Compuestos y reactivos bioquímicos

<p>Panadoxine P is a peptide that has been shown to inhibit ion channels. It is a research tool used in pharmacology and cell biology, as well as for the study of protein interactions and receptor-ligand interactions. Panadoxine P has been shown to activate ion channels in the presence of calcium ions. Its high purity makes it suitable for use in life science experiments. Panadoxine P is an oligopeptide with a molecular weight of 521 Da, whose chemical name is 3-[2-(2-benzyl-1H-benzimidazol-1-yl)ethyl] benzoic acid ethyl ester. It has CAS number 36944-85-1.</p>

<p>2-(4-Bromophenyl)-2,3-dihydro-1H-perimidine is a research tool that can be used as an activator or a ligand. It has been shown to inhibit the activity of ion channels and may be useful in pharmacology. 2-(4-Bromophenyl)-2,3-dihydro-1H-perimidine binds to an antibody and causes it to bind to a receptor on the cell surface. This ligand is able to activate the receptor by binding to it and triggering a signal transduction pathway inside the cell. 2-(4-Bromophenyl)-2,3-dihydro-1H-perimidine is also able to inhibit protein interactions with peptides.</p>

<p>Lcmv gp33-41 is a synthetic analog of the human IL2 receptor alpha chain. This molecule has been shown to bind to the IL2 receptor alpha chain and stimulate the production of antibodies that are directed against it. Lcmv gp33-41 has also been shown to inhibit protein synthesis in infected cells, which may be due to its ability to bind to toll-like receptors on macrophages. Lcmv gp33-41 has also been shown to stimulate colony-stimulating factors by binding to monoclonal antibodies, which promote the growth and differentiation of white blood cells.</p>

<p>PYD-106 is a peptide that acts as an agonist at the receptor for bradykinin, which is also known as B2R. It has been shown to have activity in animal models of inflammation and pain. PYD-106 has also been shown to inhibit the activity of ion channels, such as TRPV1, TRPA1, and TRPM8.</p>

<p>Muscarinic M1 receptor agonist; anti-psychotic</p>

<p>JNJ-17203212 is a pharmacological compound, specifically a selective antagonist of the transient receptor potential vanilloid 1 (TRPV1) receptor. This compound is derived from synthetic chemical processes, emphasizing its role in modulating ion channel activity. The TRPV1 receptor is a non-selective cation channel expressed predominantly in sensory neurons.</p>

<p>Please enquire for more information about Thalidomide-o-C8-NH2 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Inhibitor of serotonin and norepinephrine reuptake</p>

<p>2,3-Dihydro-4H-1,3-benzoxazin-2-one-3-acetamide is a high purity and potent competitive antagonist of the nicotinic acetylcholine receptor (nAChR) that binds to the extracellular domain of the α7 subtype. It can be used as a research tool in pharmacology and cell biology to study ligand binding interactions with nAChRs. It has been shown to inhibit the binding of acetylcholine in rat brain synaptosomes. 2,3-Dihydro-4H-1,3-benzoxazin-2-one-3-acetamide is also an inhibitor of protein synthesis and has been shown to bind to the peptide chain elongation factor 2 (EF2) by inhibiting its activity.</p>

<p>CD86 antibody (PE) was raised in rat using LPS-activated murine B cells as the immunogen.</p>

<p>AMG 2850 is an investigational monoclonal antibody, which is derived from recombinant DNA technology with a specific mode of action targeting cancer cells. This therapeutic agent functions by binding to specific antigens expressed on the surface of malignant cells, thereby activating immune-mediated cytotoxic mechanisms or blocking signaling pathways crucial for tumor growth and survival. The precision of this antibody in targeting cancer cell antigens minimizes its impact on healthy cells, reducing potential side effects typically associated with broader-spectrum chemotherapies.</p>

<p>BAY 57-1293 is an antiviral agent, specifically classified as a helicase-primase inhibitor. It is derived from synthetic sources, developed by Bayer. Its mode of action involves inhibiting the helicase-primase complex of the Herpes Simplex Virus (HSV), crucial for viral DNA replication. By targeting this complex, BAY 57-1293 effectively halts the replication process of the virus, thereby impeding its proliferation and infection capability.</p>

<p>Imidafenacin hydrochloride is an officinal drug that possesses both respiratory and pulmonary activity. It is used for the treatment of bronchitis, cough, and other symptoms of the common cold. Imidafenacin hydrochloride has been shown to have anesthetic properties with a rapid onset of action. The mechanism of action is not well understood but may be due to its interaction with other drugs that have anaesthetic properties such as tetrahydropalmatine and salivary alkali.</p>

<p>Serine hydrolase inhibitor-11 is a biochemical research tool designed to target the serine hydrolase enzyme class. This compound is synthesized through advanced chemical methods, offering precise inhibitory effects on serine hydrolase enzymes. It functions by covalently binding to the active serine site within the enzyme's structure, effectively blocking its catalytic action and altering substrate metabolism.</p>

<p>Loreclezole hydrochloride is a chemical compound that has both an agonist and antagonist effect on the acid receptors. It is a gamma-aminobutyric acid (GABA) receptor agonist and an insecticidal chemical. It also has no known physiological effects in humans, but it is a benzene derivative with insecticidal properties. The insecticidal composition contains juvenile hormones that inhibit the growth of insects, specifically larvae of the order Lepidoptera. The isomer of Loreclezole hydrochloride is gamma-aminobutyric acid (GABA), which is found naturally in mammals and is essential for regulating neuronal excitability.</p>

<p>Chloroacetaldehyde (2,4-dinitrophenyl)hydrazone is an anticancer compound that has been shown to exhibit inhibitory effects on tumor growth in Chinese hamsters. This compound is a potent inhibitor of kinases, which are enzymes involved in the regulation of protein activity and cell signaling pathways. Chloroacetaldehyde (2,4-dinitrophenyl)hydrazone analogs have also been shown to induce apoptosis in cancer cells by disrupting mitochondrial function and increasing oxidative stress. In addition to its antitumor properties, this compound has been used as a biomarker for testosterone metabolism in human urine samples. Chloroacetaldehyde (2,4-dinitrophenyl)hydrazone holds promise as a potential therapeutic agent for the treatment of cancer and other diseases associated with abnormal kinase activity.</p>

<p>Pi3K/mTOR Inhibitor-2 is a synthetic small molecule, which is a highly specific chemical inhibitor. It is designed to simultaneously target and inhibit the phosphoinositide 3-kinase (Pi3K) and mechanistic target of rapamycin (mTOR) pathways. The source of Pi3K/mTOR Inhibitor-2 is entirely derived from lab-based chemical synthesis, ensuring a consistent and controlled formulation conducive to experimental reproducibility.</p>

<p>T338C Src-IN-1 is an antibody that recognizes the protein tyrosine kinase Src. This antibody binds to the ATP-binding site of Src and blocks its activation. T338C Src-IN-1 is a research tool that can be used in pharmacological studies to investigate the effects of small molecule inhibitors on protein-protein interactions, ion channels, cell biology, and pharmacology. It has been shown to inhibit tumor growth in certain types of cancer cells by blocking caspases and proteases. T338C Src-IN-1 also inhibits the function of other protein kinases such as JNK and PI3K.</p>

<p>Cloethocarb is a kinase inhibitor that has shown promising results in the treatment of cancer. It works by inhibiting kinases, which are enzymes that play a crucial role in cancer cell growth and survival. In Chinese hamster ovary cells, cloethocarb has been shown to inhibit hyaluronan synthesis and induce apoptosis. Additionally, it has been found to be effective in inhibiting the growth of human tumor cells and preventing the spread of cancer. Cloethocarb also acts as an analog inhibitor of somatostatin, a hormone that regulates various physiological functions such as insulin secretion and gastric acid secretion. It can be detected in urine samples and may have potential therapeutic applications in the treatment of various cancers, including those resistant to traditional chemotherapy agents.</p>

<p>GSK1059865 is a clinical candidate for the treatment of Parkinson's disease. It is a selective and potent D2 receptor agonist that has been shown to be safe and well-tolerated in humans. GSK1059865 binds to the D2 dopamine receptor, which is located on neurons in the striatum, where it inhibits glutamate release. GSK1059865 also binds to other dopamine receptors, but with much lower affinity. This drug has been shown to increase locomotor activity in wild-type mice, as well as prevent locomotor deficits induced by the administration of 6-hydroxydopamine (6-OHDA).</p>

<p>Alofanib is a potent inhibitor of CDK4/6, which inhibits the phosphorylation of Rb and the release of E2F1. It also inhibits the phosphorylation of secretase, leading to reduced production of amyloid-beta peptides and suppression of tumor growth. Alofanib has been shown to inhibit tumor growth in animals with adrenocortical carcinoma and urothelial carcinoma. It has been studied in clinical trials for patients with cancer. The effective dose determined in mice was 0.5 mg/kg/day, but it is not yet known what the effective dose will be in humans.</p>

<p>P38 mapk-in-1 is a protein kinase that belongs to the p38 family of serine/threonine kinases. It has been shown to have an important role in inflammation and cellular proliferation by regulating the expression of NF-κB. P38 mapk-in-1 may be a potential mechanism for investigating the relationship between inflammation and cellular proliferation in vitro models. In vivo studies have also shown that p38 mapk-in-1 is involved in chronic inflammation, which may be due to its inhibition of protein synthesis and activation of NF-κB. P38 mapk-in-1 may also play an important role in the development of cancer, since it has been found to be overexpressed in human lung cancer cells (A549).</p>

<p>Aligeron is a natural alkaloid compound, which is derived from specific plant sources known for their medicinal properties. This compound functions through the inhibition of inflammatory pathways, specifically targeting mediators involved in the inflammatory response. Aligeron disrupts the activity of enzymes and signaling molecules that precipitate inflammation, thereby modulating the immune response to reduce inflammation and promote healing.</p>

<p>Please enquire for more information about 4-[[2-(Octyloxy)benzoyl]amino]benzoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Docetaxel is a chemotherapy agent that is used to treat a number of cancers, including breast cancer, prostate cancer, lung cancer, and bladder cancer. Docetaxel-d9 is a solubilized form of docetaxel that has been validated for use in the treatment of cancer. It has been shown to inhibit the growth kinetics of carcinoma cell lines in vitro. The uptake of docetaxel-d9 was studied on bladder and plasma samples. In addition, it was found that docetaxel-d9 can be detected by a Western blot assay (WST-1). Docetaxel-d9 is also soluble in water and organic solvents such as acetone or ethanol.</p>

<p>Dihydrodiol ibrutinib is a tyrosine kinase inhibitor drug that has been shown to inhibit the growth of cancer cells by targeting the epidermal growth factor receptor. It can be used to treat non-Hodgkin's lymphoma and chronic lymphocytic leukemia. Dihydrodiol ibrutinib inhibits wild-type mouse cyp3a4 and human cyp3a4, which are responsible for metabolizing this drug. This inhibition leads to an increase in the blood concentration of dihydrodiol ibrutinib, which is currently being studied as a potential treatment for autoimmune diseases. The IR spectroscopy studies show that dihydrodiol ibrutinib binds to tubule cells in the kidney, which may lead to renal toxicity. The FTIR spectroscopy also showed that this drug binds with trifluoroacetic acid (TFA) during sample preparation, which may affect its stability.</p>

<p>Ixazomib Citrate (MLN9708) is a proteasome inhibitor that belongs to the class of investigational agents. It has minimal toxicity and is being investigated for use in the treatment of multiple myeloma, a type of cancer that starts in the bone marrow. Ixazomib Citrate inhibits the activity of proteasomes, which are cellular structures responsible for degrading proteins. This inhibition leads to an increase in the number of cells with damaged DNA and an increase in apoptosis. Ixazomib Citrate synergizes with other chemotherapeutic agents, such as bortezomib, to promote apoptosis by activating caspases and decreasing cell proliferation. The biochemical properties of this drug include its ability to inhibit protein synthesis by inhibiting eukaryotic ribosomes and its ability to bind to DNA at specific sites.</p>

<p>N-Desmethyl imatinib mesylate is an active metabolite of Imatinib Mesylate, a drug used to treat metastatic colorectal cancer. The compound is an inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) and is taken orally. N-Desmethyl imatinib mesylate has been shown to be effective in women with metastatic colorectal cancer, producing a hematologic response in 67% of patients. This compound has also been found to have a longer half-life than Imatinib Mesylate and may be used as a substitute for this drug in women with metastatic colorectal cancer who are unable to take oral medications.</p>

<p>Inhibitor of Akt kinase</p>

<p>1-(2-Benzyl-5-methylpyrazol-3-yl)-3-(3,4-difluorophenyl)urea is a synthetic chemical compound, which is typically synthesized through a series of organic reactions involving substituted pyrazoles and urea derivatives. This compound is primarily sourced from laboratory synthesis using controlled conditions to ensure purity and stability. Its mode of action involves the inhibition of specific protein kinases, which are essential in various signaling pathways within cells. By targeting these enzymes, this compound can disrupt cell proliferation and induce apoptosis, making it a valuable tool in cancer research.</p>

<p>MRS 5698 is a pro-inflammatory cytokine that belongs to the adenosine family. It activates the adenosine A3 receptor and has been shown to have analgesic effects in animal models of neuropathic and traumatic brain injury. MRS 5698 has been shown to protect against cell apoptosis in vitro, which may be due to its activation of the galr1/galr2 receptor subtype.</p>

<p>TAK-071 is a small-molecule pharmaceutical compound designed to modulate neuronal signaling. It is derived from rigorous medicinal chemistry optimization processes aimed at discovering selective central nervous system agents. TAK-071 acts as a positive allosteric modulator of the muscarinic M1 receptor, which is a subtype of the acetylcholine receptor widely distributed in the brain. Its mode of action includes enhancing cholinergic neurotransmission through selective binding and modulation, thus amplifying the effects of endogenous acetylcholine without directly activating the receptor itself.</p>

<p>Pep4c is a fatty acid that is trifunctional. It has optical properties and is used for whole-cell patch-clamp studies. Pep4c has been shown to have modulating effects on excitotoxicity, which may be due to its ability to inhibit the phospholipase C/protein kinase C pathway in neurons. This compound also has functional groups, such as carboxylate, that are important for polymerization initiation. Pep4c is soluble in water and has a particle size of 20 nm and a diameter of 4 nm. Pep4c sequences are potentiated by other compounds with similar sequences.</p>

<p>PF-04701475 is a drug that inhibits the mitochondrial pathway of glutamate metabolism, which leads to the production of reactive oxygen species and neurodegeneration. PF-04701475 has been shown to be effective in treating symptoms of Alzheimer's disease in preclinical studies. It also has anti-inflammatory properties and may be useful for treating nervous system diseases, such as Parkinson's disease. PF-04701475 is currently under clinical development for the treatment of Parkinson's disease.</p>

<p>Pancoprida is a bioactive peptide, which is a synthetic compound derived from rational peptide design and combinatorial chemistry techniques. It functions through the modulation of specific receptor pathways, primarily targeting neuronal and inflammatory processes. Pancoprida exhibits high affinity for serotonin receptors, influencing neurotransmitter release and uptake, and also modulates certain cytokine pathways, thereby reducing inflammation.</p>

<p>LPA2 Antagonist 1 is a research tool that inhibits the activity of LPA2, a receptor protein. It can be used in the study of ligand-receptor interactions and cell biology. LPA2 Antagonist 1 binds to the LPA2 receptor and prevents it from activating intracellular signaling pathways. This product has high purity and is suitable for use as a pharmacological reagent or peptide.</p>

<p>CH 275 is a synthetic chemical compound that functions as an insecticide, originating from advanced chemical synthesis processes. This compound exerts its effects primarily through contact action, disrupting essential biological pathways in targeted pest species. By inhibiting neurotransmitter activity at synaptic junctions, CH 275 effectively paralyzes and neutralizes insects upon application.</p>

<p>LY2940094 is a peptide that binds to the receptor and blocks the ion channels. It is also an inhibitor of cyclic AMP-dependent protein kinase and phosphatidylinositol 3-kinase. LY2940094 has been shown to be a potent inhibitor of neurotransmitter release from nerve terminals, as well as from cultured neurons. The peptide is also used in research to study protein interactions, cell biology, ligand pharmacology, and life science.</p>

<p>GSK1324726A is a small-molecule drug that can be used to treat cancer. It inhibits the HDAC enzyme, which is required for transcriptional repression of genes involved in tumorigenesis. GSK1324726A has been shown to inhibit the expression of suppressor genes and promote apoptosis in myeloid leukemia cells. This drug also potently inhibits HIV replication in vitro and has shown promising results in clinical studies involving patients with AIDS. GSK1324726A binds to bromodomain proteins, which are domains found on histone proteins that bind to acetylated lysine residues on DNA. These domains are known for their ability to regulate gene expression by binding to acetylated lysine residues on histone proteins and blocking transcriptional activation.</p>

<p>PF-05089771 is a small molecule that binds to the human P2X7 receptor and blocks its activation by ATP. It has shown to have anti-cancer effects in preclinical studies, and is currently being evaluated in phase 1 clinical trials for various cancers. PF-05089771 has also been shown to have anti-inflammatory properties, as well as pain relief effects in an animal model of chronic pain. This drug is also expressed at high levels in cancer tissues, which may be due to its role in cell proliferation. The structural biology of PF-05089771 is not yet known.</p>

<p>Inhibitor of MEK kinases</p>

<p>CLK1-IN-1 is a small molecule compound, specifically a selective inhibitor, which is synthesized in laboratory settings. This product targets CDC-like kinases (CLKs), particularly CLK1, which are a group of serine/threonine-protein kinases involved in the regulation of alternative splicing. CLK1-IN-1 functions by binding to the active site of CLK1, thereby inhibiting its kinase activity. This inhibition can modulate the splicing of pre-mRNA, which is crucial for understanding regulatory mechanisms in gene expression.</p>

<p>Influenza A antibody was raised in mouse using Influenza A from A/Texas strain as the immunogen.</p>

<p>Cis-(-)-paroxetine hydrochloride is a medicinal drug that has shown potential in anticancer therapy. It is an analog of the antidepressant paroxetine and acts as a protein kinase inhibitor. Cis-(-)-paroxetine hydrochloride has been found to induce apoptosis in cancer cells, particularly in Chinese hamster ovary cells. It also inhibits the growth of tumor cells and has been shown to be effective against a variety of cancers. This drug is excreted mainly through urine and has been found to have synergistic effects when combined with nalbuphine, an opioid analgesic. Cis-(-)-paroxetine hydrochloride holds great promise as a potent inhibitor of protein kinases, which play crucial roles in cancer cell proliferation and survival.</p>

<p>(R)-Zinc-3573 is an antimicrobial peptide that has been expressed in the ganglia of a mouse. The peptide has shown chemotactic activity for eosinophils and vasoactive intestinal peptide-induced contraction of intestinal muscle cells. (R)-Zinc-3573 also inhibits the production of inflammatory mediators, such as chemokines and cortistatin, which are released by activated immune cells. This peptide has also shown inhibitory activities against drug reactions and allergic reactions.</p>

<p>Product is animal derived</p>

<p>MEK1 and MEK2 inhibitor</p>

<p>AZ-1355 is a novel, orally bioavailable, small molecule inhibitor of collagen-specific proteinase (MMP-1) that has been shown to be effective in preventing the development of cerebral amyloidosis in hamsters. AZ-1355 is orally bioavailable and penetrates the blood brain barrier, thus reducing the amount of MMP-1 that can enter the brain. This drug has also been shown to reduce cardiac collagen deposition and improve endothelial function. AZ-1355 has not been tested on humans or animals for its potential toxicity, but it does have a toxic profile in vitro. This drug has also been shown to have damaging effects on platelets and cause death in cultured cells.</p>

<p>SKLB-23bb is a small molecule that inhibits the polymerization of microtubules. It inhibits the assembly and stability of microtubules by binding to tubulin, preventing the formation of stable polymers. SKLB-23bb has been shown to be effective in inhibiting tumor growth in xenografts in mice. It also inhibits the proliferation of cancer cells, but not normal cells, which may be due to its ability to inhibit gene transcription. This drug also has a number of modifications, such as a hydroxy group, that allow it to be orally administered and modified with colchicine. These modifications make SKLB-23bb an attractive candidate for cancer therapy.</p>

<p>Bradykinin acetate is a synthetic form of Bradykinin that is used as a nutritional supplement for people with chronic bronchitis. It is a solid-phase synthesis of bradykinin and has been shown to have the same effects on blood pressure as bradykinin b2. Bradykinin acetate has also been shown to cause vasodilation, which may be due to its ability to bind to the ryanodine receptor and activate calcium release from intracellular stores. This drug can be detected in test samples using laser ablation waveform analysis.</p>

<p>ABC 294640, also known as opaganib, is a sphingosine kinase 2 (Sphk2) inhibitor with anti-inflammatory and anti-viral activity. Sphingosine kinases (SK1 and SK2) are enzymes involved not only in the sphingolipid metabolism pathway, but also in the promotion of tumour growth and pathologic inflammation. During the COVID-19 pandemic, ABC 294640 has been suggested for the treatment of critically ill patients.</p>

<p>RTC13 is a creatine kinase (CK) analog that is not found in any other CK family. It has been shown to be active against cell-specific CK deficiency, with no effect on other CKs. RTC13 is a purine derivative and as such, it cannot be phosphorylated by CK enzymes. This means that the drug can only inhibit protein synthesis by binding to nuclear hormone receptors, which are involved in transcriptional regulation of gene expression. Clinical studies have shown that RTC13 can improve heart function and eye disorders, as well as reduce skin cancer rates.</p>

<p>T 0156 Hydrochloride is a chemical compound used primarily in neuroscience research. It is a synthetic organic molecule developed to interact with specific neuroreceptor sites. This compound is typically sourced from advanced chemical synthesis techniques in laboratory settings, ensuring high purity and stability suitable for research applications.</p>

<p>AZ9482 is a small molecule that binds to the acceptor site of the enzyme DNA polymerase β. It has potent antitumor effects, and shows high selectivity for tumor cells over normal cells. AZ9482 inhibits the growth of tumor cells in low nanomolar concentrations. This compound has been shown to inhibit the synthesis of DNA, RNA and proteins in cancer cells, which may be due to its ability to bind to the polymerase acceptor site. AZ9482 has been shown to have anti-inflammatory properties by inhibiting nuclear factor-kappaB (NF-κB) activation.</p>

<p>GCN2-IN-6 is a potent and selective activator of the GCN2 protein kinase. GCN2 is a serine/threonine protein kinase that phosphorylates eIF2α, leading to an increase in protein synthesis. The GCN2-IN-6 peptide can be used as a research tool to investigate the role of GCN2 in cell biology and for the study of ion channels, peptides and antibodies.<br>GCN2-IN-6 has been shown to inhibit antibody production by inhibiting protein interactions with B cells and macrophages, which are important for antibody production.</p>

<p>Methylliberine is an anticancer compound that functions as a kinase inhibitor. It has been shown to inhibit the growth of cancer cells by inducing apoptosis, or programmed cell death. Methylliberine is a Chinese herbal medicine and is found in human urine after consumption of oseltamivir, an antiviral drug. Methylliberine acts as an analog to protein kinases, which are enzymes that regulate cellular signaling pathways. By inhibiting these kinases, methylliberine prevents the activation of tumor-promoting proteins and reduces the growth of cancer cells. This natural compound has great potential as a therapeutic agent for cancer treatment due to its ability to selectively target cancer cells while sparing healthy cells.</p>

<p>This tripeptide active linker is cleaved enzymatically in targeted cells. It is commonly used in ADCs and other conjugates for controlled drug release.</p>

<p>C10 Bisphosphonate is a high purity, non-toxic, and water soluble compound. It is used as a research tool for cell biology and receptor pharmacology. C10 Bisphosphonate binds to the extracellular domain of integrin receptors such as alpha v beta 3 and alpha v beta 5. It also inhibits ligand binding to the receptor, leading to inhibition of cellular functions such as cell proliferation and migration.</p>

<p>Anti Amyloid B-Protein (1-40), human serum is a recombinant inhibitor of amyloid beta protein (Aβ) that inhibits the formation of amyloid plaques in Alzheimer's disease. This product is used as a research tool for studying the mechanism of Aβ toxicity. It is also used as a reagent for antibody detection and other research purposes.</p>

<p>Edotreotide trifluoroacetate is a diagnostic agent that is used to diagnose hepatic steatosis. It is a synthetic analog of somatostatin, which can be synthesized by the reaction of trifluoroacetic acid and hydroxyl compounds. Edotreotide trifluoroacetate is radiolabeled with technetium-99m and administered intravenously. The drug binds to receptors on the surface of proximal tubule cells in the liver, causing an uptake of this radionuclide in the area of interest. This diagnostic agent has also been shown to inhibit insulin release from pancreatic beta cells and improve glucose tolerance in patients with type 2 diabetes mellitus.</p>

<p>This is a Biologically Active Peptides, Short=PN-II, Proteomics, Amyloid Precursor Protein, New England Peptide calibrated to 25nmol. This peptide has been shown to be a major component of amyloid plaques in Alzheimer's Disease. It is one of the most abundant proteins in the brain and is found in association with beta-amyloid protein (A4). The precursor protein for APP is encoded by the gene on chromosome 21. APP and its products are involved in many cellular processes such as signal transduction, cell proliferation, apoptosis and inflammation. APP can be cleaved by Beta-secretase or Gamma secretase to release A4 and N-APP.</p>

<p>3-Methyl-4H-1,4-benzothiazine-2-carbohydrazide is a peptide that has been shown to activate the immune system by binding to the Fc receptor. It also inhibits ligand and receptor interactions, which may be useful in pharmacology studies and for developing new drugs. 3-Methyl-4H-1,4-benzothiazine-2-carbohydrazide is used as a research tool for studying protein interactions and ion channels. This compound has been shown to have high purity with an analytical purity of 99%. The CAS number for 3-Methyl-4H-1,4-benzothiazine 2 carbohydrazide is 16905847.</p>

<p>Immunoglobulins IgM Light Tryptic Peptide Standard for protein identification and quantitation studies. IgM is an antibody isotype that is the first type to be produced when the body is invaded by a pathogen and therefore a key indication of infection.</p>

<p>Arg-MCA is a synthetic peptide that activates the receptor for bradykinin. It is used as a research tool in cell biology and pharmacology to study the interactions of peptides with various receptors and ion channels. Arg-MCA has been shown to inhibit the activity of ligand-gated ion channels, such as nicotinic acetylcholine receptors and glutamate receptors.</p>

<p>Insulin is a peptide hormone that regulates the metabolism of carbohydrates, fats, and proteins. Insulin has been shown to bind to insulin receptors in the cell membrane. When insulin binds to the receptor, it triggers a series of biochemical reactions that lead to increased glucose uptake by cells and increased synthesis of glycogen in the liver. Insulin also activates ion channels, which leads to an increase in calcium influx into cells. Insulin is involved in many other functions within the body, such as promoting growth and development, regulating protein synthesis, and controlling lipid storage.<br>Insulin is used as a research tool for studying carbohydrate metabolism or as an antidiabetic drug for people who have diabetes mellitus. The most common form of insulin used today is human recombinant insulin (H-insulin). Human recombinant insulin can be synthesized from genetically engineered bacteria or yeast cultures.</p>

<p>Ac-Abu-D-Tyr-Leu-Gln-VS is a synthetic peptide that can be used as a research tool, an activator, or an inhibitor. It is a high purity product that has been extensively tested for its use in ion channels and receptor pharmacology.</p>

<p>Big endothelin-1 (ET-1) is a peptide with a molecular weight of 37.7 kDa that belongs to the class of endothelin peptides. ET-1 is an activator of ion channels and has been implicated in many physiological and pathological processes, including vasoconstriction, angiogenesis, cellular proliferation, and inflammation. The antibody reacts with human ET-1 with a high degree of specificity. It has been used as an immunological reagent for Western blotting and immunoprecipitation experiments.</p>

<p>VTP50469 is a synthetic analogue of the fatty acid cay10666, which has been shown to inhibit the proliferation of leukemia cells in vitro. VTP50469 is also effective against cancer cell lines derived from various organs, including carcinoma cell lines and epidermal growth factor-secreting cells. The mechanism of action of VTP50469 may be related to its ability to interact with DNA polymerase during DNA synthesis or replication, resulting in inhibition of the enzyme's activity. The effect of VTP50469 can be synergistic with other chemotherapeutic agents such as cisplatin, doxorubicin, and vincristine. This drug has also been shown to have anti-angiogenic properties and inhibit tumor growth in vivo.</p>

<p>Please enquire for more information about Furamidine-d8 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>(αR,3R)-N-[3-[5-Fluoro-2-[(3-methoxy-1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]-1H-indol-7-yl]-α,3,4-trimethyl-1 -piperazineaceta mide is a peptide with the sequence N-(3-[5fluoro2[(3methoxy1methyl1Hpyrazol4yl)amino]4pyrimidinyl]-1Hindol7yl)α34trimethylpiperazineacetamide. It is an activator of ion channels and has been used to study the effects of ion channels on life science. The CAS number for this compound is 20911343577.</p>

<p>Anti GLP-2 (Rat) Serum is a high purity and potent activator of the GLP-2 receptor. It is a peptide that binds to the GLP-2 receptor and activates it. The GLP-2 receptor is a G protein coupled receptor that belongs to the class of receptors for peptides. Activation of this receptor leads to an increase in intracellular calcium ions and increased cell proliferation, differentiation, and survival. This product can be used as a research tool for Cell Biology, Pharmacology, or Biochemistry studies.</p>

<p>Uroguanylin is a peptide that activates the guanylate cyclase receptor. It is composed of 8 amino acids and has a molecular weight of 1036.5 Da. Uroguanylin is an agonist for the GUCY1A2 receptor, which is responsible for mediating the release of urinary and gastrointestinal hormones such as vasopressin, renin, and gastrin. Uroguanylin binds to one or more other receptors in the kidney or intestine. It can be used as a research tool in cell biology and biochemistry to study ion channels and ligands.br&gt;br&gt;<br>br&gt;br&gt;<br>Uroguanylin is also known by its CAS number 71405-27-8.BR&gt;BR&gt;</p>

<p>Cytochrome B5 Reductase 3, human, recombinant is a high-quality protein used in research and scientific studies. Produced using Escherichia Coli, this protein is essential for various biological processes. Cytochrome B5 Reductase 3 plays a crucial role in electron transfer reactions and is involved in the metabolism of drugs and toxins. It has been extensively studied for its ability to catalyze the reduction of cytochrome b5, an important component of the electron transport chain. This recombinant protein provides researchers with a reliable tool to investigate cellular processes and advance scientific knowledge.</p>

<p>3-(5-((2-(6-((2,3-Dimethylphenyl)amino)-[1,2,5]oxadiazolo[3,4-b]pyrazin-5-yl)hydrazineylidene)methyl)furan-2-yl)benzoic acid is a small molecule that interacts with ion channels and inhibits the function of ligand binding sites. It is used as a research tool in pharmacology and protein interactions. 3-(5-[(2-[6-[(2,3-dimethylphenyl)amino]-[1,2,5]oxadiazolo[3,4-b]pyrazin-5-yl)hydrazineylidene] methyl)furan-2-yl)benzoic acid has been shown to bind to the acetylcholine receptor and block ligand binding. It also inhibits activation of G protein coupled receptors by inhibiting the</p>

<p>Elafin is a peptide that is secreted by human neutrophils. It has been shown to inhibit the activity of ion channels and play a role in the regulation of cell proliferation and differentiation. Elafin also interacts with receptors and ligands, which are molecules that bind to other molecules. It is also used as a research tool for studying protein interactions in cell biology. Elafin has been shown to have an anti-inflammatory effect on cells, which may be due to inhibition of the production of prostaglandins.</p>

<p>2-Amino-N-[(1S,2R,3E)-1-[[(O-'-D-galactopyranosyl-(1'4)-O-'-D-galactopyranosyl-(1'4)-'-D-glucopyranosyl)oxy]methyl]-2-hydroxy-3-heptad ecen-1-yl]acetamide is a research tool for Cell Biology. CAS No. 1360882-59-2. It is an activator of Ligand and Receptor. This chemical has been shown to interact with Ion channels and Protein interactions. 2AAD has also been shown to act as a pharmacological inhibitor of peptides in Life Science.</p>

<p>monoFITC INSL5 is a peptide that can be used as a research tool to investigate the interactions between proteins and ligands. It is an activator of the Insulin-like growth factor 1 receptor (IGF1R). This peptide has been shown to inhibit IGF1R-mediated signaling pathways that lead to cell proliferation.</p>

<p>Please enquire for more information about SDZ 285-428 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Hepcidin is a peptide hormone that regulates iron absorption in the intestine. It is secreted by hepatocytes, the primary cells of the liver. Hepcidin-Murine Compete^TM ELISA Kit (1ea) is a competitive enzyme-linked immunosorbent assay (ELISA) kit for measuring hepcidin concentrations in mouse serum. This assay has been validated to measure hepcidin concentrations up to 1000 pg/mL with sensitivity as low as 1 pg/mL. The kit can be used to diagnose iron deficiency anemia and other diseases associated with hepcidin deficiency.</p>

<p>Bz-Gly-Ala-Pro is a synthetic tripeptide. It has been shown to have a carboxypeptidase activity, which hydrolyzes the C terminal of peptides and proteins. Bz-Gly-Ala-Pro was found to be active at a pH range of 2.0 to 10.0, with optimum activity at pH 4.5 to 6.0. The enzyme was found to be stable in captopril perfusates and showed no inhibition from trypsin or pepsin digestion. This peptide binds specifically to the carboxy terminal amino acid of dietary proteins, such as casein, soy protein, and egg albumen, and may play an important role in intestinal digestion and absorption by acting on these sites as well as on other peptidases that are present in the intestinal tract.</p>

<p>Rac-Methyl ephedrine-d3 hydrochloride is a research tool that is used to study the function of ion channels. It is a high purity ligand for the alpha2 receptor, which is found in the heart and brain. Rac-Methyl ephedrine-d3 hydrochloride has been shown to activate this receptor and may be useful for the treatment of hypertension and Parkinson's disease. This compound has also been shown to inhibit protein synthesis by binding to a specific site on ribosomes.</p>

<p>A standard for use in proteomics</p>

<p>Acid Red 1 is an optical sensor that produces a change in color when it reacts with a substance. It also has fixative properties and is used to preserve biological samples. Acid Red 1 is typically made up of two components: one that absorbs light at 660 nm and another that absorbs light at 780 nm. The rate constant for the reaction between Acid Red 1 and the substance is proportional to the concentration of the substance. Acid Red 1 has been shown to have synergistic effects when combined with other dyes, such as Sudan III. This dye can be used on biological samples such as blood, skin, or hair for genotoxic activity testing or for analytical methods such as electrochemical impedance spectroscopy.</p>

<p>Zanubrutinib is a small molecule drug that inhibits the activity of epidermal growth factor receptor (EGFR), which is involved in the development and progression of cancers. It also inhibits other targets, such as HER2+ breast cancer cells. Zanubrutinib has been shown to inhibit tumor growth in a xenograft model of skin cancer. The compound was well tolerated, with no signs of toxicity or adverse events observed at doses up to 400 mg/kg.</p>

<p>Asapiprant is a metabolic product of the drug asacol. It has been shown to have anti-inflammatory effects and has been used in studies to determine its efficacy in treating humans infected with covid-19 pandemic. Asapiprant has also been shown to be an effective diagnostic agent for detecting the presence of eicosanoids in nasal fluid. This compound has not yet been tested on animals or humans.</p>

<p>EOS 60387 is an antibody that binds to the extracellular domain of the human protein, TRPC1. It is a cell biology research tool that can be used to study protein interactions, ion channels, and other life sciences. EOS 60387 has high purity and is available in a CAS No. 1001180-45-5 form for purchase at Life Science.</p>

<p>4-N,N-Bis(4-methylphenyl)-amino-benzaldehyde-N,N-diphenylhydrazone is a research tool and can be used to study interactions of ligands with receptors. This chemical is also an activator that stimulates ion channels in cells, which can lead to a change in the membrane potential. It has been shown to be a potent inhibitor of protein interactions that are mediated by peptides. 4-N,N-Bis(4-methylphenyl)-amino-benzaldehyde-N,N-diphenylhydrazone also has high purity and is suitable for use in cell biology and pharmacology.</p>

<p>HMR 1098 is a κ-opioid receptor agonist that has shown to have the ability to protect against myocardial infarct in anesthetized animals and to increase ATP levels. This drug also has metabolic effects, as it can improve mitochondrial function and prevent mitochondrial membrane potential from being reduced by oxidative stress. HMR 1098 also prevents the activation of atp-sensitive K+ channels in ventricular myocardium, which leads to an increase in cardiac contractility and improved heart rate. This drug has been shown to be effective in vivo, as it was able to reduce infarct size in a rat model of myocardial infarct.</p>

<p>3,6,9,15-Tetrazabicyclo[9.3.1]pentadeca-1(15),11,13-triene is a ligand that binds to the nicotinic acetylcholine receptor (nAChR). It is an antagonist of nAChRs and blocks their activation by acetylcholine. 3,6,9,15-Tetrazabicyclo[9.3.1]pentadeca-1(15),11,13-triene is used as a research tool to study the function of nAChRs in cell biology and pharmacology. The ligand has been shown to be an inhibitor of ion channels, such as potassium channels.</p>

<p>Gabaa receptor agent 1 is a research tool for cell biology, pharmacology and ion channels. Gabaa receptor agent 1 has been shown to inhibit the GABAa receptor in vitro by competitive binding to the ligand binding site. This agent binds to the GABAA receptor with high affinity and selectivity. It is a potent activator of GABAA receptors and an inhibitor of GABA-gated currents. Gabaa receptor agent 1 is used as a research tool for studying protein interactions, antibody production and other applications.</p>

<p>Furobufen is a potent inhibitor of the enzyme c-Jun N-terminal kinase. It blocks the activity of this enzyme, which is involved in the regulation of cell proliferation, differentiation and apoptosis. Furobufen is therefore used as a research tool to study the role of c-Jun N-terminal kinase in these processes. Furobufen also binds to and inhibits protein interactions such as receptor and ligand interactions, and ion channel activity. Furobufen has been shown to act as an antagonist of potassium channels, which are important for regulating membrane potentials and cellular excitability.</p>

5-Fluoro-2-(1-methyl-1H-pyrrolo(2,3-B)pyridin-5-yl)oxazolo(5,4-B)pyridine is an antibody that targets the protein Ion channels. It has a high purity and is being used to study the interactions of proteins with other proteins and ions. 5FMOPP has been shown to inhibit the activation of ion channels by binding to them. This antibody is also used as a research tool for studying cell biology and pharmacology.

<p>Oxybenzone is a high-purity, synthetic peptide-based fluorescence probe that can be used to measure the activity of ion channels. Oxybenzone binds tightly to the receptor site of the ion channel and inhibits its activity. This inhibition can be measured by changes in fluorescence intensity. Oxybenzone is a competitive inhibitor and has been shown to inhibit the following channels: potassium (K+), sodium (Na+), calcium (Ca2+), and chloride (Cl-).</p>

<p>Please enquire for more information about 4-Desfluoro-6-fluoro dolutegravir including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>PC945 is a potent protein kinase inhibitor that has been shown to induce apoptosis in cancer cells. This Chinese analog of rifampicin inhibits the activity of kinases, which are enzymes that play a critical role in cell signaling and regulation. PC945 has been found to be effective against several types of cancer, including human lung and prostate cancer. This inhibitor also exhibits anti-tumor activity by blocking the growth and proliferation of tumor cells. Additionally, PC945 has been found to have potential as an anticancer agent due to its ability to inhibit the growth of cancer cells in vitro and in vivo. Its efficacy has also been tested in urine samples from patients with bladder cancer, where it showed promising results as a potential diagnostic tool for this disease.</p>

<p>Ac-Lys-Thr-Lys-Gln-Leu-Arg-AMC is a peptide that is used as a research tool in the study of protein interactions. Ac-Lys-Thr-Lys-Gln-Leu-Arg-AMC binds to the acetylcholine receptor (AChR) at the interface between two subunits, which inhibits the formation of ion channels and blocks neurotransmission. This peptide has been shown to be a potent inhibitor of AChR activation by nicotinic agonists, such as acetylcholine (ACh), nicotine, and carbachol. Acetylcholine binding to AChRs induces conformational changes in the receptor that are transmitted across the synapse to activate postsynaptic receptors on muscle cells. Acetylcholine binding triggers an allosteric change in the AChR that results in increased permeability of ion channels, leading to depolarization of</p>

<p>D-Arginyl-[Hyp3,Thi5,8,D-Phe7]-Bradykinin is a biochemicals that acts as an antagonist of bradykinin. Bradykinins are peptides that are active in the human body and have a variety of physiological effects. D-Arginyl-[Hyp3,Thi5,8,D-Phe7]-Bradykinin has been shown to inhibit the release of neurotransmitters from nerve cells and has anti-inflammatory properties. It also has been shown to inhibit the activity of protein kinase C.</p>