Toxicología

<p>Applications Tauro-α-muricholic Acid Sodium Salt is a bile acid released by the liver and is typically used in cholestasis studies.<br>References Yang, L. et al.: Chem. Res. Toxicol., 21, 2280 (2008); Holm, R. et al.: Phys. Chem. Chem. Phys., 11, 5070 (2009);<br></p>

<p>Applications 1-Hydroxypyridine-2-thione Zinc is a fungicide; used in preparation of UV antibacterial and mildew-proof topcoat with better yellowing resistance and wear resistance.<br>References Feng, S., et al.: Faming Zhuanli Shenqing, (2021);<br></p>

<p>Applications Octanoic Acid-13C4 is an isotopic analog of Octanoic Acid (O237880), which is found naturally in the milk of various mammals. Its esters can be used in perfumery and also in the manufacture of dyes. It is also an antimicrobial pesticide used as a food contact surface sanitizer. Caprylic acid is also used in the treatment of some bacterial infections.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lide, D. R., et al.: CRC Handbook chem. Phys., 70th Ed. (1990); Beare-Rogers, J., et al.: Pue Appl. Chem., 73 (4), 685 (2001);<br></p>

<p>Impurity Abacavir API<br>Applications Abacavir (Abacavir API) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.<br>References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)<br></p>

<p>Applications Stereoisomer to Darunavir (D193500), a second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral. It is a COVID19-related research product.<br>References Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003), Arasteh, K., et al.: AIDS, 19, 943 (2005), Surleraux, D.L.N.G., et al.: J. Med. Chem., 48, 1813 (2005),<br></p>

<p>Applications Propiconazole is a systemic foliar fungicide. Agricultural fungicide. Useful in cannabis testing kits as a component of pesticide mixes (P698235).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Child, R., et al.: Plant Growth Regul., 13, 203 (1993), Jaleel, C., et al.: Plant Sci., 171, 271 (2006), Jaleel, C., et al.: Pestic Biochem. Physiol., 91, 170 (2008),<br></p>

<p>Applications Methoprene-d7, is the labeled analogue of Methoprene, which is a juvenile hormone (JH) analog which can be used as an insecticide that acts as a growth regulator.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Xiao-li, M., et al.: Nongyao, 52, 380 (2013); Anon.IP.com Journal, 12, 9 (2012);<br></p>

<p>Applications Methyl Trithion, is used as an insecticide in biological studies to determine the effect on agriculture. Also, this compound was used evaluate the repellency in deer mouse and house mouse to determine the toxicity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Burden, G.S., et al.: J. Econ. Entomol., 61, 1565 (1968); Schafer, E. W., et al.: Arch. Environ. Con. Tox., 14, 111, (1985)<br></p>

<p>Applications Guthoxon is an organophosphorus anticholinesterase pesticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Murphy, S., et al.: Toxicol Appl Pharmacol, 12, 22 (1968); Wong, J., et al.: J. Agric. Food Chem., 55, 1117 (2007);<br></p>

<p>Stability Hygroscopic<br>Applications Avilamycin is an antimicrobial agent used against methicillin resistant Staphylococcus.<br>References Flora, D. et al.: J. Coastal Life Med., 3, 193 (2015);<br></p>

<p>Applications Pexidartinib Hydrochloride is RTK inhibitor. It can be used in pharmacological activity, therapeutic use, and biological study of inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition.<br>References Mok, S., et al.: BMC Cancer, 15, 1, 2015<br></p>

<p>Applications Spinetoram J is a component of Spinetoram (S683650), a compound that belongs to the spinosyn family of insecticides and shows potential of natural products research. Useful in cannabis testing kits as a component of pesticide mixes (P698240).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kirst H. A.: J. Antibiot., 63, 101-111 (2010)<br></p>

<p>Applications 6-(tert-Butylamino)-3-methyl-1,3,5-triazine-2,4(1H,3H)-dione is a metabolite of Terbuthylazine (T110500) a triazine herbicide.<br>References Schenck, F., et al.: Bull Environ. Contam. Toxicol., 73, 24 (2004),<br></p>

<p>Applications Fluazinam is a broad spectrum fungicide. Fluazinam is commonly used for control of Sclerotinia blight and other soilborne pathogens of peanut as well for the control of potato blight.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Smith, F.D. et al.: Peanut Sci., 19, 115 (1992); Roques, J.-F. et al.: Phytoma, 460, 48 (1994); Platt, H.W. et al.: Tests Agrochem. Cult., 15, 36 (1994);<br></p>

<p>Applications 5-Chloro-3-methyl-4-nitro-1H-pyrazole (CMNP) is a pyrazole-derived plant growth regulator used as a citrus abscission agent.<br>References Barcelo, J., et al.: J. Plant Nutr., 13, 1 (1990), Delessert, C., et al.: Plant Mol. Biol., 55, 165 (2004), Both, M., et al.: The Plant Cell, 17, 2107 (2005),<br></p>

<p>Applications Bitertanol is a foliar-applied triazole fungicide used to protect tropical and subtropical crops in agriculture, in particular bananas. Bitertanol has effects on behavior that are similar to those of psychomotor stimulants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Allen, A.R. et al.: Neurotoxicol. Teratol., 15, 237 (1993); Scheinpflug, H. et al.: Pflanzsensch.-Nach., 34, 8 (1981);<br></p>

<p>Applications Nebivolol (N387896) metabolite.<br></p>

<p>Applications Propyzamide-d3 (phenyl-2,4,6-d3) (CAS# 1219805-79-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled Bosentan (B675900). A mixed endothelin receptor antagonist. Used as a vasodilator. Antihypertensive.<br>References Clozel, M., et al.: J. Pharmacol. Exp. Ther., 270, 228 (1994), Gutsch, G., et al.: Cardiovasc. Drugs Ther., 10, 717 (1996), Weber, C., et al.: Clin Pharmacol. Ther., 60, 124 (1996), Krum, H., et al.: N. Engl. J. Med., 338, 784 (1998)<br></p>

<p>Stability Hygroscopic<br>Applications A new nitrification inhibitor to be used on solid and in liquid fertilizers and slurry.<br></p>

<p>Stability Light Sensitive<br>Applications A PAH metabolite having a toxic effect on fish bone metabolite. Also, it is used as a marker of the carcinogenic potency of the polycyclic aromatic hydrocarbons (PAH) mixture. A genotoxic agent.<br>References Ebright, R., et al.: Cancer Res., 46, 2349 (1986), Morito, K., et al.: Biol. Pharm. Bull., 24, 351 (2001), Billiard, S., et al.: Toxicol. Sci., 92, 526 (2006),<br></p>

<p>Applications Ethylmorphine impurity.<br>References Pfeifer, S., et al.: Pharmazie, 27, 648 (1972),<br></p>

<p>Applications Echothiophate Iodide is an anticholinesterase drug.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ashani, Y., et al.: Biochem. Pharm., 30, 2593 (1981)<br></p>

<p>Stability Hygroscopic<br>Applications Acarviosin is a part of the potent α-amylase inhibitor, Acarbose (A123500), an anti-diabetic drug used to treat type 2 diabetes mellitus (1,2,3).<br>References (1) Shibata, Y., et al.: Carbohydrate. Res., 228, 377 (1992) (2) Raimbaud, E., et al.: Carbohydrate. Res., 227, 351 (1992) (3) Geng, P., et al.: Carbohydr Res. 343, 882 (2008)<a href="https://www.ncbi.nlm.nih.gov/pubmed/18294624PMID" target="_blank" rel="noreferrer noopener">https://www.ncbi.nlm.nih.gov/pubmed/18294624PMID</a>: 18294624<br></p>

<p>Applications A natural product with significant antitumor activities.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sah, N., et al.: J. Biol. Chem., 278, 20593 (2003), Lu, D., et al.: J. Int. Med. Res., 32, 488 (2004), Yunmbam, M., et al.: Oncol. Rep., 11, 833 (2004), Shao, S., et al.: Cell Biol. Int., 32, 893 (2008),<br></p>

<p>Applications Telmisartan-d4 is deuterium labelled Telmisartan (T017000). Telmisartan is an angiotensin II receptor antagonist.<br>References Wienen, W. et al.: Br. J. Pharmacol., 110, 245 (1993); Neutel, J.M. et al: Adv. Therap., 15, 206 (1998)<br></p>

<p>Stability Unstable in Solution<br>Applications A psychotropic benzodiazepine derivative with hypnotic and anxiolytic properties. Controlled Substance.<br>References Sethy, V.H. et al.: Naun.-Schmeid. Atch. Pharmacol., 301, 157 (1978); Moore, S. et al.: Curr. Therap. Res., 29, 704 (1981); Gutierrez, S.F. et al.: Cien. Pharmac., 5, 37 (1995);<br></p>

<p>Applications Hexaflumuron is an benzoylphenylurea based chitin synthesis inhibitor used against Ephestia figulilella.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sun, C.X., et al.: Bull. Environ. Contamin. Toxicol., 89, 868 (2012); Khajepour, S., et al.: J. Insect. Sci., 12, 102 (2012);<br></p>

<p>Applications DL-Lauroylcarnitine Chloride is a permeation enhancer that has been used to enhance the intestinal absorption of salmon calcitonin.<br>References Welling, S.H., et. al.: Eur. J. Pharm. Biopharm., 86, 544 (2014); Song, K., et. al.: J. Control Release, 106, 298 (2005)<br></p>

<p>Stability Hygroscopic<br>Applications Single factor antibiotic comprising about 10% of nebramycin, the aminoglycosidic antibiotic complex produced by Streptomyces tenebrarius. Antibacterial.A representative lot contains d4, d5, d6, d7, d8, and d9.<br>References Koch, K.F., et al.: Antimicrob. Agents Chemother., 309 (1970), Welles, J.S., et al.: Toxicol. Appl. Pharmacol., 22, 332 (1972), Dash, A.K., et al.: Anal. Profiles Drug Subs. Excip., 24, 579 (1996),<br></p>

<p>Applications Eslicarbazepine acetate, (BIA 2-093), is a promising antiepileptic drug structurally related to Carbamazepine and Oxcarbazepine. Neuroprotective &amp; Neuroresearch product.<br>References Benes, J., et al.: J. Med. Chem., 42, 2582 (1999), Tong, X., et al.: Br. J. Pharmacol., 133, 867 (2001), Almeida, L., et al.: J. Clin. Pharmacol., 45, 1062 (2005), Elger, C., et al.: Epilepsia, 48, 497 (2007),<br></p>

<p>Applications Isotope labelled Nonacetylated aspirin analog. Analgesic, anti-inflammatory.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Harrison, L.L., et al.: J. Pharm. Sci., 69, 1268 (1980), Dromgoole, S.M., et al.: J. Pharm. Sci., 73, 1657 (1984),<br></p>

<p>Applications 2-Amino-1-(4-methylphenyl)-1-propanone, also known as Nor-mephedrone is a synthetic cathinone.<br>References Watanabe, K.; et al.: Bioorg. Med. Chem. Lett., 18, 1478 (2008)<br></p>

<p>Applications 1-Methylfluoranthene is an environmental pollutant that has been found to be a mutagen.<br>References Wise, S.A., et. al.: Environ. Int., 11, 147 (1985)<br></p>

<p>Impurity Erythromycin EP Impurity E<br>Applications Erythromycin A Enol Ether (Erythromycin EP Impurity E) is an impurity of Erythromycin.<br>References McGuire, J.M., et al.: Antibiot. Chemother., 6, 281 (1952), Steffansen, B., et al.: Int. J. Pharm., 56, 159 (1989), Goldman, R.C., et al.: Antimicrob. Agents Chemother., 34, 1973 (1990),<br></p>

<p>Applications A metabolite of Fulvestrant (F862500).<br>References Rao, P., et al.: J. Steroid Biochem., 25, 417 (1986), Wakeling, A., et al.: J. Steroid Biochem. Mol. Biol., 43, 173 (1992), DeFriend, D., et al.: Cancer Res., 54, 408 (1994),<br></p>