Toxicología

<p>Applications 2-Methylphenyl Diethylcarbamate is an intermediate in the synthesis of o-Cresol (C781910), which is a compound used as a disinfectant and have also been used as antiseptic in surgery.<br>References Razavi, S.M., et al.: Nat. Prod. Res., 26, 2148 (2012); Asadollahi-B. M., et al.: Environ. Toxicol. Pharmacol., 34, 826 (2012);<br></p>

<p>Applications (S)-Efaveirenz N-β-Glucoronide-Methyl Ester is an intermediate in the synthesis of (S)-Efavirenz N-β-D-Glucuronide, the N-glucuronide derivative of (S)-Efavirenz (E425000); a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>

<p>Applications Used for the preparation of heterocyclic sulfonamide compounds as Edg-1 antagonists useful in the treatment of cancer.<br></p>

<p>Applications Testosterone-2,2,4,6,6-d5 Acetate is a useful isotopically labeled compound of Testosterone 17-O-Acetate (T155025)<br></p>

<p>Applications Chloramphenicol-3-O-sulfate Sodium Salt is a salt version of Chloramphenicol-3-O-sulfate (CAS 116512-90-4) which can be used in study for evidence for new metabolic pathways of Chloramphenicol in the duck. Metabolite of the drug Chloramphenicol (C325030).<br>References Cravedi, J. P., et al.: Drug Metab Dispos, 22, 578 (1994)<br></p>

<p>Impurity Emtricitabine Impurity 14<br>Applications An intermediate in the synthesis of Emtricitabine (E525000). A reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. A nucleoside analog structurally related to Lamivudine (L172500). Emtricitabine Impurity 14.<br>References Schinazi, R.F., et al.: Antimicrob. Ag. Chemother., 36, 2423 (1992), Shockeor, J.P., et al.: Xenobioica, 26, 189 (1996), Feng, J.Y., et al.: FASEB J., 13, 1511 (1999), Molina, J.-M., et al.: J. Infec. Dis., 182, 599 (2000)<br></p>

<p>Applications (4-(3-Methylbutan-2-yl)phenyl)methanol is an intermediate used in the synthesis of 1-Desmethyl-2-methylpropyl Amorolfine (D292315), which is an analogue of Amorolfine Hydrochloride (A634170). Amorolfine hydrochloride is a salt of Amorolfine which is a morpholine antifungal drug. It is a topical solution for the treatment of toenail infections.<br>References Rotta, I., et al.: JAMA Dermatol., 149, 341 (2013); Espinel-Ingroff, A., et al.: Antimicrob. Agents Ch., 26, 5 (1984)<br></p>

<p>Applications 4-(2-methyl-1,3-oxazol-4-yl)benzene-1-sulfonyl chloride (cas# 1086376-81-9) is a useful research chemical.<br></p>

<p>Applications 4-Nitrophenyl-methoxycarbonylamino Amoxicillin is an intermediate used in the synthesis of N-(Penicillan-6-yl) Open Ring Amoxicillinamide Disodium Salt (P223050), which is an impurity of Amoxicillin (A634235); a semi-synthetic antibiotic related to Penicillin (P233500). Antibacterial.<br>References Brogden, R.N., et al.: Drugs, 18, 169 (1979); Bird, A.E., et al.: Anal. Profiles Drug Subs. Excip., 23, 1 (1994)<br></p>

<p>Applications Flucloxacillin-O-ethylacetate is an intermediate used in the synthesis of 6-APA Flucloxacillin (A726105), which is an impurity of Flucloxacillin (F419200), which is a new semi-synthetic penicllin.<br>References Markovich, M., et al.: Antibiot. Med. Biotekhnol., 31, 603 (1986), Rahman, M., et al.: Biochem. Pharmacol., 46, 1721 (1993), Silva, D., et al.: Med. Biol. Res., 37, 963 (2004)<br></p>

<p>Applications AHR 10240 Dimer is a dimer of 7-(4-Bromobenzoyl)-1,3-dihydro-2H-indol-2-one (B680190); a cyclic metabolite of Bromfenac (B678550).<br>References Osman, M.A. et al.: J. Chrom. Biomed. Appl., 489, 452 (1989); Isaka, M. et al.: Yakub. Dot., 14, 32 (1999)<br></p>

<p>Applications Quinolin-8-yl 2,2,5,5-Tetramethylthiazolidine-4-carboxylate is an intermediate in the synthesis of D,L-Penicillamine O-Lactose Adduct (P223020), which is an impurity of D-Penicillamine (P223000), a Penicillin metabolite used in the treatment of Wilson’s disease, Cystinuria, Scleroderma and arsenic poisoning.<br>References Marti-Prats, L., et al.: Neurosci. Lett., 483, 143 (2010); Singh, A., et al.: J. Pharm. Sci., 99, 3931 (2010); Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010);<br></p>

<p>Applications Desoxymycin is a derivative of streptomycin(S687223) which is an antibiotic produced by aerobic fermentation. Antibacterial (tuberculostatic).<br>References Weiss, et al.: Antibiot. Chemother., 7, 374 (1957), Umezawa, et al.: J. Antibiot., 27, 997 (1974), Mossa, J., et al.: Anal. Profiles Drug Subs., 16, 507 (1986),<br></p>