Toxicología

<p>Applications Hexaflumuron-D3 is an isotope labeled compound of Hexaflumuron (H293885). Hexaflumuron is an benzoylphenylurea based chitin synthesis inhibitor used against Ephestia figulilella.<br>References Sun, C.X., et al.: Bull. Environ. Contamin. Toxicol., 89, 868 (2012); Khajepour, S., et al.: J. Insect. Sci., 12, 102 (2012);<br></p>

<p>Applications An anti-inflammatory corticosteroid.<br>References Weber, D., et al.: J. Pharm. Sci., 61, 689 (1972), Biagi, G., et al.: J. Med. Chem., 18, 873 (1975),<br></p>

<p>Applications b-Phenylethyl Furoate (cas# 7149-32-8) is a useful research chemical.<br></p>

<p>Applications A key intermediate in production of HCV (Hepatitis C virus) antivirals.<br>References McGowan, D., et al.: Bioorg. Med. Chem. Lett., 19, 2492 (2009), Birch, A., et al.: J. Med. Chem., 52, 1558 (2009),<br></p>

<p>Stability Light Sensitive<br>Applications Efavirenz 1-Desamine is an analog of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>

<p>Applications 4,4-Dibromo-2,4-dihydro-5-methyl-3H-pyrazol-3-one is used in the preparation of antimoebic compounds such as thiosemicarbazide derivatives. Also used in the preparation of triazine molecules displaying antifungal activity.<br>References Singh, S. et al.: Eur. J. Pharm. Sci., 25, 255 (2005); Tewari, A. et al.: Indian. J. Chem. B., 41B, 664 (2002);<br></p>

<p>Applications Intermediate in the preparation of antifungal agents.<br>References Saksena, A., et al.: Bioorg. Med. Chem. Lett., 4, 2023 (1994),<br></p>

<p>Applications Isotope labelled Deschloro Ticlopidine is an impurity of Ticlopidine (T438325), an antithrombotic. A platelet aggregation inhibitor.<br>References Leblonde, G., et al.: Biochem. Pharmacol., 27, 2099 (1978), O’Brien, J.R., et al: Thromb. Res., 13, 245 (1978), Katsumura, T., et al.: Angiology, 33, 357 (1982),<br></p>

<p>Applications 5-epi Emtricitabine is an epimer of Emtricitabine (E525000), a nucleoside reverse transcriptase inhibitor approved for treatment of human immunodeficiency virus (HIV) 1, and also has antagonistic activity against the hepatitis B virus. 5-epi Emtricitabine is also used as a reagent for the synthesis of β-L-(2R,5S)- and α-L-(2R,5R)-1,3-oxathiolane-pyrimidine and -purine nucleosides as potential HIV agents.<br>References Jeong, L., et al.: J. Med. Chem., 36, 181 (1993); Lim, S. et al.: Arch. Intern. Med., 166, 49 (2006); Smith, K., et al.: AIDS, 23, 1547 (2009)<br></p>

<p>Applications 6-Methylmercaptopurine Riboside-d3 is the isotope labelled analog of 6-Methylmercaptopurine Riboside (M321035); a thiopurine prodrug used as potential treatment for patients with inflammatory bowel disease.<br>References Haglund, S., et al.: Therap. Drug. Monitor., 33, 200 (2011); Arendt, C.S., et al.: J. BIol. Chem., 285, 6024 (2010); Fotoohi, A.K., et al.: Biochem. Pharmacol., 72, 816 (2006)<br></p>

<p>Applications Protected Morphine, a principal alkaloid of opium.<br>References Buchwald, M.E., et al.: J. Pharmacol. Exp. Ther., 71, 197 (1941), Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 17, 259 (1988),<br></p>

<p>Impurity Clarithromycin Impurity O EP<br>Stability Hygroscopic<br>Applications Clarithromycin (9Z)-O-Methyloxime is an impurity of Clarithromycin (C559750); a semi-synthetic macrolide antibiotic and derivative of Erythromycin (E650000).<br>References Morgan, D., et al.: J. Chromatogr., 502, 351 (1990); Benson, C., et al.: Eur. J. Clin. Microbiol., 6, 173 (1987); Boyanova, L., et al.: J. Med. Microb., 61, 85 (2012); Lin, Z., et al.: Toxicol. Sci., 126, 114 (2012)<br></p>

<p>Applications 4-(Dimethylamino)butanal Hydrochloride is the HCl salt of D492530, which was one of the reagents in discovery of a novel series of quinolone a6 nicotinic acetylcholine receptor agonists.<br>References McDonald, I., et al.: Bioorganic Med. Chem. Lett., 23, 1684 (2013).<br></p>

<p>Applications A cyclopropyldipyridodiazepinone derivative for use as non-nucleoside reverse transcriptase inhibitors.<br>References Couture, R., et al.: Eur. J. Pharmacol., 429, 161 ( 2001), Kuduk, S., et al.: J. Med. Chem., 47, 6439 (2004), Feng, D., et al.: Bioorg. Med. Chem. Lett., 15, 2385 (2005),<br></p>

<p>Stability Very Hygroscopic<br>Applications Tenofovir Dimer is a dimer of Tenofovir (T018500). Tenofovir is a reverse transcriptase inhibitor. Used as an anti-HIV agent.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),<br></p>

<p>Applications An Estradiol (E888000) 17-monoester. Short-chain fatty acid esters have a higher binding potency to the estrogen receptor than long-chain fatty acid esters. Estradiol fatty acyl esters act as a storage form from which estradiol is released by enzymic hydrolysis.<br>References Rifici, V., et al.: Metabolism, 41, 1110 (1992), Larner, J., et al.: J. Biol. Chem., 268, 13893 (1993), Tikkanen, M., et al.: Biochem. Pharmacol., 60, 1 (2000),<br></p>

<p>Applications (2R,3R)- 2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol Methanesulfonate is a useful synthetic intermediate in the synthesis of Efinaconazole (E435070); a topical antifungal for onychomycosis. (2R,3R)- 2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol Methanesulfonate is also used as a reagent in the synthesis of Ravuconazole (R128000); an ergosterol biosynthesis inhibitor and antifungal.<br>References Sugiura, K., et. al.: Antimicrob. Agents CH., 58, 3837 (2014); Pesti, J., et al.: Org. Process Res. Dev., 13, 716 (2009); Fung-Tomc., J.C., et al.: Antimicrob. Agents Chemother., 42, 313 (1988); Tsuruoka, A., et al.: Chem. Pharm. Bull., 46, 623 (1998); Gupta, A.K., et al.: J. Eur. Acad. Dermatol. Venereol., 19, 437 (2005)<br></p>

<p>Stability Light Sensitive<br>Applications Metabolite of the immunosuppressant macrolide SDZ RAD (also known as Everolimus E945400) which is an analog of the parent drug Rapamycin (R124000).<br>References Vidal, C. et al.: J. Am. Soc. Mass Spec., 9, 1267 (1998); Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2001);<br></p>

<p>Applications Chlorpropham is particularly useful in agricultural settings. It is used in pesticide products for treatment of plants and soil.<br>References Wozniak, E., et al.: PCT Int. Appl. (2020), WO 2020118278 A1<br></p>

<p>Applications 2-(1-(Ethylsulfonyl)-3-(4-(7-(hydroxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile is an impurity of Baricitinib (B118690), which is a JAK1 and JAK2 inhibitor and has been studied as a promising treatment for rheumatoid arthritis.<br>References Rodgers, J., et. al.: PCT Int. Appl. 185 pp.Patent (2009), WO 2009114512 A1 20090917;Dasari, S., et. al.: Russ. J. Org., 55, 1569 (2019);<br></p>

<p>Applications A labeled derivative of Amoxicillin (A634235), a semi-synthetic antibiotic related to penicillin. Antibacterial.<br>References Brogden, R.N., et al.: Drugs, 18, 169 (1979), Bird, A.E., et al.: Anal. Profiles Drug Subs. Excip., 23, 1 (1994),<br></p>

<p>Applications Erythromycin Cyclocarbonate is a derivative of Erythromycin (E649950), an antibcterial agent working on the 50S ribosomal subunit.<br>References Champney, W. et al.: Curr. Microbiol., 38, 342 (1999); Koch, W.L., et al.: Anal. Profiles Drug Subs., 8, 157 (1979),<br></p>

<p>Applications Mycophenolic Acid Carboxybutoxy Ether Dimethyl Ester is a metabolite of Mycophenolic Acid (M831500).<br>References Wieland, E., et al.: Clin. Biochem., 33, 107 (2000), Shipkova, M., et al.: Ther. Drug Monit., 25, 1 (2003),<br></p>

<p>Applications Fenarimol is a pyrimidine based fungicide which acts against rusts, blackspot and mildew fungi and it works by inhibiting the fungus’s biosynthesis of important steroid molecules.<br>References Zeiman, E., et al.: J. Parasitol., 94, 280 (2008); Lozano, A., et al.: J. Chromatograph. A., 1268, 109 (2012);<br></p>

<p>Applications Adefovir Dipivoxil Dimer is a formed from the dimerization of Adefovir Dipivoxil (A280465) which is used as an oral reverse transcriptase inhibitor in the treatment of hepatitis B. Adefovir Dipivoxil Dimer’s presence indicates the degradation of Adefovir Dipivoxil under specific conditions suggesting the stability of Adefovir Dipivoxil is compromised under such conditions.<br>References Yuan, L., et al.: Pharm. Res., 17, 1098 (2000); Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Fourches, D., et al.: Chem. Res. Toxicol., 23, 171 (2010), Ming, X., et al.: Biochem. Pharmacol., 79, 455 (2010)<br></p>

<p>Stability Hygroscopic<br>Applications A reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. A nucleoside analog structurally related to Lamivudine (L172500).<br>References Mellors, J., et al.: Science, 72, 1167 (1996), Reimann, K., et al.: J. Virol., 79, 8878 (2005), Rose, J., et al.: J. Biol. Chem., 280, 7413 (2005), Acierno, P., et al.: J. Immunol., 176, 5338 (2006),<br></p>

<p>Applications 4-Mercaptobenzonitrile is a building block used as a reactant in the synthesis and in vitro anti-hepatitis B virus activities of some ethyl 6-bromo-5-hydroxy-1H-indole-3-carboxylates.<br>References Chai, H., et al.: Bioorg. Med. Chem., 14, 911 (2006);<br></p>

<p>Applications A glucuronide of monohydroxylated Warfarin metabolite, 7-Hydroxy Warfarin (H996130).<br>References Zielinska, A., et al.: J. Pharmacol. Exp. Ther., 324, 139 (2008);<br></p>

<p>Impurity Mometasone Furoate EP Impurity H<br>Applications 21-Hydroxy Deschloromometasone Furoate (Mometasone EP Impurity H) is an impurity of Mometasone Furoate (M490000), a topical corticosteroid used as an anti-inflammatory.<br>References Shapiro, E.L., et al.: J. Med. Chem., 30, 1581 (1987); Graft, D., et al.: J. Allergy Clin. Immunol., 98, 724 (1996);<br></p>

<p>Applications (2S,4S)-Itraconazole is an enantiomer of Itraconazole (I937500), an orally active antimycotic structurally related to Ketoconazole. Antifungal. It is a COVID19-related research product.<br>References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984), Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989), Sugar, A.M.,et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993),<br></p>

<p>Applications N-(4-(4-(4-(((2R,4S)-2-((1H-1,2,4-Triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)hydrazinecarboxamide is an intermediate in the synthesis of derivatives of Itraconazole (I937500), an orally active antimycotic and antifungal compound.<br>References Heeres, J., et al.: J. Med. Chem., 27. 894 (1984);<br></p>

<p>Applications 8-Hydroxy Efavirenz is a metabolite of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor.<br>References Gorski, J., et al.: Biochem. Pharmacol., 47, 1643 (1994), Desta, Z., et al.: J. Pharmacol. Exp. Ther., 285, 428 (1998), Langmann, P., et al.: Eur. J. Med. Res., 7, 309(2002), Chang, T., et al.: Drug Metab. Dispos., 31, 7 (2003),<br></p>

<p>Applications p-Chloro-N,N-diethylaniline-d10 is derived from 4-Chlorophenylamine (C421894), which is an organic chemical reagent and precursor in the synthesis of various drugs and dyestuffs. It is a building block and degradation product of Chlorhexidine (C335045), an antiseptic as well as azo dyes and pigments in printing and textiles.<br>References Leucea, D. et al.: Ind. Text., 61, 304 (2010); Below, H. et al.: Microchim. Acta 146, 129 (2004);<br></p>

<p>Applications 5-cis-Tetradecenoyl-d3 Carnitine is labelled 5-cis-Tetradecenoyl Carnitine (T291425) which is one of the metabolites found in the lymph fluid collected from dietary stressed rats.<br>References Ardawi, M., et al.: Biochem. J., 212, 835 (1983), Otton, R., et al.: J. Endocrinol., 174, 55 (2002), Gu, H., et al.: Anal. Chem., 79, 89 (2007),<br></p>

<p>Applications Fluoxetine (F597100) derivative. A stereoselective inhibitor of serotonin re-uptake and phosphodiesterase. Potential antidepressants<br>References Cashman, J. et al.: Bioorgan Med. Chem. 17, 337 (2009)<br></p>

<p>Applications Testosterone 17-Hexahydrobenzoate-d11 is the isotope analog of Testosterone 17-Hexahydrobenzoate. Testosterone 17-Hexahydrobenzoate is a metabolite of testosterone (T155000), which is used in biological studies to determine the hemolytic and lipophilic activity of this anabolic steroid.<br>References Biagi, G.L., et al.: J. Med. Chem., 13, 944 (1970); Biagi, G. L., et al.: J. Med. Chem., 18, 873 (1975)<br></p>

<p>Applications Triasulfuron<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Isotope labelled (R,R,S,R)-Nebivolol Hydrochloride is a stereoisomer of rac Nebivolol (N387900) which is a β1-Adrenergic blocker. Nebivolol is used as an antihypertensive.<br>References Van de Water, A., et al.: J. Cardiovasc. Pharmacol., 11, 552 (1988); De Cree, J., et al.: Angiology, 41, 95 (1990)<br></p>

<p>Applications 3,4-Dichloroaniline-d2 (cas# 1219803-22-1) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Desamino Chloro Carbamazepine-d2 is an intermediate in the synthesis of Carbamazepine-d2,15N (C175841), the labeled analogue of Carbamazepine (C175840), used in treatment of pain associated with trigeminal neuralgia. Anticonvulsant.<br>References Stenger, E.G., et al.: Med. Exp., 11, 191 (1964), Pynnonen, S., et al.: Ther. Drug Monit., 1, 409 (1979), Sidebottom, A., et al.: J. Clin. Pharm. Ther., 20, 31 (1995)<br></p>

<p>Applications Afatinib N-Oxide is a derivative of Afatinib {BIBW 2992) (B377000), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder. An anilino-quinazoline that irreversibly inhibits EGFR and HER2 kinase activity.<br>References Ham, J. et al.: Cancer Cell., 29, 159 (2016);<br></p>

<p>Applications 17α-Testosterone-16,16,17-d3 Cypionate is the isotope labelled analog of 17α-Testosterone Cypionate (T155155); the 17α-isomer of Testosterone Cypionate (T155100) which is an anabolic steroid with androgenic properties. Also used for testosterone therapy in males with hypogonadism.<br>References Rabkin, J.G. et al.: J. Clin. Psychopharmacol., 19, 19 (1999); Hajjar, R. et al.: J. Clin. Endocrinol. Metab., 82, 3793 (1997); Rhoden, E. et al.: J. Sex Med., 7, 277 (2010)<br></p>

<p>Applications A deuterated 4-chloro Bupropion (B689625) analogue used in the preparation of compounds for indirect dopamine agonist pharmacotherapy for treating cocaine, methamphetamine, nicotine, and other drugs of abuse addiction.<br>References Carroll, F.I. et al.: J. Med. Chem., 52, 6768 (2009);<br></p>

<p>Applications A metabolite of Demeton-S (D231360).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Szeto, S.Y., et al.: J. Agric. Food Chem., 30, 1082 (1982),<br></p>

<p>Applications 3-Methylphosphinicopropionic Acid-d3 Diethyl Ester is a derivative of 3-Methylphosphinicopropionic Acid-d3 Sodium Salt (M326162), a metabolite of Glufosinate (G596950). 3-Methylphosphinicopropionic Acid-d3 Diethyl Ester is used in the preparation of the naturally occurring amino acid, Phosphinothricin.<br>References Zeiss, H.: J. Org. Chem., 56, 1783 (1991)<br></p>

<p>Applications Cholic Acid (C432600) derivative.<br></p>

<p>Applications Used in the synthesis of novel phosphorothioates and phosphorodithioates as cholinesterase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Millard, C., et al.: J. Neurochem., 64, 1909 (1995), Nicolet, Y., et al.: J. Biol. Chem., 278, 41141 (2003), Casida, J., et al.: Chem. Res. Toxicol., 17, 983 (2004),<br></p>

<p>Applications 1S-cis-Bifenthrin is a pyrethroid which was evaluated in vitro and the interactions with estrogen receptor were predicted to determine disruption of the hormonal network and the enantioselectivity of bifenthrin in trophoblast. 1S-cis-Bifenthrin was observed to have greater effects of consistent enantioselective interference o hormone signaling. Thus, 1S-cis-Bifenthrin are of significant concern to maternal-fetal health.Third generation synthetic pyrethroid. Insecticide, acaricide. Used in Pesticide detection<br>References Zhao, Meirong., Environmental Science &amp; Technology, 48, 8109-8116, (2014)Plummer, E.L., et al.: Pestic. Sci., 14, 560 (1983), Trumble, J.T., et al.: J. Econ. Entomol., 81, 608 (1988), Ross, M., et al.: Biochem. Pharmacol., 71, 657 (2006), Hillegass, J., et al.: Toxicol. Sci., 102, 413 (2008),<br></p>