpes, pseudomonas, staph, hepatitis and other infectious diseases.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Berr, S., et al.: J. Phys. Chem., 91, 4760 (1987), Jones, M., et al.: Eur. J. Pharm. Biopharm., 48, 101 (1999), Okano, L., et al.: Langmuir, 16, 3119 (2000),<br></p>

<p>Stability Hygroscopic<br>Applications Vapreotide is a synthetic somatostatin (S676750) analog predominately used for the treatment of acute variceal bleeding.<br>References Fortune, B.E., et al.: Expert. Opin. Pharmacother., 10, 14 (2009); Paul, C., et al.: Eng. J. Med., 344, 23 (2001);<br></p>

<p>Impurity Clarithromycin EP Impurity C<br>Applications Clarithromycin 9-Oxime (Clarithromycin EP Impurity C) is an impurity of Clarithromycin (C559750), a macrolide antibiotic.<br>References Stephanic, V. et al.: J. Med. Chem., 54, 719 (2011); Chen, X. et al.: Zhong. Yao., 17, 32 (2008);<br></p>

<p>Applications Labelled β-Hyodeoxycholic Acid. A potential bile acid metabolite.<br>References Abadie, C., et al.: Biochem. J., 299, 725 (1994), Taniguchi, T., et al.: J. Biol. Chem., 269, 10071 (1994), Davis, R., et al.: J. Lipid Res., 43, 533 (2002),<br></p>

<p>Applications A muscarinic receptor used as nootropic agent.<br>References Wolf-Pflugmann, M., et al.: Arzneim-Forsch./Drug Res., 39(1), 5, 539 (1989),<br></p>

<p>Applications Ezetimibe-d4 is the labeled analogue of Ezetimibe (E975000), an antihyperlipoproteinemic. A cholesterol absorption inhibitor.<br>References van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997); van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>

<p>Applications Systemic agricultural fungicide.<br>References Ozer, N., et al.: J. Phytopathol., 158, 744 (2010), Schafer, R., et al.: Environ. Sci. Technol., 45, 1665 (2011),<br></p>

<p>Applications Picoxystrobin is a methoxyacrylate strobilurin fungicide designed for the control of wide range of cereal diseases.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Walorczyk, S., et al.: J. Chromatograph. A., 1251, 219 (2012); Roszko, M., et al.: J. Am. OIl. Chemist. Soc., 89, 389 (2012);<br></p>

<p>Applications Ethoprophos is an organophosphate non-systemic nematicide and soil insecticide (1). Ethoprophos is an acetylcholinesterase (AChE) inhibitor (2,3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. Used as a standard for Pesticide detection. Ethoprophos is also useful in cannabis testing kits as a component of pesticide mixes (P698230).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Wing, K. et al.: Pest. Biochem. Physiol. 1984. Feb:21(1) pp22-302. Opperman, C. et al.: J. Nematol. 1990 Oct;22(4):481-83. Nordmeyer, D. et al.: Plant. Dis. J. 1985 Jan:69: 67-69<br></p>

<p>Applications Controlled substance (opiate). Used in treatment of opioid dependence.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bishara, R.H., et al.: Anal. Profiles Drug Subs., 3, 365 (1974), Senay, E.C., et al.: Int. J. Addict., 20, 803 (1985), Inturrisi, C.E., et al.: Clin. Pharmacol. Ther., 41, 392 (1987), Sees, K.L., et al.: J. Am. Med. Assoc., 283, 1303 (2000),<br></p>

<p>Applications A cell-permeable fluorescent probe selective for Zinc. Fluorescence: max. Em. l = 515nm<br>References Koh, J., et al.: Science, 272, 1013 (1996), Suh, S., et al.: Brain Res., 852, 268 (2000), Finney, L., et al.: Science, 300, 931 (2003), Lopantsev, V., et al.: Neuroscience, 116, 237 (2003), Kambe, T., et al.: Cell Mol. Life Sci., 61, 49 (2004),<br></p>

<p>Applications A fodder additive for poultry used to prevent coccidiosis infections. Antiprotozoan drug.<br>References Morrison, W.D. et al.: Poult. Sci., 46, 391 (1967); Davis, J.L. et al.: Vet. Pharmacol. Therap., 9, 1145 (2009);<br></p>

<p>Stability Hygroscopic<br>Applications N-Ethyl-N-(3-sulfobenzyl)sulfanilic Acid Disodium Salt can be obtained from 3-Sulfobenzaldehyde Sodium Salt (S689165) which can be used for the preparation of a series of novel sulfonamide derivatives, as inhibitors of the enzyme histone deacetylase (HDAC) as a novel approach to the treatment of cancer.<br>References Finn, P., et al.: Helvetica Chimica Acta, 88 (7), 1630 (2005);<br></p>

<p>Stability Moisture Sensitive<br>Applications Orthosulfamuron can be used in biological study and agricultural use of herbicidal composition comprising erlukuilincaotong, cyhalofop-​butyl and sulfonylurea herbicide, and its application in controlling annual weed of rice field.<br>References Wang, L., et al.: Faming Zhuanli Shenqing, CN 106386836 A 20170215 (2017)<br></p>

<p>Applications Codeine 6-β-D-Glucuronide-d6 is the labelled analogue of Codeine 6-β-D-Glucuronide (C634090), a metabolite of Codeine (C634075). Analgesic (narcotic); antitussive.<br>References Frances, B., et al.: J. Pharm. Exp. Ther., 25, 262 (1992), Osborne, R., et al.: Br. J. Clin. Pharm., 34, 130, (1992),<br></p>

<p>Applications Benzamide is a compound that is widely used as a starting material for various organic syntheses and reactions. Benzamide derivatives are prevalent in the pharmaceutical industry, for example Raclopride (R070800), a Dopamine (D533780) D-2 agonist that is used to treat patients with Parkinson’s Disease. Benzamide derivatives are also used in chemistry, for example N-nitrophenyl benzamide derivatives are used as chromosensors to detect cyanide in aqueous environments.<br>References Ehrin, E., et al.: Int. J. Appl. Rad. Isot., 36, 269 (1985); Sun, Y., et al.: Tetrahedron, 65, 3480 (2009); Terai, M., et al.: Eur. J. Pharm., 173, 177 (1989)<br></p>

<p>Stability Unstable in DMSO solution<br>Applications Chlorimuron-ethyl is used in weed control method as herbicide.<br>References Sada, Y., et al.: PCT Int. Appl. 45 pp. (2020)<br></p>

<p>Applications Tropine derivative with anticholinergic activity. Antispasmodic; used in treatment of urinary incontinence.<br>References Antweiler, H., et al.: Arzneim.-Forsch., 16, 1581 (1966), Lux, G., et al.: Fortschr. Med., 96, 2113 (1978), Madersbacher, H., et al.: Br. J. Urol., 75, 452 (1995), Zinner, N.R., et al.: Expert Opin. Pharmacother., 6, 1409 (2005),<br></p>

<p>Applications Selexipag is an orally available, highly selective, long-acting prostacyclin (IP) receptor agonist prodrug. It is a potential drug for the treatment of various vascular disorders such as pulmonary arterial hypertension and arteriosclerosis obliterans.<br>References Kuwano, K., et al.: J. Pharm. Exp. Ther., 322, 1181 (2007);<br></p>

<p>Applications A chloroacetanilide herbicide used on vegetable crops.<br>References Matthies, M., et al.: Environ. Sci. Technol., 43, 9223 (2009); Hollender, J., et al.: Environ. Sci. Technol., 43, 7862 (2009); Dresen, S., et al.: Anal. Bioanal. Chem., 396, 2425 (2010); Liu, B., et al.: J. Agric. Food Chem., 58, 2673 (2010);<br></p>

<p>Applications Macitentan-d4 is an isotopic form of Macitentan (M105005). Macitentan, is an orally active endothelin receptor antagonist used for pulmonary arterial hypertension.<br>References Emoto, N. Ensho to Men'eki, 20, 487 (2012);<br></p>

<p>Applications Bisphenol AP-d5 is the isotope labelled analog of Bisphenol AP. Bisphenol AP is used to prepare triphenylmethane derivatives as inhibitors of hepatitis C virus helicase. It is a derivative of Bisphenol A (B519495) which is a monomer used for policarbonate and epoxy resins.<br>References Chen, C., et al.: J. Med. Chem., 52, 2716 (2009); Krishnan, A.V., et al.: Endocrinology, 132, 2279 (1993); Steinmetz, R., et al.: Trends Endocrinol. Metab., 9, 124 (1998); Petersen, H., et al.: Eur. Food Res. Technol., 216, 355 (2003)<br></p>

<p>Applications Labelled antihyperthyroid. Has been used to promote fattening. This substance is reasonably anticipated to be a human carcinogen.<br>References Aboul-Enein, H.Y., et al.: Anal. Profiles Drug Subs., 6, 457 (1977), Cooper, D.S., et al.: N. Engl. J. Med., 311, 1353 (1984),<br></p>