Toxicología

<p>Applications The primary metabolite of Diazepam. A ligand for the GABAA receptor benzodiazepine modulatory site. Anxiolytic.Controlled substance (depressant).<br>References Klotz, U., et al.: Br. J. Clin. Pharmacol., 7, 119 (1979), Konishi, M., et al.: J. Pharm. Sci., 67, 1777 (1978), Andreoli, V., et al.: Arzneim.-Forsch., 27, 436 (1977), Miller, R.P., et al.: Toxicol. Appl. Pharmacol., 25, 453 (1973), Margolis, J., et al.: Drug Metab. Dispos., 31, 606 (2003),<br></p>

<p>Stability Extremely Hygroscopic<br>Applications Nabam (Hydrate) is used a fungicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Virk, K.S., Gemawat, P.D.: Pesticides, 15, 25 (1981)<br></p>

<p>Applications A novel inhibitor of antiapoptotic BCL-2 proteins; a new promising anticancer drug candidate.<br>References Adams, J., et al.: Science, 281, 1322 (1998), Degterev, A., et al.: Nat. Cell. Biol., 3, 173 (2001), Kitada, S., et al.: J. Med. Chem., 46, 4259 (2003), Danial, N., et al.: Clin. Cancer Res., 13, 7254 (2007),<br></p>

<p>Stability Hygroscopic<br>Applications Labelled Serotonin (S274980). Serotonin is a monoamine neurotransmitter.<br>References Kuraishi, Y., et al.: Biol. Pharm. Bull., 31, 2143 (2008); Morera, E., et al.: Bioorg. Med. Chem. Lett., 19, 6806 (2009); Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010);<br></p>

<p>Applications 2-Chlorobenzonitrile is an activated aryl chloride that is commonly used in reactions that involve the Palladium-catalyzed direct arylation of heteroaromatics (e.g. 3-aminopicolinic acid [A627800]). 2-Chlorobenzonitrile and its substituted derivatives (e.g. 2,3-dichloro-6-nitrobenzonitrile [2112-22-3]) also have potential anti-inflammatory properties.<br>References Andreu, M., et al.: Chem. Commun., 24, 2475 (2000); Hellman, W., et al.: J. Med. Chem., 21, 906 (1978); Roy, D., et al.: ACS Catal., 2, 1033 (2012);<br></p>

<p>Applications Fluopyram is a succinate dehydrogenase inhibitor (SDHI) used as a fungicide. It is also useful in cannabis testing kits as a component of pesticide mixes (P698240).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Amiri, A. et. al.: Plant Disease, 98, 532 (2014); Ishii, H., et. al.: Pest. Manag. Sci., 67, 474 (2011)<br></p>

<p>Applications A metabolite of Atrazine (ATR) (A794600).<br>References Compton, D., et al.: Eur. J. Pharmacol., 110, 157 (1985), Das, P., et al.: Toxicol. Sci., 59, 127 (2001), Das, P., et al.: Life Sci., 73, 3123 (2003), Coban, A., et al.: J. Neurochem., 100, 1177 (2007),<br></p>

<p>Stability Light Sensitive<br>Applications 1-o-Tolueneazo-2-naphthol is a potent cytochrome P-488 inducer. Dyes and metabolites.<br>References Adachi, S., Fujita, S., Uesugi, T.: J Pharmaceut. Biomed., 5, 273 (1982)<br></p>

<p>Applications Decapeptide LH-RH antagonist. Used in treatment of infertility.<br>References Strickley, R.G., et al.: Pharm. Res., 7, 530 (1990), Jung, G., et al.: J. Med. Chem., 35, 3942 (1992), Rabinovici, J., et al.: J. Clin. Endocrinol. Metab., 75, 1220 (1992), Devroey, P., et al.: Hum. Reprod., 13, 3023 (1998),<br></p>

<p>Applications Monosulfuron is a sulfonylurea herbicide that inhibits Acetohydroxyacid synthase enzyme.<br>References Wang, J., et al.: J. Comput. Aided Mol. Des., 19, 801 (2005);<br></p>

<p>Applications Hexythiazox is a mite growth regulator and a thiazolidine based acaricide that has long-lasting effects against many kinds of mites and is applied at any stage of the plant growth from budding to fruiting. Useful in cannabis testing kits as a component of pesticide mixes (P698240).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Martini,X., et al.: Pest. Manage. Sci., 68, 1471 (2012); Gilbert-Lopez, B., et al.: Food. Control., 26, 341 (2012);<br></p>

<p>Stability Light Sensitive<br>Applications Chlorothalonil is a polychlorinated aromatic broad spectrum non-systematic fungicide. Chlorothalonil is used heavily in agriculture field on crops such as peanuts, potatoes and tomatoes. Chlorothalonil is a probable human carcinogen (Group B2) and is highly toxic to fish and aquatic invertabrates.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tillman, R. et al.: Pest. Biochem. Physiol., 3, 160 (1973); White, L. et al.: Pest. Manag. Sci., 62, 126 (2006); Haugaard, J.: Dask Kemi, 76, 29 (1995);<br></p>

<p>Stability Hygroscopic<br>Applications An impurity in the synthesis of Erythromycin (E649950). An antibacterial.<br>References Zhang, L. et al.: J. Antibio., 64, 243 (2011); Koch, W.L., et al.: Anal. Profiles Drug Subs., 8, 157 (1979),<br></p>

<p>Stability Hygroscopic<br>Applications Anesthetic (local); antiarrhythmic (class IB). Long-acting, membrane stabilizing agent against ventricular arrhythmia. Originally developed as a local anesthetic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Duce, R., et al.: J. Pharmacol. Exp. Ther., 179, 580 (1971), Kronberg, G.H., et al.: J. Med. Chem., 16, 739 (1973), Groningsson, K., et al.: Anal. Profiles Drug Subs., 14, 207 (1985), Davies, P.S., et al.: Drugs, 64, 937 (2004),<br></p>

<p>Applications 4-[4-[2-(2-Pyridinyloxy)propoxy]phenoxy]phenol is a metabolite of Pyriproxyfen (P998850); a pyridine-based pesticide used against a variety of arthropoda, in particular to protect cotton crops against whitefly.<br>References Amiri, A., et al.: J. Agri. Sci. Technol., 14, 1205 (2012); Basit, M., et al.: Crop. Protect., 44, 135 (2013); Yoshino, H., et al.: J. Agr. Food Chem., 43, 2681 (1995); Zhang, L., et al.: Arch. Insect Biochem., 37, 215 (1998)<br></p>

<p>Stability Hygroscopic<br>Applications Estriol 3-O-β-D-Glucuronide Sodium Salt is a metabolite found in the urine of pregnant women.<br>References Simkins, A., Worth, H.G.J., Anals Clin. Biochem., 12, 233 (1975)<br></p>

<p>Stability Hygroscopic<br>Applications Disodium salt of Mosapride (M731000) derivative.<br>References Yoshida, N., et al.: Arch. Int. Pharmacodyn. Ther., 300, 51 (1989), Yatera, S., et al.: Japan. Pharmacol. Ther., 21, 21 (1993), Ruth, M., et al.: Aliment Pharmacol. Ther., 12, 35 (1998),<br></p>

<p>Impurity Salmeterol EP Impurity B<br>Applications A novel antibacterial analog of the antibacterial drug Sulfamethoxazole (S699086).<br></p>

<p>Applications Allobarbital is a barbiturate derivative that is primarily used as an anticonvulsant. Allobarbital also shows hypnotic activity and is used to boost the activity of analgesic drugs. Studies show that Allobarbital is an effective promoters of hepatocarcinogenesis. Allobarbital is a Controlled Substance.<br>References Tateoka, Y. et al.: Yakug. Zas., 106, 504 (1986); Crawford, J.M. et al.: Neuropharmacology, 9, 31 (1970); Rice, J.M. et al.: Carcinogenesis, 15, 395 (1994);<br></p>

<p>Applications Mesosulfuron is used in synergistic herbicidal combinations.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Baur, P., et al.: PCT Int. Appl. (2020), WO 2020173719 A1<br></p>

<p>Applications ent-Lamivudine Triphosphate Triethylammonium Salt is a metabolite of Lamivudine (L172500), which is a potent nucleoside reverse transcriptase inhibitor. Antiviral. Lamivudine has been used for treatment of chronic hepatitis B.<br>References Burgess, K., et al.: Chem. Rev., 100, 2047 (2000), Gallois-Montbrun, S., et al.: Biochem. Pharmacol., 68, 1749 (2004); Morris, D.M., J. Pharm. Biomed. Anal., 12, 255 (1944), Nevens, B.F., et al.: Gastroenterology, 113, 1258 (1997), Perry, C.M., et al.: Drugs, 53, 657 (1977)<br></p>

<p>Applications Methyl Benzilate is a reactant in the synthesis of Trimethadione (T796155), an anticonvulsant and antiepileptic agent used in the treatment of pregnant women. Prenatal exposure to snti-epileptic drugs (AEDs) has indicated increased risk of major or minor congenital malformation.<br>References Pastore, V., et. al.: Bioorg. Med. Chem., 21, 841 (2013); Ahir, B. et al.: Toxicol. Vitro., 28, 948 (2014); Pastore, V. et al.: Bioorg. Med. Chem., 21, 841 (2013)<br></p>

<p>Applications Nebivolol (N387896) metabolite.<br></p>

<p>Applications β-Endosulfan is the beta isomer of Endosulfan (E555505), an insecticide that poses health risks to humans and animals that acquire it through ingension, inhalation, and percutaneous contact. One of the new POPs under the Stockholm Convention. Useful in cannabis testing kits as a component of pesticide mixes (P698230).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bhalerao, T. &amp; Puranik, P.: Int. Biodeter. Biodegr., 59, 315 (2007); Kalender, S., et al.: Toxicology, 202, 227 (2004); Naqvi, S. &amp; Vaishnavi, C.: Comp. Biochem. Phys. C, 105, 347 (1993)<br></p>

<p>Applications S-Enantiomer of Baclofen. Specific GABA-B receptor agonist. Muscle relaxant (skeletal).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ahuja, S., et al.: Anal. Profiles Drug Subs., 14, 527 (1985), Brogden, R.N., et al.: Drugs, 8,1 (1974)<br></p>

<p>Applications A sonic hedgehog inhibitor. Also a possible inhibitor of prostaglandin endoperodixide synthases.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kalgutkar, A.S., et al.: J. Med. Chem., 39, 8, 1692 (1996), Biochem., 40, 4359 (2001),<br></p>

<p>Applications (E)-Isomer of Entacapone polymorphic form A. Peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Antiparkinsonian.<br>References Karlsson, M., et al.: J. Pharm. Biomed. Anal., 10, 593 (1992); Nissinen, E., et al.: Arch. Pharmacol., 346, 262 (1992); Wikberg, T., et al.: Eur. J. Drug Metab. Pharmacokinet., 18, 359 (1993);<br></p>

<p>Applications A protected metabolite of the fluorinated quinolone antibacterial Ciprofloxacin.<br></p>

<p>Impurity Fluconazole EP Impurity D<br>Applications 2-Desfluoro Fluconazole (Fluconazole EP Impurity D) is an impurity of the antifungal agent Fluconazole (F421000).<br>References Ramesh, B. et al.: J. Pharm. Res., 4, 1401 (2011); Al-Rimawi, F.: Jor. J. Chem., 4, 357 (2009);<br></p>

<p>Applications A metabolite of Quinidine.<br>References Small, D.L., et al.: J. Chem. Med., 22, 1014 (1979), Guentert, T.W., et al.: Eur. J. Drug Metab. Pharmacokinet., 7, 31 (1982), Rakhir, A., et al.: J. Pharmacokinet. Biopharm., 12, 1 (1984), Christie, D.J., et al.: J. Lab. Clin. Med., 112, 92 (1988),<br></p>

<p>Applications Psychotropic agent with anxiolytic and anticonvulsant activity.<br>References Boissier, J.R., et al.: Therapie, 27, 325 (1972), Bente, D., et al.: Arzneim. Forsch., 25, 944 (1975),<br></p>

<p>Applications 3-Hydroxykynurenine is a metabolite of tryptophan. 3-Hydroxykynurenine filters UV light in the human lens. Studies suggest that Hydroxykynurenine is an endogenous oxidative stress generator and a potential endogenous neurotoxin.<br>References Malina, H.Z. et al.: Graefes. Arch. Clin. Exp. Ophthalmol., 233, 38 (1995); Okuda, S. et al.: J. Neurochem., 70, 299 (1998);<br></p>

<p>Applications Labelled Cephapirin (C261500). An antimicrobial agent.<br>References Tan, J.S., et al.: Antimicrob. Agents Chemother., 15, 510 (1979),<br></p>

<p>Applications (1R,2S)-erythro-Dihydro Bupropion is a metabolite of Bupropion (B689625), a selective inhibitor of dopamine uptake.<br>References Writer, J.H., et. al.: Sci. Total Environ., 461 (2013)<br></p>

<p>Applications BUTAN-2-YL 4-HYDROXYBENZOATE (cas# 17696-61-6) is a useful research chemical.<br></p>

<p>Applications Hexadecyl Acetate is a plant sex pheromone.<br>References Brasero, N., et al.: J. Chem. Ecol., 44, 9 (2018); Cuervo, M., et al.: J. Chem. Ecol., 43, 469 (2017)<br></p>

<p>Applications Pretilachlor is a chloroacetanalide herbicide. Pretilachlor is commonly used for weed control in wet seeded rice<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mohankumar, P.D. et al.: J. Trop. Agric., 34, 149 (34, 149 (1996); Ravisankar, N. et al.: Ind. J. Agron., 53, 57 (2008); Singh, S. et al.: Crop Prot., 27, 660 (2008);<br></p>

<p>Applications Artemether- 13C, d3, is the labeled analogue of Artemether (A777400), which is a derivative of Artemisinin (A777500). Antimalarial, used to treat strains of malaria which are multi-drug resistant.<br>References Hombhanje, F., et al.: Pharma., 3, 3581 (2010), Michael, O., et al.: Malaria J., 9, 335 (2010), Cesar, I., et al.: J. Pharm. Biomed. Anal., 54, 114 (2011),<br></p>

<p>Applications One of the bioactive forms of Riboflavin. Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, leafy vegetables. Richest natural source is yeast. Minute amounts present in all plant and animal cells. Vitamin (enzyme cofactor).<br>References Unna, K., et al.: J. Pharmacol. Exp. Ther., 76, 75 (1942), Rivlin, et al.: N. Engl. J. Med., 283, 463 (1970), Al-Shammary, F.J., et al.: Anal. Profiles Drug Subs., 19, 429 (1990),<br></p>

<p>Applications 17-epi-Testosterone Enanthate, is a derivative of 17-epi-Testosterone (T155005).Testosterone and epitestosterone are endogenous steroids that differ in the configuration of the hydroxyl-bearing carbon at C-17. Testosterone is the predominant male sex hormone, whereas the role of epitestosterone is largely unclear. In humans, both androgens are excreted mainly as glucuronide conjugates.<br>References Wudy, S., et al.: Steroids, 66, 759 (2001), Kootstra, P., et al.: Anal. Chim. Acta., 586, 82 (2007), Sten, T., et al.: Drug Metab. Dispos., 37, 417 (2009),<br></p>

<p>Applications Copper Acetoarsenite has been used as a rodenticide and insecticide, and also as a pigment, despite its toxicity. It is also used as a blue colorant for fireworks.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gaines, T.: Toxicol. Appl. Pharm., 2, 88 (1960); Jameson, F.: Paint Manu., 13, 6 (1943)<br></p>

<p>Impurity Cefuroxime Axetil EP Impurity A<br>Applications Δ2-Cefuroxime Axetil (Cefuroxime Axetil EP Impurity A) is an oral prodrug of Cefuroxime (C248060), an injectable second generation cephalosporin with an excellent antibacterial activity. This ester is applied in therapy as a mixture of the R and S diastereoisomers.<br>References Nguyen, N., et al.: Pharm. Res., 8, 893 (1991), Stoeckel, K., et al.: Antimicrob. Agents Chemother., 42, 2602 (1998), Scott, L., et al.: Drugs, 61, 1455 (2001),<br></p>

<p>Applications Labelled Diltiazem (D460620). A calcium channel blocker with vasodilating activity. Antianginal; antihypertensive; antiarrhythmic (class IV).<br>References Sato, et al.: Arzneim.-Forsch., 21, 1338 (1971), Smirnov, S.R.: Eur. J. Pharmacol., 360, 81 (1998), Hansson, L., et al.: Lancet, 356, 359 (2000),<br></p>

<p>Applications Desmedipham is a carbanilate based herbicide used in the weed control programs in sugar beet.<br>References Kittlaus, S., et al.: J. Chromatograph. A., 1283, 98 (2013); Wujek, B., et al.: J. Food. Agri. Environ., 10, 606 (2012);<br></p>

<p>Stability Hygroscopic<br>Applications Ticagrelor, the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),<br></p>

<p>Stability Hygroscopic<br>Applications Mefruside is a diuretic used for the treatment of edema and hypertension.<br>References Johansen, A., et al.: Euro. J. Epidemiol., 27, 63 (2012); Hasegawa, Y., et al.: Blood. Press. Supple., 1, 10 (2010);<br></p>

<p>Applications Reagent used in the preparation of antifungal agents and MDMA analogs.<br>References Obase, H., et al.: Chem. Pharm. Bull., 30, 462 (1982), Zacchino, S., et al.: J. Nat. Products, 62, 1353 (1999),<br></p>

<p>Stability Hygroscopic<br>Applications A biochemical marker of bone turnover for management of metabolic bone diseases.<br>References Turner, W., et al.: Biol. Psychiatry, 14, 177 (1979), Miyata, T., et al.: Kidney Int., 60, 2351 (2001), Politi, P., et al.: Neurosci. Lett., 396, 163 (2006),<br></p>

<p>Applications Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol<br>References Akiyama, T., et al.: J. Biol. Chem., 262, 5592 (1987), O'Dell, T.J., et al.: Nature, 353, 588 (1991), Aharonovits, O., et al.: Biochim Biophys. Acta, 1112, 181 (1992), Platanias, L.C., et al.: J. Biol. Chem., 267, 24053 (1992), Yoshida, H., et al.: Biochim. Biophys. Acta, 1137, 321 (1992), Uckun, F.M., et al.: Science, 267, 886 (1995)Merck Index 12th ed. 43952. Huang, R.Q.; Fang, M.J.; Dillon, G.H., Mol. Brain Res. 67: 177-183 (1999)<br></p>

<p>Stability Very Moisture Sensitive<br>Applications Chlorotriphenylstannane is used in the synthesis of nanoparticles which bear triamide ligands.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Shariatinia, Z. et al.: Beil. J. Nanotech., 4, 94 (2013);<br></p>

<p>Applications An agricultural fungicide. Kresoxim-methyl is also useful in cannabis testing kits as a component of pesticide mixes (P698235).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gold, R.E. et al.: Pestic. Sci., 43, 250 (1995); Creemers, P. et al.: Meded. Fac. Landbouwwet. Univ. Gent, 61, 431 (1996); Gold, R.E. et al: Mod. Fungic. Antifungal Compd., 11, 79 (1996);<br></p>

<p>Applications Labelled Tolvaptan. It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).<br>References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000), Udelson, J., et al.: Circulation, 104, 2417 (2001), Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005), Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006),<br></p>

<p>Applications Isocarbofos D7 (isopropyl D7) is the labelled analogue of Isocarbophos(I789303). Isocarbophos is an organophosphorus pesticide residue found in spicy foods and nuts.<br>References Gao, Y., et al.: Huaxue Shiji, 39, 1083 (2017); Dong, Y., et al.: Fenxi Huaxue, 45, 1397 (2017)<br></p>

<p>Applications Primary alkaloid of various species of Cinchona (Rubiaceae). Optical isomer of Quinidine. Antimalarial; muscle relaxant (skeletal).<br>References Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 12, 547 (1983), Kremsner, P.G., et al.: J. Infect. Dis., 169, 467 (1994),<br></p>

<p>Applications Labelled Aldicarb (A514650). Aldicar is used as an insecticide. Used in Pesticide detection.<br>References Ashby, J., et al.: Environ. Mutagen., 7, 919 (1985), Ashby, J., et al.: Mutat. Res., 257, 229 (1991), Kazius, J., et al.: J. Med. Chem., 48, 312 (2005), Benigni, R., et al.: Mutagenesis, 25, 335 (2010),<br></p>

<p>Applications Des-[(E)-Methyl-3-methyoxyacrylate] Picoxystrobin is an impurity of Picoxystrobin(P437600). Picoxystrobin is a methoxyacrylate strobilurin fungicide designed for the control of wide range of cereal diseases.<br>References Walorczyk, S., et al.: J. Chromatograph. A., 1251, 219 (2012); Roszko, M., et al.: J. Am. OIl. Chemist. Soc., 89, 389 (2012);<br></p>

<p>Applications Flumetralin is a pesticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fillion, J., et al.:J. AOAC Int., 83, 698(2000); Judson, R., et al.: Environ. Health Perspectives, 118, 485 (2010)<br></p>

<p>Impurity Oxifloxacin EP Impurity F<br>Applications Levofloxacin N-oxide is an impurity of Ofloxacin (O245750), which is a fluorinated quinolone antibacterial.<br>References Horstkotter, C., et al.: J. Chromatography Biomed. Sci. Appli., 754, 169 (2001); Monk, J.P., et al.: Drugs, 33, 346 (1987), Drlica, K., Curr. Opin. Microbiol. 2, 504 (1990)<br></p>

<p>Impurity Clindamycin Phosphate EP Impurity F<br>Applications Lincomycin 2-Phosphate (Clindamycin Phosphate EP Impurity F) is the derivative of Lincomycin (L466200), a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of the 23S rRNA. Inhibits bacterial protein synthesis. Antibacterial.<br>References Mason, D.J., et al.: Antimicrob. Agents Chemother., 555 (1962), Gray, et al.: Toxicol. Appl. Pharmacol., 6, 476 (1964), Muti, H.Y., et al.: Anal. Profiles Drug Subs. Excip., 23, 269 (1994),<br></p>

<p>Applications Used as an antibacterial agent. LD50 &gt;5000 mg/kg for oral administration to rats.<br>References Goldenthal, E.I.: Toxicol. Appl. Pharmacol., 18, 185 (1971)<br></p>

<p>Applications Isotope labelled Digitoxin (D445950), is used as a cardiotonic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Foerster, et al.: Arch. Int. Pharmacodyn. Ther., 159, 1 (1966), Jakovljevic, I.M., Anal. Profiles Drug Subs., 3, 149 (1974)<br></p>

<p>Impurity Levothyroxine EP Impurity D / T4-Acetic Acid (USP)<br>Applications Thyroid hormone analogue. A potent Thyroxine impurity. T4-Acetic Acid (USP).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Horst, C., et al.: Biochem. J., 261, 945 (1989), Kvetny, J., et al.: Horm. Metab. Res., 24, 322 (1992), Yamauchi, K., et al.: J. Biol. Chem., 274, 8460 (1999), Davis, P., et al.: J. Endocrinol. Invest., 25, 377 (2002),<br></p>

<p>Stability Light Sensitive<br>Applications A novel pharmaceutical compound based on PDE IV inhibitors; used in the treatment of respiratory complaints.<br>References Gomez, et al.: Br. J. Anaesth., 74, 549 (1995),<br></p>

<p>Applications A potentially related compound in cephalosporin antibacterial compounds. An isomer of Cefuroxime (C248050).<br>References Chavette, R., et al.: J. Med. Chem., 9, 741 (1966), Miyouchi, M., et al.: J. Chem. Pharm. Bull., 38, 1906 (1990), Sugioka, T., et al.: Chem. Pharm. Bull., 38, 1998 (1990),<br></p>

<p>Applications Used for oral gel patch or film containing herb extracts or Chinese medicine, fruit extract, spearmint, and menthol for smoking cessation.<br>References Gillet, Y., et al.: Lancet, 359, 753 (2002), Turos, E., et al.: Bioorg. Med. Chem. Lett., 2002, 12, 2229 (2002),<br></p>

<p>Applications Deguelin exhibits potent apoptotic and antiangiogenic activities in a variety of transformed cells and cancer cells. Deguelin also exhibits potent tumor suppressive effects in xenograft tumor models for many human cancers.<br>References Chang, D.J.. et al.: J. Med. Chem., 55, 10863 (2012);<br></p>

<p>Applications Used as insecticide for terminate control; pre-harvest defoliant; general herbicide. Antimicrobial preservative and fungicide for wood, wood products, starches, textiles, paints, adhesives, leather, pulp, paper, industrial waste systems, building materials; Surface disinfectant. Exposure to PCP is also associated with carcinogenic, renal, and neurological effects. This compound is a contaminant of emerging concern (CECs). One of the new POPs under the Stockholm Convention<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gaines, T.B., et al.: Toxicol. Appl. Pharmacol., 14, 515 (1969),<br></p>

<p>Applications N-(3-Phenylpropionyl)glycine-3C2,15N is a labelled analogue of N-(3-Phenylpropionyl)glycine (P336210), which is a useful diagnostic tool in the diagnosis of many organic acidemias and mitochondrial fatty acid β-oxidation defects. N-(3-Phenylpropionyl)glycine is present in the urine of medium-chain acyl-CoA dehydrogenase deficient (MCAD) patients who orally ingested 3-phenylpropionic acid.<br>References Duran, M. et al.: Prog. Clin. Biol. Res., 321, 419 (1988); Bonafe, L. et al.: Mol. Gen. Metab., 69, 311 (2000); Ombrone, D. et al.: Anal. Biochem., 417, 122 (2011);<br></p>

<p>Applications Bromadiolone is an anticoagulant rodenticide used on non-crop areas.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cherry, L., et al.: Toxicologist, 2, 108 (1992), Park, B., et al.: Biochem. Pharmacol., 31, 3635 (1992), Thijssen, H., et al.: Pestic Sci., 43, 73 (1995), Howald, G., et al.: Conserv. Biol., 21, 1258 (2007),<br></p>

<p>Applications Oseltamivir EP Impurity E Glucose Adduct is a byproduct in the synthesis of Oseltamivir Glucose Adduct 1 (O701035), which is derived from Oseltamivir Phosphate (O701000), which is an orally active inhibitor of influenza virus neuraminidase; converted in vivo to the active acid metabolite (an antiviral drug). It is a COVID19-related research product.<br>References Oliyai, R., et al.: Pharm. Res., 15, 1300 (1998), Kim, C.U., et al.: Med. Chem. Res., 8, 392 (1998), Hayden, F.G., et al.: N. Engl. J. Med., 341, 1336 (1999), Treanor, J.J., et al.: J. Am. Med. Assoc., 283, 1016 (2000)<br></p>

<p>Applications This is a controlled substance (depressant). Anticonvulsant; sedative; hypnotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Chao, M.K.C., et al.: Anal. Profiles Drug Subs., 7, 359 (1978),<br></p>

<p>Applications Fumagillol is an analog of Fumagillin (F862650), a compound isolated from the fungus Aspergillus fumigatus. Fumagillin is an antimicrobial agent used in the treatment of microsporidiosis. Fumagillin shows promise as both an an anti-infective and antiangiogenic agent.<br>References Molina, J.M. et al.: N. Eng. J. Med., 346, 1963 (2002); Hou, L. et al.: Pathol. Int., 59, 448 (2009); Ingber, D. et al.: Nature, 348, 555 (1990);<br></p>

<p>Applications PSI-6130 is an experimental treatment for hepatitis C. PSI-6130 is a member of a class of antiviral drugs known as nucleoside polymerase inhibitors. PSI-6130 inhibits the hepatitis C virus RNA dependant RNA polymerase called NS5B.<br>References Clark, J., et al.: J. Med. Chem., 48, 5504 (2005); Stuyver, L., et al.: Antiviral Chem. Chem., 17, 79 (2006)<br></p>