Agentes antineoplásicos

Nilotinib Related Compound B (25 mg) (Methyl 3-amino-4-methylbenzoate)

Nilotinib Related compound C (25 mg) (3-Amino-4-methylbenzoic acid)

Nilotinib Related Compound A (25 mg) (3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline)

Erlotinib is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of …

Pemetrexed, a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).

Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. Ifosfamide …

Dasatinib is a potent inhibitor of the Bcr-Abl and Src family (IC50s: 0.6, 0.8, 79 …

Erlotinib is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of …

Carboplatin is an organoplatinum compound that possesses antineoplastic activity.

Gefitinib is an EGFR tyrosine kinase inhibitor and can inhibit Tyr1173, Tyr992, Tyr1173 and Tyr992 …

Cisplatin, a DNA-crosslinking agent, is able to suppress DNA synthesis by conforming DNA adducts in …

Sunitinib, a multi-targeted RTK inhibitor, is targeting PDGFRβ and VEGFR2 (Flk-1) with IC50 of 2 …

Clofarabinem, a second generation purine nucleoside analog with antineoplastic activity, inhibits the enzymatic activities of …

Ftorafur is a congener of the antimetabolite fluorouracil with antineoplastic activity. Ftorafur is a prodrug …

Fluorouracil interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells.

Nilotinib is a second-generation Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.

Decitabine is a DNA methyltransferase inhibitor that incorporates into DNA resulting in hypomethylation of DNA …

Fludarabine is a nucleic acid synthesis Inhibitor and a STAT1 activation inhibitor.

Nedaplatin is a derivative of cisplatin and DNA damage agent for tumor colony forming units …

Cytarabine is converted to the triphosphate form within the cell and then competes with cytidine …

Lenalidomide is a potent inhibitor of TNF-α that, at 10 μM, alters gene expression and …

ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch …

Sorafenib is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).

Doxorubicin intercalation between base pairs in the DNA helix, thereby preventing DNA replication. It also …

Lapatinib is a dual inhibitor of Lapatinib is a dual ErbB2/EGFR (IC50: 9.2/10.8 nM) inhibitor

Docetaxel is a microtubule inhibitor that inhibits microtubule disassembly (IC50: 0.2 μM).

Mercaptopurine is an antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis …

Dacarbazine is an antineoplastic agent. It has significant activity against melanomas.

Vorinostat is a pan-inhibitor of Histone Deacetylase with antineoplastic activity (IC50: ~10 nM).

Axitinib is an orally bioavailable tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.7, …

Capecitabine is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As …

N-Desmethyl imatinib is a metabolite of Imatinib, which is a multi-target inhibitor of c-Kit, v-Abl, …

Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50: 60.3 …

Gemcitabine is a DNA synthesis inhibitor that can inhibit the growth of MIAPaCa2, BxPC3 and …

Paclitaxel is a cyclodecane isolated from the bark of the Pacific yew tree. It stabilizes …

Imatinib mesylate is a tyrosine kinase receptor inhibitor with antineoplastic activity (IC50s: 0.6 μM, 0.1 …

Thalidomide is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic …

Pemetrexed is a parenterally administered folate antagonist and antineoplastic agent, used in the treatment of …

Pazopanib, a small molecule inhibitor, inhibits multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib …

Bendamustine hydrochloride (IC50 of 50 μM) is an alkylating agent associated with DNA damage.

Altretamine is an alkylating agent with antineoplastic activity.

Sorafenib is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-4/B-Raf).

Oxaliplatin inhibits DNA synthesis by conforming DNA adducts.

Vincristine binds irreversibly to microtubules (Ki: 85 nM) and spindle proteins in S phase of …

Vinorelbine is a semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents the formation of …

Topotecan hydrochloride is an antineoplastic agent used to treat ovarian cancer.

CG347B is a selective inhibitor of HDAC6.

O-Desmethyl gefitinib inhibits EGFR (IC50: 36 nM in subcellular assays). In human plasma, O-Desmethyl gefitinib …

Mitoxantrone Hydrochloride is the hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. It is …

Dasatinib is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to …

Teniposide, a semisynthetic derivative of podophyllotoxin with antitumor activity, inhibits DNA synthesis by forming a …

Epirubicin hydrochloride is an antineoplastic agent which can inhibit Topoisomerase.

Chlorambucil is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all …

Procarbazine Hydrochloride is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. …

Bosutinib is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl (IC50: …

Sunitinib is an indolinone-based tyrosine kinase inhibitor. It blocks the tyrosine kinase activities of VEGFR2, …

Busulfan is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism …

Daunorubicin hydrochloride, an anthracycline aminoglycoside antineoplastic, inhibits DNA replication and repair and RNA and protein …