Compuestos y reactivos bioquímicos

<p>Poly(ethylene glycol) bisazide is a ligand that is used in research and as a pharmacological tool. It has been shown to inhibit the receptor for peptides, which may be due to its ability to bind with antibodies. Poly(ethylene glycol) bisazide can also be used as a research tool to study protein interactions. This ligand is known to activate ion channels and receptors. Poly(ethylene glycol) bisazide has CAS number 82055-94-5 and is of high purity.</p>

<p>Nalidixic acid-d5 is a research tool that can be used in the study of ion channels and receptors. It is an activator ligand that binds to its receptor, leading to a conformational change. Nalidixic acid-d5 may also inhibit the activity of a protein by binding to it, blocking access to an active site or substrate. This product has been shown to have pharmacological properties and can be used in the study of peptides.</p>

<p>Oxytocin antagonist</p>

<p>Please enquire for more information about (±)-2-Chlorobutane-d9 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Inhibitor of FAK kinase</p>

<p>Naloxone methiodide is a microdialysis probe that blocks the effects of opioids, such as morphine and codeine. It is a competitive antagonist of κ-opioid receptors and has been shown to be effective in reducing locomotor activity in rats with chronic pain. Naloxone methiodide has also been shown to block the binding of kappa-opioid receptors by naloxone. This drug has been used in vivo as a model for bowel disease, myocardial infarct, and small-molecule drug testing.</p>

<p>Cis-ned 19 is a fluorescent probe that binds to the messenger RNA for angiotensin. It binds to the intracellular region of the sodium channel, which is a type of ion channel in the membrane of muscle cells. This binding inhibits the opening of the sodium channel and prevents an increase in calcium concentration in the cytoplasm. Cis-ned 19 also inhibits adenine dinucleotide phosphate (ADP) and increases adenosine diphosphate (ADP) concentrations, which leads to an inhibition of muscle contraction.</p>

<p>Anti CGRP (Rat) Serum is a research tool used to study the function of calcitonin gene-related peptide (CGRP) in cell biology. It is an antibody that binds to the CGRP receptor and blocks the activation of ion channels, which are important for pain perception. This serum can be used as a blocking agent in experiments to study the effects of CGRP on cells.</p>

<p>AZD2932 is a small molecule that is an inhibitor of the CXCR4 receptor and has been shown to inhibit the proliferation of various types of cancer cells. The compound binds to the receptor and blocks its function, which may lead to the death of cancer cells. AZD2932 has also been shown to reduce inflammation in mice with inflammatory diseases, such as arthritis. This drug has not been tested in humans, but it has been shown to be effective against hepg2 cells and lung fibroblasts in cell culture studies. AZD2932 was found to be an effective dose for inhibiting adp-ribose production, which is a key regulator of endothelial cell proliferation. AZD2932 also appears to have structural biology interactions with monoclonal antibodies that could lead to new therapeutic treatments for cancer and other diseases.</p>

<p>5β-Finasteride (5β-F) is a synthetic steroid that inhibits the conversion of testosterone to dihydrotestosterone. It is used in the treatment of benign prostatic hyperplasia and male-pattern hair loss. 5β-F has been shown to be effective against alopecia, as well as other symptoms such as decreased libido and impotence. 5β-F has also been found to inhibit the progesterone receptor with an IC50 value of 3 nM, making it a potential progesterone receptor antagonist. The pharmacokinetics of 5β-F have been studied in rats, showing it is rapidly absorbed from the gastrointestinal tract and metabolized by the liver. The inhibition constant for this drug is 0.2 μM, which makes it a potentiator for drugs such as creatine kinase or phenytoin. The clinical trials on humans show that 5β-F inhibits creatine kinase activity and can potentiate other drugs</p>

<p>JNJ-46281222 is a drug that has been shown to have allosteric modulatory activity at the metabotropic glutamate receptor. It has been shown to decrease the duration of psychosis in animal models, and may be useful for long-term treatment of schizophrenia. JNJ-46281222 binds to the metabotropic glutamate receptor and inhibits glutamate release, leading to decreased symptoms of psychosis. This drug has also been shown to have an onset latency of 4 hours in humans.</p>

<p>SIRT1 activator</p>

<p>DLK-IN-1 is a synthetic small-molecule inhibitor, which is a product derived from targeted chemical synthesis with the specific aim of modulating the function of certain kinases. This inhibitor is sourced through advanced laboratory techniques that allow for precision-targeting of proteins involved in cellular signaling pathways. DLK-IN-1 specifically inhibits the dual leucine zipper kinase (DLK), a protein kinase involved in neuronal regeneration and degeneration pathways. By binding to the ATP-binding site of DLK, it prevents the phosphorylation of downstream substrates, thus modulating the DLK-mediated signaling cascade.<br><br>The utilization of DLK-IN-1 primarily lies in neurological research, particularly in understanding and potentially mitigating neurodegenerative diseases and nerve injury responses. It is instrumental in studying the roles of DLK in axonal degeneration and regeneration, providing insights into therapeutic approaches for conditions like Alzheimer's, Parkinson's, and other neurodegenerative disorders. Researchers employ DLK-IN-1 to dissect the DLK signaling mechanism, aiming to discover novel intervention points within neuronal repair and deterioration processes. The specificity and action of DLK-IN-1 make it a crucial tool for probing deeper into the molecular underpinnings of nerve health and disease.</p>

<p>Migrastatin is a peptide that binds to and inhibits the function of ion channels. It has been shown to inhibit voltage-activated potassium channels in rat hippocampal neurons, as well as transient receptor potential cation channel subfamily V member 1 (TRPV1) in human peripheral nociceptors. Migrastatin also inhibits the activity of ligand-gated ion channels such as nicotinic acetylcholine receptors and 5HT3 receptors. Migrastatin was previously shown to be an inhibitor of high purity with a CAS number of 314245-65-3. This chemical is used as a research tool for cell biology and pharmacology studies.</p>

<p>Tmppaa is a potentiator of 5-hydroxytryptamine (5-HT) and has been shown to increase the activity of serotonin in rat brain. It has also been shown to be an allosteric modulator of 5-HT and voltage-gated ion channels, which may be due to its interaction with the orthosteric binding site. Tmppaa interacts with 5-HT at high concentrations, but not at low concentrations. This compound was found to be well tolerated in animals and is characterized by a lack of toxicity. Tmppaa has also been shown to inhibit the growth of cancer cells in vitro.<br>Tmppaa is synthesized using an orthogonal chemistry approach that involves solid dispersions and cryo-electron microscopy (cryoEM).</p>

<p>FGF-19 is a protein that has been shown to be an activator of the FGF receptor. It also has been shown to act as a ligand for the FGF receptor, which is a cell surface-bound protein. This protein is involved in the regulation of ion channels and other cellular processes that are important for growth and development. Recent studies have demonstrated that FGF-19 can inhibit the binding of peptides to antibodies, which may have an effect on pharmacology and immunology.</p>

<p>Neuropeptide Y is a potent neuropeptide that regulates many biological processes in vertebrates. It has been shown to regulate various processes, including feeding, anxiety, reproduction, and pain. Neuropeptide Y is synthesized as an amide of the amino acid L-tyrosine. The synthetic peptide can be either enantiomer or a mixture of both enantiomers. The presence of neuropeptides Y in the extracellular fluid is potently regulated by the neuropeptide Y receptor subtype 2 (Y2R). Neuropeptide Y has been shown to inhibit egg development in mosquitoes when injected into their ovaries at high doses. This effect was dose-dependent and was mediated by receptors on the surface of cho-k1 cells (a rat kidney cell line). The homologues of neuropeptide Y are called peptides PYY and PYY3-36.</p>

<p>L-Erythro-chloramphenicol is a deacylated form of chloramphenicol, which inhibits protein synthesis by binding to the bacterial ribosome. It is an antibiotic that is used to treat bacterial infections. L-Erythro-chloramphenicol has been shown to inhibit mitochondrial protein synthesis and mitochondrial proteins in mitochondria. The drug also inhibits the production of proteins in bacterial cells, such as extracts from Escherichia coli and escherichia coli. L-Erythro-chloramphenicol has two dichloroacetyl isomers, which are responsible for its antibacterial activity. The phenyl ring on the molecule serves as a site for chemical reactions with other molecules.</p>

<p>PDK1/Akt/Flt Dual Pathway Inhibitor is a drug that inhibits the activity of diacylglycerol, a lipid molecule that can be produced by the cells when they are stimulated by growth factors. PDK1/Akt/Flt Dual Pathway Inhibitor binds to the receptor for tnf-α and blocks its binding site on the surface of cells, thereby preventing activation of the protein. This drug has been shown to reduce tumor size in animals with cancer and has been shown to enhance the effectiveness of other drugs used in cancer treatment. PDK1/Akt/Flt Dual Pathway Inhibitor also has been shown to cause thrombocytopenia in humans.</p>

<p>7S,8R,17S-RctR1 is an analog found in urine that has been identified as a potent kinase inhibitor. It is derived from Chinese medicinal plants and has shown significant anticancer activity against various types of cancer cells. 7S,8R,17S-RctR1 specifically targets kinases that are involved in tumor growth and progression, leading to apoptosis or programmed cell death. This protein inhibitor has been extensively studied and has shown promising results in preclinical trials as a potential therapeutic agent for cancer treatment. Its ability to selectively target cancer cells without affecting healthy cells makes it a promising candidate for future development of anticancer drugs.</p>

<p>4-(4-Amino-2,6-dimethylphenyl)morpholin-3-one (4ADMPMO) is a research tool designed to study protein interactions. 4ADMPMO is an inhibitor that binds to the ligand binding site of ion channels, peptides, and receptors. 4ADMPMO also has been shown to activate certain ion channels such as potassium channels and calcium channels. This drug can inhibit the activity of voltage gated sodium channels.</p>

<p>Oxendolone is a synthetic, non-steroidal hormone that stimulates the release of growth hormone (GH) from the anterior pituitary gland. It is used in the treatment of GH deficiency and Turner syndrome. Oxendolone also has been found to act as an activator of ion channels, as well as binding to other receptors such as dopaminergic, serotoninergic and benzodiazepine receptors. This drug binds to protein ligands by binding to the amino acid residues near the active site of enzymes or receptors. It also can be used as a research tool for pharmacology and cell biology studies in order to study protein interactions and peptides.BR&gt;</p>

<p>TIP39 is a peptide inhibitor that is a member of the TIP family. It inhibits the activity of calcineurin, a calcium-dependent phosphatase enzyme, and thereby prevents it from dephosphorylating nuclear factor of activated T cells cytoplasmic 1 (NFATc1), which regulates signaling pathways that control inflammatory responses. TIP39 has been shown to inhibit calcineurin in both human and bovine cell lines. This drug has been used as a research tool to study peptide-receptor interactions and ion channels.</p>

<p>BI-3812 is a selective metal-ion sensor that can be used to detect the presence of metal ions in a sample. The BI-3812 has an operable design and is positioned axially, which increases its sensitivity to ion detection. It also has high photometric accuracy and can be used with a plate or orbital photometer. The BI-3812 uses spectroscopic analysis to measure the element present in the sample, which is then converted into an optical density value using photometry. This process is interactive and can be done in real time.</p>

<p>Matrix Metalloproteinase-13 is a metalloproteinase with a broad substrate specificity. It is used as a prognostic factor for cancer patients, and is also used to diagnose and monitor inflammatory bowel disease. In addition, it has been shown to have chemiluminescence activity in the presence of hydrogen peroxide. The MMP-13 protein can be detected using Western blotting with monoclonal antibodies against the human MMP-13 protein. This recombinant human Matrix Metalloproteinase-13 (rMMP-13) can be used as an antigen for immunoassays such as ELISA and RIA.</p>

<p>Azapropazone is a nonsteroidal anti-inflammatory drug that has been used to treat rheumatoid arthritis, osteoarthritis, and pain. It is also used as an adjunct therapy for the treatment of myocardial infarct. Azapropazone inhibits the synthesis of prostaglandins, leukotrienes, and thromboxanes by blocking cyclooxygenase enzymes. The inhibition of these enzymes by azapropazone may be due to its structural similarity to coumarin derivatives such as warfarin or dicumarol. Azapropazone has been shown to interact with other drugs such as nonsteroidal anti-inflammatory drugs (NSAIDs) and may lead to gastrointestinal bleeding.</p>

<p>AS 101 is a mixture of polyunsaturated fatty acids that are produced by the hydrolysis of vegetable oils and animal fats. The product is used to produce supernatants for use in cancer research. AS 101 has been shown to inhibit tumor growth, as well as inhibit HIV infection in vitro. The mechanism of action is not yet known, but it may be due to its ability to increase IL-10 production and transcriptional activity in mononuclear cells.</p>

<p>Milnacipran A is an analog of the Chinese medicinal plant-derived compound, milnacipran. It is a potent kinase inhibitor that has been shown to induce apoptosis in various cancer cells. This anticancer drug has been tested on human urine samples and demonstrated significant inhibition of tumor growth in leukemia and other cancers. Milnacipran A works by inhibiting specific proteins involved in cell division and proliferation, which ultimately leads to the death of cancer cells. This inhibitor has shown promising results as a potential treatment for various types of cancers due to its ability to target specific proteins involved in tumorigenesis.</p>

<p>SIB 1893 is a potent antagonist of the NMDA receptor. It blocks glutamate-induced excitotoxicity in the bladder, which is a major cause of bladder dysfunction in patients with spinal cord injury. SIB 1893 also protects neurons from oxidative stress-induced neuronal death. This drug has been shown to be neuroprotective against necrotic cell death induced by potassium deprivation and guanylate cyclase inhibitor.<br>SIB 1893 is not an effective agent for treating Parkinson's disease due to its low potency at the D2 receptor.</p>

<p>SU5205 is a growth factor that has been shown to inhibit the growth of cancer cells. It binds to receptor-2, which is located on the surface of cancer cells, and modulates the activity of tyrosine kinase. SU5205 has also been shown to inhibit angiogenesis in crop plants by binding to lectin receptors. In simulations, SU5205 inhibited the growth of cancer cells and reduced their migration. Pharmacokinetic properties have not been studied for this drug. Molecular modeling studies have shown that SU5205 inhibits cancer cell proliferation by binding to receptor-2.</p>

<p>Methost-8-enol is a potent inhibitor of kinases, which are enzymes involved in the regulation of various cellular processes. It is an analog of a natural product found in Chinese medicinal plants and has been shown to have anticancer properties. Methost-8-enol inhibits the growth of cancer cells by blocking the cell cycle and inducing apoptosis, or programmed cell death. This compound has been found in human urine and shows promise as a potential protein kinase inhibitor for the treatment of cancer. Its unique structure makes it an attractive target for drug development in the field of medicinal chemistry.</p>

<p>Lonapalene is a prodrug that can be converted to its active form, lonaprazan. It is used in the treatment of asthma and inflammatory bowel disease. Lonapalene inhibits the enzyme phospholipase A2 (PLA2) by binding to the hydroxyl group of arachidonic acid, which prevents arachidonic acid from being released as a substrate for PLA2. This inhibition results in an anti-inflammatory effect. Lonapalene also inhibits other enzymes such as cyclooxygenase and lipoxygenase, which are involved in the synthesis of prostaglandins and leukotrienes. Lonapalene has been shown to have anti-inflammatory activity due to its ability to inhibit prostaglandin synthesis, which may be due to its ability to bind with fatty acids.br&gt;<br>br&gt;</p>

<p>Inhibitor of adenylate cyclase</p>

<p>CGS 9343B is a fatty acid that binds to calcium and calmodulin. It has been shown to have cytosolic calcium-dependent activity in skin cells, which may be due to its ability to induce the release of epidermal growth factor (EGF). CGS 9343B also inhibits atp levels and ATP-sensitive potassium channels in experimental models. This drug has been shown to inhibit the growth of diarrheal pathogens such as Clostridium difficile and Salmonella enterica.</p>

<p>L-alpha-methyldopa hydrochloride is a peptide that is used as a research tool. It is an activator, which means it promotes the activity of other substances. L-alpha-methyldopa hydrochloride is a ligand, which means it binds to receptors and can activate them. L-alpha-methyldopa hydrochloride has high purity, and this product is for use in life science research only. It has CAS number 88439-9.</p>

<p>Dovitinib is a tyrosine kinase inhibitor that is used for the treatment of non-small cell lung cancer, renal cell carcinoma and other cancers. Dovitinib inhibits tumor growth by blocking the cell factor (c-KIT) and the stem cell factor receptor (c-MET). It also inhibits tumor angiogenesis through its inhibition of the colony-stimulating factor 1 receptor (CSF1R), which is involved in regulating hematopoietic stem cells. Dovitinib has been shown to inhibit tumor growth by blocking antiapoptotic genes, such as Bcl2, BclxL, Bfl-1 and Mcl-1. This drug has a terminal half-life of 15 hours.</p>

<p>Biotin is a coenzyme that plays an important role in the metabolism of fat and protein. Biotin is required for the synthesis of fatty acids and for the production of acetyl-coenzyme A from pyruvate. It also participates in gluconeogenesis, the conversion of pyruvate to glucose, and in cholesterol synthesis. Biotin deficiency may lead to skin rash, hair loss, impaired growth, or nerve degeneration. Biotin is a ligand for certain receptors such as the retinoic acid receptor and thyroid hormone receptor. In addition to its role as a ligand, biotin has been shown to act as an activator for some ion channels such as calcium channels.</p>

<p>AZD4320 is a molecule that binds to the CDK4/CDK6 complex, which controls the cell cycle. AZD4320 has been shown to induce apoptosis in cancer cells by triggering mitochondrial membrane depolarization and long-term treatment of chronic lymphocytic leukemia. AZD4320 also inhibits the proliferation of leukemic cells by binding to CDK4/CDK6. This agent has potential as an anti-leukemic drug because it can be used in combination with monoclonal antibodies and thrombocytopenia drugs.</p>

<p>Glutapyrone is a polymeric matrix that is composed of glutamic acid, polyethylene glycol, and polyvinyl alcohol. It is used to treat acute liver failure by reducing the amount of free fatty acids in the blood. Glutapyrone prevents the formation of conjugates with fatty acids and also has antioxidative activity. In rat kidneys, glutapyrone reduces the level of ubiquitin-proteasome system and increases mitochondrial membrane potential. This drug also has respiratory control effects, which may be due to its ability to increase mitochondrial membrane potential and reduce respiratory chain inhibition caused by lipopolysaccharide.</p>

<p>GLP-2 is a gut peptide that belongs to the glucagon-like peptide family. It is produced by K cells in the ileum and colon, and also by L cells in the stomach. GLP-2 is composed of 31 amino acids, has a molecular weight of 3,000 daltons, and has an amino acid sequence that is highly conserved among species. The EIA kit for human GLP-2 (GLP-2 Human) is designed to detect the presence of GLP-2 in samples from human serum or plasma.</p>

<p>PF 06260933 is a small-molecule that induces apoptosis in glioma cells by targeting mitogen-activated protein kinase (MAPK) and inhibiting the tumor suppressor gene p53. PF 06260933 binds to and inhibits MAPK, preventing the activation of downstream signaling proteins. PF 06260933 activates a process called large-scale genomic reorganization, which leads to cancer cell death. It is being investigated for the treatment of glioblastoma and other brain tumors. The drug has been shown to be effective in patients with malignant gliomas who have progressed on standard therapies.</p>

<p>Ilginatinib maleate is a kinase inhibitor that is used to treat tumor diseases. Ilginatinib maleate inhibits the growth of cancer cells by blocking the epidermal growth factor receptor and epidermal growth factor. It also inhibits the activity of the receptor kinase, which blocks tumor cell growth. Ilginatinib maleate is a human-specific medicine that has been shown to have no effect on healthy cells, making it an attractive treatment for patients with certain types of neoplastic disease.</p>

<p>(1R,3S,5Z)-5-{2-[(1S,3aS,4E,7aS)-1-[(1R)-1-[(3-Ethyl-3-hydroxypentyl)oxy]ethyl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}-4 -methylidenecyclohexane-1,3-diol is a synthetic compound that is a potent and selective inhibitor of the protein kinase C (PKC) family of serine/threonine kinases. The PKC family consists of 12 members and is involved in many cellular functions including cell proliferation, differentiation, apoptosis, and the immune response. PKC plays an important role in the regulation of ion channels and is a key regulator of calcium channel function. This compound binds to the ATP binding site on PKC. The molecule has been shown</p>

<p>Difelikefalin is a non-opioid, non-NSAID analgesic that is used to treat inflammatory skin diseases. It has been shown in clinical studies to be effective for the treatment of chronic kidney disease and bowel disease. Difelikefalin has also been shown to be an effective analgesic in patients with inflammatory bowel disease and infectious diseases. Difelikefalin acts as a nicotinic acetylcholine receptor agonist, increasing the release of acetylcholine from nerve cells. This drug is thought to have anti-inflammatory properties by inhibiting prostaglandin synthesis or blocking the production of leukotrienes and cytokines.</p>

<p>(R)-BAY1238097 is a research tool that is used to activate the receptor. It binds to the ligand-binding site of the receptor and can be used for pharmacological studies. (R)-BAY1238097 has been shown to bind to calcium channels and inhibit ion channel activity, suggesting that it can act as an inhibitor. (R)-BAY1238097 has also been shown to bind to proteins such as antibodies, human growth hormone, and insulin-like growth factor-1 receptor.</p>

<p>3-[[3-[2-(7-Chloroquinolin-2-yl)ethenyl]phenyl]-[3-(dimethylamino)-3-oxopropyl]sulfanylmethyl]sulfanylpropanoic acid is a naturally occurring fatty acid that has been shown to have immunomodulatory effects in experimental models. This compound inhibits the leukotriene receptor, which may be due to its ability to bind to it and prevent the release of inflammatory mediators, such as prostaglandins. 3-[2-(7-Chloroquinolin-2-yl)ethenyl]phenol has been shown to inhibit prostaglandin synthesis in rat liver microsomes at concentrations of 1 µM or higher. 3-[2-(7-Chloroquinolin-2-yl)ethenyl]phenol also exhibits antiinflammatory properties in experimental models by inhibiting the production of TNFα and IL</p>

<p>Agistatin D is a metabolite of the fungus Penicillium agaricoides. It has been shown to have antimicrobial activity against Gram-negative bacteria such as Escherichia coli and Pseudomonas aeruginosa, as well as some Gram-positive bacteria such as Staphylococcus aureus. Agistatin D's antimicrobial activity is due in part to its ability to inhibit the growth of target organisms through inhibition of protein synthesis by binding to ribosomes. This compound also inhibits the production of certain secondary metabolites (e.g., indole-3-acetic acid) that are often associated with plant pathogenicity. The organic solvent used in this study was methanol, which was evaporated before extraction and analysis.</p>

<p>Talipexole is a dopamine receptor agonist that stimulates the D2 receptor. It is used to treat Parkinson's disease and restless leg syndrome. This drug has been shown to have a high degree of purity, with no significant impurities detected by HPLC analysis. Talipexole can be used as a research tool for studies involving the effects of dopamine on cells and ion channels, or as an antibody to study protein interactions.</p>

<p>16:0-d31-16:0 Pc is a research tool for studying protein interactions. It has been shown to be an activator of the ion channel TRPV1, which is involved in pain and inflammatory responses. 16:0-d31-16:0 Pc also binds to the receptor CXCR2, which is involved in inflammatory responses. 16:0-d31-16:0 Pc has been used as a ligand for studying protein interactions with antibodies and receptors.</p>

<p>COTI-2 is a copper complex that has been shown to selectively bind to the tumor suppressor protein, annexin A2. It inhibits tumor growth and induces apoptosis in cancer cells in vitro and in vivo. The mechanism of action of COTI-2 is not known but it may inhibit the activity of efflux pumps, leading to increased accumulation of anticancer drugs in tumor cells. In addition, COTI-2 may be a predictive biomarker for radiation exposure and an indicator for the development of cancer. Clinical studies have shown that COTI-2 is a potential biomarker for identifying patients who are at risk for developing lung cancer.</p>

<p>IL 4R is a receptor for Interleukin-4. It is a member of the type II cytokine receptor family and has been shown to be an inhibitor of cell proliferation. IL 4R also interacts with the protein tyrosine phosphatase SHP2, which plays a role in signaling pathways. IL 4R binds to specific Ligands, such as IL-4 and IL-13, that are found in the extracellular matrix and on the surface of cells. These interactions activate the receptor and lead to intracellular signaling cascades. The protein's activation can be inhibited by small molecules like peptides or antibodies that bind to its extracellular domain.</p>

<p>SB 399885 Hydrochloride is a selective 5-HT2A receptor antagonist, which has been shown to reduce food intake and body weight in animal models. SB 399885 Hydrochloride is also a potent and selective 5-HT6 receptor antagonist, with an IC50 of 0.4 nM. SB 399885 Hydrochloride inhibits the activation of the paraventricular nucleus (PVN) neurons by 5-hydroxytryptamine (5-HT) and attenuates the activation of the nucleus accumbens (NAc) neurons by 5-HT. SB 399885 Hydrochloride also blocks the appetitive responses induced by stimulation of the PVN or NAc by 5-HT.</p>

<p>Ribosomal S6 kinase inhibitor</p>

<p>Des-Arg9-Bradykinin is a peptide that is structurally related to bradykinin. It is synthesized by removing the first two amino acids from the N terminus of bradykinin and replacing them with an acetyl group. It has been shown to have potent activity against inflammatory cells in vitro, including mast cell degranulation and histamine release. Des-Arg9-Bradykinin also inhibits the production of nitric oxide, which may be responsible for its anti-inflammatory effects.</p>

<p>Deltarasin hydrochloride is a peptide inhibitor of the protein tyrosine kinase receptor. It has been shown to inhibit a number of receptors, including the LERK-2 receptor, which is expressed in peripheral nerve cells and is involved in pain transmission. Deltarasin hydrochloride is a high-purity reagent that can be used as a research tool for studying protein interactions and binding properties. The CAS number for this product is 1613404-76-4.</p>

<p>Seletalisib is a novel, potent, and selective inhibitor of the lipid kinase activity. It blocks protein synthesis by binding to the ribosomal protein S6 kinase-1 (RSK1) which is involved in regulating cell proliferation and differentiation. Seletalisib has been shown to be effective in clinical studies for treatment of autoimmune diseases such as systemic lupus erythematosus (SLE). This drug also has pharmacokinetic properties that are suitable for hepatic impairment. Seletalisib also inhibits the production of chemokines, which are inflammatory cytokines that induce chemotaxis of leukocytes and promote inflammation.</p>

<p>Inhibitor of BET bromodomain</p>

<p>SCR-1481B1 is an innovative nanocarrier system, which is developed from biomimetic polymers with ligand-targeted capabilities. This system functions by leveraging surface-functionalized nanoparticles to deliver therapeutic agents directly to specific cell types, thereby enhancing efficacy and reducing off-target effects. The intricate design of SCR-1481B1 allows it to bypass common biological barriers and achieve high-efficiency delivery, making it a compelling tool in precision medicine.</p>

<p>N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-carbamic acid (1S)-1-phenylethyl ester is a peptide that has been shown to inhibit the interactions of proteins. It also has been found to be an activator of protein interactions and ligand for a receptor or ion channel. N-(2-Aminoethyl)-N-[(3-methoxy-4-(phenylmethoxy)phenyl]methyl]-carbamic acid (1S)-1-phenylethyl ester is used in research as a tool for studying the structure, function, and regulation of proteins and ions channels.</p>

<p>CP-775146 is a molecule that has been shown to have pharmacological effects on the body. It is currently being researched as a potential treatment for cancer and metabolic disorders such as obesity and diabetes. CP-775146 binds to the beta-3 adrenergic receptor, which regulates blood pressure and insulin sensitivity. This binding increases the production of cyclic AMP, leading to increased thermogenesis in adipose tissue, increased lipolysis and decreased triglyceride lipase activity. CP-775146 also blocks fatty acid synthesis in cancer cells by inhibiting cytochrome P450 enzymes (Cyp1a2, Cyp2b6, Cyp2c8), which are involved in the conversion of arachidonic acid into prostaglandins.</p>

<p>GSK481 is an investigational therapeutic product, which is a pharmaceutical compound developed by the global healthcare company GlaxoSmithKline (GSK). The source of this compound derives from extensive medicinal chemistry and drug development processes aimed at addressing specific molecular targets. GSK481 functions through a targeted mode of action that modulates particular biochemical pathways implicated in disease pathophysiology. The compound's mechanism involves binding to specific molecular targets to inhibit or modify their activity, thereby altering the progression of the disease process.</p>

<p>653-47 is a synthetic peptide that binds to the extracellular domain of the human angiotensin II type 1 receptor. It has been shown to be an inhibitor of protein interactions and activator of ligand-receptor interactions. 653-47 is used as a research tool for studying the role of angiotensin II receptors in cell biology and as a reagent for antibody production. 653-47 is also used as an ion channel blocker. This peptide has high purity, and can be obtained from many manufacturers.</p>

<p>PBI 51 is a monoclonal antibody that binds to the extracellular domain of human Epidermal Growth Factor Receptor 2 (HER2). It is used as an experimental research tool in cell biology, pharmacology, and other life science fields. PBI 51 has been shown to inhibit the activation of HER2-dependent signaling pathways by preventing ligand binding and receptor dimerization. It also blocks the opening of ion channels, which leads to inhibition of calcium-dependent signal transduction pathways. PBI 51 is a high purity antibody with a CAS number 130694-74-5.</p>

<p>Sevoflurane is an experimental drug that belongs to the group of intravenous anaesthetics. It has been shown to be effective in the prevention and treatment of myocardial infarcts. Sevoflurane inhibits polymerase chain reaction by binding to dinucleotide phosphate, which prevents DNA synthesis. It also inhibits oxidative injury in the heart, as well as genotoxic activity. Sevoflurane is a potent chemical inhibitor of the ryanodine receptor, which regulates calcium release from the sarcoplasmic reticulum. This inhibition results in reduced contractility and relaxation of vascular smooth muscle cells, leading to vasodilation and increased blood flow.</p>

<p>Please enquire for more information about 3,5-Didemethoxy piperlongumine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>TENOVIN-5 is a peptide inhibitor of the P2X7 receptor. It is a high purity, stable, and water insoluble compound that can be used as a research tool to study protein interactions, ligand binding and activation of the P2X7 receptor. TENOVIN-5 has been shown to bind to the extracellular domain of the P2X7 receptor and inhibit its function. TENOVIN-5 also activates the P2Y1 receptor in a dose-dependent manner.</p>

<p>Pipernonaline is a bioactive phytochemical that has been shown to inhibit the growth of prostate cancer cells by mitochondrial membrane depolarization. It also inhibits the production of growth factors and cytokines, which may be due to its ability to inhibit the activity of tyrosinase and protein kinase C. Pipernonaline has potent inhibitory activity against infectious diseases such as pneumonia, bronchitis, tuberculosis, and leprosy. It also shows potent inhibitory activity against chronic inflammatory diseases including thp-1 cells and asthma. The mechanism of action for pipernonaline is through cation channel opening leading to an influx of calcium ions into the cell.</p>

<p>sAJM589 is a bifunctional molecule that contains an active methylene group and a photophysical group. In the presence of acid, its fluorescence is enhanced, which may lead to skin cancer. Specifically, sAJM589 has been shown to be cytotoxic in both cancer cells and normal cells. It also induces apoptosis in cancer cells by inhibiting DNA synthesis, protein synthesis, and cell proliferation. The functional theory of this molecule is not yet clear but it may be related to the metal ion binding properties of the molecule.</p>

<p>2-(4-Aminophenyl)-6-methoxybenzothiazole is a drug that is used for the diagnosis of Alzheimer's disease. It is also used to study the amyloid protein, which accumulates in the brain and forms plaques. The drug binds to apolipoprotein E (ApoE) and amyloid β (Aβ) and provides an imaging technique for alzheimer 's disease. This drug is useful in diagnosing familial Alzheimer's disease because it can distinguish between heterozygotes and homozygotes.</p>

<p>3-Fluoro-afatinib is a potent anticancer drug that belongs to the class of kinase inhibitors. It is an analog of afatinib, which is used in the treatment of various types of cancer. 3-Fluoro-afatinib has been shown to inhibit the activity of certain protein kinases that are involved in tumor growth and proliferation. This drug induces apoptosis in human cancer cells by inhibiting the phosphorylation of specific proteins that are essential for cell survival. 3-Fluoro-afatinib has been used as a medicinal agent in China for its potent anticancer properties. It is excreted primarily through urine and has demonstrated promising results in preclinical studies as a potential therapy for various types of cancer.</p>

<p>N1-Hydroxy-N8-[4-[4-[(1-oxo-5-hexyn-1-yl)amino]benzoyl]phenyl]-octanediamide is a molecule with chemical structure of a benzamide. It has been shown to have inhibitory properties against histone deacetylase (HDAC), an enzyme that regulates gene expression by removing acetyl groups from the lysine residues in histones. The compound was found to be an estrogen receptor modulator and inhibits the growth of cancer cells in culture. In rat cardiomyocytes, it increased contractility and inhibited calcium uptake. N1-Hydroxy-N8-[4-[4-[(1-oxo-5-hexyn-1-yl)amino]benzoyl]phenyl]-octanediamide binds to the protein target HDAC2, which is associated with breast cancer progression, highlighting its potential as a therapeutic drug for</p>

<p>TAK-828F is a monoclonal antibody that targets IL-17A. IL-17A is an inflammatory cytokine that has been shown to play a role in the development of autoimmune diseases and bowel disease. TAK-828F binds to IL-17A with high affinity and specificity, inhibiting its inflammatory effects on the immune system. TAK-828F was studied in clinical trials for use in the treatment of Crohn's disease, ulcerative colitis, and psoriasis. The drug was successful in treating Crohn's disease and psoriasis but not ulcerative colitis. TAK-828F is currently being developed for use as a treatment for inflammatory bowel disease and other autoimmune diseases.</p>

<p>Activates Oct-4 transcription factor; enhances iPSCs reprogramming</p>

<p>1-Heptanoyl-2-hydroxy-sn-glycero-3-phosphocholine is a phospholipid compound that has been extensively studied in various experiments involving peroxisomes and human cells. It is known to enhance the activity of luciferases when used as a substrate in luciferase assays. Additionally, this compound has shown potential in promoting particle formation and increasing the expression of specific genes, such as those involved in salvianolic acid biosynthesis. Furthermore, 1-Heptanoyl-2-hydroxy-sn-glycero-3-phosphocholine has been found to have an impact on fructan metabolism and may play a role in regulating erythropoietin production. This versatile research chemical offers exciting possibilities for further exploration in various scientific fields.</p>

<p>TASP0415914 is a molecule that inhibits the activity of matrix metalloproteinases (MMPs) and is used for the treatment of osteoarthritis. TASP0415914 binds to collagen in cartilage, inhibiting the release of MMP-3 and MMP-13. TASP0415914 has been shown to have an inhibitory effect on autoimmune diseases in mice, such as rheumatoid arthritis. This drug also has a protective effect against cancer, although it does not affect tumor size. TASP0415914 also has pharmacokinetic properties that suggest it can be used as an oral drug.</p>

<p>Inhibitor of PI3K? kinase</p>

<p>Ipsalazide is a drug used to treat bowel disease. It is an amide that has been shown to have iontophoretic properties. Ipsalazide inhibits the production of prostaglandins and leukotrienes, which are inflammatory mediators in the intestine. Ipsalazide also reduces pain, cramps, and diarrhea from colitis and other inflammatory bowel diseases. Ipsalazide should not be administered orally because of its high oral toxicity (LD50 = 2 mg/kg).</p>

<p>Please enquire for more information about [Gln18]-Platelet Factor 4 (15-22) (human) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>PD 118057 is a drug that is used to treat congestive heart failure. It is an inhibitor of histone deacetylase (HDAC) and has been shown to be effective in experimental models of cardiac hypertrophy. The drug has been shown to have a depressant effect on the heart, which may be due to its ability to inhibit the production of potassium ion channels that are responsible for maintaining the resting membrane potential. PD 118057 has also been shown to decrease the number of damaged ventricular myocytes in animal models.</p>

<p>Antagonist of CGRP receptor</p>

<p>Methyl 4,6-o-benzylidene-2-benzyloxycarbonylamino-2-deoxy-alpha-D-glucopyranoside is a research tool that binds to the activator, ligand, or receptor of a cell. It has been used to study ion channels and peptides. Methyl 4,6-o-benzylidene-2-benzyloxycarbonylamino-2-deoxy -alpha -D -glucopyranoside is also an inhibitor of protein interactions.</p>

<p>Charybdotoxin is a peptide toxin that is found in scorpion venom. It acts as a potent inhibitor of the adenylyl cyclase, which is an enzyme that catalyzes the formation of cAMP from ATP. Charybdotoxin binds to the cavity of the enzyme and blocks access to ATP, preventing the accumulation of cAMP. This inhibition leads to a decrease in calcium ions in cells, and thus causes relaxation of smooth muscle tissue. Charybdotoxin has been shown to cause relaxation of bowel disease in mice by inhibiting contraction of intestinal muscle tissue. Charybdotoxin also has been shown to have therapeutic effects on pluripotent cells such as miapaca-2 cells by increasing their ability to form new blood vessels.</p>

<p>(R)-2-(N-Benzyl-4-(2-fluoroethoxy)phenylsulfonamido)-N-hydroxy-3-methylbutanamide is a fatty acid ester with a reactive functional group. It is used as a radiation sensitizer and has been shown to cause neuronal death in rats. This drug also inhibits the uptake of serotonin by neurons, which may be related to its cancer protective effects. (R)-2-(N-Benzyl-4-(2-fluoroethoxy)phenylsulfonamido)-N-hydroxy-3-methylbutanamide increases the alkoxy radical production in cells, which may contribute to its ability to suppress collagenase activity and matrix metalloproteinase in the skin.</p>

<p>1-(4-Fluorophenyl)-5-(4-methylsulfonylphenyl)pyrazole-3-carbonitrile is a high purity, cell biology research tool for protein interactions, ion channels, and receptor pharmacology. It is also used as an inhibitor or activator of the ligand binding site on a receptor. Ligands are small molecules that bind to receptors and activate them. 1-(4-Fluorophenyl)-5-(4-methylsulfonylphenyl)pyrazole-3-carbonitrile is an activator of the GABAA receptor and can be used in the treatment of epilepsy. This compound has been shown to have a potent inhibitory effect on peptide ligands, including bradykinin (BK), substance P (SP), and vasoactive intestinal polypeptide (VIP).</p>

<p>OSMI-4 is a synthetic substrate that can be used to study the enzymatic activity of O-glycosylation. It is a small molecule that can be incorporated into proteins and peptides in vitro, allowing for the study of O-glcnacylation. OSMI-4 has been shown to inhibit prostate cancer cell growth by ligation with an antigen receptor. This compound has also been shown to have regulatory effects on chronic lymphocytic leukemia cells, which may be due to its ability to inhibit glycolysis in these cells.</p>

<p>Progoitrin is a protein that has been found to have potential as an anticancer agent. It acts by inducing apoptosis, or programmed cell death, in cancer cells. Progoitrin also contains inhibitors that can inhibit the activity of certain enzymes involved in cancer cell growth and proliferation. This compound has been used in traditional Chinese medicine for its medicinal properties and has shown promising results in inhibiting tumor growth. Additionally, progoitrin has been found to have inhibitory effects on chitinase and heparinase, which may be useful for treating diseases such as asthma and thrombosis. Research has also shown that progoitrin can act as a kinase inhibitor, which could be useful for developing new treatments for cancer.</p>

<p>2-methyl-4-[(Z)-[3-(2-methylphenyl)-4-oxo-2-propylimino-1,3-thiazolidin-5-ylidene]methyl]phenyl] acetate is a research tool that is used as an activator or a ligand. It has been shown to bind to receptors such as ion channels and cell biology. This chemical has shown to inhibit the activity of an antibody in high purity. 2-methyl-4-[(Z)-[3-(2-methylphenyl)-4-oxo-2-propylimino-1,3-thiazolidin-5-ylidene]methyl]phenyl] acetate binds to cell surface receptor proteins and modulates their activity by changing the protein conformation.</p>

<p>Thiorphan disulfide is a compound known as an enkephalinase inhibitor, which is derived synthetically for research purposes. Its mode of action involves the inhibition of enkephalinase, an enzyme responsible for the degradation of enkephalins, which are endogenous peptides that modulate pain and emotion. By preventing the breakdown of these peptides, Thiorphan disulfide enhances their activity, resulting in increased analgesic effects.</p>

<p>Azelastine is a drug that belongs to the group of antihistamines. It is used to treat allergic rhinitis, as well as chronic idiopathic urticaria and other hypersensitivity reactions. Azelastine also has an inhibitory effect on the release of histamine from mast cells and other tissues. Azelastine inhibits polymorphonuclear leucocyte chemotaxis, activation, and degranulation. This drug is metabolized in the liver by cytochrome P450 enzymes into metabolites that are excreted in urine. Azelastine is available in both an oral form and a nasal spray form for the treatment of allergic rhinitis.</p>

<p>Ubiquitin is a small protein that is covalently attached to other proteins. It plays an important role in the regulation of cellular processes such as cell growth, DNA repair, and apoptosis. The most common form of ubiquitin is ubiquitin from bovine erythrocytes. Ubiquitin has been shown to have hydration properties, which have been used in assays for the determination of molecular weight. It also has been used to determine the phosphatase activity of collagenase by titration calorimetry. Proteolytic cleavage can be achieved with the use of collagenases, which are enzymes that hydrolyze peptide bonds and break down proteins into smaller polypeptides. The ubiquitin-proteasome pathway is responsible for this process and can be inhibited by the administration of proteasome inhibitors such as MG132 or lactacystin. Ubiquitination may also play a role in inflammatory diseases such</p>

<p>TG 6-129 is a peptide that interacts with the receptor of the human protein C-reactive protein. It has been shown to activate the receptor, leading to downstream effects on ion channels and ligand binding. TG 6-129 is an inhibitor of the human protein C-reactive protein, which is involved in inflammation and immunity. This peptide can be used as a research tool for studying cell biology or pharmacology.</p>

<p>This product is a research tool that is used to study ion channels and ligand-receptor interactions. It is an inhibitor of ligand-gated chloride channels, which are important for the conduction of nerve impulses. This product is a high purity, water soluble, and stable reagent that can be used in pharmacological experiments. It has been shown to activate the GABA receptor and inhibit the activity of neurotensin.</p>

<p>N-[3-(1H-Imidazol-5-ylmethyl)phenyl]ethanesulfonamide is a ligand that binds to and activates the ion channel TRPV2. This compound is used in research as a tool for studying the function of ion channels. It has been shown to bind to and activate TRPV2 which is found in many cells, including human colon cancer cells. N-[3-(1H-Imidazol-5-ylmethyl)phenyl]ethanesulfonamide also binds to the receptor CXCR4 and inhibits cell proliferation, which may be due to its inhibition of protein synthesis. This active form is an agonist of the vasopressin V2 receptor and has been shown to inhibit the production of inflammatory cytokines such as IL-1β, IL-6, and TNFα.</p>

<p>A 844606 is a flavanones drug which has been shown to inhibit the proliferation of human tumor cells. It also induces tumor cell apoptosis and inhibits tumor growth in mice. A 844606 has been shown to bind to nicotinic acetylcholine receptors, and as such is an agonist for these receptors. It is a subtype-selective antagonist of nicotinic acetylcholine receptor subtypes α3β4 and α7, but not for α3β2. A 844606 has also been shown to have antitussive properties, indicating that it may be useful in the treatment of chronic obstructive pulmonary disease.</p>