Toxicología

<p>Applications 4-(Trifluoromethyl)nicotinamide (TFNA-AM) is a metabolite of Flonicamid (F405710); a novel insecticide with rapid inhibitory effect against aphid feeding.<br>References Chen, G., et al.: Sepu, 30, 555 (2012); Morita, M., et al.: Pest. Manag. Sci.,63, 969 (2007); Sabatino, L., et al.: Food. Additive. Contamin., 6, 11 (2013)<br></p>

<p>Applications An internal standard in the analysis of the rodenticide Warfarin.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dikshith, T., et al.: J. Exp. Biol., 29, 149 (1991),<br></p>

<p>Applications Maleic Hydrazide is used in plant growth regulator formulations.<br>References Calliera, M., et al.: Pest Manag. Sci., 62, 1168 (2006), Berrada, H., et al.: Food Control., 21, 36 (2010), Nougadere, A., et al.: Food Chem. Toxicol., 49, 1484 (2011),<br></p>

<p>Applications (±)-Mianserin-d3 HCl (methyl-d3) (CAS# 1219804-97-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications A structural derivative of Trimethoprim (T795615). A selective dihydrofolate reductase inhibitor; diaminopyridine antibacterial agent.<br>References Thomson, C.J. et al.: J. Chemother., 5, 458 (1993); Hawserl, S. et al.: Biochem. Pharmacol., 71, 941 (2006); Conforti, A. et al.: Br. J. Clin. Pharmacol., 44, 411 (1997);<br></p>

<p>Applications A labelled metabolite of Estradiol.<br>References Bucala, R., et al.: J. Clin. Endocrinol. Metab., 60, 841 (1985), Telang, N., et al.: Anticancer Res., et al.: 11, 1021 (1991), Seeger, H., et al.: Med. Sci. Res., 26, 481 (1998), Bolton, J., et al.: Chem. Res. Toxicol., 13, 135 (2000),<br></p>

<p>Applications Nilotinib (AMN1O7) might be useful in treatment of chronic myelogenous leukemia. It is a COVID19-related research product.<br>References Corbin, A., et al.: J. Biol. Chem., 277, 32214(2002), Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005), Gleixner, K., et al.: Blood, 107, 752 (2006), Nicolini, F., et al.: Leukemia, 20, 1061 (2006),<br></p>

<p>Applications An acylamino acid fungicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ravelo-Perez, L., et al.: Food Chem., 111, 764 (2008), Wong, J., et al.: J. Agric. Food Chem., 58, 5897 (2010),<br></p>

<p>Applications 4-Dimethylaminosulfotoluidide is an intermediate in the synthesis of Tolylfluanide (T536730), a polyvalent sulfamide fungicide that is closely related to dichlofluanide.<br>References Wainwright, A. et al.: Bright. Crop Prot. Conf. Pests Dis., 1, 275 (1996)<br></p>

<p>Applications Flufenacet is an anilide based herbicide that is applied to the soil surface or incorporated before the crop is emerged. Flufenacet is often used in field corn, corn grown for silage or soybeans to control annual grasses and broadleaf weeds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hulting, A.G., et al.: Weed. Technol., 26, 230 (2012); Bailly, G.C., et al.: Crop Protect., 34, 96 (2012);<br></p>

<p>Applications Glycochenodeoxycholic Acid Sodium Salt is a bile salt formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic.<br>References Ollila, F., et al.: Langmuir, 17, 7107 (2001); Uekama, K., et al.: Chem. Pharm. Bull., 52, 900 (2004); Tongiani, S., et al.: J. Pharm. Sci., 94, 2380 (2005)<br></p>

<p>Applications Difluoroacetic acid<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Endosulfan Sulfate is a pesticide used in the control and protection of plant and vegetation. Endosulfan Sulfate is useful in cannabis testing kits as a component of pesticide mixes (P698230).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Weston, D. et al.: Env. Sci. Tech., 38, 2752 (2004); Antonious, G. et al.: Env. Tox. Chem., 16, 644 (1997);<br></p>

<p>Applications Labelled Bifenthrin (B383000). Third generation synthetic pyrethroid. Insecticide, acaricide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Plummer, E.L., et al.: Pestic. Sci., 14, 560 (1983), Trumble, J.T., et al.: J. Econ. Entomol., 81, 608 (1988), Ross, M., et al.: Biochem. Pharmacol., 71, 657 (2006), Hillegass, J., et al.: Toxicol. Sci., 102, 413 (2008),<br></p>

<p>Applications Diphenyl Phosphate is an organophosphate diester and metabolite of the flame retardant Triphenyl Phosphate (T808990) and also a metabolite of 2-Ethylhexyl diphenyl phosphate.<br>References Cooper, E.M. et al.: Anal. Bioanal. Chem., 401, 2123 (2011); Nishimaki-Mogami, T. et al.: Arch. Toxicol., 61, 259 (1988);<br></p>

<p>Applications Boscalid is a fungicide belonging to the class of carboxamides. Boscalid acts by inhibiting spore germination, germ tube elongation and is also effective on all other stages of fungal development. Boscalid is used in the agriculture to protect crops from gray mold, powdery mildew and other fungus. Used in Pesticide detection. Boscalid is useful in cannabis testing kits as a component of pesticide mixes (P698235).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yan, F. et al.: Nongyao, 47, 132 (2008); Lozowicka, B. et al.: Prog. Plant Prot., 48, 1211 (2008); Stammler, G. et al.: Int. Plant Prot. Cong. Proc. 16th Glas. U.K., 1, 40 (2007);<br></p>

<p>Impurity Dexamethasone Sodium Phosphate EP Impurity B<br>Stability Hygroscopic<br>Applications Betamethasone 21-Phosphate Disodium Salt (Dexamethasone Sodium Phosphate EP Impurity B) is a Betamethasone derivative. It is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties which can be used in treatment of asthma and itching.<br>References Kerns, E., et al.: J. Pharm. Sci., 90, 1838 (2001), Seidler, J., et al.: J. Med. Chem., 46, 4477 (2003), Alsenz, J., et al.: J. Pharm. Sci., 96, 1748 (2007),<br></p>

<p>Stability Hygroscopic<br>Applications Antipsychotic.<br>References Schafer, E.W., et al.: Toxicol. Appl. Pharmacol., 21, 315 (1972),<br></p>

<p>Applications Metolachlor OA is a derivative of Metolachlor (M338700), a selective pre-emergence herbicide. Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br>References 1. McGahen, L. et al.: J. Agric. Food Chem. 1978 26 (2), pp 414–4192. Chesters, G. et al.: Rev. Environ Contam Toxicol. 1989;110:1-74.<br></p>

<p>Applications A Phenothiazine (P318040) analog. Antipsychotic.<br>References Sartorelli, A.C., et al.: Experientia, 21, 457 ( 1965),<br></p>

<p>Applications Labelled Clopidogrel, an antithrombotic.<br>References Mills, D.C.B., et al.: Arterioscler. Thromb., 12, 430 (1992), Feuerstein, G., et al.: Exp. Opin. Invest. Drugs, 4, 425 (1995)<br></p>

<p>Applications Orally active inhibitor of central and peripheral catechol-O-methyltransferase (COMT). Antiparkinsonian.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dingemanse, J., et al.: Clin. Pharmacol. Ther., 57, 508 (1995), Keating, K.A., Drugs, 19, 165 (2005),<br></p>

<p>Applications (-)-Hycosamine-d3, is the labeled analogue of (-)-Hycosamine (H674300), a natural compound that has inhibitory activity against cholinesterases.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Brunhofer, G. et al.: Bioorg. Med. Chem., 20, 6669 (2012);<br></p>

<p>Impurity Efavirenz USP Related Compound B<br>Applications (E)-Dihydro Efavirenz (Efavirenz USP Related Compound B) is an impurity of the nonnucleoside HIV-1 reverse transcriptase inhibitor Efavirenz (E425000).<br>References Weissburg, R.P. et al.: J. Pharmac. Biomed. Anal., 28, 45 (2002); Ribeiro, J.A.A. et al.: J. Pharmac. Biomed. Anal., 43, 298 (2007);<br></p>

<p>Applications Antibacterial.<br>References Manius, G.J., et al.: Anal. Profiles Drug Subs., 7, 445 (1978), Roth, B., et al.: J. Med. Chem., 23, 379 (1980), Brogden, R.N., et al.: Drugs, 23, 405 (1982),<br></p>

<p>Applications Antineoplastic; one derivative of cyclophosphamide (NSC-26271).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Potel, J., et al.: Arzneim.-Forsch., 21, 1250 (1971), Bria, E., et al.: Cancer Treat. Rev., 32, 583 (2006), Faivre, S., et al.: J. Clin. Oncol., 24, 25 (2006).<br></p>

<p>Applications Methotrexyl-N’-biotinylethylenediamine is a compound useful in organic synthesis.<br></p>

<p>Applications It is a peroxisome proliferator-activated receptor (PPAR) α/γ dual agonist.<br>References Barlocco, D., et al.: Curr. Opin. Invest. Drugs, 6, 427 (2005), Devasthale, P.V., et al.: J. Med. Chem., 48, 2248 (2005), Kendall, D.M., et al.: Diabetes care, 29, 1016 (2006),<br></p>

<p>Applications 17beta-Estradiol-16,16,17-d3 3-Benzoate (CAS# 1192354-74-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications A stable labelled selective HIV protease inhibitor Ritonavir (R535000). It is a COVID19-related research product.<br>References Daluge, S., et al.: Antimicrob. Agents Chemother., 38, 1590 (1994), Ammaranond, P., et al.: J. Clin. Virol., 26, 153(2003), Harrigan, P., et al.: J. Infect. Dis., 191, 339 (2005), Miller, J., et al.: Bioorg. Med. Chem. Lett., 16, 1788 (2006)<br></p>

<p>Applications A metabolite of Levofloxacin.<br>References Sudo, K., et al.: Xenobiotica, 16, 72 (1986), Wong, F., et al.: Drug Metab. Dispos., 18, 1103 (1990), Aminimanizani, A., et al.: J. Clin. Pharmacokinet., 40, 169 (2001), Athamna, A., et al.: J. Antimicrob. Chemother., 53, 247 (2004), Tanaka, M., et al.: J. Pharmacol., 56, 463 (2004),<br></p>

<p>Impurity Azithromycin EP Impurity B<br>Applications Azithromycin B (Azithromycin EP Impurity B), is an impurity of Azithromycin (A927000), a semi-synthetic macrolide antibiotic, and related to Erythromycin A.<br>References Langtry, H.D., et al.: Drugs, 56, 273 (1998),<br></p>

<p>Applications Bictegravir, is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.<br>References Tsiang M. et al.: Antimicrob Agents Chemother. 2016 Nov 21;60(12):7086-7097;<br></p>

<p>Applications A metabolite of Tapentadol (T007200).<br>References Terlinden, R., et al.: Eur. J. Drug Metab. Pharmacokinet., 32, 163 (2007), Tzschentke, T., et al.: J. Pharmacol. Exp. Ther., 323, 256 (2007), Wade, W., et al.: Clin. Ther., 31, 2804 (2009),<br></p>

<p>Impurity Norethindrone EP Impurity D<br>Applications Norethynodrel (Norethindrone EP Impurity D) is a progestin used in Enovid, an oral contraceptive, also used in the treatment of endometriosis and hypermenorrhea.<br>References Palmer K., et al.: J. Pharmacol. Exp. Ther., 167, 207 (1969), Liu, L., et al.: Endocrinology., 151, 5782 (2010), Sonneveld, E., et al.: Toxicol. in Vitro, 25, 545 (2011)<br></p>

<p>Applications (9Z,12E)-Tetradecadien-1-yl Acetate is a sex pheromone component of Noctuidae in Antilles.<br>References Renou, M., et al.: Colloques - Institut National de la Recherche Agronomique, 46, 21 (1988); Teal, P. E. A., et al.: J. Chem. Ecol., 11, 717 (1985); Tamaki, J., et al.: Dokl. Soobshch. - Mezhdunar. Kongr. Zashch., 5, 132 (1975)<br></p>

<p>Stability Light Sensitive<br>Applications Second generation tetracycline antibiotic. This compound has neuroprotective properties.<br>References Zbinovsky, V., et al.: Anal. Profiles Drug Subs., 6, 323 (1977), Oringer, R.J., et al.: J. Periodontol., 73, 835 (2002),<br></p>

<p>Impurity Cefuroxime Sodium EP Impurity A<br>Stability Hygroscopic<br>Applications Descarbamoyl Cefuroxime (Cefuroxime Sodium EP Impurity A) is a degradation product of Cefuroxime, and an intermediate for the synthesis of Cephalosporin antibiotics<br>References Nomura, H., et al.: J. Med. Chem., 17, 12 (1974), Takaya, T., et al.: J. Antibiotics, 34, 1300 (1981), Wang, D., et al.: J. Pharm. Sci., 83, 577 (1994), Okamoto, Y., et al.: J. Pharm. Sci., 85, 985 (1996),<br></p>

<p>Applications A classical β-adrenergic agonist in retina in interlaboratory study.<br>References Horwitz, W., et al.: Anal. Chem., 54, 67 (1982), Gowik, P., et al.: Analyst, 125, 1103 (2000),<br></p>

<p>Applications Labelled Levamisole. Biological response modifier with anthelmintic activity. Anthelmintic (nematodes); immunomodulator.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Thienpoint, D., et al.: Nature, 209, 1084 (1966), Bullock, M.W., et al.: J. Med. Chem., 11, 169 (1968), Miller, M.J., et al.: Drugs, 20, 122 (1980), Stevenson, H.C., et al.: J. Clin. Oncol., 9, 2052 (1991), Amery, W.K., et al.: Int. J. Immunopharmacol., 14, 481 (1992),<br></p>

<p>Applications Controlled substance (depressant). Sedative; hypnotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Horwitz, et al.: Drug Metab. Dispos., 8, 77 (1980),<br></p>

<p>Applications An echinocandin that inhibits the synthesis of β (1,3)-D-glucan, an integral component of the fungal cell wall. An antifungal drug used in the treatment of invasive fungal infections.<br>References Sandhu, P. et al.: Antimicrob. Agents Chemorther., 48, 1272 (2004); Bertsche, T. et al.: Pharamaz. Zeit., 148, 34 (2003); Hoang, A.: Am. J. Health-Sys. Pharm., 58, 1206 (2001);<br></p>

<p>Applications Labelled Efavirenz (E42500). A nonnucleoside HIV-1 reverse transcriptase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995),<br></p>

<p>Applications Pyribenzoxim can be used in biological study of production of acetolactate synthase inhibitor herbicide tolerant Brassica napus mutants.<br>References Ruiter, R., et al.: U.S. Pat. Appl. Publ., US 20150089682 A1 20150326 (2015)<br></p>

<p>Stability Hygroscopic<br>Applications A medicinal agent for treating viral infections.<br>References Chiou, W., et al.: J. Pharm. Sci., 60, 1281 (1971), Ford, J., et al.: J. Pharm. Pharmacol., 31, 726 (1979), Tamblyn, S., et al.: Eur. J. Epidemiol., 10, 503 (1994), Suzuki, H., et al.: Chem. Pharm. Bull., 45, 1688 (1997),<br></p>

<p>Applications Labelled Entecavir. An oral antiviral drug used in the treatment of hepatitis B infection. A guanine analogue that inhhibits all three steps in the viral replication process.<br>References Innaimo, S.F., et al.: Antimicrob. Agents Chemother., 41, 1444 (1997), Honkoop, P., et al.: Expert Opin. Invest. Drugs, 12, 683 (2003), Chang, T.-T., et al.: N. Engl. J. Med., 354, 1001 (2006),<br></p>

<p>Applications Albendazole Sulfoxide-d7 is the isotope labelled metabolite of Albendazole (A511620), an anthelmintic agent.<br>References Dominguez, L., et al.: Farmaco, 50, 697 (1995), De Laurentis, N., et al.: Pharm. Pharmacol Lett., 6, 2: 51 (1996)<br></p>

<p>Applications A nitrogenous compound from octopus muscles. It is used for producing seasoning and food additive.<br>References Brown, A., et al.: J. Gen. Microbiol., 72, 589 (1972), Larher, F., et al.: Plant Physiol. Biochem., 41, 657 (2003),<br></p>

<p>Applications N-(Carboxymethyl)amphetamine Hydrochloride is a synthetic amphetamine-class analyte with potential pharmaceutical properties.<br>References Seiler, N. et al.: Tetrahedron Lett., 38, 4603 (1966);<br></p>

<p>Applications Ondansetron is a specific serotonin (5-HT3) receptor antagonist. Antiemetic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kris, M.G., et al.: J. Clin. Oncol., 6, 659 (1988); Faris, P..L., et al.: Lances, 355, 792 (2000)<br></p>

<p>Stability Hygroscopic<br>Applications Labelled analogue of 3-Hydroxykynurenine is a metabolite of tryptophan. 3-Hydroxykynurenine filters UV light in the human lens. Studies suggest that Hydroxykynurenine is an endogenous oxidative stress generator and a potential endogenous neurotoxin.<br>References Malina, H.Z. et al.: Graefes. Arch. Clin. Exp. Ophthalmol., 233, 38 (1995); Okuda, S. et al.: J. Neurochem., 70, 299 (1998);<br></p>

<p>Applications Chlordimeform is an unique insecticide and acaricide. It displays synergistic effects and was detected in Spanish commercial beeswax.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ahmed, M.A.I., et al.: J. Med. Entomol., 49, 1405 (2012); Serra-Bonvehi, J., et al.: Pest Manag. Sci., 66, 1230 (2010)<br></p>

<p>Applications Fungicide. Antimicrobial agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Oestman, M. et al.: Sci. Total Env., 649, 1117 (2019);<br></p>

<p>Impurity Clarithromycin EP Impurity H/ Erythromycin EP Impurity L<br>Applications N-Demethyl-N-formylclarithromycin (Clarithromycin EP Impurity H) is an impurity of the semi-synthetic macrolide antibiotic Clarithromycin (C559750).<br>References Chen, X. et al.: Zhong. Yao., 17, 32 (2008);<br></p>

<p>Impurity Abacavir - In House Impurity<br>Applications Abacavir Sulfate (Abacavir - In House Impurity) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.<br>References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)<br></p>

<p>Applications An antimalarial.<br>References Natarajan, L., et al.: Arzneim.-Forsch., 22, 1230 (1972), Kracmer, J., et al.: Pharmazie, 29, 773 (1974), Ahmad, I., et al.: Anal. Profiles Drug Subs., 21, 43 (1992),<br></p>

<p>Applications A fat-metabolism stimulator. Antioxidant.<br>References Plotzker, R., et al.: Am. J. Med. Sci., 283, 79 (1982), Evans, J., et al.: Diabetes Technol. Ther., 2, 401 (2000), Konrad, D., et al.: Diabetes, 50, 1464 (2001), Lockhart, B., et al.: Brain Res., 855, 292 (2000),<br></p>

<p>Applications 1-Decanol is a long chain alcohol that has been seen to enhance homomeric glycine receptor function. In addition, the 5HT2α receptors were inhibited by the presence of 1-decanol. This action has many psychological repercussions on an individual.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mascia, M. et al.: Brit. J. Pharm., 119, 1311 (1996); Minami, K. et al.: J. Pharm. Exp. Ther., 281, 1136 (1997);<br></p>

<p>Applications Analgesic, antipyretic, anti-inflammatory.<br>References Tubaro, E., et al.: Arzneim.-Forsch., 20, 1024 (1970),<br></p>

<p>Applications 3-Desmethyl Trimethoprim is a metabolite of Trimethoprim (T795615); an antibacterial agent that is commonly prescribed in conjunction with Sulfametoxazole (S699086) to treat patients afflicted with urinary tract infections. 3-Desmethyl Trimethoprim gets excreted in the urine of rats, dogs, and man in the form of glucuronides.<br>References Roth, B., et al.: J. Med. Chem., 24, 933 (1981); Liu, Z., et al.: Biomed. Chromatogr., 26, 1101 (2012); Schwartz, D. E., Arzneimittel-Forsch., 20, 1867 (1970)<br></p>

<p>Applications High-ceiling loop diuretic; structurally related to Bumetanide (B689550). Diuretic.<br>References Merkel, W., et al.: Eur. J. Med. Chem., 11, 399 (1976), Pozet, N., et al.: Br. J. Clin. Pharmacol., 9, 577 (1980), Clissold, S.P., et al.: Drugs, 29, 489 (1985),<br></p>

<p>Impurity Doxycycline EP Impurity C<br>Stability Light Sensitive, Unstable in Solution<br>Applications An alternative to doxycycline to control gene expression.<br>References Schiffer, I., et al.: Cancer Res. 63, 7221 (2003) , Eger, K. , et al.: Biochem. Biophys. Res. Comm., 323, 979, (2004).<br></p>

<p>Applications A major metabolite of Zolpidem.<br>References Crestani, F., et al.: Br. J. Pharmacol., 131, 1251 (2000), Li, Q., et al.: Bioorg. Med. Chem. Lett., 12, 465 (2002), Goulle, J., et al.: Ther. Drug Monit., 26, 206 (2004), Ohkanda, J., et al.: J. Med. Chem., 47, 432 (2004), Blackaby, W., et al.: Bioorg. Med. Chem. Lett., 16, 1175 (2006),<br></p>

<p>Applications Aclonifen-d5, is the labeled analogue of Aclonifen, which is used as a pesticide and herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Laini, A., et al.: Sci. Total Environ., 438, 312 (2012); Fantke, P., et al.: Enviorn. Int., 49, 9 (2012);<br></p>

<p>Stability Hygroscopic<br>Applications Pancratistatin acts as an anti-cancer compound that initiates cell-death in cancer cells.<br>References McLachlan, A. et al.: Apoptosis, 10, 619 (2005);<br></p>

<p>Applications Clopidogrel derivative. It is used as internal standard.This compound is a single pair of enantiomers but the relative stereochemistry is unknown.<br>References Savi, P., et al.: Biochem. Pharmacol., 44, 527 (1992), Pereillo, J., et al.: Drug Metab. Dispos., 30, 1288 (2002), Ksycinska, H., et al.: J. Pharm. Biomed. Anal., 41, 533 (2006), Farid, N., et al.: Clin. Pharmacol. Ther., 81, 735 (2007),<br></p>

<p>Applications Deuterated Mycopheolate Mofetil, an immunosuppressant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lee, W.A., et al.: Pharm. Res., 7, 161 (1990), Bullingham, R.E.S., et al.: Transplant. Proc., 28, 925 (1996), Keown, P.A., et al.: Transplantation, 61, 1029 (1996),<br></p>

<p>Stability Moisture Sensitive<br>Applications Tetramethylphosphorodiamidic Fluoride is a type of pesticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hayat, K., et al.: Afr. J. Environ., 4, 666 (2010)<br></p>

<p>Applications A nootropic drug that produced a significant increase in β-wave activity and stimulated α-wave activity dose-dependently. It has been used in studies to alleviate the effects of memory retrieval deficits in rats.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sara, S.J.: Psychopharmacology, 68, 235 (1980); Wolthuis, O.L.: Pharamacol. Biochem. Behav., 15, 247 (1981); Saletu, B. et al.: Prog. Neuro-Psychopharmacol., 4, 469 (1980);<br></p>

<p>Applications 1,1,3,3,5,5,7,7,9,9,11,11-DODECAMETHYLHEXASILOXANE (cas# 995-82-4) is a useful research chemical.<br></p>

<p>Applications 3-O-(E)-Feruloylquinic Acid is a phenolic acid with potential antioxidant and antifungal activities. Secondary metabolite in the coffee brewing process.<br>References Dzamic, A. et al.: Ind. Crop. Prod., 51, 407 (2013); Stalmach, A. et al.: Food. Func., 5, 1727 (2014); Matei, M. et al.: J. Agri. Food Chem., 60, 12105 (2012); Dokli, I. et al.: Tetrahedron Asymm., 24, 785 (2013);<br></p>

<p>Applications An antibacterial.<br>References Bauernfeind, A.: J. Antimicro. Chemother., 40, 639 (1997), Fukuda, H., et al.: Antimicrob. Ag. Chemother., 42, 1917 (1998),<br></p>

<p>Applications Labelled Dimethomorph (D460530). Agricultural fungicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lu, X., et al.: Phytopathol., 100, 1162 (2010), Schafer, R., et al.: Environ. Sci. Technol., 45, 1665 (2011),<br></p>

<p>Stability Light Sensitive, Temperature Sensitive<br>Applications Xanthophyll is one of the most widespread carotenoid alcohols in nature. Originally isolated from egg yolk, also isolated by chromatography from nettles, algae, and petals of many yellow flowers.<br>References van het Hof, K., et al.: J. Nutr., 130, 503 (2000), Cooper, D., et al.: J. Nutr., 134, 221S (2004), Faulks, R., et al.: Biochim. Biophys. Acta, 1740, 95 (2005), Rao, A., et al.: Pharmacol. Res., 55, 207 (2007), Tuberoso, C., et al.: Food Chem., 103, 149 (2007),<br></p>

<p>Stability Hygroscopic<br>Applications Plerixafor is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). This agent was approved on Dec. 15, 2008, as treatment in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM). Selective CXCR4 antagonist.<br>References Xie, T., et al.: Science, 290, 328 (2000), Leone, D., et al.: J. Pharmacol. Exp. Ther., 305, 1150 (2003), Chigaev, A., et al.: J. Immunol. 178, 6828 (2007), Kiel, M., et al.: Cell Stem Cell, 1, 204 (2007),<br></p>

<p>Applications Bisphenol AF-13C12 is the isotope labelled analog of Bisphenol AF (2,2-Bis-(4-hydroxyphenyl)hexafluoropropane). 2,2-Bis-(4-hydroxyphenyl)hexafluoropropane acts as an endocrine-disrupting chemical (EDC), activating estrogen through the estrogen receptor ERα. It is a full agonist for the estrogen receptor.<br>References Matsushima, A. et al.: Environ. Health, Perspect. 118, 1267 (2010);<br></p>

<p>Applications A labelled form of Ethoprophos (E890530), which is an organophosphate non-systemic nematicide and soil insecticide.<br>References Lehotay, S. J.; Chromatographia (2018).<br></p>

<p>Stability Unstable in Solution<br>Applications Iodosulfuron is a weed management herbicide used in crop protection.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bro, E. et al.: Sci. Total Env., 521, 315 (2015); Gandy, M. et al.: Org. Biomol. Chem., 13, 5586 (2015);<br></p>

<p>Applications An antipsychotic.A representative lot was 92% d8, 8% d7.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Stille, et al: Farnaco, Ed. Prat., 26, 603 (1971), Hane, J.M., et al.: Psychopharmacol. Bull., 24, 62 (1988), Meltzer, H.Y.: J. Clin. Psychiatry, 55, Suppl. B, 47 (1994)<br></p>

<p>Impurity Ondansetron EP Impurity E / Clotrimazole EP Impurity D<br>Applications Imidazole (Ondansetron EP Impurity E) is a versatile heterocycle used in the preparation of various biologically active compounds such as the amino acid histidine and is present in many antifungal medication. It is also used extensively as a corrosion inhibitor on transition metals such as copper.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Arispe, N. et al.: Biophys. J., 95, 4879 (2008); Troesken, E.R. et al.: Endo. Res., 30, 387 (2004); Otmacic Curkovic, H. et al.: Corr. Sci., 51, 2342 (2009);<br></p>

<p>Stability Hygroscopic<br>Applications Pizotifen Malate is an anti migraine drug.<br>References Serna-Jimenez. et al.,Int. J. Pharm. 492, 223-232(2015);<br></p>

<p>Applications Flutriafol is a systemic fungicide of the triazole class. Flutriafol has broad spectrum fungicidal activity and is used to control effectively cereal powdery mildew, cloud disease, leaf spot disease and rust disease.<br>References Gozzo, F. et al.: Pest. Biochem. Physiol., 40, 68 (1991); Cao, W. et al.: Jing. Huag. Zhong., 36, 33 (2006); Evans, V.J. et al.: BCPC Conf. Pests Dis., 1, 511 (2000);<br></p>

<p>Impurity Levofloxacin Descarboxy Impurity<br>Applications A degradation product of Levofloxacin (L360000).<br>References Wong, F., et al.: J. Pharm. Biomed. Anal., 15, 765 (1997), Singh, G., et al.: Pharmazie, 43, 134 (1988), Radi, A., et al.: Talanta, 58, 319 (2002),<br></p>