Toxicología

<p>Applications N-Desmethyl Imatinib Mesylate is a metabolite of Gleevec, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.<br>References Schindler, T., et al.: Science, 289, 1938 (2000), Drucker, B.J., et al.: N. Engl. J. Med., 344, 1031 (2001),<br></p>

<p>Applications Tebufenozide is a synthetic nonsteroidal ecdysone agonist used in pesticide formulations (1) that causes premature molting; novel insect growth regulator (2,3,4) specific to lepidopteran species. Drinking water Contaminant Candidate List 3 (CCL3) as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Jordan T, et al.: Anal Bioanal Chem. 2009 Aug;394(8):2257-66 2. Vianna U. Et al.: Ecotoxicology. 2009 Feb;18(2):180-6. 3. Rose, G. et al. Food. Chem. 2009 Dec;117(4) pp634-6404. Wang, J. et al.: J. Agric. Food Chem. 2009 Mar 25;57(6):2162-73.<br></p>

<p>Applications Labelled 1,3-Phenylenediamine (P319835). 1,3-Phenylenediamine is used in the foaming-type hair dye composition.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kano, K., et al.: Biochim. Biophys Acta, 509, 289 (1978), Yu, Z., et al.: Mol. Membr. Biol., 15, 59 (1998),<br></p>

<p>Stability Hygroscopic<br>Applications m-(Trifluoromethyl)acetophenone Oxime is a reactant in the synthesis of Trifloxystrobin (T778900) which is a broad-spectrum foliar fungicide used in plant protection.<br>References Chen, W., et al.: Huaxue Yanjiu, 25, 16 (2014); Margot, P. et al.: Bright. Crop Prot. Conf. Pest Dis., 2, 375 (1998); Karadimos, D.A. et al.: Crop Prot., 24, 23 (2005); Prom, L.K. et al.: Plant Dis., 87, 252 (2003);<br></p>

<p>Applications Anxiolytic; muscle relaxant (skeletal); anticonvulsant; ligand for the GABAA receptor benzodiazepine modulatory site. Controlled substance (depressant).<br>References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Sisenwine, et al.: Arzneim. Forsch., 22, 682 (1972), Shearer, C.M., et al.: Anal. Profiles Drug Subs., 3, 441 (1974), Greenblatt, D.J., et al.: Clin. Pharmacokinet., 6, 89 (1981),<br></p>

<p>Stability Light Sensitive<br>Applications N-tert-Butyl-3-(2-hydroxypropan-2-yl)-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-carboxamide is a metabolite of Amicarbazone (A605040); a triazolinone herbicide with a broad spectrum of weed control.<br>References Dayan, F., et al.: Weed Science, 57, 579 (2009); Elmore, M., et al.: Weed Technol., 27, 596 (2013); Dong, M., et al.: J. Sep. Sci., 38, 2245 (2015)<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Tramadol.<br>References Raffa, R., et al.: J. Pharmacol. Exp. Ther., 267, 331 (1993), Pospisilova, M., et al.: J. Pharm. Biomed. Anal., 18, 777 (1998), Scott, L., et al.: Drugs, 60, 139 (2000), Wu, W., et al.: Xenobiotica, 32, 411 (2002),<br></p>

<p>Stability Light Sensitive<br>Applications α-Chlordane is an organochlorine pesticide/insecticide used in the protection of crops from pests.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Shoeib, M., et al.: Env. Toxicol. Chem., 21, 984 (2002); Parlar, H. et al.: J. Agric. Food. Chem., 27, 278 (1979);<br></p>

<p>Applications Labelled Cefazolin (C242500). Semi-synthetic antibiotic derived from 7-amino-cephalosporanic acid. An antibacterial.<br>References Kozatani, et al.: Chem. Pharm. Bull., 20, 1105 (1972), Birkhead, H.A., et al.: J. Infect. Dis., 128, 379 (1973), Zappala, A.E., et al.: Anal. Profiles Drug Subs., 4, 1 (1975),<br></p>

<p>Applications Irbesartan-d4 is the labeled analogue of Irbesartan (I751000), an angiotensin II type 1 (AII1)-receptor antagonist.<br>References Gillis, J.C. and Markham, A.: Drugs, 54, 885 (1997); Chando, T.J., et al.: Drug. Metabol. Dispos., 26, 408 (1998); Massie, B., et al.: New Eng. J. Med., 359, 2456 (2008); Ren, X., et al.: Pharmacol., 83, 80 (2009)Aromatics, Heterocycles, Inhibitors, Isotope Labelled Compounds, Pharmaceuticals, Intermediates &amp; Fine Chemicals<br></p>

<p>Stability Hygroscopic<br>Applications Dexon<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications N-[(4-chlorophenyl)methyl]cyclopentanamine is a useful reagent for the preparation of γ-​lactams.<br>References Fujii, T., et al.: Tetrahedron Letters, 61, 152276 (2020)<br></p>

<p>Applications Pirimicarb-desmethyl is a metabolite of Pirimicarb, which is a carbamate pesticide.<br>References Climent, M., Miranda, M.: J. Chromatogr. A, 738, 225 (1996); Pirisi, F., et al.: J. Agric. Food Chem., 44, 2417 (1996); Blasco, C., et al.: Electrophoresis, 30, 1698 (2009);<br></p>

<p>Stability Volatile<br>Applications PERILLEN (cas# 539-52-6) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Hygroscopic<br>Applications Haloxyfop-R-methyl-d3 is a labeled analogue of (R)-Haloxyfop Methyl Ester (H104020), which is a herbicide. It is used in the study of reduced rates of the acetyl-co enzyme A carboxylase (ACCase)-inhibiting herbicide.<br>References Neve, P., et al.: Theoretical and Applied Genetics, 110, 1154 (2005); Delye, C., et al.: Pest Management Sci., 58, 474 (2002)<br></p>

<p>Applications Labelled analog of a triazinetrione anticoccidial. Coccidiostat.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Eberts, T., et al.: Clin. Chem., 25, 1440 (1979), Goodwin, M., et al.: Avian Dis., 29, 630 (1985), Sorensen, S., et al.: Clin. Chim. Acta, 264, 103 (1997), Conway, D., et al.: Poult. Sci., 280, 426 (2001),<br></p>

<p>Applications 4-[(1-Ethylpropyl)amino]-2-methyl-3,5-dinitro-benzoic Acid is a metabolite of Pendimethalin (P221900), an herbicide used to control the spread of weedgrass.<br>References Haith, D., et al.: Environ. Sci. Technol., 44, 6496 (2010); Jabran, K., et al.: Int. J. Agric. Biol., 12, 335 (2010); Rahaman, S., et al.: Environ. Ecol., 28, 1 (2010); Zulalian, J., et al.: J. Agric. Food Chem., 38, 1743-54 (1990);<br></p>

<p>Applications 3-Chlorobenzotrichloride may be used as mosquito larvicide.<br>References Deonier, C.C., et. al.: Soap and Sanitary Chemicals, 22, 118 (1946)<br></p>

<p>Applications Antihistaminic, antiemetic, CNS depressant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Edge, W., et al.: J. Pharm. Pharmacol., 5, 279 (1953), Huang, et al.: J. Pharm. Sci., 59, 772 (1970), Shearer, C.M., et al.: Anal. Profiles Drug Subs., 5, 429 (1976)<br></p>

<p>Applications 2-Cyano-2-(methoxyimino)acetic Acid is a cyano-oxime derivative used as a fungicide.<br>References Tellier, F., et al.: Pestic Biochem Physiol., 78, 151-160 (2004)<br></p>

<p>Applications Anti-inflammatory. Selective cyclooxygenase-2 (COX-2) inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Glasson, et al.: Biochem, Pharmacol., 18, 633 (1969), Boissier, et al.: Therapie, 26, 211 (1971), Sorenson, J.R.J., et al.: J. Med. Chem., 19, 135 (1976), Barnett, J., et al.: Biochim. Biophys. Acta, 1209, 130 (1994), Johnson, J.L., et al.: Arch. Biochem. Biophys., 324, 26 (1995),<br></p>

<p>Applications Antibacterial.<br>References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Dunham, J.M., et al.: Anal. Profiles Drug Subs., 1, 249 (1972),<br></p>

<p>Applications (R)-(+)-Verapamil Hydrochloride and both of its isomers inhibit the p-glycoprotein efflux pump in multidrug resistant tumor cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Peroutka, S., et al.: J. Ann. Neurol, 23, 500 (1988); Eliason, J.F., et al.: Int. J. Cancer, 46, 113 (1990);<br></p>

<p>Applications Flurochloridon<br></p>

<p>Applications 2-(Methylthio)Benzothiazole could be useful for removing pollutants in drinking water.<br>References Di Marcantonio, C., et al.: Chemosphere, 260, 127630 (2020)<br></p>

<p>Applications Amylocaine Hydrochloride, is used mostly in spinal anesthesia.<br>References Fourneau, E.: Bulletin des sciences pharmacologiques, 10, 141 (1904); Debue-Barazer, C., et al.: Gesnerus, 64, 24 (2007)<br></p>

<p>Applications Macitentan, is an orally active endothelin receptor antagonist used for pulmonary arterial hypertension.<br>References Emoto, N. Ensho to Men'eki, 20, 487 (2012);<br></p>

<p>Applications Toremifene is an analog of chlorinated tamoxifen and an antiproliferative agent.<br>References Verma, V., et al.: Toxicol. Appl. Pharmacol., 280, 323 (2014); Hong, A., et al.: Chemotherapy 48, 238 (2002)<br></p>

<p>Applications Amitraz (A633320) impurity, its degradation products in fruits.<br>References Hernando, M., et al.: Anal. Bioanal. Chem., 389, 1815 (2007), Pico, Y., et al.: Anal. Chem., 79, 9350 (2007),<br></p>

<p>Stability Hygroscopic<br>Applications (R)-(-)-Littorine is a tropane alkaloid found in a variety of plants and have been found to potentially detoxify cells in overproducing conditions.<br>References Al Balkhi, M.H., et al.: Phytochem., 74, 105 (2012); Pavlov, A., et al.: App. Biochem. Biotechnol., 157, 210 (2009);<br></p>

<p>Applications A major oxidative labelled metabolite of Pentoxifylline. A potent inhibitor of phosphatidic acid generation (IC50=0.6uM). Protects mice from endotoxic shock and attenuates sepsis-induced acute lung injury in pig.<br>References Clarke, E., et al.: Cancer Res., et al.: 56, 105 (1996), Itani, S., et al.: Metabolism, 50, 553 (2001), Itani, S., et al.: Diabetes, 51, 2005(2002), Yu, C., et al.: J. Biol. Chem., 277, 50230 (2002),<br></p>

<p>Applications Pirimiphos-methyl is a phosphorothioate used as an insecticide. Pirimiphos-methyl is commonly used for mosquito control as well as control of greenhouse crop pests and stored-product insects.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Deighton, J. et al.: Mosq. News, 34, 163 (1974); LaHue, D.W.: J. Econ. Entomol., 68, 236 (1975); Antonious, G.F. et al.: J. Entomol. Sci., 30, 191 (1995):<br></p>

<p>Applications Dalfampridine is used in characterizing subtypes of potassium channel, and has also been used to manage some of the symptoms of multiple sclerosis, and is indicated for symptomatic improvement of walking in adults with several variations of the disease. Dalfampridine is a precursor to the drug Pinacidil.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Judge S., et al.: Pharmacol. Ther., 111, 224 (2006), Wu, Z.Z., et al.: J. Biol. Chem., 284. 36453 (2009),<br></p>

<p>Applications Astragaloside IV has cardiovascular protective effects, protecting the vascular endothelial cells. In addition it is attributed to have anti0inflammatory and anti-virus effects as well. This is due to its scavenging ability of oxygen free radicals, regulation of mineral homeostasis and antioxidative effects.<br>References Liu, S. et al.: J. Chinese Pharm. Sci., 22, 222 (2013);<br></p>

<p>Applications Dichlobentiazox is a pesticide.<br>References Tanaka, R., et al.: From PCT Int. Appl. (2017), WO 2017170792 A1 20171005; Reinhard, R., et al.: From PCT Int. Appl. (2020), WO 2020169414 A1 20200827<br></p>

<p>Stability Light Sensitive<br>Applications Labelled rac-Nicotine (N412420). Nicotine is an alkaloid isolated from plants. Nicotine is an active stimulant, having both addictive and carcinogenic properties. Nicotine can be absorbed through the alimentary canal, respiratory tract and intact skin. Nicotine is used in the treatment of smoking withdrawal syndrome. Nicotine has been used as an anthelmintic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ferretti, G., et al.: J. Med. Chem., 45, 4724 (2002), Guillen, M., et al.: J. Agric. Food Chem., 53, 1093 (2005), Ramunno, A., et al.: Bioorg. Med. Chem. Lett., 15, 3237 (2005), Alburges, M., et al.: Eur. J. Pharmacol., 573, 124 (2007),<br></p>

<p>Stability Moisture sensitive<br>Applications Deethylphosphamidon is an insecticide used in the protection of crops.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ferreira, J. et al.: Pest. Sci., 14, 167 (1983); Hung, L. et al.: Bull. Env. Cont. Toxicol., 8, 297 (1972);<br></p>

<p>Applications Fluindapyr is a fungicide, is used to control pests of sugarcane, citrus, rapeseed, and potato plants.<br>References Huang, H., et al.: PCT Int. Appl., (2020);<br></p>

<p>Applications Flubromazepam is a designer benzodiazepine drug structurally related to Phenazepam (P295300); a drug used in the treatment of neurological disorders such as epilepsy, alcohol withdrawal and insomnia. Phenazepam (P295300) can also be used as a premedication before surgery as it augments the effects of anesthetics and reduces anxiety.<br>References Moosmann, B., et al.: J. Mass Spectrom., 48, 1150 (2013); Ogiso, T., et al.: Chem. Pharm. Bull., 37, 446 (1989); Gu, Q., et al.: J. Med. Chem., 36, 1001 (1993); Bekhterev, V.N., et al.: Pharm. Chem. J., 42, 95 (2008)<br></p>

<p>Applications Sisapronil is Fluorinated Cyclopropylphenylpyrazole injectable compound.<br>References Derose, Guy F., et al.: U.S. Pat. Appl. Publ., (2015);<br></p>