Compuestos y reactivos bioquímicos

<p>IRF3 antibody was raised in mouse using recombinant Interferon Regulatory Factor 3</p>

<p>Binds to the cysteine rich domain of the Frizzled 7 receptor and inhibits Wnt signalling in cultured cells and stem cell function in intestinal organoids.</p>

<p>Adenosine A2A receptor antagonist; anti-parkinsonian</p>

<p>Peptide Ac-CGVNNSNEDFREENLKTAN-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Region of Pleiotrophin protein corresponding to amino acids GKKEKPEKKV KKSDCGEWQW SVCVPTSGDC GLGTREGTRT GAECKQTMKT QRCKIPCNWK KQFGAECKYQ FQAWGECDLN TALKTRTGSL KRALHNAECQ KTVTISKPCG KLTKPKPQAE SKKKKKEGKK QEKMLD.</p>

<p>Purified Thyroxine-Alk Phos hapten</p>

<p>Inhibitor of monoamine oxidase</p>

<p>Peptide H-GGEIEGFR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Prolactin, Recombinant is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about Prolactin, Recombinant including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Peptide H-IAEYMNHLIDIGVAGFR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>PRF protein is a growth factor that plays a crucial role in various biological processes. It is involved in glycosylation, which is the process of adding sugar molecules to proteins. In the field of Life Sciences, PRF protein is widely studied and utilized. Monoclonal antibodies specific to PRF protein have been developed for research purposes. Recombinant Proteins &amp; Antigens containing PRF protein are available for purchase.</p>

<p>Galanin is a neuropeptide synthesised and released by the brainstem locus coeruleus (LC). Galanin is expressed in most LC neurons in rodents and humans. Galanin has been shown to inhibit LC activity by hyperpolarising LC neurons, suppressing their spontaneous firing rate, and enhancing alpha2-adrenergic receptor-mediated negative feedback. Galanin is also a potent trophic and neuroprotective factor throughout the nervous system.Galanin is widely distributed in the central nervous, peripheral, and endocrine systems. Galanin's overarching function is as an inhibitory, hyper-polarizing neuromodulator for classical neurotransmitters like acetylcholine and serotonin. Galanin interacts with 3 receptor subtypes, GalR1-3, these G protein-coupled receptors are inserted into the plasma membrane. GalR1 is believed to activate a Gβγ pathway to regulate MAPK activation. GalR2 can also activate the MAPK pathway, but unlike GalR1, there is detectable inositol phosphate production. GalR3 is associated with the Galphai/o pathway. Activation of the receptor leads to a cellular influx of K+. Each receptor has been associated with neurological diseases such as GalR3 with epilepsy.N-terminal fragments naturally occur in vivo, but their relevance is unclear. Some N-terminal fragments reduce metabolic and functional disorders in experimental heart damage. Using N-terminal fragments such as galanin (3-13) can clarify the function of full-length galanin during myocardial ischemia and reperfusion injury. This may highlight new agonists/antagonists for the galanin GalR receptors that can be putative therapeutic targets.</p>

<p>Conjugated Estradiol 6-CMO-BSA hapten</p>

<p>Eliglustat is an oral medication used as a substrate reduction therapy for Gaucher disease type 1, which is an inherited lysosomal storage disorder. This product is a small-molecule inhibitor derived via chemical synthesis. Its primary mode of action involves the selective inhibition of glucosylceramide synthase, an enzyme responsible for the first committed step in glycosphingolipid biosynthesis. By reducing the production of glucosylceramide, eliglustat decreases the substrate accumulation that contributes to the pathophysiology of Gaucher disease.</p>

<p>Steroid Receptor Coactivator - 1 (676-700).</p>

<p>An immuno-receptor tyrosine-based activation motif (ITAM) is a phosphorylation site consisting of a conserved sequence of four amino acids that is repeated twice in the cytoplasmic tails of cell-surface non-catalytic tyrosine-phosphorylated receptors. ITAMs are involved activation of immune cells. The motif has the following structure: YxxL/I. where xx are any two amino acids. Two of these motifs are typically separated by between 6 and 8 amino acids in the cytoplasmic tail of the molecule (YxxL/Ix(6-8)YxxL/I). ITAMs are found in the CD3 and θ¶-chains of the T cell receptor (TCR) complex. TCR is a multi-subunit receptor on the surface of T cells which contains two ligand binding chains containing 20 phosphorylation sites, distributed on 10 ITAMs. The TCR θ¶-chain is a homodimer subunit that contains six ITAMs (12 sites). These sites are phosphorylated by the membrane-anchored Src family tyrosine kinase Lck and Fyn and are dephosphorylated by the transmembrane phosphatases CD148 and CD45. When both tyrosines in an ITAM are phosphorylated they generate docking sites for the tandem SH2 domains of the cytosolic tyrosine kinase ZAP-70. Bound ZAP-70 can phosphorylate tyrosines on other substrates that initiate the signal transduction that leads to T cell activation. The multiple ITAMs on the TCR function mainly to amplify subsequent signalling.T cells rely on the TCR to recognize antigens, in the form of peptides bound to major histocompatibility complexes (MHC), on the surfaces of antigen-presenting cells. Binding of TCR to antigen-MCH complexes leads to proliferation, differentiation, and the secretion of effector cytokines, contributing to the elimination of infections.</p>

<p>The Testosterone antibody is a powerful tool for researchers and scientists working in the field of endocrinology. This monoclonal antibody specifically targets testosterone, a hormone that plays a crucial role in various physiological processes. The Testosterone antibody has been extensively tested and validated for its specificity and sensitivity. It binds to testosterone with high affinity, allowing for accurate detection and quantification of this hormone in biological samples. One of the key applications of the Testosterone antibody is its use in immunoassays, such as ELISA or Western blotting. By utilizing this antibody, researchers can measure testosterone levels in serum, plasma, or tissue extracts with great precision. Additionally, the Testosterone antibody can be used for immunohistochemistry (IHC) to visualize the localization of testosterone within tissues. This technique provides valuable insights into the distribution and expression patterns of testosterone in various organs and cell types. Moreover, this antibody has been shown to have minimal cross-reactivity with other related hormones or compounds, ensuring accurate</p>

<p>Pathogenic Staphylococcus aureus strains produce N-formylmethionyl containing peptides. Peptides starting with an N-formylated methionyl group constitute a unique hallmark of bacterial as well as mitochondrial metabolism, and professional phagocytes of our innate immune system recognise this microbial/mitochondrial pattern as a danger signal that guides innate immune cells.All PSMα peptides have the same basic functions and promote virulence through effects on discrete neutrophil functions (i.e. chemotaxis) and by being cytotoxic at higher concentrations. PSMα2 and PSMα3 can both bind to FPR2 and trigger superoxide release in neutrophils at low nanomolar concentrations. In addition, at high nanomolar concentrations they display cytotoxicity selectively on apoptotic neutrophil membranes and this occurs in an FPR2 independent manner.</p>

<p>Peptide H-IQIIP^K-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>FABP antibody was raised in mouse using human heart FABP as the immunogen.</p>

<p>IKZF3 antibody was raised in rabbit using the N terminal of IKZF3 as the immunogen</p>

<p>TAT 2-4 is derived from human immunodeficiency virus (HIV) transactivator of transcription (TAT) residues 47-58. TAT (47-58) is a cell penetrating cationic peptide derived from the N-terminus of the Tat protein, which is a trans-activator of the transcription protein present in the human immunodeficiency virus (HIV). As a cell penetrating peptide (CPP) TAT aids in the cellular uptake of molecules and hence serves a valuable purpose in transduction methods. TAT 2-4 are residues (47-58) of HIV TAT protein repeated back to back, this dimer of TAT sequences has been shown to be the most efficient oligomer for cell penetration. This TAT dimer has been used in previous studies to deliver a wide variety of cargoes including fluorophores, chelators and DNA to target cells.</p>

<p>Peptide H-NIFSFYLNR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>CP-105,696 is a monoclonal antibody that binds to the chemoattractant protein (CXCL12) and blocks its activity. CP-105,696 has been shown to inhibit the growth of cancer cells in vitro and in vivo by binding to CXCR4, a receptor for CXCL12. It is also used for the treatment of inflammatory bowel disease and other autoimmune diseases. CP-105,696 inhibits inflammatory responses by blocking the release of proinflammatory cytokines IL-1β and TNFα from activated macrophages. The drug binds to a region on the chemokine that is involved in cell signaling, preventing it from interacting with its receptor. CP-105,696 also inhibits angiogenesis by inhibiting vascular endothelial growth factor (VEGF).</p>

<p>A potent and selective inhibitor of cell death-inducing kinase RIP2 (IC50 = 5 nM). Reduces release of pro-inflammatory cytokines. Inhibits production of TNF-α and IL-6 in intestinal explants from patients with Crohn's disease and ulcerative colitis.</p>

<p>Pregnant Mare Serum Gonadotropin (PMSG) is a peptide hormone that belongs to the group of glycoprotein hormones. It is found in the serum of pregnant mares and has pluripotent cell-differentiating properties, which may be due to its ability to regulate mitochondrial functions. PMSG also has biological effects on protein and nucleic acid synthesis, as well as on reproduction and development. PMSG is used in vitro methods for studying biological processes such as cell differentiation and proliferation, ocular disorders, and eye muscle function. The biological properties of PMSG have been studied in vivo using sephadex G-100 gel electrophoresis.</p>

<p>Peptide H-GTVGGYFL^AGR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Portion of EBV</p>

<p>C.I.Reactive Red 111 is a reactive dye that can be used in the manufacture of textile and paper products. It has been shown to have optimum reactivity with anionic groups, such as sulfonic acid and carboxylate, at pH levels between 2-11. This dye has a wide range of application parameters, including stability and color development time. C.I.Reactive Red 111 is also resistant to oxidation by sulfuric acid and other corrosive chemicals at high concentrations, which makes it suitable for use in industrial environments where strong oxidizing agents are present.</p>

<p>Sunitinib is a receptor tyrosine kinase inhibitor and a chemotherapeutic agent used for the treatment of renal cell carcinoma. This drug can also be used to treat gastrointestinal tumors that are resistant to imatinib. Sunitinib inhibits VEGFR1, VEGFR2, VEGFR3, PDGFR and KIT tyrosine kinases.</p>

<p>Maier8 is a short basic amphipathic peptide that functions as a cell-penetrating peptide (CPP). Maier8 has been studied in comparison to other CPPs and found to be highly efficient at crossing into the cell without causing cytotoxicity. Furthermore, Maier8 has a long half-life which is vital for effective delivery of the conjugate.Maier8 is labelled at the N-terminus with an alkyne attachment for ease of reaction with an opposite Click reactive partner (azide). Azide-alkyne cycloaddition has become the most popular Click reaction. Alkyne-Maier8 allows a wide variety of applications, particularly for conjugation, modification, and drug delivery.</p>

<p>Peptide H-LGGDLGTYVINK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Ac-Leu-Gly-Pro-Lys-Acc-NH2 is a peptide that has the amino acid sequence of Leu, Gly, Pro and Lys. It is an enzyme substrate that has a high specificity for thrombin. Ac-Leu-Gly-Pro-Lys-Acc-NH2 has been shown to have a kinetic constant of 0.063/min/mg and a kinetic rate of 0.21/min when incubated with thrombin at 37°C in phosphate buffer (pH 7.4).</p>

<p>H-Dab-Pip is a peptidase inhibitor that inhibits the enzyme known as dipeptidyl peptidase. It also inhibits the enzyme known as dipeptidyl peptidase, which is involved in the breakdown of dipeptides. H-Dab-Pip is an inhibitor of this enzyme and can be used to regulate blood pressure by inhibiting the breakdown of angiotensin II, a potent vasoconstrictor. H-Dab-Pip may also be used for diabetes treatments or for the treatment of inflammatory bowel disease.</p>

<p>Peptide Ac-CTQRGNVAKTSRNAPEEK-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Goat anti rabbit IgG was raised in goat using highly purified rabbit IgG as the immunogen.</p>

<p>The renin angiotensin system (RAS) consists of many angiotensin peptides involved in regulating functions such as blood pressure, cardiovascular function and energy balance. RAS activity is elevated in obesity and RAS is widely studied in relation to lifestyle-related diseases.Angiotensin 1-7 (Ang-(1-7)) is a component of the RAS. Ang-(1-7) is produced by angiotensin-converting enzyme 2 (ACE2), from the angiotensin II (Ang-II) peptide, as well as by prolylendopeptidase (PEP) and neutral endopeptidase (NEP) which produce Ang1 7 directly from angiotensin I (Ang-I).Ang-(1-7) broadly opposes Ang-II actions. Ang-(1-7) has vasodilatory and anti-oxidative effects, and exerts protective actions in hypertension, diabetes, and other cardiovascular disorders, Ang-(1-7) therefore represents a promising therapeutic target for cardiovascular and metabolic diseases. Ang (1-7) exerts its actions via its G-protein-coupled receptor, Mas. This novel arm of the RAS has effects that counterbalance those mediated by the classical ACE/Ang-II pathway.The C-terminal proline fro this peptide is in the D enantiomer.</p>

<p>The CKMB Antibody is a highly specific monoclonal antibody that targets the CK-MB isoform of creatine kinase. This antibody is widely used in Life Sciences research to study various aspects of cardiac health and disease. It has been shown to effectively detect and quantify CK-MB levels in human serum, providing valuable insights into cardiac muscle damage and myocardial infarction. Additionally, this antibody has proven utility in immunohistochemistry studies, where it can be used to visualize CK-MB expression in tissue samples, such as amyloid plaques or liver microsomes. With its high specificity and sensitivity, the CKMB Antibody is an indispensable tool for researchers investigating the role of CK-MB in cardiovascular physiology and pathology.</p>

<p>CHKtide is a synthetic peptide substrate for checkpoint kinase 1 and 2 (CHK1/CHK2) as well as salt-inducible kinase (SIKs) for use in kinase assays. CHKtide has been derived from CDC25C which is phosphorylated by CHK1/CHK2 in one of the DNA repair pathways. SIKs are serine/threonine kinases that are part of a complex network that regulate sodium homeostasis and blood pressure.The serine residue at position 5 has been phosphorylated and the valine residue at positon 4 has been isotopically labelled with carbon-13(5) and nitrogen-15(1).</p>

<p>Synthetic anti-microbial peptide originally identified and isolated form the skin secretions of the midwife toad,-Alytes maurus. Alyteserin-2Mb has 82% homology to alyteserin-2, from the closely related midwife toad-Alytes obstetricans.Alyteserin-2Mb has strong activity against Gram-positive-bacteria such as Staphylococcus aureus and weak activity against gram negative bacteria such as Escherichia coli and fungi such as Candida albicans.</p>

<p>Peptide H-VYLILEYAPLGTVYR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Ac-RKAPNASDFDQW-NH2 is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. Ac-RKAPNASDFDQW-NH2 is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer Ac-RKAPNASDFDQW-NH2 in bulk quantities in addition to our standard pack sizes.Please enquire for more information about Ac-RKAPNASDFDQW-NH2 at the technical inquiry form on this page</p>

<p>An agonist of anti-TNFalpha-induced apoptosis (ATIA) whose function is to provide cells with protection from TNFalpha and hypoxia-induced apoptosis. It has been labelled with tetramethylrhodamine (5-TAMRA).</p>

<p>H-RRRNGYRALMDKSLH-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-RRRNGYRALMDKSLH-OH is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-RRRNGYRALMDKSLH-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-RRRNGYRALMDKSLH-OH at the technical inquiry form on this page</p>

<p>Estradiol-BSA is a product that falls under the category of Life Sciences and Proteins and Antigens. It is a monoclonal antibody that has various applications in the field of research and diagnostics. Estradiol-BSA is commonly used in studies involving adalimumab, dopamine, and other monoclonal antibodies.</p>

<p>Conjugated Propoxyphene-BSA hapten</p>

<p>Peptide LCBiot-LLGIWGC-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>SARS-CoV-2 is an enveloped single-stranded, positive-sense RNA virus. The SARS-CoV-2 nucleocapsid (N) protein is essential for viral RNA replication and new virion assembly. The N protein assembles the positive strand viral genome RNA forming a helical ribonucleocapsid (RNP) during the packaging of the RNA genome. The N protein is also involved in regulating viral RNA synthesis during replication and RNA transcription and modulating metabolism in infected subjects.</p>

<p>Inhibits the epigenetic reader YEATS domain of the Eleven-nineteen leukemia (ENL) protein and perturbs the recruitment of ENL onto chromatin. Induces downregulation of a set of genes that are essential for leukemogenesis and leukaemia maintenance.</p>

<p>Peptide Ac-SNKDRHIDSSC-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>