Compuestos y reactivos bioquímicos

<p>AL 3152 is a galactose-binding lectin that binds to the carbohydrate moiety of galactose and galactosamine. It is used as a marker for the detection of inflammatory cells in tissues. The pharmacokinetics of AL 3152 in Sprague Dawley rats have been studied using biochemical and histological methods. The elimination phase was found to be rapid, with only about one third of the drug being eliminated in urine and about two thirds being eliminated in bile.</p>

<p>Hemoglobin A1c antibody was raised in sheep using human hemoglobin A1c as the immunogen.</p>

<p>GDC 0575 is a potent and selective inhibitor of the N-type voltage-gated calcium channel. It binds to the ligand binding site of the channel and blocks the flow of calcium ions through these channels. This inhibits the release of neurotransmitters, leading to an anti-convulsant effect. GDC 0575 has also been shown to have activity as an activator, which increases intracellular calcium levels by blocking potassium channels.</p>

<p>Temporin A is a short, linear, basic and highly hydrophobic anti-microbial peptide (AMP) isolated from the frog, Rana temporaria. Temporin A is particularly active against Gram-positive bacteria including those arranged in biofilms. Temporin A is also active against some Gram-negative bacteria and Leishmania parasites.Temporin A adopts an alpha-helical conformation in a membrane-mimicking environment and is able to perturb the membrane of microbial cells. Temporin A is practically non-haemolytic up to concentrations five-times higher than their minimum inhibitory concentration (MIC) against Gram-positive bacteria.</p>

<p>Peptide H-SVSEIQLMHNLGK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide Casein Kinase II Assay Kit is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Morphine antibody was raised in mouse using morphine-BSA as the immunogen.</p>

<p>H-GQELGALR-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-GQELGALR-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-GQELGALR-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-GQELGALR-OH at the technical inquiry form on this page</p>

<p>Peptide Ac-Ipy-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Pigment Yellow 126 is a nitro-fatty acid ester, which has an average particle diameter of 3.5 microns and a hydroxyl group at the terminal position of the molecule. This product can be used in coatings, plastics, paper, textiles, and paints. Pigment Yellow 126 is also used as a radiation absorber in x-ray films and fluorescent lamps. This product reacts with deionized water to form fatty acids and aliphatic hydrocarbons.</p>

<p>Peptide H-AILAELTGR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>H-VLVEVLADPLDHR-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-VLVEVLADPLDHR-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-VLVEVLADPLDHR-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-VLVEVLADPLDHR-OH at the technical inquiry form on this page</p>

<p>Peptide H-GILGFVFTL^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Peptide H-SGYLLPDTK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Native Melan-A (26-35) decapeptide derives from the melanocyte lineage-specific protein Melan-A/MART-1, which is expressed in almost 75-100% of primary and metastatic melanomas.<br>The region 26-35 of Melan-A protein acts as an antigenic peptide that is recognized by CD8+ tumor-reactive cytolytic T lymphocytes (CTLs) for designing antigen-specific cancer vaccines1. It has been shown that CD8+ Melan-A-specific CTLs isolated from melanoma patients efficiently lyse the Melan-A-expressing HLA-A*0201+ melanoma cell line. However, CTLs preferentially recognize the Melan-A (26-35) peptide as compared with the Melan-A (27-35) peptide. Moreover, the Melan-A (26-35) A27L analog (ELAGIGILTV) has a higher binding affinity to HLA-A*0201 than the native Melan-A (26-35) peptide (EAAGIGILTV), and consequently displays more potent antigenicity and immunogenicity.<br>It has been reported that the concentration of Melan-A (26-35) A27L analog required to obtain 50% of maximal antigenic activity (EC50) is 0.01nM, whereas that of the native Melan-A (26-35) peptide is 0.25nM1. Therefore, the relative activity of Melan-A (26-35) A27L analog is 25 fold higher than that of the native Melan-A (26-35) peptide.<br>Furthermore, functional competition assay has shown that the concentration of Melan-A (26-35) A27L analog required to achieve 50% inhibition (IC50) of tumor lysis is 2nM, which is 10 fold lower than that of the native Melan-A (26-35) peptide. Regarding peptide stability in human serum, the half-lifes (t1/2) of the native Melan-A (26-35) peptide and the A27L analog are quite similar (45 and 40min, respectively) as measured by HPLC-ESI-MS, but much higher than that of the Melan-A (27-35) nonapeptide (5min).</p>

<p>Human Plasma with CPD</p>

<p>Peptide H-LTILDQSEAPVR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>IRF5 antibody was raised in Rabbit using Human IRF5 as the immunogen</p>

<p>NARS antibody was raised in rabbit using the N terminal of NARS as the immunogen</p>

<p>Peptide Ac-PHSRN-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>H-VEPQKFAEELIHRLERVQ-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-VEPQKFAEELIHRLERVQ-OH is provided at greater that &gt;75% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-VEPQKFAEELIHRLERVQ-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-VEPQKFAEELIHRLERVQ-OH at the technical inquiry form on this page</p>

<p>The 6-Fluoro-3-indoxyl-beta-D-galactopyranoside is a potent antituberculosis drug belonging to the class of rifamycins. It is highly effective in treating tuberculosis infections due to its bactericidal activity. This active compound works by inhibiting bacterial growth through binding to DNA-dependent RNA polymerase, preventing transcription and replication. Extensive studies have shown its high frequency of human activity using the patch-clamp technique on human erythrocytes. The drug undergoes various metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Additionally, it specifically targets markers expressed at high levels in Mycobacterium tuberculosis strains and inhibits their cell growth in culture.</p>

<p>Peptide H-YSPWTNF-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>1-387 amino acids: MKIEEGKLVI WINGDKGYNG LAEVGKKFEK DTGIKVTVEH PDKLEEKFPQ VAATGDGPDI IFWAHDRFGG YAQSGLLAEI TPDKAFQDKL YPFTWDAVRY NGKLIAYPIA VEALSLIYNK DLLPNPPKTW EEIPALDKEL KAKGKSALMF NLQEPYFTWP LIAADGGYAF KYENGKYDIK DVGVDNAGAK AGLTFLVDLI KNKHMNADTD YSIAEAAFNK GETAMTINGP WAWSNIDTSK VNYGVTVLPT FKGQPSKPFV GVLSAGINAA SPNKELAKEF LENYLLTDEG LEAVNKDKPL GAVALKSYEE ELAKDPRIAA TMENAQKGEI MPNIPQMSAF WYAVRTAVIN AASGRQTVDE ALKDAQTNSS SNNNNNNNNN NLGIEGR</p>

<p>Peptide Ac-SHLVEALYLVCGERG-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>The SARS-CoV-2 non-structural protein 13 (NSP13) has been identified as a target for anti-viral therapeutics due to its highly conserved sequence and is essential for viral replication.  NSP13 is part of the helicase superfamily 1B. As an NTPase and RNA helicase, NSP13 binds to RNA-dependent RNA polymerase and acts in concert with the replication-transcription complex to stimulate backtracking and further activate NSP13 helicase activity. These factors make NSP13 a good target for developing new antiviral drugs. In addition, the identification of epitopes within the NSP13 sequence can help design more effective SARS-CoV-2 vaccines.Models have predicted epitopes exhibiting antigenicity, stability and interactions with MHC class-I and class-II molecules. NSP13 (326-340) is an epitope candidate with various HLA restrictions. This epitope can be used to better vaccine design for more durable CD4+ and CD8+ T cell responses for long-lasting immunity.</p>

<p>Ac-DPGANAAAAKIQASFR-NH2 is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. Ac-DPGANAAAAKIQASFR-NH2 is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer Ac-DPGANAAAAKIQASFR-NH2 in bulk quantities in addition to our standard pack sizes.Please enquire for more information about Ac-DPGANAAAAKIQASFR-NH2 at the technical inquiry form on this page</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Peptide H-FVQENYLEY^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>H-HNLEARIKEKIEELQQALI-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-HNLEARIKEKIEELQQALI-OH is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-HNLEARIKEKIEELQQALI-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-HNLEARIKEKIEELQQALI-OH at the technical inquiry form on this page</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Peptide H-YFLLRN-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide LCBiot-SYIRIADTNIT-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>17:0-20:4 PI (3,4,5) P3 is a synthetic phosphoinositide, a type of lipid molecule, which is typically derived from chemical synthesis using specialized lipid chemistry techniques. This product is designed to mimic natural phosphoinositides found within the cellular membranes. Its mode of action involves acting as a substrate for studying kinase activities and phosphatase interactions within signaling pathways. 17:0-20:4 PI (3,4,5) P3 plays a critical role in cellular signaling by serving as a docking site for signaling proteins with specific lipid-binding domains, influencing downstream signaling pathways.</p>

<p>Peptide Ac-Hpr-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Please enquire for more information about RNP Antibody Positive Human Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Chlamydia pneumoniae OMP recombinant protein</p>

<p>Peptide H-ELLQTELSGFLDAQK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Histone H3 (1-20)-[S]-Biotin is derived from Histone 3 (H3) which is one of the four core histones (H2A, H2B, H3 and H4) fundamental in compacting eukaryotic DNA into a structure known as the nucleosome. The nucleosome arises when 147 base pairs of DNA wrap around a H3-H4 tetramer and two H2A-H2B dimers, forming the histone octamer core. Both H4 and H3 are highly conserved and perform roles in binding to segments of DNA which enter and leave the nucleosome and in chromatin formation. Similar to the other core histone, H3 has a globular domain and a flexible N-terminal domain, 'histone tail' which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination. Due to histones containing a large number of lysine and arginine residues they have a positive net charge which interacts in an electrostatic manner with the negatively charged phosphate groups in DNA. The transcriptional activation or silencing of the chromatin is controlled by ATP-dependent chromatin remodelling factors and histone modifying enzymes which target histone proteins. Both processes function to alter the positioning of the nucleosome, allowing the DNA it to be either available or inaccessible to the transcription machinery.Another modification process histones can undergo is biotinylation where the covalent attachment of a biotin molecule is catalysed by the enzyme Biotinidase. This cleaves biocytin to generate a biotinyl-thiester intermediate. The biotinyl can then be transferred onto the histone lysine ɛ-amino group which in this case it is covalently attached to Histone 3. Overall the biotinylation sites identified in histone 3 are: K4, K9 and K18. The presence of biotinylated histones have been detected in human cells such as lymphocytes and lymphomas.</p>

<p>IL6 antibody was raised in rabbit using highly pure recombinant hIL-6 as the immunogen.</p>

<p>Atorvastatin-d5 sodium is an isotopically labeled pharmaceutical compound, which is derived from atorvastatin by incorporating deuterium atoms. This synthetic modification is essential for tracing and quantification in pharmacokinetic studies. As a statin, its mode of action involves the selective inhibition of the enzyme HMG-CoA reductase, a crucial catalyst in the mevalonate pathway responsible for cholesterol biosynthesis in the liver. By inhibiting this enzyme, atorvastatin-d5 effectively lowers the production of low-density lipoprotein (LDL) cholesterol.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Parainfluenza Virus 1/2/3 IgG Positive Human Plasma is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about Parainfluenza Virus 1/2/3 IgG Positive Human Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Rabbit polyclonal NFKB-p65 antibody</p>

<p>Fragment of Family with sequence similarity 49 member B (FAM49B), a mitochondria-localized protein that regulates mitochondrial fission and cancer progression. Within tumour environments, such as those seen in pancreatic ductal adenocarcinoma, the expression of FAM49B is reduced. The ability of FAM49B to control redox reactions in the mitochondria allows it to suppress cancer cell proliferation.</p>

Peptide H-VDLLNQEIEFLK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

<p>The HbA1c Antibody is a highly specialized protein complex used in the field of Life Sciences. It is an elastomeric monoclonal antibody that is designed to specifically target and bind to HbA1c, which is a form of hemoglobin associated with diabetes.</p>