Toxicología

<p>Applications Spinosyn D is a potent insecticide for pathogens of crops.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Nonsteroidal anti-inflammatory agent (NSAID).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Salari, H., et al.: Prostagland. Leukotrienes Med., 13, 53 (1984), Lehmann, J.M., et al.: J. Biol. Chem., 272, 3406 (1997)<br></p>

<p>Applications A by-product of Fluorescein.<br>References Ames, B., et al.: Mutation Res., 31, 347 (1975),<br></p>

<p>Applications A new benzodiazepine derivative as a new anti-anxiety drug. Ethyl Loflazepate and its metabolite were compared with those of Diazepam (D416855), Nitrazepam (N490140) and Lorazepam (L469850). The anticonflict effect of Ethyl Loflazepate was slightly more potent than that of Diazepam and much more potent than that of Lorazepam. Controlled substance.<br>References Cano J.P., et al.: J. Chromatogr., 226, 413 (1981), Tanaka M., et al.: Clin. Neuropharmacology, (1985), 8,  271 (1985),<br></p>

<p>Applications Hormone; mediates photoperiodicity in mammals; inhibits cerebellar nitric oxide synthetase; peroxynitrite scavenger. Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell death of cancer cells. Inhibits proliferation/metastasis of breast cancer cells by inhibiting estrogen receptor action.<br>References Barchas, et al.: Nature, 214, 919 (1967), Glass, J.D., et al.: Science, 214, 821 (1981),<br></p>

<p>Applications A isothiazolidin-3-one derivative as antimicrobial. It was tested for inhibition of PCAF activity. 5-Chloroisothiazolinones showed the most potent inhibition of PCAF.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sadhale, P.P., et al.: J. Biol. Chem., 279, 33716 (2004), Thomsen, R., et al.: J. Med. Chem., 49, 3315 (2006),<br></p>

<p>Applications 3-Hydroxystearoylcarnitine Hydrochloride is found in overweight patients.<br>References Rodriguez-Gutierrez, R., et. al.: J. Int. Society Sports Nutrition, 9, 22, (2012)<br></p>

<p>Applications Antitumor agent. A potent inhibitor of dihydropyrimidine dehydrogenase (DPD).<br>References Shirasaka, T., et al.: Cancer Res., 56, 2602 (1996), Patt, Y., et al.: J. Clin. Oncol., 22, 271 (2004), Shirao, K., et al.: Cancer, 100, 2355 (2004), Kelly, H., et al.: J. Clin. Oncol., 23, 4553 (2005),<br></p>

<p>Applications A deuterated selective acetylcholinesterase inhibitor. Useful for the treatment of Alzheimer's disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bickel, U., et al.: Clin. Pharmacol. Ther., 50, 420 (1991), Maelicke, A., et al.: Drugs Dis Today, 1, 53 (1996), Sauvaltre, T., et al.: J. Med. Chem., 50, 5311 (2007),<br></p>

<p>Stability Very Hygroscopic<br>Applications Labelled Emtricitabine. A reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. A nucleoside analog structurally related to Lamivudine (L172500).<br>References Schinazi, R.F., et al.: Antimicrob. Ag. Chemother., 36, 2423 (1992), Shockeor, J.P., et al.: Xenobioica, 26, 189 (1996), Feng, J.Y., et al.: FASEB J., 13, 1511 (1999), Molina, J.-M., et al.: J. Infec. Dis., 182, 599 (2000)<br></p>

<p>Stability Light Sensitive<br>Applications Used as a broad range pesticide against insects, fungi, vegetation and bacteria. It has become a common environmental contaminant and probable human carcinogen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gulcan, H., et al.: Chem. Res. Toxicol., 21, 1503 (2008), Toropov, A., et al.: Bioorg. Med. Chem., 16, 5999 (2008), Franco, A., et al.: Envir. Toxicol. Chem., 28, 2018 (2009), Jensen, S., et al.: J. Agric. Food Chem., 57, 5872 (2009),<br></p>

<p>Applications Ketorolac is an analgesic; anti-inflammatory.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Etman, M., et al.: Pharm. Technol., 32, 58 (2008), Chelladurai, S., et al.: Chem. Pharm. Bull., 56, 1596 (2008), Sanderson, H., et al.: Toxicol. Lett., 187, 84 (2009),<br></p>

<p>Stability Light Sensitive<br>Applications Methyl Oleate can be used as a plasticizer. It is one of the biodiesel constituent fluids.<br>References Ben Amara, A., et al.: Energ. Fuel, 27, 6125 (2013); Arca, M., et al.: J. Am. Oil Chem. Soc., 89, 987 (2012)<br></p>

<p>Applications Ethiprole is a phenylpyrazole based insecticide used in rice ecosystem on Trichogramma japonicum, and egg parasitoid of rice lepidopterans.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhao, X.P., et al.: J. Economic. Entomol., 105, 92 (2012); Gomez-P. M.L., et al.: J. Chromatograph. A., 1248, 130 (2012);<br></p>

<p>Applications An anti-inflammatory, analgesic, antipyretic. A non-steroidal anti-inflammatory.<br>References Harrison, I.T., et al.: J. Med. Chem., 13, 203 (1970)<br></p>

<p>Applications Etoricoxib-d6 is the labelled analog of Etoricoxib (E934100), a specific inhibitor of COX-2 .<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References McGeer, P.L., et al.: Exp. Gerontol., 37, 925 (2002), Chenevard, R., et al.: Circulation, 107, 405 (2003)<br></p>

<p>Applications Spirotetramat-​keto-​hydroxy can be used in analytical study and biological study multi-​residue method for the determination of pesticides and pesticide metabolites in honeybees by liquid and gas chromatography coupled with tandem mass spectrometry-​Honeybee poisoning incidents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kiljanek, T., et al.: J Chromtagr A, 1435, 100 (2016)<br></p>

<p>Applications Alanycarb is a oxime carbamate inseciticide with acetylcholinesterase inhibitor activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dulin, F., et al.: Ecotoxicol. Environ. Safety., 90, 183 (2013); Kawazu,K., et al.: J. App. Entomol. 135, 647 (2011);<br></p>

<p>Applications Mofebutazone is an anti-inflammatory drug used on the gastrointestinal and renal tissues.<br>References Khayyal, M.T., et al.: Int. J. Clin. Pharmacol. Res., 15, 145 (1995); Safwat, S.M., et al.: Drug. Deve. Indust. Pharm., 15, 2605 (1988);<br></p>

<p>Applications Labelled racemic analogue of Ruxolitinib (R702000). Ruxolitinib is a selective Janus tyrosine kinase (JAK1 and JAK2) inhibitor used in the treatment of myeloproliferative neoplasms and psoriasis.<br>References Shilling, A.D. et al.: Drug Metab. Disp., 38, 2023 (2010); Mesa, R.A.: IDrugs, 13, 394 (2010); Campas-Moya, C.: Drugs Fut., 35, 457 (2010);<br></p>

<p>Applications Chenodeoxycholic Acid 24-Acyl-β-D-glucuronide is a glucuronide metabolite of Chenodeoxycholic Acid (CDCA) (C291900).<br>References Alme, B., et al.: J. Steroid Biochem., 13, 907 (1980), Goto, J., et al.: Steroids, 63, 186 (1998), Barbier, O., et al.: J. Steroid Biochem. Mol. Biol., 85, 235 (2003),<br></p>

<p>Applications A neuroprotective agent. Modulates glutamatergic transmission. A glutamate release inhibitor. An anticonvulsant. Neuroprotective agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mizoule, J., et al.: Neuropharmacology, 24, 767 (1985), Wahl, F., et al.: Eur. J. Pharmacol., 230, 209 (1993) Bensimon, G., et al.: N. Engl. J. Med., 330, 585 (1994)<br></p>

<p>Applications Methoxyphenone is a pesticidal compound, and it is used in preparation of Nitrones as herbicides.<br>References Campbell, Matthew J., et al:. PCT Int. Appl., (2018); Garizi, N., et al:.U.S. Pat. Appl. Publ., (2014);<br></p>

<p>Applications (R)-10-Monohydroxy-10,11-dihydro Carbamazepine-d3 is labelled (R)-10-Monohydroxy-10,11-dihydro Carbamazepine which is the metabolite of Oxcarbazepine (OXC) and Eslicarbazepine acetate, (BIA 2-093, ESL), novel central nervous system drugs.<br>References Duncan, J., et al.: Br. J. Clin. Pharmacol., 53, 123 (2002), Almeida, L., et al.: J. Clin. Pharmacol., 45, 1062 (2005), Coppola, G., et al.: CNS Drugs, 18, 133 (2004),<br></p>

<p>Applications Labelled Dacarbazine (D101400). Dacarbazine is used as an antineoplastic for treatment of malignant melanoma and sarcomas.<br>References Shealy, et al.: Biochem. Pharmacol., 11, 674 (1962), Carter, et al.: Eur. J. Cancer, 8, 85 (1972),<br></p>

<p>Applications Perampanel is a novel, noncompetitive AMPA receptor antagonist for the treatment of epilepsy. Also in the treatment of primary generalized tonic-clonic seizures in idiopathic generalized epilepsy. Perampanel is a selective non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor antagonist that reduces neuronal excitation (1,2,3,4).<br>References (1) Shih, J., et al.: Therap. Clinical Risk Management, 9, 285 (2013)(2) Rogawski, M. A., et al.: Epilepsy Curr., 11, 56 (2011)(3) Franco, V., et al.: Ther Drug Monit. 38, 744 (2016) (4) Rudzinski, L. A., et al.: J Investig Med. 64, 1087 (2016)<br></p>

<p>Applications Carbocisteine is a mucolytic agent used in the treatment of respiratory disorders ranging from the influenza virus infection to chronic obstructive pulmonary disease (COPD).<br>References Stevenson, G.B. et al.: Eur. Resp. J., 27, 865 (2006); Suer, E. et al.: J. Infect. Chemother., 14, 333 (2008); Yamaya, M. et al.: Am. J. Physiol., 299, L160 (2010);<br></p>

<p>Applications Selective pre-emergence herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Viste, K.L., et al.: Science, 167, 280 (1970), Yoshii, K., et al.: J. Agric. Food Chem., 48, 2502 (2000), Paya, P., et al.: Anal. Bioanal. Chem., 389, 1697 (2007),<br></p>

<p>Applications Labelled (S)-Amphetamine. CNS stimulant; anorexic. More active isomer of Amphetamine. Induces release of catecholamines and serotonin by displacing the monoamines from their vesicular storage sites; blocks catecholamine reuptake.Controlled substance (stimulant).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Warren, M.R., et al.: J. Pharmacol. Exp. Ther., 85, 119 (1945), Behrendt, W.A, et al.: Arzneim.-Forsch., 13, 711 (1963), Seiden, L.S., Annu. Rev. Pharmacol. Toxicol., 32, 639 (1993),<br></p>

<p>Stability Light Sensitive<br>Applications S-Hydroprene, is an insect growth regulator used as an insecticide. It is used against cockroaches, beetles, and moths.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Environmental Protection Agency, Federal Register, 62, 61645 (1997); Bell, H. A., et al.: J. Stored Produc. Res., 35, 117 (1999);<br></p>

<p>Applications A labelled opioid analgesic. Used as a substitute to morphine for postoperative pain in children.<br>References Lundeberg, S. et al.: Acta Anaesthesiol. Scand., 54, 435 (2010); Christensen, T. et al.: Neurosci. Res. Comm., 26, 77 (2000);<br></p>

<p>Applications Calcitonin, Salmon is a calcium regulating hormone which exhibits hypocalcaemic and hypophosphatemic properties.<br></p>

<p>Applications Zolmitriptan is a serotonin 5HTID-receptor agonist and used to treat migraine (1,2,3).<br>References (1) Glen, R.C., et al.: J. Med. Chem., 38, 3566 (1995)(2) Seaber, E., et al.: Brit. J. Clin. Pharmacol., 41, 141 (1996)(3) Tepper, S.J., et al.: Curr. Med. Res. Opin., 15, 254 (1999)<br></p>

<p>Applications 4-(Trifluoromethyl)nicotinoyl Glycine-13C2,15N is the isotope labelled analog of 4-(Trifluoromethyl)nicotinoyl Glycine (T791375); a metabolite of Flonicamid (F405710), which is a novel insecticide with rapid inhibitory effect against aphid feeding.<br>References Lee, Sung Woo., et al.: J. Chrom. A., 1218(28), 4366-4377 (2011); Hengel, Matt J., et al.: J. Agr. Food Chem., 55(20), 8033-8039 (2007); Morita, M., et al.: Pest. Manag. Sci.,63, 969 (2007); Sabatino, L., et al.: Food. Additive. Contamin., 6, 11 (2013);<br></p>

<p>Applications A synthetic opioid similar in structure to Methadone (M225865). It acts as a μ-opioid receptor agonist and evokes heroin-like discriminative stimulus effects.<br>References Newman, J.L. et al.: Psychopharmacol., 164, 108 (2002); Brase, D.A. et al.: Biochem. Pharmacol., 25, 1684 (1976);<br></p>

<p>Applications 4-Amino-N-(1,1-dimethylethyl)-4,5-dihydro-3-(1-methylethyl)-5-oxo-1H-1,2,4-triazole-1-carboxamide is a triazolinone herbicide with a broad spectrum of weed control.<br>References Dayan, F., et al.: Weed Science, 57, 579 (2009); Elmore, M., et al.: Weed Technol., 27, 596 (2013)<br></p>

<p>Applications RTI-113 is a 3-phenyltropane analogue that acts as a potent and selective dopamine uptake inhibitor. RTI-113 has been shown to reduce cocaine self-administration at high occupancy of dopamine transporter. Studies suggest that RTI-113 and its analogs may be useful tools for developing potential agonist therapies for cocaine dependence.<br>References Dworkin, S. et al.: Synapse, 30, 49 (1998); Negus, S.S. et al.: Pharmacol. Biochem. Behav., 91, 333 (2009); Cook, C. et al.: Eur. J. Pharmacol., 442, 93 (2002);<br></p>

<p>Applications Propaquizafop is used in the studies of the pesticides residue in tomatoes and cucumbers and the associated health risks.<br>References Lozowicka, B., et al.: Environ. Monit. Assess., 187, 1 (2015)<br></p>

<p>Applications Scopolamine Hydrobromide Hydrate is an acetylcholine antagonist. Used in treatment of motion sickness; antiemetic; antispasmodic; mydriatic; preanesthetic medicant. Neuroprotective &amp; Neuroresearch Product.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Brand, J.J., et al.: Lancet, 2, 232 (1970); Bowles, J.B., et al.: Anaesthesia, 34, 476 (1979); Clissold, S.P., et al.: Drugs, 29, 189 (1985); Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 19, 477 (1990);<br></p>

<p>Applications A novel labelled intermediate of Fexofenadine (F322470).<br>References McTavish, D., et al.: Drugs, 39, 552 (1990), Honig, P., et al.: Clin. Pharmacol. Ther., 52, 231 (1992), Yun, C., et al.: Drug Metab. Dispos., 21 403 (1993),<br></p>