Toxicología

<p>Applications Selective inhibitor of phosphodiesterase V (PDE 5); potent coronary vasodilator drug; adenosine transport inhibitor; inhibitor of platelet aggregation.A representative lot was: 36% d20; 25% d19; 13%d18; 24% d17; 1% d16.<br>References Buchalter, M.B., et al.: Postgrad. Med. J., 66, 531 (1990), Sundaram, M., et al.: J. Biol. Chem., 273, 21519 (1998), Denis, D., et al.: Eur. J. Pharmacol., 367, 343 (1999),<br></p>

<p>Applications 4-(Trifluoromethyl)nicotinamide (TFNA-AM) is a metabolite of Flonicamid (F405710); a novel insecticide with rapid inhibitory effect against aphid feeding.<br>References Chen, G., et al.: Sepu, 30, 555 (2012); Morita, M., et al.: Pest. Manag. Sci.,63, 969 (2007); Sabatino, L., et al.: Food. Additive. Contamin., 6, 11 (2013)<br></p>

<p>Applications A labelled metabolite of Estradiol.<br>References Bucala, R., et al.: J. Clin. Endocrinol. Metab., 60, 841 (1985), Telang, N., et al.: Anticancer Res., et al.: 11, 1021 (1991), Seeger, H., et al.: Med. Sci. Res., 26, 481 (1998), Bolton, J., et al.: Chem. Res. Toxicol., 13, 135 (2000),<br></p>

<p>Applications Ancymidol is a growth retardant found in plants. It affects a gibberellin-induced growth response, most likely by inhibiting gibberellin biosynthesis.<br>References Shive Jr., J.B., Sisler, H.D., Plant Physiol., 57, 640-644 (1976)<br></p>

<p>Applications O-Des-(2,2-methylbutyryl) Spirodiclofen is a metabolite of Spirodiclofen (S682990) in animals and plants. Spirodiclofen is a tetronic acid acaricide used in controlling red mites.<br>References Demaeght, P., et al.: Insect Biochem. Molec., 43, 544 (2013); Koester, J.: Pflanzenschutz-Nachrichten Bayer, 55, 237 (2002); Rauch, N., et al.: Pestic. Biochem. Phys., 74, 91 (2003)<br></p>

<p>Applications An oral antiviral drug used in the treatment of hepatitis B infection. A guanine analogue that inhhibits all three steps in the viral replication process.<br>References Innaimo, S.F., et al.: Antimicrob. Agents Chemother., 41, 1444 (1997), Honkoop, P., et al.: Expert Opin. Invest. Drugs, 12, 683 (2003), Chang, T.-T., et al.: N. Engl. J. Med., 354, 1001 (2006),<br></p>

<p>Applications Pyflubumide is an acaricide used in the control of phytophagous mites.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhang, Y.: Shijie Nongyao, 38, 15 (2016), Furuya, T., et al.: J. Pest. Sci. , 40, 38 (2015), Van L., et al.: Pest. Biochem. Physiol., 121, 12 (2015)<br></p>

<p>Applications Disodium Salt of 3-Methylphosphinicopropionic Acid, the major metabolite of Glufosinate (G596950), used as herbicide.<br>References Royer, A., et al.: Anal. Chem., 72, 3826 (2000), Muller, B., et al.: Pestic. Manag. Sci., 57, 46 (2001), Duke, S., et al.: J. Agric. Food Chem., 51, 340 (2003),<br></p>

<p>Applications Labelled Neratinib (N390090). An oral, irreversible dual EGFR/HER2 inhibitor for breast and non-small cell lung cancer. Antitumor agent.<br>References Vogel, C., et al.: J. Clin. Oncol., 20, 719 (2002), Ji, H., et al.: Cancer Cell., 9, 485 (2006), Sequist, L., et al.: Oncologist, 12, 325 (2007),<br></p>

<p>Applications 2-Isopropyl-6-methyl-4-pyrimidone, is an intermediate used for the synthesis of various benzophenone derivatives, having antifungal and antibacterial activities. It can also be used for the synthesis of Diazinon (D416880), and Diazoxon (D416890), the organophosphate insecticides.<br>References Sun, L., et al.: Molecules, 16, 9739 (2011); Pasti, T. L., J. Environ. Protect. Ecology, 12, 1168 (2011);<br></p>

<p>Applications Clindamycin is a semi-synthetic antibiotic. Antibacterial.<br>References Birkenmeyer, R.D., et al.: J. Med. Chem., 13, 616 (1970); Oesterling, et al.: J. Pharm. Sci., 59, 63 (1970); Gray, J.E., et al.: Toxicol. Appl. Pharmacol., 21, 516 (1972); Brown, L.W., et al.: Anal. Profiles Drug Subs., 10, 75 (1981);<br></p>

<p>Applications Bendiocarb is a benzodioxolyl carbamate derivative. Bendiocarb is commonly used as an insecticide in agriculture against a wide range of pests and insects. Bendiocarb is one of the insecticides recommended by world health organization (WHO) for use in malaria control.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sadasivaiah, S. et al.: Am. J. Trop. Med. Hyg., 77, 249 (2007); Brooker, P. J. et al.: Pest. Sci., 3, 735 (1972);<br></p>

<p>Applications Promecarb-d3 is the isotope labelled analog of Promecarb (P756500); a carbamate pesticide.<br>References Knowles, C.O., et al.: B. Environ. Contam. Tox., 27, 529 (1981); Pacioni, N.L., et al.: Anal. Chim. Acta, 583, 63 (2007); Sanchez, F.G., et al.: Analyst, 116, 851 (1991)<br></p>

<p>Applications A structural derivative of Trimethoprim (T795615). A selective dihydrofolate reductase inhibitor; diaminopyridine antibacterial agent.<br>References Thomson, C.J. et al.: J. Chemother., 5, 458 (1993); Hawserl, S. et al.: Biochem. Pharmacol., 71, 941 (2006); Conforti, A. et al.: Br. J. Clin. Pharmacol., 44, 411 (1997);<br></p>

<p>Applications 1,2,4,5-Tetrachloro-3-nitrobenzene, is a metabolite of pentachloronitrobenzene (P237990), used as fungicide, and pesticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Renner, G., et al.: Appl. Envi. Miroc., 46, 465 (1983);<br></p>

<p>Stability Hygroscopic<br>Applications A labelled metabolite of Mycophenolic Acid, an antibiotic produced by Penicillium brevi-compactum, P. Stoloniferum and related spp. A selective inhibitor of lymphocyte proliferation by blocking inosine monophosphate dehydrogenase, an enzyme involved in the de novo synthesis of purine nucleotides.<br>References Senda, M., et al.: Transplantation, 60, 1143 (1995), Nimmesgern, E., et al.: J. Biol. Chem., 271, 19421 (1996), Gummert, J.F., et al.: J. Pharmacol. Exp. Ther., 291, 1100 (1999),<br></p>

<p>Applications Labelled Astemizole. Nonsedating-type histamine H1-receptor antagonist. Potential for combination therapy with antivancer drugs such as doxorubicin in resistant leukemia. Antihistaminic.<br>References Wauquier, A., et al.: Eur. J. Pharmacol., 72, 245 (1981), Laduron, P.M., et al.: Mol. Pharmacol., 21, 294 (1982), Richards, D.M., et al.: Drugs, 28, 38 (1984), Al-Obaid, A.M., et al.: Anal. Profiles Drug Subs., 20, 173 (1991), Ishikawa, M., et al.: Biol. Pharm. Bull., 23, 112 (2000),<br></p>

<p>Applications Potassium channel blocker.<br>References Carmeliet, D., et al.: J. Pharmacol. Exp. Ther., 262, 809 (1992), Norgaard, B.L., et al.: Am. Heart J., 137, 1062 (1999), Torp-Pedersen, C., et al.: N. Engl. J. Med. 341, 857 (1999)<br></p>

<p>Applications Flavokavain B is a secondary metabolite of the kava plant (Piper methysticum Forst. f., Piperaceae, which has anticancer properties and demonstrated oral efficacy in murine cancer models.  Futhermore, it also has suspected roles in rare cases of kava-induced hepatotoxicity. In addition, it is a potential candidate for the development of novel antifungal phytotherapic products.<br>References Pinner, K. D., et al.: Pharmaceutical Biology (Abingdon, United Kingdom), 54, Epub ahead of print (2016); Rowe A., et al.: Phytotherapy Research, 26, 1768 (2012); Alves dos Santos, R., et al.: Journal of Chemistry, (2013)<br></p>

<p>Applications 1,4-Dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester has been studied as a novel influenza endonuclease inhibitor. They also function as high-affinity ligands at the benzodiazepine site of brain GABAA receptors.<br>References Baughman, B. et al.: ACS. Chem. Biol., 7, 526 (2012); Gaurav, A. et al.: Medicin. Chem. Res., 20, 192 (2011);<br></p>

<p>Stability Hygrscopic<br>Applications Emtricitabine Tenofovir Monosoproxil is a derivative of Emtricitabine (E525000). Emtricitabine is a reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner.<br>References FASEB J., 13, 1511 (1999), Molina, J.-M., et al.: J. InfecSchinazi, R.F., et al.: Antimicrob. Ag. Chemother., 36, 2423 (1992), Shockeor, J.P., et al.: Xenobioica, 26, 189 (1996), Feng, J.Y., et al.: . Dis., 182, 599 (2000)<br></p>

<p>Stability Sample is unstable in solution<br>Applications Erythromycin A N-oxide is a facile metabolite of erythromycin A.<br></p>

<p>Applications Foramsulfuron is used in weed control practises in reduced tillage production. It also functions as a new herbicide with ALS-inhibiting active ingredient for the control of troublesome weeds in sugar beet.<br>References Wendt, M. J., et al.: Weed Res., 57, 267 (2017); Isik, D., et al.: Phytoparasitica, PagesAhead of Print (2017)<br></p>

<p>Stability Hygroscopic<br>Applications A labelled serotonin 5-HT2A receptor antagonist. Used as potential controls in various biological studies.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wong, D.F., et al.: Science, 226, 1393 (1984), Blin, J., et al.: Eur. J. Pharmacol., 147, 73 (1988), Kehne, J.H., et al.: J. Pharmacol. Exp. Ther., 277, 968 (1996),<br></p>

<p>Applications Acriflavine is an topical antiseptic agent and has also been used for the treatment of external fungal infections. Dyes and metabolites.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Weisman, J.L., et al.: Chem. Biol. Drug. Des., 67, 409 (2006); Sala, C., et al.: Antimicro. Agents. Chemother., 54, 4150 (2010);<br></p>

<p>Impurity Doxycycline Related Compound A<br>Stability Hygroscopic, Light Sensitive, Temperature Sensitive<br>Applications 6-Epi Doxycycline is an antibiotic used in the treatment of bacterial and certain parasitic infections. Doxycycline Related Compound A<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jutglar, M., et al.: J. Pharm. Biomed. Anal., 159, 60 (2018); Metsemakers, W., et al.: J. Control. Release, 209, 47 (2015)<br></p>

<p>Applications Strobilurin fungicide; inhibits mitochondrial respiration by blocking electron transfer between cytochromes b and c1. Agricultural fungicide. Used in Pesticide detection. Useful in cannabis testing kits as a component of pesticide mixes (P698240).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Smalling, K., et al.: Environ. Toxicol. Chem., 29, 2593 (2010), Lu, X., et al.: Phytopathol., 100, 1162 (2010), Schafer, R., et al.: Environ. Sci. Technol., 45, 1665 (2011),<br></p>

<p>Applications 1-Docosanol-d45 is the labelled form of 1-Docosanol (D678855). 1-Docosanol works as a surfactant in cosmetics. 1-Docosanol cream has also been approved by the US Food and Drug Administration as a safe and effective topical treatment for herpes labialis.<br>References Noweck, K., et al.: Ullmann's Encyclopedia of Industrial Chemistry (2006); McKeough, M., et al.: Arch. Dermatol., 137, 1153 (2001)<br></p>

<p>Applications Labelled Albendazole (A511610). An anthelmintic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhao, Y., et al.: Org. Biomol. Chem., 6, 4509 (2008), Sanderson, H., et al.: Toxicol. Lett., 187, 84 (2009),<br></p>

<p>Applications A nonsteroidal, selective estrogen receptor modulator (SERM). Antiosteoporotic.Insoluble in water.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jone, C.D., et al.: J. Med. Chem., 27, 1057 (1984), Buelke-Sam, J., et al.: Reprod. Toxicol., 12, 217 (1998),<br></p>

<p>Applications Nilotinib (AMN1O7) might be useful in treatment of chronic myelogenous leukemia. It is a COVID19-related research product.<br>References Corbin, A., et al.: J. Biol. Chem., 277, 32214(2002), Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005), Gleixner, K., et al.: Blood, 107, 752 (2006), Nicolini, F., et al.: Leukemia, 20, 1061 (2006),<br></p>

<p>Applications Triforin is an amide fungicide.<br></p>

<p>Stability Light Sensitive<br>Applications Isotope labelled S-enantiomer metabolite of tobacco, a specific N-nitrosamines with carcinogenic activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hoffmann, D., et al.: Cancer Res., 39, 2505 (1979), Hecht, S., et al.: Chem. Res. Toxicol., 11, 559 (1998), Hecht, S., et al.: Mutation. Res., 424, 127 (1999), Wang, M., et al.: Chem. Res. Toxicol., 16, 616 (2003),<br></p>

<p>Applications 3,6-Dichloro-2-hydroxybenzoic acid (cas# 3401-80-7) is a useful research chemical.<br></p>

<p>Applications Triclosan is used as bactericide and preservative for cosmetic and detergent compositions (1). Broadly used as an antiseptic and disinfectant (2).This compound is a contaminant of emerging concern (CECs). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Lindström, A. et al.: Environ. Sci. Technol. 2002 Jun 1;36(11):2322-9. 2. Ruszkiewicz, J. et al.: J. Toxicol. Environ. Health B. Crit. Rev. 2017;20(2):104-117.<br></p>

<p>Applications Labelled Dopamine. Endogenous catecholamine with α and β-adrenergic activity. Cardiotonic; antihypotensive.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Carter, J.E., et al.: Anal. Profiles Drug Subs., 11, 257 (1982), Dasta, J.F., et al.: Pharmacotherapy, 6, 304 (1986),<br></p>

<p>Applications Semisynthetic labelled Erythromycin derivative. Antibacterial.<br>References Jones, R.N., et al.: Antimicrob. Agents Chemother., 24, 209 (1983), Barry, A.L., et al.: Eur. J. Clin. Microbiol., 5, 536 (1986), Grassi, C., et al.: Chemioterapia, 6, 41 (1987),<br></p>

<p>Applications A major product formed from the photochemical reaction of Dextromethorphan (D299455) after light or sunlight exposure.<br>References Halstead, G.W., et al.: J. Pharm. Sci., 71, 1108 (1982), Koeppel, C., et al.: Arzneim.-Forsch., 37, 1304 (1987),<br></p>

<p>Impurity Ritonavir EP Impurity N<br>Applications 4-Dehydroxy-5-Hydroxy Ritonavir (Ritonavir EP Impurity N) is an impurity of the selective HIV protease inhibitor Ritonavir (R535000). It is a COVID19-related research product.<br>References Kempf, D.J. et al.: J. Med. Chem., 41, 602 (1998); Mekapati, S.B. et al.: J. Enzyme Inhib., 16, 185 (2001);<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Mosapride (M731000).<br>References Chen, H., et al.: J. Pharm. Biomed. Anal., 40, 142 (2006), Pedraglio, S., et al.: J. Pharm. Biomed. Anal., 44, 665 (2007), Christopher, L., et al.: Drug Metab. Dispos., 36, 1341 (2008), Curran, M., et al.: Drugs, 68, 981 (2008),<br></p>

<p>Applications 4-Tolyl-d4-sulfonamide is the labeled analogue of 4-Tolylsulfonamide (T536630), a carbonic anhydrase inhibitor used the synthesis of antiglaucoma and anticancer drugs.<br>References Vullo, D. et al.: Bioorg. Med. Chem. Lett., 15, 963 (2005); Vullo, D. et al.: Bioorg. Med. Chem. Lett., 15, 971 (2005);<br></p>

<p>Applications Metolachlor is an acyanilide herbicide similar to selective pre-emergence herbicides (1). It is a contaminant in the groundwater and potential pollutant (2). This compound is a contaminant of emerging concern (CECs). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br>References 1. McGahen, L. et al.: J. Agric. Food Chem. 1978 26 (2), pp 414–4192. Chesters, G. et al.: Rev. Environ Contam Toxicol. 1989;110:1-74.<br></p>

<p>Applications Carboxyformamido Metazachlor Benzoic Acid is a metabolite of Metazachlor (M225855) which is a chloroacetanilide herbicide used on vegetable crops.<br>References Hollender, J., et al.: Environ. Sci. Technol., 43, 7862 (2009); Dresen, S., et al.: Anal. Bioanal. Chem., 396, 2425 (2010); Liu, B., et al.: J. Agric. Food Chem., 58, 2673 (2010);<br></p>

<p>Applications N-Nitrosodiethylamine-d10 is a labelled form of N-Nitrosodiethylamine (N525465) which is a widely occurring nitrosamine that is one of the most important environmental carcinogens primarily inducing tumors of liver.NDMA and NDEA were found as an impurity in generic versions of valsartan, losartan and irbesartan.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Oda, Y., et al.: Mutation Research, Genetic Toxicology and Environmental Mutagenesis, 584, 1 (2005); Yamazaki, H., et al.: Carcinogenesis, 13, 1789 (1992);Chem. and Eng. News, p.5, Feb. 25, 2019<br></p>

<p>Stability Light Sensitive<br>Applications Germacrone is an antiviral isolate of Geranium macrorrhizum which inhibits and prevents early stage influenza virus infection. It also inhibits the proliferation of glioma cells by promoting apoptosis.<br>References Liao, Q. et al.: Antiviral. Res., 100, 578 (2013); Liu, B. et al.: Mol. Med. Reports., 10, 1046 (2014);<br></p>

<p>Applications A commonly used herbicide/pesticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ait-Aissa, S., et al.: Toxicol., 24, 1979 (2010),<br></p>

<p>Applications Ibudilast-d7 is the labeled analogue of Ibudilast (I125000), a leukotriene D4 antagonist. Used as an antiallergic, antiasthmatic, and vasodilator (cerebral).<br>References Nishino, K., et al.: Japan J. Pharmacol., 33, 267 (1983); Ohashi, M., et al.: Arch. Int. Pharmacodyn., 280, 216 (1986); Armstead, W.M., et al.: J. Pharmacol., Exp. Ther., 244, 138 (1988)<br></p>

<p>Applications 4-Dimethylaminosulfotoluidide is an intermediate in the synthesis of Tolylfluanide (T536730), a polyvalent sulfamide fungicide that is closely related to dichlofluanide.<br>References Wainwright, A. et al.: Bright. Crop Prot. Conf. Pests Dis., 1, 275 (1996)<br></p>

<p>Applications Elaiophylin is a macrolide antibiotic with immunosuppresive activity.<br></p>

<p>Applications Prazosin is a useful α1 and α2B-adrenoceptor antagonist.<br></p>

<p>Stability Hygroscopic<br>Applications D-(+)-2-Phosphoglyceric Acid Sodium Hydrate (cas# 70195-25-4) is a compound useful in organic synthesis.<br></p>

<p>Applications HIV protease inhibitor; water soluble prodrug of amprenavir.<br>References Falcoz, C., et al.: J. Clin. Pharmacol., 42, 887 92002), Chapman, T.M., et al.: Drugs, 64, 2101 (2004)<br></p>

<p>Applications L-Cycloserine is an irreversible inhibitor of 3-ketodihydrosphingosine synthetase.<br></p>

<p>Stability Very Hygroscopic<br>Applications A Desfuroyl Ceftiofur-related metabolite that have the potential to be microbiologic active in swine muscle, kidney, liver and fat.<br>References Gilbertson, T., et al.: J. Agric. Food Chem., 43, 229 (1995), Olson, S., et al.: Vet. Pharmacol. Therap., 21, 112 (1998), Hornish, R., et al.: Curr. Top Med. Chem., 2, 717 (2002),<br></p>

<p>Applications Pharmaceutic aid (emulsifying agent).<br>References Lewis, G., et al.: Int. J. Pharm., 3, 319 (1979); Ruelle, P., et al.: J. Pharm. Sci., 33. 396 (1994);<br></p>

<p>Applications Methylstenbolone is an anabolic androgenic steroid that have been studied in respect of testosterone-receptor interaction and in the development of QSAR models.<br>References Singh, D., et al.: J. Chem. Pharma. Rsch., 3, 1 (2011); McFarland, K., et al.: Science, 245, 494 (1989); Heckert, L., et al.: Mol. Endocrinol., 12, 1499 (1998); Themmen, A., et al.: Endocr. Rev. 21, 551 (2000); Kumar, R., et al.: Biol. Reprod., 65, 710 (2001)<br></p>

<p>Applications An intermediate of Indapamide (I500100), as bactericide, disinfectant, and antiseptic.<br>References Kumar, P., et al.: Arch. Pharma., 316, 759 (1983), Rival, Y., et al.: Eur. J. Med. Chem., 26, 13 (1991),<br></p>

<p>Applications 2-​Chloro-​N-​[4-​chloro-​2-​(2-​chlorobenzoyl)​phenyl]​acetamide is a potential anticancer agent and is used in the synthesis of 4-​Aryl-​6-​chloro-​quinolin-​2-​ones and 5-​Aryl-​7-​chloro-​1,​4-​benzodiazepines, anti-​hepatitis B virus compounds.<br>References Kamal, A., et al.: Indian Pat. Appl, IN 2007DE00698 A 20120217 (2012); Cheng, P., et all.: Biorg. Med. Chem. Lett., 18, 3787 (2008)<br></p>

<p>Impurity Oseltamivir EP Impurity F;<br>Applications 3-Des(1-ethylpropoxy)-3-(1-methylpropoxy) Oseltamivir (Oseltamivir EP Impurity F) is an impurity of the antiviral drug Oseltamivir (O700100). It is a COVID19-related research product.<br></p>

<p>Applications Troglitazone is an an oral hypoglycemic agent which improves insulin sensitivity and decreases hepatic glucose production. Antidiabetic.<br>References Ciaraldi, T.P., et al.: Metabolism, 39, 1056 (1990), Kuzuya, T., et al.: Diabetes Res. Clin. Pract., 11, 147 (1991), Kellerer, M., et al.: Diabetes, 43, 447 (1994),<br></p>

<p>Applications Ginsenoside Rh4 possesses inhibitory and antifungal activity.<br>References Xue, P., et al: RSC Adv., 7, 10939-10946 (2017)<br></p>

<p>Applications Isotope labelled enantiomer of Voriconazole (V760000), an antifungal agent and an ergosterol biosynthesis inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sanati, H., et al.: Antimicrob. Ag. Chemother., 41, 2492 (1997),<br></p>

<p>Applications Labelled Thiamine (T344185). Essential nutrient required for carbohydrate metabolism; also involved in nerve function. Biosynthesized by microorganisms and plants. Dietary sources include whole grains, meat products, vegetables, milk, legumes and fruit. Also present in rice husks and yeast. Converted in vivo to Thiamine diphosphate, a coenzyme in the decarboxylation of α-keto acids. Chronic deficiency may lead to neurological impairment, bariberi, Wernicke-Korsakoff syndrome.<br>References Kawaski, T., et al.: Methods Enzymol., 122, 15 (1986), Mascher, H., et al.: J. Pharm. Sci., 82, 56 (1993),<br></p>

<p>Applications A trizolopyrazine dipeptidyl peptidase IV inhibitor. It has recently been approved for the therapy of type II diabetes.<br>References Kim, D., et al.: J. Med. Chem., 48, 141 (2005), Ahren, B., et al.: Eur. J. Pharmacol., 521 164 (2005), Bergman, A., et al: Clin. Ther., 28, 55 (2006).<br></p>

<p>Stability Hygroscopic<br>Applications Metoprolol Succinate is used in the treatment of patients suffering from chronic heart failure, as well as to treat blood pressure from mild hypertension. β-adrenoceptor antagonist or β-blocker.<br>References Yazici, H. et al Sci. World J., 608683/1, 7 (2013); Studinger, P. et al.: J. Clin. Hyper., 15, 910 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications Semisynthetic aminoglycoside antibiotic derived from Kanamycin A. Antibacterial.<br>References Cabana, T., et al.: Antimicrob. Agents Chemother., 3, 478 (1973), Cappelletti, L.M., et al.: J. Antibiot., 36, 328 (1983), Monteleone, P.M., et al.: Anal. Profiles Drug Subs., 12, 37 (1983),<br></p>

<p>Applications A prototypical BCRP inhibitor. Inhibits the Bcrp1-mediated transport.<br>References Neville, K., et al.: Clin. Cancer Res., 10, 2525 (2004), Reardon, D., et al.: J. Clin. Oncol. 23, 9359 (2005), Pan, G., et al.: Drug Metab. Dispos., 35, 1165 (2007).<br></p>

<p>Applications Dicyclopentadiene is used in the preparation of poly(ionic liquid) brushes, used in anti-bacterial and anti-biofouling applications. Also used in the preparation of copolymer structures in the synthesis of nanocapsules.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ye, Q. et al.: J. Mat. Chem., 22, 13123 (2012); Fickert, J. et al.: Macromol., 46, 573 (2013);<br></p>

<p>Applications Nafronyl is a selective inhibitor of serotonin receptors. Nafronyl is a vasodilator used in the treatment of intermittent claudication.<br>References Fontaine, et al.: Chim. Ther., 4, 44 (1969), Bessin, P., et al.: Eur. J. Med. Chem., 10, 291 (1975), Clyne, C.A., et al.: Br. J. Surg., 67, 347 (1980),<br></p>

<p>Applications A diphenhydramine (D486900) analog classified as an antihistaminic.<br>References Bakker, R.A. et al.: Mol. Pharm., 60, 1133 (2001); Rekker, R.F. et al.: Arzneim.-Forsch., 21, 688 (1971);<br></p>

<p>Applications Valifenalate is used in antibacterial compositions and method for controlling of plant disease with improved effect, fungicides preparation and phytosanitary treatments with fungicides.<br>References Gonnzalez-Alvarez, M., et al.: Food Chem., 131 826 (2012); Ogawa, M., et al.: PCT Int. Appl. (2016), WO 2016194971 A1 20161208<br></p>

<p>Applications It inhibits PDGFR tyrosine kinase with IC50=83nM. It is useful for the treatment of inflammation and as an anti-proliferative agent. Dual action VEGFR &amp; Raf inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Leuner, C., et al.: Eur. J. Pharm. Biopharm., 50, 47 (2000),<br></p>

<p>Applications Isotope labelled Bisphenol A β-D-Glucuronide is the glucuronide conjugate and metabolite of bisphenol A (B519495), an monomer used for policarbonate and epoxy resins.<br>References Zalko, D., et al.: Drug Metab. Dispos., 26, 28 (1998), Matthews, J., et al.: Chem. Res. Toxico., 14, 149 (2001), Kinjo, J., et al.: Biol. Pharm. Bull., 27, 185 (2004), Murata, M., et al.: Biochemistry, 43, 2569 (2004),<br></p>

<p>Applications Ethynyl Estradiol-13C2 is isotope labelled version of Ethynyl Estradiol (E685100) which can be used in biological and analytical studies of simultaneous determination of UV-​filters and estrogens in aquatic invertebrates by modified Quick, Easy, Cheap, Effective, Rugged, and Safe extraction and liquid chromatography tandem mass spectrometry.<br>References 1. Koetsawang, S. et al.: Contraception. 1982 March:25(3) p231-2412. Cuttler, L. et al.: J. Endocrinol. Metab. 1985 Jun;60(6):1087-92.<br></p>

<p>Applications Endosulfan Sulfate is a pesticide used in the control and protection of plant and vegetation. Endosulfan Sulfate is useful in cannabis testing kits as a component of pesticide mixes (P698230).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Weston, D. et al.: Env. Sci. Tech., 38, 2752 (2004); Antonious, G. et al.: Env. Tox. Chem., 16, 644 (1997);<br></p>